| MeSH term | MeSH ID | Detail |
|---|---|---|
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Headache | D006261 | 4 associated lipids |
| Drug Eruptions | D003875 | 30 associated lipids |
| Folliculitis | D005499 | 7 associated lipids |
| Dyskinesia, Drug-Induced | D004409 | 15 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Muscular Dystrophy, Animal | D009137 | 5 associated lipids |
| Actinobacillus Infections | D000189 | 4 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Frölich JC et al. | Advances in the analysis of eicosanoids by ELISA and GC/MS/MS. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949561 |
| Burrall B and Ziboh VA | Increased biosynthesis of lipoxygenase products by UVB-irradiated guinea pig epidermis: evidence of a cyclooxygenase inhibitor. | 1986 | J. Invest. Dermatol. | pmid:3086462 |
| Saito H et al. | Bio-synthesis of PGD2 and TXB2 by rabbit blood monocytes. | 1986 | Prostaglandins | pmid:3086936 |
| Hattori Y and Levi R | Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3012066 |
| Tsao CJ et al. | In-vitro effects of antineoplastic prostaglandins on human leukemic cell growth and normal myelopoiesis. | 1986 | Leuk. Res. | pmid:3012210 |
| Halenda SP et al. | Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets. | 1986 | FEBS Lett. | pmid:3015684 |
| Todo S et al. | Cell kinetic studies of PGD2 cytotoxicity on the in vitro growth of human neuroblastoma. | 1986 | Prostaglandins Leukot Med | pmid:3016753 |
| Bhattacharya SK | The antinociceptive effect of intracerebroventricularly administered prostaglandin D2 in the rat. | 1986 | Psychopharmacology (Berl.) | pmid:3016786 |
| Hamid-Bloomfield S and Whittle BJ | Prostaglandin D2 interacts at thromboxane receptor-sites on guinea-pig platelets. | 1986 | Br. J. Pharmacol. | pmid:3017497 |
| Shalit M et al. | New role for heparan sulfate: regulator of leukotriene generation in mouse E-mast cells. | 1986 | Life Sci. | pmid:3018403 |
| Kuno S et al. | Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3010301 |
| Peters SP et al. | Mediator release from human lung under conditions of reduced oxygen tension. | 1986 | J. Pharmacol. Exp. Ther. | pmid:2425080 |
| MacDermot J | Desensitization of prostacyclin responsiveness in platelets. Apparent differences in the mechanism in vitro or in vivo. | 1986 | Biochem. Pharmacol. | pmid:2427086 |
| Heavey DJ et al. | Prostaglandin D2 and histamine release in cold urticaria. | 1986 | J. Allergy Clin. Immunol. | pmid:2428856 |
| Eady RP | The pharmacology of nedocromil sodium. | 1986 | Eur J Respir Dis Suppl | pmid:2429854 |
| Kleeberger SR et al. | Central role of cyclooxygenase in the response of canine peripheral airways to antigen. | 1986 | J. Appl. Physiol. | pmid:2430928 |
| Wells E et al. | Characterization of primate bronchoalveolar mast cells. II. Inhibition of histamine, LTC4, and PGD2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mast cells. | 1986 | J. Immunol. | pmid:2431049 |
| Ashby B | Kinetic evidence indicating separate stimulatory and inhibitory prostaglandin receptors on platelet membranes. | 1986 | J Cyclic Nucleotide Protein Phosphor Res | pmid:2432105 |
| Koro O et al. | Release of prostaglandin D2 and histamine in a case of localized heat urticaria, and effect of treatments. | 1986 | Br. J. Dermatol. | pmid:2432916 |
| Blomgren H et al. | Prostaglandin sensitivity of the PHA-response of blood lymphocytes following radiation therapy for breast cancer. | 1986 | Radiother Oncol | pmid:3466235 |
| Eling TE et al. | Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase. | 1986 | J. Biol. Chem. | pmid:3007487 |
| Narumiya S and Fukushima M | Site and mechanism of growth inhibition by prostaglandins. I. Active transport and intracellular accumulation of cyclopentenone prostaglandins, a reaction leading to growth inhibition. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3772804 |
| Zavoico GB et al. | Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs. | 1986 | J. Biol. Chem. | pmid:3020026 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Peters SP et al. | The pharmacologic control of mediator release from human basophils and mast cells. | 1986 | Respiration | pmid:3494282 |
| Bhuyan BK et al. | Cell cycle effects of prostaglandins A1, A2, and D2 in human and murine melanoma cells in culture. | 1986 | Cancer Res. | pmid:3456266 |
| Brooks DP et al. | Role of brain prostaglandins in the control of vasopressin secretion in the conscious rat. | 1986 | Endocrinology | pmid:3456303 |
| Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3456602 |
| Maclouf J et al. | Development of a radioimmunoassay for prostaglandin D2 using an antiserum against 11-methoxime prostaglandin D2. | 1986 | Prostaglandins | pmid:3456623 |
| Rees MC and Kelly RW | Prostaglandin D2 release by endometrium and myometrium. | 1986 | Br J Obstet Gynaecol | pmid:3466645 |
| Hardy CC et al. | Evidence against the formation of 13,14-dihydro-15-keto-prostaglandin F2 alpha following inhalation of prostaglandin D2 in man. | 1986 | Br. J. Pharmacol. | pmid:3467804 |
| Makhoul RG and Gewertz BL | Renal prostaglandins. | 1986 | J. Surg. Res. | pmid:3511324 |
| Inoué S | Multifactorial humoral regulation of sleep. | 1986 | Clin Neuropharmacol | pmid:3471328 |
| Bhuyan BK et al. | Cytotoxicity of combinations of prostaglandin D2 (PGD2) and antitumor drugs for B16 melanoma cells in culture. | 1986 | Invest New Drugs | pmid:3473056 |
| Lumsden MA et al. | Changes in the concentration of prostaglandins in preovulatory human follicles after administration of hCG. | 1986 | J. Reprod. Fertil. | pmid:3459888 |
| Watanabe Y et al. | Modulation by prostaglandin D2 of mitral cell responses to odor stimulation in rabbit olfactory bulb. | 1986 | Brain Res. | pmid:2873871 |
| Hiroshima O et al. | Basal level of prostaglandin D2 in rat brain by a solid-phase enzyme immunoassay. | 1986 | Prostaglandins | pmid:3532208 |
| Strobl-Jäger E et al. | Influence of type IIa, IIb and IV-hyperlipoproteinemia on platelet prostaglandin sensitivity, plasma thromboxane B2 and platelet half-life. | 1986 | Prostaglandins Leukot Med | pmid:3540998 |
| Holgate ST | The role of mast cells in the pathogenesis of asthma. | 1985 Sep-Oct | Bull Eur Physiopathol Respir | pmid:2415192 |
| Korbut R and Gryglewski RJ | Anti-aggregatory prostanoids. Part I. | 1985 Sep-Dec | Acta Physiol Pol | pmid:3915631 |
| Nolan PN et al. | Participation of prostanoids in chemical activation of the pericardial pressor reflex in dogs. | 1985 Jan-Feb | Clin. Exp. Pharmacol. Physiol. | pmid:3924453 |
| Kimura H et al. | Modulatory effects of prostaglandin D2, E2 and F2 alpha on the postsynaptic actions of inhibitory and excitatory amino acids in cerebellar Purkinje cell dendrites in vitro. | 1985 | Brain Res. | pmid:2859088 |
| Lewis RA et al. | Pharmacologic regulation of mediator generation and release from the murine bone marrow derived mast cell. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:2409010 |
| Norman PS et al. | Mediator release after allergic and physical nasal challenges. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:2409027 |
| Schleimer RP et al. | Role of human basophils and mast cells in the pathogenesis of allergic diseases. | 1985 | J. Allergy Clin. Immunol. | pmid:2410478 |
| Majewska MD and Chuang DM | Benzodiazepines enhance the muscimol-dependent activation of phospholipase A2 in glioma C6 cells. | 1985 | J. Pharmacol. Exp. Ther. | pmid:2857784 |
| Westcott JY and Murphy RC | Effect of alcohols on arachidonic acid metabolism in murine mastocytoma cells and human polymorphonuclear leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:2982416 |
| Bhattacharya SK et al. | Prostaglandin D2 mediated specific increase in rat brain serotonin. | 1985 | Proc. West. Pharmacol. Soc. | pmid:3865228 |
| Walenga RW et al. | Re-examination of the assay for plasma prostanoids by solid-phase extraction, and radioimmunoassay. | 1985 | Prostaglandins Leukot Med | pmid:3865240 |
| Pugliese G et al. | Hepatic transformation of prostaglandin D2 to a new prostanoid, 9 alpha,11 beta-prostaglandin F2, that inhibits platelet aggregation and constricts blood vessels. | 1985 | J. Biol. Chem. | pmid:3863819 |