PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Atherosclerosis D050197 85 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Cryptorchidism D003456 2 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Dehydration D003681 11 associated lipids
Encephalitis D004660 15 associated lipids
Cholangitis D002761 3 associated lipids
Meningoencephalitis D008590 4 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
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Fogel-Petrovic M et al. Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2. 2004 Immunol. Cell Biol. pmid:14984594
Cheng S et al. Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. 2004 J. Biol. Chem. pmid:15023995
Alvarez-Maqueda M et al. 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. 2004 J. Biol. Chem. pmid:15024026
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Qin C et al. A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. 2004 Mol. Cancer Ther. pmid:15026545
Hashimoto K et al. Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. 2004 Pancreas pmid:15028947
Toyomoto M et al. Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures. 2004 FEBS Lett. pmid:15044028
Tanaka K et al. Effects of prostaglandin D2 on helper T cell functions. 2004 Biochem. Biophys. Res. Commun. pmid:15044085
Onozaki A et al. Rapid change of glucose concentration promotes mesangial cell proliferation via VEGF: inhibitory effects of thiazolidinedione. 2004 Biochem. Biophys. Res. Commun. pmid:15047143
Koda N et al. Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: new enzyme assay method using LC/ESI/MS. 2004 Arch. Biochem. Biophys. pmid:15047184
Saydam O et al. Transactivator protein BICP0 of bovine herpesvirus 1 (BHV-1) is blocked by prostaglandin D2 (PGD2), which points to a mechanism for PGD2-mediated inhibition of BHV-1 replication. 2004 J. Virol. pmid:15047795
Woolhiser MR et al. Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a. 2004 Clin. Immunol. pmid:15003814
Relic B et al. 15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. 2004 J. Biol. Chem. pmid:15004016
Tsuji T et al. Differential effects of beta2-adrenoceptor desensitization on the IgE-dependent release of chemical mediators from cultured human mast cells. 2004 Biol. Pharm. Bull. pmid:15467193
Konopleva M et al. Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias. 2004 Mol. Cancer Ther. pmid:15486192
Ishii T and Uchida K Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2. 2004 Chem. Res. Toxicol. pmid:15487891
Li Z et al. Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: a death wish? 2004 J. Neurosci. Res. pmid:15523637
Liu JD et al. Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. 2004 Life Sci. pmid:14998722
Yuan Z et al. Peroxisome proliferator-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis associated with inhibition of self-sensitive T cells. 2004 J. Cardiovasc. Pharmacol. pmid:15167281
Lee KJ et al. Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g. 2004 Exp. Mol. Med. pmid:15665586
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Bochenek G et al. Plasma 9alpha,11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma. 2004 Thorax pmid:15170023
Cheron A et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process. 2004 J. Immunol. pmid:15187150
Maddox JF et al. 15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes. 2004 Toxicol. Sci. pmid:14657518
Baek SJ et al. Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. 2004 J. Biol. Chem. pmid:14662774
Zhang X et al. Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells. 2004 Kidney Int. pmid:14871400
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Cheng J et al. Peroxisome proliferator-activated receptor gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2, and ciglitazone, induce growth inhibition and cell cycle arrest in hepatic oval cells. 2004 Biochem. Biophys. Res. Commun. pmid:15325252
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Fernández-Tome M et al. p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis. 2004 Biochem. Biophys. Res. Commun. pmid:15249196
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Hofnagel O et al. Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15271788
Park KS et al. Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. 2004 Exp. Cell Res. pmid:15212945
Shan ZZ et al. A potential role of 15-deoxy-delta(12,14)-prostaglandin J2 for induction of human articular chondrocyte apoptosis in arthritis. 2004 J. Biol. Chem. pmid:15213234
Tanaka Y et al. Enhanced release of prostaglandin D2 during re-incubation of RAW 264.7 macrophage-like cells after treatment of both lipopolysaccharide and non-steroidal anti-inflammatory drugs. 2004 Biol. Pharm. Bull. pmid:15256727
Jawerbaum A et al. Influence of peroxisome proliferator-activated receptor gamma activation by its endogenous ligand 15-deoxy Delta12,14 prostaglandin J2 on nitric oxide production in term placental tissues from diabetic women. 2004 Mol. Hum. Reprod. pmid:15258247
Zhao ML et al. 15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression. 2004 J. Neuroimmunol. pmid:15265671
Zhang X et al. Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells. 2004 Blood pmid:15265789
Azuma Y et al. Induction of proliferation by 15-deoxy-delta12,14-prostaglandin J2 and the precursors in monocytic leukemia U937. 2004 Pharmacology pmid:15240994
Chana RS et al. Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists. 2004 Kidney Int. pmid:15149321
Garg TK and Chang JY 15-deoxy-delta 12, 14-Prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress. 2004 BMC Pharmacol. pmid:15149553
Park EY et al. Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer. 2004 Cancer Res. pmid:15150131
Akbiyik F et al. Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. 2004 Blood pmid:15130939
Han S et al. Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression. 2004 Chest pmid:15136464
Collin M et al. Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin. 2004 Crit. Care Med. pmid:15090969
Baolin L et al. Resveratrol inhibits the release of mediators from bone marrow-derived mouse mast cells in vitro. 2004 Planta Med. pmid:15095144
Zang C et al. Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. 2004 Leuk. Res. pmid:15109539
Jakob M et al. Chondrogenesis of expanded adult human articular chondrocytes is enhanced by specific prostaglandins. 2004 Rheumatology (Oxford) pmid:15113997
Verrier E et al. PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase. 2004 Circ. Res. pmid:15117825
Leung WK et al. Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. 2004 Gut pmid:14960510
Mouihate A et al. A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain. 2004 J. Neurosci. pmid:14960602
Chatterjee PK et al. The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure. 2004 Cardiovasc. Res. pmid:14962493
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