Wang Y et al. |
Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism. |
2012 |
Bioorg. Med. Chem. Lett. |
pmid:22119474
|
Alba G et al. |
Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils. |
2012 |
PLoS ONE |
pmid:23115616
|
Hossain MS et al. |
Stable expression of lipocalin-type prostaglandin D synthase in cultured preadipocytes impairs adipogenesis program independently of endogenous prostanoids. |
2012 |
Exp. Cell Res. |
pmid:22100987
|
Pettipher R et al. |
Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. |
2012 |
J. Pharmacol. Exp. Ther. |
pmid:22106101
|
Bain G et al. |
Pharmacodynamics, pharmacokinetics, and safety of AM211: a novel and potent antagonist of the prostaglandin D2 receptor type 2. |
2012 |
J Clin Pharmacol |
pmid:22110163
|
Gates D et al. |
Apo J/clusterin expression and secretion: evidence for 15-deoxy-Δ(12,14)-PGJ(2)-dependent mechanism. |
2012 |
Biochim. Biophys. Acta |
pmid:22138303
|
Ruiz M et al. |
A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. |
2012 |
PLoS ONE |
pmid:23056435
|
Ravindra KC et al. |
Targeting of histone acetyltransferase p300 by cyclopentenone prostaglandin Δ(12)-PGJ(2) through covalent binding to Cys(1438). |
2012 |
Chem. Res. Toxicol. |
pmid:22141352
|
Maurer M and Church MK |
Inflammatory skin responses induced by icatibant injection are mast cell mediated and attenuated by H(1)-antihistamines. |
2012 |
Exp. Dermatol. |
pmid:22142018
|
Fujimori K et al. |
Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase. |
2012 |
J. Neurochem. |
pmid:22043816
|
Bardelli C et al. |
Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPARγ ligands. |
2012 |
Br. J. Pharmacol. |
pmid:21745193
|
Kanakasabai S et al. |
PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes. |
2012 |
PLoS ONE |
pmid:23185633
|
Kaneko K et al. |
Novel orexigenic pathway prostaglandin D2-NPY system--involvement in orally active orexigenic δ opioid peptide. |
2012 |
Neuropeptides |
pmid:23141054
|
Higuchi S et al. |
Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury. |
2012 |
J Appl Toxicol |
pmid:21735453
|
Pasvanis S et al. |
High sodium butyrate levels induce MDR1 activation in colorectal cells: Impact of 15-deoxy-Δ(12,14)-prostaglandin J(2) on the resistance to saquinavir. |
2012 |
Biochem. Biophys. Res. Commun. |
pmid:22293191
|
Li X et al. |
Natural vanadium-containing Jeju groundwater inhibits immunoglobulin E-mediated anaphylactic reaction and suppresses eicosanoid generation and degranulation in bone marrow derived-mast cells. |
2012 |
Biol. Pharm. Bull. |
pmid:22293352
|
Springstead JR et al. |
Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function. |
2012 |
J. Lipid Res. |
pmid:22550136
|
Hossain MS et al. |
Prostaglandin J2 series induces the gene expression of monocyte chemoattractant protein-1 during the maturation phase of cultured adipocytes. |
2012 |
Gene |
pmid:22561694
|
Oda A et al. |
Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic-like activity. |
2012 |
J. Neurochem. |
pmid:22564055
|
Clemente-Napimoga JT et al. |
15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. |
2012 |
Life Sci. |
pmid:22564409
|
Inceoglu AB et al. |
Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice. |
2012 |
J. Cardiovasc. Pharmacol. |
pmid:22526297
|
Higashi N et al. |
Aspirin-intolerant asthma (AIA) assessment using the urinary biomarkers, leukotriene E4 (LTE4) and prostaglandin D2 (PGD2) metabolites. |
2012 |
Allergol Int |
pmid:22627848
|
Kristensen DM et al. |
Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis. |
2012 |
Int. J. Androl. |
pmid:22612476
|
Fredman G et al. |
Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. |
2012 |
Sci Rep |
pmid:22957142
|
Matzkin ME et al. |
Exploring the cyclooxygenase 2 (COX2)/15d-Δ(12,14)PGJ(2) system in hamster Sertoli cells: regulation by FSH/testosterone and relevance to glucose uptake. |
2012 |
Gen. Comp. Endocrinol. |
pmid:22974512
|
Myeku N et al. |
cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons. |
2012 |
Neurosci. Lett. |
pmid:22982149
|
Mechiche H et al. |
Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes. |
2012 |
PLoS ONE |
pmid:22984630
|
Shim J et al. |
Change in prostaglandin expression levels and synthesizing activities in dry eye disease. |
2012 |
Ophthalmology |
pmid:22858125
|
Chae HS et al. |
Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells. |
2012 |
Immunopharmacol Immunotoxicol |
pmid:22229445
|
Nakahigashi K et al. |
PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis. |
2012 |
J. Allergy Clin. Immunol. |
pmid:22206772
|
Lu Y et al. |
Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells. |
2012 |
Food Chem. Toxicol. |
pmid:22154852
|
Hewson CA et al. |
Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma. |
2012 |
J. Pharmacol. Exp. Ther. |
pmid:22160268
|
Mantel A et al. |
Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. |
2012 |
J. Invest. Dermatol. |
pmid:22170488
|
Farnesi-de-Assunção TS et al. |
PPAR-γ agonists, mainly 15d-PGJ(2), reduce eosinophil recruitment following allergen challenge. |
2012 |
Cell. Immunol. |
pmid:22192475
|
Kuriyan AE et al. |
Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring. |
2012 |
Exp. Eye Res. |
pmid:22178289
|
Yang K et al. |
[Changes of prostaglandin D2,carboxypeptidase A3 and platelet activating factor in guinea pig in anaphylactic shock]. |
2012 |
Fa Yi Xue Za Zhi |
pmid:22812216
|
Sykes L et al. |
Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2. |
2012 |
Mediators Inflamm. |
pmid:22690041
|
Raman P et al. |
15-Deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor γ ligand, modulates nuclear factor of activated T cells. |
2012 |
J. Pharmacol. Exp. Ther. |
pmid:22700433
|
Cao DS et al. |
Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. |
2012 |
PLoS ONE |
pmid:22701540
|
Yue L et al. |
Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway. |
2012 |
Bone |
pmid:22705147
|
Napimoga MH et al. |
Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. |
2012 |
J. Immunol. |
pmid:22706081
|
Qiu H et al. |
Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia. |
2012 |
Cardiovasc. Res. |
pmid:22707158
|
Luyer MD |
Enteric neuroprotection. |
2012 |
J. Physiol. (Lond.) |
pmid:22707588
|
Nagata N and Urade Y |
[Sleep-wake regulation by prostaglandin D2 and adenosine]. |
2012 |
Brain Nerve |
pmid:22647469
|
Fujimori K et al. |
Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways. |
2012 |
Gene |
pmid:22664386
|
Cebola I and Peinado MA |
Epigenetic deregulation of the COX pathway in cancer. |
2012 |
Prog. Lipid Res. |
pmid:22580191
|
Liu X et al. |
15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines. |
2012 |
Eur. J. Cell Biol. |
pmid:22560326
|
Gross-Sondej I et al. |
[Measurement of bronchoconstrictive eicosanoids in chronic obstructive pulmonary disease]. |
2012 |
Pneumonol Alergol Pol |
pmid:22370980
|
Han Z et al. |
15-deoxy-Δ12,14 -prostaglandin J2 reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury in mice. |
2012 |
Hepatology |
pmid:22371273
|
Syeda PK et al. |
Generation of monoclonal antibody for 15-deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚ and development of enzyme-linked immunosorbent assay for its quantification in culture medium of adipocytes. |
2012 |
Appl. Biochem. Biotechnol. |
pmid:22391692
|
Quinteiro MS et al. |
The indirect antinociceptive mechanism of 15d-PGJ2 on rheumatoid arthritis-induced TMJ inflammatory pain in rats. |
2012 |
Eur J Pain |
pmid:22354681
|
Neri T et al. |
Role of NF-kappaB and PPAR-gamma in lung inflammation induced by monocyte-derived microparticles. |
2011 |
Eur. Respir. J. |
pmid:21148223
|
Kumar VB et al. |
Angiogenic effect of laminin involves modulation of cyclooxygenase-2 and prostaglandin levels. |
2011 |
Exp. Biol. Med. (Maywood) |
pmid:21148739
|
Higuchi S et al. |
IL-4 mediates dicloxacillin-induced liver injury in mice. |
2011 |
Toxicol. Lett. |
pmid:21094227
|
Afrin LB |
Polycythemia from mast cell activation syndrome: lessons learned. |
2011 |
Am. J. Med. Sci. |
pmid:21642812
|
Kajiwara D et al. |
Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis. |
2011 |
Eur. J. Pharmacol. |
pmid:21645503
|
Erttmann SF et al. |
PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2. |
2011 |
Free Radic. Biol. Med. |
pmid:21651978
|
Chiba T et al. |
The opposing role of two prostaglandin D2 receptors, DP and CRTH2, in human eosinophil migration. |
2011 |
Ann. Allergy Asthma Immunol. |
pmid:21624751
|
Liu TY et al. |
[Advances in the study of histaminergic systems and sleep-wake regulation]. |
2011 |
Yao Xue Xue Bao |
pmid:21626776
|
Zhang Y et al. |
Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers. |
2011 |
J Mass Spectrom |
pmid:21706677
|
Ugajin T et al. |
FcεRI, but not FcγR, signals induce prostaglandin D2 and E2 production from basophils. |
2011 |
Am. J. Pathol. |
pmid:21712025
|
Tobiasova Z et al. |
Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells. |
2011 |
Circulation |
pmid:21690493
|
Menon R et al. |
Amniotic fluid eicosanoids in preterm and term births: effects of risk factors for spontaneous preterm labor. |
2011 |
Obstet Gynecol |
pmid:21691170
|
Chowdhury AA et al. |
15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes. |
2011 |
Prostaglandins Other Lipid Mediat. |
pmid:21699992
|
Ebersberger A et al. |
Effects of prostaglandin D2 on tetrodotoxin-resistant Na+ currents in DRG neurons of adult rat. |
2011 |
Pain |
pmid:21345590
|
Farhat A et al. |
Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology. |
2011 |
J Ovarian Res |
pmid:21352547
|
Luker T et al. |
Zwitterionic CRTh2 antagonists. |
2011 |
J. Med. Chem. |
pmid:21355602
|
Flachs P et al. |
Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. |
2011 |
Diabetologia |
pmid:21779874
|
Raman P et al. |
15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. |
2011 |
Mol. Pharmacol. |
pmid:21511917
|
Lin TH et al. |
15-deoxy-Δ(12,14) -prostaglandin-J2 and ciglitazone inhibit TNF-α-induced matrix metalloproteinase 13 production via the antagonism of NF-κB activation in human synovial fibroblasts. |
2011 |
J. Cell. Physiol. |
pmid:21344384
|
Lalier L et al. |
Prostaglandins antagonistically control Bax activation during apoptosis. |
2011 |
Cell Death Differ. |
pmid:20966963
|
Hernandez JM and Janssen LJ |
Thromboxane prostanoid receptor activation amplifies airway stretch-activated contractions assessed in perfused intact bovine bronchial segments. |
2011 |
J. Pharmacol. Exp. Ther. |
pmid:21768224
|
Sharma I et al. |
In vitro effects of peroxisome proliferator-activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells. |
2011 |
Fertil. Steril. |
pmid:20970133
|
Tanaka A et al. |
Mast cells function as an alternative modulator of adipogenesis through 15-deoxy-delta-12, 14-prostaglandin J2. |
2011 |
Am. J. Physiol., Cell Physiol. |
pmid:21865589
|
Larsson AK et al. |
Prostaglandin Dâ‚‚ induces contractions through activation of TP receptors in peripheral lung tissue from the guinea pig. |
2011 |
Eur. J. Pharmacol. |
pmid:21872585
|
Degousee N et al. |
Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia. |
2011 |
J. Biol. Chem. |
pmid:21849511
|
Mesquita-Santos FP et al. |
Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils. |
2011 |
Br. J. Pharmacol. |
pmid:20973774
|
Wienecke T et al. |
Discrepancy between strong cephalic arterial dilatation and mild headache caused by prostaglandin Dâ‚‚ (PGDâ‚‚). |
2011 |
Cephalalgia |
pmid:20974593
|
El-Shazly AE et al. |
IFN-γ and TNF-α potentiate prostaglandin D2-induced human eosinophil chemotaxis through up-regulation of CRTH2 surface receptor. |
2011 |
Int. Immunopharmacol. |
pmid:21835268
|
Kuehn HS et al. |
Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release. |
2011 |
J. Biol. Chem. |
pmid:20980255
|
Surh YJ et al. |
15-Deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling. |
2011 |
Biochem. Pharmacol. |
pmid:21843512
|
Bräutigam K et al. |
Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines. |
2011 |
J. Cancer Res. Clin. Oncol. |
pmid:20878528
|
Alves C et al. |
Effects of 15d-PGJâ‚‚-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation. |
2011 |
Br. J. Pharmacol. |
pmid:20883476
|
Lu Y et al. |
Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. |
2011 |
Biochem. Pharmacol. |
pmid:21907188
|
Kanda N et al. |
The antimycotic drugs itraconazole and terbinafine hydrochloride induce the production of human β-defensin-3 in human keratinocytes. |
2011 |
Immunobiology |
pmid:20875690
|
Burke SJ and Collier JJ |
The gene encoding cyclooxygenase-2 is regulated by IL-1β and prostaglandins in 832/13 rat insulinoma cells. |
2011 |
Cell. Immunol. |
pmid:21885043
|
Crosignani S et al. |
Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. |
2011 |
J. Med. Chem. |
pmid:21916510
|
Moniot B et al. |
Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein. |
2011 |
Dev. Dyn. |
pmid:21887724
|
Kanai Y et al. |
Identification of novel oxidized levuglandin D2 in marine red alga and mouse tissue. |
2011 |
J. Lipid Res. |
pmid:21893678
|
Jakob S and Lovell-Badge R |
Sex determination and the control of Sox9 expression in mammals. |
2011 |
FEBS J. |
pmid:21281448
|
Hardy KD et al. |
Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ(12,14)-prostaglandin J₂-like compounds (deoxy-J₂-isoprostanes) in vivo. |
2011 |
J. Lipid Res. |
pmid:20944061
|
Matsushima Y et al. |
Distinct roles of prostaglandin D2 receptors in chronic skin inflammation. |
2011 |
Mol. Immunol. |
pmid:21943706
|
Shinozawa T et al. |
Tetranor PGDM analyses for the amyotrophic lateral sclerosis: positive and simple diagnosis and evaluation of drug effect. |
2011 |
Biochem. Biophys. Res. Commun. |
pmid:22027143
|
Chang MC et al. |
Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. |
2011 |
Atherosclerosis |
pmid:21993412
|
de Jong E et al. |
Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. |
2011 |
PLoS ONE |
pmid:21957481
|
Jin M et al. |
Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ production in mouse bone marrow-derived mast cells. |
2011 |
Arch. Pharm. Res. |
pmid:21975811
|
Urade Y and Hayaishi O |
Prostaglandin D2 and sleep/wake regulation. |
2011 |
Sleep Med Rev |
pmid:22024172
|
Wan CJ et al. |
[PPARgamma agonists against respiratory syncytial virus infection in vitro study]. |
2011 |
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi |
pmid:22734242
|
Wang P et al. |
Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1. |
2011 |
FASEB J. |
pmid:21715681
|
Ahmed SR et al. |
Prostaglandin D2 regulates CD4+ memory T cell trafficking across blood vascular endothelium and primes these cells for clearance across lymphatic endothelium. |
2011 |
J. Immunol. |
pmid:21715691
|