| MeSH term | MeSH ID | Detail |
|---|---|---|
| HIV Seropositivity | D006679 | 15 associated lipids |
| Fetal Alcohol Spectrum Disorders | D063647 | 6 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Chondrosarcoma | D002813 | 9 associated lipids |
| Dirofilariasis | D004184 | 3 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Retinopathy of Prematurity | D012178 | 9 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Down Syndrome | D004314 | 18 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Barrow SE et al. | Measurement of prostaglandin D2 and identification of metabolites in human plasma during intravenous infusion. | 1984 | Prostaglandins | pmid:6441188 |
| Bertelé V et al. | Pharmacologic inhibition of thromboxane synthetase and platelet aggregation: modulatory role of cyclooxygenase products. | 1984 | Blood | pmid:6426554 |
| Gresele P et al. | Serum albumin enhances the impairment of platelet aggregation with thromboxane synthase inhibition by increasing the formation of prostaglandin D2. | 1984 | Biochem. Pharmacol. | pmid:6430299 |
| Vicenzi E et al. | Human mononuclear phagocytes from different anatomical sites differ in their capacity to metabolize arachidonic acid. | 1984 | Clin. Exp. Immunol. | pmid:6432383 |
| Nishi S et al. | Different effects of prostaglandin E1, E2 and D2 on pancreatic somatostatin release. | 1984 | Horm. Metab. Res. | pmid:6152434 |
| Neely SM et al. | Mechanism and characteristics of platelet activation by haematin. | 1984 | Br. J. Haematol. | pmid:6383458 |
| Dembinska-Kieć A et al. | Formation of leukotriene C4-like material by rat brain tissue. | 1984 | Eur. J. Pharmacol. | pmid:6426980 |
| Kawamura M and Koshihara Y | Prostaglandin D2 lowers nuclear DNA polymerase activity in cultured mastocytoma cells. | 1984 | Prostaglandins | pmid:6427850 |
| Vincent JE et al. | The effect of 5-(2-chlorobenzyl)-5,6,7,7a-tetrahydro 4H-thieno (3.2-C)-pyridine-2-one hydrochloride (PCR 3787), a metabolite of ticlopidine, on the aggregation of human platelets in vitro and on the aggregation inhibiting action of PGI2 and PGD2. | 1984 | Prostaglandins Leukot Med | pmid:6396655 |
| Weichman BM et al. | SK&F 88046: a unique pharmacologic antagonist of bronchoconstriction induced by leukotriene D4, thromboxane and prostaglandins F2 alpha and D2 in vitro. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6582266 |
| Higashida H et al. | Facilitation of synaptic transmission by prostaglandin D2 at synapses between NG108-15 hybrid and muscle cells. | 1984 | Brain Res. | pmid:6324947 |
| Bertelé V et al. | SQ 22536, an adenylate-cyclase inhibitor, prevents the antiplatelet effect of dazoxiben, a thromboxane-synthetase inhibitor. | 1984 | Thromb. Haemost. | pmid:6326343 |
| Chapnick BM | Divergent influences of leukotrienes C4, D4, and E4 on mesenteric and renal blood flow. | 1984 | Am. J. Physiol. | pmid:6326595 |
| Gardiner PJ and Browne JL | Tussive activity of inhaled PGD2 in the cat and characterisation of the receptor(s) involved. | 1984 | Prostaglandins Leukot Med | pmid:6328541 |
| Zavoico GB and Feinstein MB | Cytoplasmic Ca2+ in platelets is controlled by cyclic AMP: antagonism between stimulators and inhibitors of adenylate cyclase. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329175 |
| Pan IQ et al. | Alteration of platelet responses to metabolites of arachidonic acid by oral contraceptives. | 1984 | Br. J. Haematol. | pmid:6089860 |
| Nilsson J and Olsson AG | Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor. | 1984 | Atherosclerosis | pmid:6093830 |
| Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
| Ikai K et al. | Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice. | 1984 | Prostaglandins | pmid:6435183 |
| Uemura S et al. | Inotropic effects of prostaglandin D2 and E1 on the newborn rabbit heart. | 1984 | Pediatr. Res. | pmid:6596550 |
| Heavey DJ et al. | Effects of intravenous infusions of prostaglandin D2 in man. | 1984 | Prostaglandins | pmid:6596653 |
| Mahmud I et al. | On the identification and biological properties of prostaglandin J2. | 1984 | Prostaglandins Leukot Med | pmid:6597446 |
| Arisawa M et al. | Direct suppressive effect of prostaglandin D2 on growth hormone secretion from rat anterior pituitary. | 1984 | Asia Oceania J Obstet Gynaecol | pmid:6598030 |
| Newman JH and Sheller JR | Arachidonic acid metabolites in the healthy and diseased lung. | 1984 | Am. J. Med. Sci. | pmid:6091454 |
| Ogorochi T et al. | Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain. | 1984 | J. Neurochem. | pmid:6427411 |
| Imashuku S et al. | [Differentiation induction and potentiation of chemotherapy by PGE1 infusion in patients with neuroblastoma--effect of PGE1 on metastatic potential of neuroblastoma]. | 1984 | Gan To Kagaku Ryoho | pmid:6585182 |
| Nakajima M and Toda N | Neuroeffector actions of prostaglandin D2 on isolated dog mesenteric arteries. | 1984 | Prostaglandins | pmid:6587438 |
| Andersen NH and Hartzell CJ | High-field 1H NMR studies of prostaglandin H2 and its decomposition pathways. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6587849 |
| Gal D et al. | Effect of radiation on prostaglandin production by human bowel in vitro. | 1984 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:6588048 |
| Brus R et al. | Effect of prostaglandins on morphine-induced catalepsy in mice. | 1983 Sep-Dec | Acta Physiol Pol | pmid:6679984 |
| Gaetani P et al. | [Prostaglandin D2 in subarachnoid hemorrhage. Biological and diagnostic implications]. | 1983 Jul-Aug | Riv Patol Nerv Ment | pmid:6598516 |
| Ogino N et al. | Phagocytic activity of cultured retinal pigment epithelial cells from chick embryo: inhibition by melatonin and cyclic AMP, and its reversal by taurine and cyclic GMP. | 1983 | Ophthalmic Res. | pmid:6136017 |
| Ruzicka T et al. | Inhibition of rat mast cell arachidonic acid cyclooxygenase by dapsone. | 1983 | J. Allergy Clin. Immunol. | pmid:6413566 |
| Whittle BJ et al. | Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue. | 1983 | Prostaglandins | pmid:6344147 |
| Naclerio RM et al. | Mediator release after nasal airway challenge with allergen. | 1983 | Am. Rev. Respir. Dis. | pmid:6354022 |
| Inoué S | [Sleep substances: their roles and evolution]. | 1983 | Seikagaku | pmid:6355327 |
| Tasaka K et al. | Prostaglandin D2 induces release of luteinizing hormone from the rat pituitary gland without the modulation of hypothalamic luteinizing hormone releasing hormone. | 1983 | J. Endocrinol. | pmid:6361197 |
| Schleimer RP et al. | Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. | 1983 | J. Clin. Invest. | pmid:6134755 |
| Gimeno AL et al. | Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats. | 1983 | Prostaglandins | pmid:6361911 |
| Scott HW et al. | Hazards in operative management of patients with systemic mastocytosis. | 1983 | Ann. Surg. | pmid:6189461 |
| Stringfellow DA | Prostaglandins and metastasis. | 1983 | Symp Fundam Cancer Res | pmid:6206537 |
| Feinstein MB et al. | The cytoplasmic concentration of free calcium in platelets is controlled by stimulators of cyclic AMP production (PGD2, PGE1, forskolin). | 1983 | Biochem. Biophys. Res. Commun. | pmid:6307295 |
| Ruzicka T et al. | Changes in arachidonic acid metabolism in UV-irradiated hairless mouse skin. | 1983 | J. Invest. Dermatol. | pmid:6578273 |
| Soifer SJ et al. | The developmental effects of prostaglandin D2 on the pulmonary and systemic circulations in the newborn lamb. | 1983 | J. Dev. Physiol. | pmid:6579103 |
| Miyake A et al. | Prostaglandin D2 stimulates secretion of luteinizing hormone from pituitary gland in vitro. | 1983 | Acta Endocrinol. | pmid:6579807 |
| Belegu M et al. | beta-Adrenergic blockade of prostaglandin E2- and D2-induced erythroid colony formation. | 1983 | Am. J. Physiol. | pmid:6579847 |
| Lysz TW et al. | Measurement of prostaglandin biosynthetic capacity in discrete areas of the rabbit hippocampal formation. | 1983 | J. Neurosci. Res. | pmid:6580469 |
| Ishizawa M | Contractile effects of PGD2 and PGF2 alpha on mechanical and electrical activities in longitudinal and circular muscles of the guinea-pig colon. | 1983 | Prostaglandins | pmid:6580679 |
| Bregman MD and Meyskens FL | In vitro modulation of human and murine melanoma growth by prostanoid analogues. | 1983 | Prostaglandins | pmid:6581509 |
| Carr BR et al. | Prostaglandin secretion by the neocortex and fetal zones of the human fetal adrenal gland. | 1983 | J. Clin. Endocrinol. Metab. | pmid:6313732 |