| MeSH term | MeSH ID | Detail |
|---|---|---|
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Gastrointestinal Hemorrhage | D006471 | 27 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Drug Eruptions | D003875 | 30 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Siegl AM and Daly JW | Receptor (norepinephrine), P-site (2',5'-dideoxyadenosine), and calcium-mediated inhibition of prostaglandin and forskolin-activated cyclic AMP-generating systems in human platelets. | 1985 | J Cyclic Nucleotide Protein Phosphor Res | pmid:2991349 |
| Hall TJ et al. | Decreased natural killer cell activity in atopic eczema. | 1985 | Immunology | pmid:3876984 |
| Förstermann U et al. | Studies on the mechanism of central cardiovascular and temperature responses to prostaglandin D2. | 1985 | Prostaglandins Leukot Med | pmid:2991946 |
| Hamid S and Whittle BJ | Interaction of prostaglandin D2 with prostacyclin, carbacyclin and the hydantoin prostaglandin, BW245C, in guinea-pig platelets. | 1985 | Br. J. Pharmacol. | pmid:2992652 |
| Narumiya S and Toda N | Different responsiveness of prostaglandin D2-sensitive systems to prostaglandin D2 and its analogues. | 1985 | Br. J. Pharmacol. | pmid:2992661 |
| Bertelé V et al. | Refractoriness of platelets to prostaglandins after infusion in rabbits. | 1985 | J. Lab. Clin. Med. | pmid:2997353 |
| Watanabe K et al. | Biosynthesis of prostaglandin F2 alpha from prostaglandins H2 and D2 by an apparently homogeneous enzyme. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936081 |
| Liston TE et al. | Prostaglandin D2 is metabolized in humans to 9 alpha,11 beta-prostaglandin F2, a novel biologically active prostaglandin. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936123 |
| Toda N et al. | Neuroeffector actions of prostaglandins on isolated arteries. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936153 |
| Ueno R et al. | Prostaglandin D2: a cerebral sleep-regulating substance in rats. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936173 |
| Robin JL et al. | Regulation of mediator release from mouse bone marrow-derived mast cells by glucocorticoids. | 1985 | J. Immunol. | pmid:3161947 |
| Baud L et al. | Lipoxygenase products mediate the attachment of rat macrophages to glomeruli in vitro. | 1985 | Kidney Int. | pmid:3927056 |
| Abbate R et al. | Decreased number of PGD2 binding sites on platelets from patients with type IIa hyperlipoproteinemia. | 1985 | Atherosclerosis | pmid:3857047 |
| Watanabe K et al. | Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung. | 1985 | J. Biol. Chem. | pmid:3858278 |
| Gause GE et al. | Hemodynamic effects of postpulmonary administration of prostaglandin D2 in fetal animals. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:3858885 |
| Seregi A et al. | The formation and regional distribution of prostaglandins D2 and F2 alpha in the brain of spontaneously convulsing gerbils. | 1985 | Brain Res. | pmid:3859353 |
| Ikai K et al. | Effect of ultraviolet irradiation on mast cell-deficient W/Wv mice. | 1985 | J. Invest. Dermatol. | pmid:3859552 |
| Arisawa M et al. | Suppressive effect of prostaglandin D2 on prolactin secretion from rat anterior pituitary. | 1985 | Asia Oceania J Obstet Gynaecol | pmid:3860198 |
| Spannhake EW et al. | Influence of mediators of anaphylaxis on collateral ventilation and the lung periphery of the dog. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3860642 |
| Liston TE and Roberts LJ | Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3862115 |
| Tanaka H et al. | The effects of PGD2 and 9-deoxy-delta 9-PGD2 on colony formation of murine osteosarcoma cells. | 1985 | Prostaglandins | pmid:3863195 |
| Liston TE and Roberts LJ | Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. | 1985 | J. Biol. Chem. | pmid:3863815 |
| Roberts LJ and Sweetman BJ | Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. | 1985 | Prostaglandins | pmid:3864190 |
| Mendieta CF et al. | Biosynthesis of prostaglandins in gingiva of patients with chronic periodontitis. | 1985 | J. Periodontol. | pmid:3919173 |
| Bhattacharya SK and Parmar SS | Prostaglandin D2-induced potentiation of hexobarbitone hypnosis in rats: role of 5-hydroxytryptamine. | 1985 | J. Pharm. Pharmacol. | pmid:2868104 |
| Whittle BJ et al. | Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:2871707 |
| Gay SW and Kosher RA | Prostaglandin synthesis during the course of limb cartilage differentiation in vitro. | 1985 | J Embryol Exp Morphol | pmid:3867724 |
| Shimatsu A et al. | Prostaglandin D2 stimulates vasoactive intestinal polypeptide release into rat hypophysial portal blood. | 1984 Mar-Apr | Peptides | pmid:6591147 |
| Rao PS et al. | Prostaglandin D2 in canine endotoxic shock. Hemodynamic, hematologic, biochemical, and blood gas analyses. | 1984 | Am. J. Obstet. Gynecol. | pmid:6424477 |
| Schick B et al. | Activation of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1984 | J. Immunol. | pmid:6425408 |
| Dembinska-Kieć A et al. | Formation of leukotriene C4-like material by rat brain tissue. | 1984 | Eur. J. Pharmacol. | pmid:6426980 |
| Kawamura M and Koshihara Y | Prostaglandin D2 lowers nuclear DNA polymerase activity in cultured mastocytoma cells. | 1984 | Prostaglandins | pmid:6427850 |
| Vincent JE et al. | The effect of 5-(2-chlorobenzyl)-5,6,7,7a-tetrahydro 4H-thieno (3.2-C)-pyridine-2-one hydrochloride (PCR 3787), a metabolite of ticlopidine, on the aggregation of human platelets in vitro and on the aggregation inhibiting action of PGI2 and PGD2. | 1984 | Prostaglandins Leukot Med | pmid:6396655 |
| Higashida H et al. | Facilitation of synaptic transmission by prostaglandin D2 at synapses between NG108-15 hybrid and muscle cells. | 1984 | Brain Res. | pmid:6324947 |
| Bertelé V et al. | SQ 22536, an adenylate-cyclase inhibitor, prevents the antiplatelet effect of dazoxiben, a thromboxane-synthetase inhibitor. | 1984 | Thromb. Haemost. | pmid:6326343 |
| Chapnick BM | Divergent influences of leukotrienes C4, D4, and E4 on mesenteric and renal blood flow. | 1984 | Am. J. Physiol. | pmid:6326595 |
| Gardiner PJ and Browne JL | Tussive activity of inhaled PGD2 in the cat and characterisation of the receptor(s) involved. | 1984 | Prostaglandins Leukot Med | pmid:6328541 |
| Zavoico GB and Feinstein MB | Cytoplasmic Ca2+ in platelets is controlled by cyclic AMP: antagonism between stimulators and inhibitors of adenylate cyclase. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329175 |
| Ennis M et al. | Prostaglandin and histamine release from stimulated rat peritoneal mast cells. | 1984 | Agents Actions | pmid:6203356 |
| Inoué S et al. | Little sleep-promoting effect of three sleep substances diurnally infused in unrestrained rats. | 1984 | Neurosci. Lett. | pmid:6593603 |
| Marsden KA et al. | The effect of prostaglandin D2 (PGD2) on circulating eosinophils. | 1984 | Prostaglandins Leukot Med | pmid:6593748 |
| Uemura S et al. | Inotropic effects of prostaglandin D2 and E1 on the newborn rabbit heart. | 1984 | Pediatr. Res. | pmid:6596550 |
| Heavey DJ et al. | Effects of intravenous infusions of prostaglandin D2 in man. | 1984 | Prostaglandins | pmid:6596653 |
| Mahmud I et al. | On the identification and biological properties of prostaglandin J2. | 1984 | Prostaglandins Leukot Med | pmid:6597446 |
| Arisawa M et al. | Direct suppressive effect of prostaglandin D2 on growth hormone secretion from rat anterior pituitary. | 1984 | Asia Oceania J Obstet Gynaecol | pmid:6598030 |
| Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human malignant tumor cells. | 1984 | Prostaglandins | pmid:6584941 |
| Imashuku S et al. | [Differentiation induction and potentiation of chemotherapy by PGE1 infusion in patients with neuroblastoma--effect of PGE1 on metastatic potential of neuroblastoma]. | 1984 | Gan To Kagaku Ryoho | pmid:6585182 |
| Nakajima M and Toda N | Neuroeffector actions of prostaglandin D2 on isolated dog mesenteric arteries. | 1984 | Prostaglandins | pmid:6587438 |
| Andersen NH and Hartzell CJ | High-field 1H NMR studies of prostaglandin H2 and its decomposition pathways. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6587849 |
| Gal D et al. | Effect of radiation on prostaglandin production by human bowel in vitro. | 1984 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:6588048 |