| MeSH term | MeSH ID | Detail |
|---|---|---|
| HIV Seropositivity | D006679 | 15 associated lipids |
| Fetal Alcohol Spectrum Disorders | D063647 | 6 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Chondrosarcoma | D002813 | 9 associated lipids |
| Dirofilariasis | D004184 | 3 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Retinopathy of Prematurity | D012178 | 9 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Down Syndrome | D004314 | 18 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamaguchi K and Hama H | Separation of periventricular dopaminergic and alpha-adrenergic systems from the vasopressin-secreting mechanisms activated by prostaglandin D2. | 1991 | Brain Res. | pmid:1665382 |
| Giles H et al. | A comparative study of the prostanoid receptor profile of 9 alpha 11 beta-prostaglandin F2 and prostaglandin D2. | 1991 | Br. J. Pharmacol. | pmid:1665742 |
| Georgitis JW et al. | Nasal inflammatory mediator release in ragweed allergic rhinitis: correlation with cellular influx into nasal secretions. | 1991 | Int. Arch. Allergy Appl. Immunol. | pmid:1666629 |
| Takayanagi I et al. | Effects of aging on alpha 2-adrenoceptor mechanisms in isolated guinea-pig tracheal preparations. | 1991 | Eur. J. Pharmacol. | pmid:1674919 |
| Goerg KJ et al. | Antisecretory effect of prostaglandin D2 in rat colon in vitro: action sites. | 1991 | Am. J. Physiol. | pmid:1676243 |
| Fox CC et al. | Modulation of mediator release from human intestinal mast cells by sulfasalazine and 5-aminosalicylic acid. | 1991 | Dig. Dis. Sci. | pmid:1703070 |
| Massey WA et al. | Profile of prostanoid release following antigen challenge in vivo in the skin of man. | 1991 | Br. J. Dermatol. | pmid:1760357 |
| Watanabe T et al. | Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01s. | 1991 | Blood | pmid:1718495 |
| Minc-Golomb D et al. | Gene dosage of CuZnSOD and Down's syndrome: diminished prostaglandin synthesis in human trisomy 21, transfected cells and transgenic mice. | 1991 | EMBO J. | pmid:1829676 |
| Fukushima M | [Prostaglandins and cell proliferation]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024021 |
| Morii H and Watanabe Y | Solubilization of prostaglandin D2 binding protein from porcine temporal cortex. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1989614 |
| Dore-Duffy P et al. | Cerebrospinal fluid eicosanoid levels: endogenous PGD2 and LTC4 synthesis by antigen-presenting cells that migrate to the central nervous system. | 1991 | Neurology | pmid:1992386 |
| Walmrath D et al. | Intravascular anti-IgE challenge in perfused lungs: mediator release and vascular pressor response. | 1991 | J. Appl. Physiol. | pmid:1723406 |
| Francis HP et al. | BAY u3405 an antagonist of thromboxane A2- and prostaglandin D2-induced bronchoconstriction in the guinea-pig. | 1991 | Br. J. Pharmacol. | pmid:1797323 |
| Jongejan R et al. | Effect of epithelial denudation, inflammatory mediators and mast cell activation on the sensitivity of isolated human airways to methacholine. | 1991 | Eur. J. Pharmacol. | pmid:1800116 |
| Raphael GD et al. | The pathophysiology of rhinitis. V. Sources of protein in allergen-induced nasal secretions. | 1991 | J. Allergy Clin. Immunol. | pmid:1712803 |
| Massey WA et al. | Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology. | 1991 | J. Immunol. | pmid:1715365 |
| Butchers PR et al. | Salmeterol: a potent and long-acting inhibitor of inflammatory mediator release from human lung. | 1991 | Br. J. Pharmacol. | pmid:1724629 |
| Misawa M and Kanai Y | Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs. | 1991 | Arzneimittelforschung | pmid:1725697 |
| Abman SH and Accurso FJ | Sustained fetal pulmonary vasodilation with prolonged atrial natriuretic factor and GMP infusions. | 1991 | Am. J. Physiol. | pmid:1847014 |
| Sladek K et al. | Formation of PGD2 after allergen inhalation in atopic asthmatics. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1847781 |
| King LS et al. | Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation. | 1991 | Circ. Res. | pmid:1825033 |
| Arzubiaga C et al. | Neuropeptide Y, a putative cotransmitter in noradrenergic neurons, induces mast cell degranulation but not prostaglandin D2 release. | 1991 | J. Allergy Clin. Immunol. | pmid:1825102 |
| Koshihara Y et al. | Prostaglandin D2 stimulates calcification by human osteoblastic cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825424 |
| Atsmon J et al. | Modulation of the antiproliferative activity of 9-deoxy-delta 9,delta 12(E)-PGD2 by conjugation with intracellular glutathione. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825432 |
| Koizumi K et al. | Induction of 31,000 protein by PGD2-treated vascular endothelial cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825433 |
| Morrow JD et al. | A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825560 |
| Howarth P et al. | The comparative nasal effects of prostaglandin D2 in normal and rhinitic subjects. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825579 |
| Gundel RH et al. | The effects of a 5-lipoxygenase inhibitor on antigen-induced mediator release, late-phase bronchoconstriction and cellular infiltrates in primates. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825582 |
| Watanabe K et al. | The structure and function of prostaglandin F synthase. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825592 |
| Gebicke-Haerter PJ et al. | Regulation and glucocorticoid-independent induction of lipocortin I in cultured astrocytes. | 1991 | J. Neurochem. | pmid:1828830 |
| Francis HP et al. | The thromboxane receptor antagonist BAY u3405 reverses prostaglandin D2 (PGD2)-induced bronchoconstriction in the anaesthetised guinea pig. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1835329 |
| Murakami M et al. | Eicosanoid generation from antigen-primed mast cells by extracellular mammalian 14-kDa group II phospholipase A2. | 1991 | FEBS Lett. | pmid:1756867 |
| McMahon TJ et al. | Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed. | 1991 | J. Appl. Physiol. | pmid:1837015 |
| D'Onofrio C et al. | The antiproliferative effect of prostaglandin A and J on HTLV-I transformed cells is associated with induction of a heat-shock protein. | 1990 Sep-Oct | Pharmacol. Res. | pmid:2284244 |
| Khan SH and Sorof S | Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2251282 |
| Nishimura G | [Antitumor activity and cell cycle effects of delta 12-PGJ2 in vivo]. | 1990 | Nihon Gan Chiryo Gakkai Shi | pmid:2351856 |
| Ford WD et al. | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. | 1990 | J. Pediatr. Surg. | pmid:2352080 |
| Okumura T and Saito K | Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver. | 1990 | Prostaglandins | pmid:2353117 |
| Perreault T et al. | Pulmonary vascular effects of prostaglandin D2 in newborn pig. | 1990 | Am. J. Physiol. | pmid:2337164 |
| Ingenito EP et al. | Bronchoalveolar lavage cell and mediator responses to hyperpnea-induced bronchoconstriction in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2339838 |
| Vigano' T et al. | Binding sites for histamine and sulfidopeptide leukotrienes in normal and hypersensitized human lung fragments. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2144691 |
| Fukushima M | Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved. | 1990 | Eicosanoids | pmid:2073399 |
| Inoue M et al. | Interactions between the brain renin-angiotensin system and brain prostanoids in the control of vasopressin secretion. | 1990 | Exp Brain Res | pmid:2073934 |
| Bennegård B et al. | Luteotropic effects of prostaglandins I2 and D2 on isolated human corpora luteum. | 1990 | Fertil. Steril. | pmid:2168845 |
| Bettazzoli L et al. | Incorporation of arachidonic acid into glycerophospholipids of a murine bone marrow derived mast cell. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2169185 |
| Brass EP and Garrity MJ | Structural specificity for prostaglandin effects on hepatocyte glycogenolysis. | 1990 | Biochem. J. | pmid:2158311 |
| Virgolini I et al. | Effects of bopindolol on platelet function in hypertension at rest and during exercise. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2143586 |
| Nakahata N et al. | PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells. | 1990 | Prostaglandins | pmid:2177901 |
| Massey WA and Lichtenstein LM | The effects of antihistamines beyond H1 antagonism in allergic inflammation. | 1990 | J. Allergy Clin. Immunol. | pmid:1979797 |