| MeSH term | MeSH ID | Detail |
|---|---|---|
| HIV Seropositivity | D006679 | 15 associated lipids |
| Fetal Alcohol Spectrum Disorders | D063647 | 6 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Chondrosarcoma | D002813 | 9 associated lipids |
| Dirofilariasis | D004184 | 3 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Retinopathy of Prematurity | D012178 | 9 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Down Syndrome | D004314 | 18 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ito S et al. | Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. | 1990 | Br. J. Pharmacol. | pmid:2158830 |
| Saitoh O et al. | Effect of amogastrin on the release of various prostaglandins into gastric lumen in man. | 1989 Mar-Apr | Jpn. J. Med. | pmid:2733241 |
| Tejedor M et al. | Potentiation of radiation toxicity in C-6 glioma cells by prostaglandin D2. | 1989 Jul-Aug | Anticancer Res. | pmid:2817802 |
| Black PN et al. | Effect of inhaled leukotriene B4 alone and in combination with prostaglandin D2 on bronchial responsiveness to histamine in normal subjects. | 1989 | Thorax | pmid:2548300 |
| Rossi AG and O'Flaherty JT | Prostaglandin binding sites in human polymorphonuclear neutrophils. | 1989 | Prostaglandins | pmid:2549574 |
| Kuiper J et al. | Induction of ornithine decarboxylase in rat liver by phorbol ester is mediated by prostanoids from Kupffer cells. | 1989 | J. Biol. Chem. | pmid:2708347 |
| Ishikawa H et al. | [Changes of protein and RNA content in accumulated G1 cells by delta12-PGJ2]. | 1989 | Gan To Kagaku Ryoho | pmid:2930205 |
| Koshihara Y and Kawamura M | Prostaglandin D2 stimulates calcification of human osteoblastic cells. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2930558 |
| Ohuchi K et al. | Stimulation of histamine release and arachidonic acid metabolism in rat peritoneal mast cells by thapsigargin, a non-TPA-type tumor promoter. | 1989 | Biochim. Biophys. Acta | pmid:2469475 |
| Ikai K et al. | Inhibitory effect of tranilast on prostaglandin D synthetase. | 1989 | Biochem. Pharmacol. | pmid:2475113 |
| Shram SI et al. | [Preparation and properties of prostaglandin D2 labelled with tritium with high molar radioactivity]. | 1989 | Bioorg. Khim. | pmid:2590255 |
| Yamada K | [The effect of prostaglandin D2 on rat testicular testosterone levels]. | 1989 | Nihon Naibunpi Gakkai Zasshi | pmid:2591605 |
| Goto H et al. | The role of prostaglandin D2 in the genesis of indomethacin-induced gastric lesions in rats. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595317 |
| Woodward DF et al. | Marked differential effects of prostanoid metabolites on rabbit intraocular pressure. | 1989 | Ophthalmic Res. | pmid:2626239 |
| Busshardt E et al. | Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A. | 1989 | Biochim. Biophys. Acta | pmid:2563228 |
| Nishino S et al. | Salivary prostaglandin concentrations: possible state indicators for major depression. | 1989 | Am J Psychiatry | pmid:2627202 |
| Triggiani M et al. | Inhibition of histamine and prostaglandin D2 release from human lung mast cells by ciclosporin A. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468619 |
| Charlesworth EN et al. | Cells and secretagogues involved in the human late-phase response. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468620 |
| Church MK et al. | Interaction of neuropeptides with human mast cells. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468622 |
| Charlesworth EN et al. | Cutaneous late-phase response to allergen. Mediator release and inflammatory cell infiltration. | 1989 | J. Clin. Invest. | pmid:2468688 |
| Charlesworth EN et al. | Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction. | 1989 | J. Allergy Clin. Immunol. | pmid:2469708 |
| Church MK et al. | Mast cells, neuropeptides and inflammation. | 1989 | Agents Actions | pmid:2473641 |
| Robinson C et al. | The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways. | 1989 | Biochem. Pharmacol. | pmid:2818626 |
| van Overveld FJ | Mediator release from human lung mast cell subtypes in chronic bronchitis and emphysema. | 1989 | Agents Actions | pmid:2473645 |
| Benyon RC et al. | Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli. | 1989 | Br. J. Pharmacol. | pmid:2474353 |
| Emery DL et al. | Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea. | 1989 | J. Appl. Physiol. | pmid:2793725 |
| Dubertret L et al. | Biological and cellular responses to grass pollen in sensitive patients. | 1989 | Dermatologica | pmid:2476344 |
| Wachs M et al. | Observations on the pathogenesis of nasal priming. | 1989 | J. Allergy Clin. Immunol. | pmid:2477429 |
| Yoshimura S et al. | Prostaglandin D2 receptor of mastocytoma P-815 cells--possible regulation by phosphorylation and dephosphorylation. | 1989 | Biochim. Biophys. Acta | pmid:2497784 |
| Ikai K et al. | Prostaglandin D2, a mediator in both immediate and delayed-type immune reactions in the skin. | 1989 | Dermatologica | pmid:2506083 |
| Hatanaka M et al. | Late-phase accumulation of inositol phosphates stimulated by prostaglandins D2 and F2 alpha in neuroblastoma x glioma hybrid NG108-15 cells. | 1989 | J. Neurochem. | pmid:2507741 |
| Urade Y et al. | The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. | 1989 | J. Immunol. | pmid:2509561 |
| Lapointe DS and Olson MS | Platelet-activating factor-stimulated hepatic glycogenolysis is not mediated through cyclooxygenase-derived metabolites of arachidonic acid. | 1989 | J. Biol. Chem. | pmid:2501299 |
| Robinson C et al. | The IgE- and calcium-dependent release of eicosanoids and histamine from human purified cutaneous mast cells. | 1989 | J. Invest. Dermatol. | pmid:2504819 |
| Asbóth G et al. | The relation between thromboxane and prostaglandin synthesis in human decidua tissue: a comparison of eicosanoid synthesis in minced tissue with that in a cell-free preparation. | 1989 | Biochim. Biophys. Acta | pmid:2493805 |
| Sugama K et al. | Stimulation of cAMP formation by prostaglandin D2 in primary cultures of bovine adrenal medullary cells: identification of the responsive population as fibroblasts. | 1989 | Biochim. Biophys. Acta | pmid:2538150 |
| Beasley RC et al. | Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction. | 1989 | J. Appl. Physiol. | pmid:2525122 |
| Hayaishi O | Prostaglandin D2 and sleep. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526481 |
| Watanabe Y et al. | Positron emission tomography studies using [11C]ester of prostaglandin D2. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526503 |
| Fukushima M et al. | Prostaglandin A and J: antitumor and antiviral prostaglandins. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526507 |
| Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526554 |
| Froissart P et al. | Modulation by phorbol 12-myristate 13-acetate of arachidonic acid release from rat basophilic leukemia cells stimulated with A23187. | 1989 | Biochim. Biophys. Acta | pmid:2496761 |
| Watanabe K | [Structure and function of prostaglandin F synthetase]. | 1989 | Seikagaku | pmid:2693551 |
| Preclik G et al. | Alimentary tract and pancreas. Stimulation of mucosal prostaglandin synthesis in human stomach and duodenum by antacid treatment. | 1989 | Gut | pmid:2703138 |
| Napier FE and Temple DM | The influence of xanthines on the contractile responses of PGF2 alpha and PGD2 in human parenchymal strips. | 1989 | Prostaglandins | pmid:2772222 |
| Dieter P et al. | 4-Bromophenacyl bromide inhibits prostaglandin D2 synthesis from arachidonic acid rather than phospholipase A2 activity in liver macrophages. | 1989 | Biol. Chem. Hoppe-Seyler | pmid:2775481 |
| Keenan CM and Rangachari PK | Eicosanoid interactions in the canine proximal colon. | 1989 | Am. J. Physiol. | pmid:2539737 |
| Hayaishi O | Prostaglandin D2 and sleep. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2774407 |
| Deckers IA et al. | Evidence for the involvement of prostaglandins in modulation of acetylcholine release from canine bronchial tissue. | 1989 | Eur. J. Pharmacol. | pmid:2806380 |
| Kuiper J et al. | Cellular communication inside the liver. Binding, conversion and metabolic effect of prostaglandin D2 on parenchymal liver cells. | 1989 | Biochem. J. | pmid:2818563 |