| MeSH term | MeSH ID | Detail |
|---|---|---|
| HIV Seropositivity | D006679 | 15 associated lipids |
| Fetal Alcohol Spectrum Disorders | D063647 | 6 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Chondrosarcoma | D002813 | 9 associated lipids |
| Dirofilariasis | D004184 | 3 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Retinopathy of Prematurity | D012178 | 9 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Down Syndrome | D004314 | 18 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Campbell AM et al. | Conjunctival provocation tests with codeine phosphate. Effect of disodium cromoglycate. | 1993 | Ann Allergy | pmid:7687104 |
| Charlesworth EN et al. | Cutaneous late-phase response in food-allergic children and adolescents with atopic dermatitis. | 1993 | Clin. Exp. Allergy | pmid:7687509 |
| al-Laith M and Pearce FL | On the mechanism of action of sodium orthovanadate in inducing histamine release from rat peritoneal mast cells. | 1993 | Int. Arch. Allergy Immunol. | pmid:7689004 |
| Marone G et al. | Mechanisms of activation of human mast cells and basophils by general anesthetic drugs. | 1993 | Ann Fr Anesth Reanim | pmid:7690200 |
| Naclerio RM | Effects of antihistamines on inflammatory mediators. | 1993 | Ann Allergy | pmid:7690526 |
| Kitanaka J et al. | Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes. | 1993 | J. Neurochem. | pmid:8093482 |
| Itabashi S et al. | Late asthmatic response causes peripheral airway hyperresponsiveness in dogs treated with metopirone. | 1993 | Int. Arch. Allergy Immunol. | pmid:8508057 |
| Spitzer JA and Mayer AM | Hepatic neutrophil influx: eicosanoid and superoxide formation in endotoxemia. | 1993 | J. Surg. Res. | pmid:8412083 |
| Baker DG et al. | Cellular and chemical mediators of type 1 hypersensitivity in calves infected with Ostertagia ostertagi: histamine, prostaglandin D2, prostaglandin E2 and leukotriene C4. | 1993 | Int. J. Parasitol. | pmid:8359983 |
| Faili A et al. | Reduction by arachidonic acid of prostaglandin I2-induced cyclic AMP formation. Involvement of prostaglandins E2 and F2 alpha. | 1993 | Biochem. Pharmacol. | pmid:8388209 |
| Huttemeier PC et al. | Microdialysis measurements of PGD2, TXB2 and 6-KETO-PGF1 alpha in rat CA1 hippocampus during transient cerebral ischemia. | 1993 | Prostaglandins | pmid:8430228 |
| Matsuo T and Cynader MS | The EP2 receptor is the predominant prostanoid receptor in the human ciliary muscle. | 1993 | Br J Ophthalmol | pmid:8435410 |
| Nakazawa I et al. | Some features in prostaglandin synthesis of the cancer cells which metastasized into liver from intestinal cancer lesions. | 1993 | Tohoku J. Exp. Med. | pmid:8266326 |
| Koizumi T et al. | Activation of heat shock transcription factors by delta 12-prostaglandin J2 and its inhibition by intracellular glutathione. | 1993 | Biochem. Pharmacol. | pmid:8328983 |
| Furukawa F et al. | Relationship between heat shock protein induction and the binding of antibodies to the extractable nuclear antigens on cultured human keratinocytes. | 1993 | J. Invest. Dermatol. | pmid:8345220 |
| Harada T et al. | Arachidonic acid metabolism by isolated and cultured middle ear epithelial cells from the chinchilla. | 1993 | Eur Arch Otorhinolaryngol | pmid:8369117 |
| Takagi T et al. | Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats. | 1993 | Calcif. Tissue Int. | pmid:8369992 |
| Püschel GP et al. | Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a. | 1993 | Hepatology | pmid:8244278 |
| Neuschäfer-Rube F et al. | Characterization of prostaglandin-F2 alpha-binding sites on rat hepatocyte plasma membranes. | 1993 | Eur. J. Biochem. | pmid:8425526 |
| Hata Y et al. | Primary colonic epithelial cell culture of the rabbit producing prostaglandins. | 1993 | Prostaglandins | pmid:8430223 |
| Jaffar ZH and Pearce FL | Some characteristics of the ATP-induced histamine release from and permeabilization of rat mast cells. | 1993 | Agents Actions | pmid:7511869 |
| Gyenes M and De Groot H | Prostanoid release by Kupffer cells upon hypoxia-reoxygenation: role of pHi and Cai2+. | 1993 | Am. J. Physiol. | pmid:8384798 |
| Twentyman OP et al. | The effect of H1-receptor blockade on the development of early- and late-phase bronchoconstriction and increased bronchial responsiveness in allergen-induced asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8099592 |
| Inase N et al. | Mitogen-inducible prostaglandin G/H synthase is expressed in canine mastocytoma cells. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8217194 |
| Itoh Y et al. | [Inhibitory effects of AA-2414, a thromboxane (Tx) A2 receptor antagonist, on U-46619-, prostaglandin (PG) D2- and 9 alpha, 11 beta PGF2-induced contractions of guinea pig tracheas and isolated human bronchi]. | 1993 | Arerugi | pmid:8279967 |
| Campbell AM et al. | Modulation of eicosanoid and histamine release from human dispersed lung cells by terfenadine. | 1993 | Allergy | pmid:7681268 |
| Maxwell DL et al. | Inhaled nedocromil sodium reduces histamine release from isolated large airway segments of asthmatic subjects in vivo. | 1993 | Eur. Respir. J. | pmid:7693506 |
| Xu L et al. | Effect of culture conditions on mast cell eicosanoid synthesis. | 1993 | Prostaglandins | pmid:8493360 |
| Sinzinger H et al. | Isradipine improves platelet function in hypertensives. | 1992 | Eur. J. Clin. Pharmacol. | pmid:1531796 |
| Ito S et al. | Type-1 and type-2 astrocytes are distinct targets for prostaglandins D2, E2, and F2 alpha. | 1992 | Glia | pmid:1324890 |
| Katz HR et al. | Secretory granule mediator release and generation of oxidative metabolites of arachidonic acid via Fc-IgG receptor bridging in mouse mast cells. | 1992 | J. Immunol. | pmid:1309842 |
| Smith JB et al. | Cyclic AMP does not inhibit collagen-induced platelet signal transduction. | 1992 | Biochem. J. | pmid:1375452 |
| Ikai K et al. | Induction of 72-kD heat shock protein and cytoskeleton damage by cytotoxic prostaglandin delta 12-PGJ2 in transformed human epidermal cells in culture. | 1992 | J. Invest. Dermatol. | pmid:1375619 |
| Yu SM et al. | Dicentrine, a novel antiplatelet agent inhibiting thromboxane formation and increasing the cyclic AMP level of rabbit platelets. | 1992 | Biochem. Pharmacol. | pmid:1310852 |
| Lippton HL et al. | Mechanisms of signal transduction for adenosine and ATP in pulmonary vascular bed. | 1992 | Am. J. Physiol. | pmid:1348400 |
| Crea AE et al. | Mediator concentrations in bronchoalveolar lavage fluid of patients with mild asymptomatic bronchial asthma. | 1992 | Eur. Respir. J. | pmid:1348480 |
| Shin MH et al. | The effect of azelastine on the early allergic response. | 1992 | Clin. Exp. Allergy | pmid:1349259 |
| Molderings G et al. | Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3-subtype. | 1992 | Br. J. Pharmacol. | pmid:1330175 |
| Conti P et al. | Role of lipoxins A4 and B4 in the generation of arachidonic acid metabolites by rat mast cells and their effect on [3H]serotonin release. | 1992 | Immunol. Lett. | pmid:1612634 |
| Björnsson OG et al. | Prostaglandins suppress VLDL secretion in primary rat hepatocyte cultures: relationships to hepatic calcium metabolism. | 1992 | J. Lipid Res. | pmid:1331281 |
| Emery BE et al. | The effect of IL-4 on human nasal mucosal responses. | 1992 | J. Allergy Clin. Immunol. | pmid:1430703 |
| Barrett KE | Effect of histamine and other mast cell mediators on T84 epithelial cells. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456653 |
| Diener M et al. | Characterization of the antisecretory action of prostaglandin D2 in the rat colon. | 1992 | Acta Physiol. Scand. | pmid:1502910 |
| Virgolini I et al. | Characterization of prostaglandin (PG)-binding sites expressed on human basophils. Evidence for a prostaglandin E1, I2, and a D2 receptor. | 1992 | J. Biol. Chem. | pmid:1377673 |
| Watanabe-Kohno S et al. | MCI-826 is a potent and selective antagonist of peptide leukotrienes (p-LTs) and has characteristics distinctive from those of FPL 55712. | 1992 | Jpn. J. Pharmacol. | pmid:1460800 |
| Shimakura S and Boland CR | Eicosanoid production by the human gastric cancer cell line AGS and its relation to cell growth. | 1992 | Cancer Res. | pmid:1551103 |
| Lee DY et al. | Prostaglandin profile and synthetic capacity of the colon: comparison of tissue sources and subcellular fractions. | 1992 | Prostaglandins | pmid:1542741 |
| Picado C et al. | Release of peptide leukotriene into nasal secretions after local instillation of aspirin in aspirin-sensitive asthmatic patients. | 1992 | Am. Rev. Respir. Dis. | pmid:1309968 |
| Kawada N et al. | Possible induction of fatty acid cyclo-oxygenase in lipopolysaccharide-stimulated rat Kupffer cells. | 1992 | Gastroenterology | pmid:1499903 |
| Rangachari PK | Concerning prostaglandin D2: forgotten, promiscuous, capricious. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456655 |