| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Multiple Sclerosis, Relapsing-Remitting | D020529 | 7 associated lipids |
| Cryptorchidism | D003456 | 2 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
| Liver Failure, Acute | D017114 | 11 associated lipids |
| Dehydration | D003681 | 11 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Cholangitis | D002761 | 3 associated lipids |
| Meningoencephalitis | D008590 | 4 associated lipids |
| Thyroiditis, Autoimmune | D013967 | 9 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yagami T et al. | Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis. | 2002 | Mol. Pharmacol. | pmid:11752212 |
| Fu Y et al. | Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. | 2002 | Atherosclerosis | pmid:11755918 |
| Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
| Shibata T et al. | 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes. | 2002 | J. Biol. Chem. | pmid:11786541 |
| Simonin MA et al. | PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:11742805 |
| Hirai H et al. | Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2. | 2002 | J. Immunol. | pmid:11801628 |
| Kwak BR et al. | PPARgamma but not PPARalpha ligands are potent repressors of major histocompatibility complex class II induction in atheroma-associated cells. | 2002 | Circ. Res. | pmid:11861426 |
| Shimada T et al. | Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. | 2002 | Gut | pmid:11950812 |
| Pestel S et al. | Inhibition by prostaglandin E(2) of anaphylatoxin C5a- but not zymosan-induced prostanoid release from rat Kupffer cells. | 2002 | Lab. Invest. | pmid:11950903 |
| Nishida K et al. | Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferator-activated receptor-gamma. | 2002 | Br. J. Cancer | pmid:11953889 |
| Finck BN and Johnson RW | Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11959686 |
| Bureau F et al. | A proinflammatory role for the cyclopentenone prostaglandins at low micromolar concentrations: oxidative stress-induced extracellular signal-regulated kinase activation without NF-kappa B inhibition. | 2002 | J. Immunol. | pmid:11994490 |
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| Sharif NA and Davis TL | Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. | 2002 | J. Pharm. Pharmacol. | pmid:11999132 |
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| Jeng JH et al. | Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. | 2002 | Free Radic. Biol. Med. | pmid:11978487 |
| Yu Y et al. | Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. | 2002 | Biochim. Biophys. Acta | pmid:12020636 |
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| Garcia Palacios V et al. | Expression of adipogenesis markers in a murine stromal cell line treated with 15-deoxy Delta(12,14)-prostaglandin J2, interleukin-11, 9-cis retinoic acid and vitamin K2. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728175 |
| Levine L | Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728177 |
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| Yamamoto K et al. | Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes. | 2001 | Circulation | pmid:11581147 |
| Mizoguchi A et al. | Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11562489 |
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| Clay CE et al. | Early de novo gene expression is required for 15-deoxy-Delta 12,14-prostaglandin J2-induced apoptosis in breast cancer cells. | 2001 | J. Biol. Chem. | pmid:11668172 |
| Monneret G et al. | Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. | 2001 | Blood | pmid:11535533 |
| Akrishnan VR and Menon VP | Potential role of antioxidants during ethanol-induced changes in the fatty acid composition and arachidonic acid metabolites in male Wistar rats. | 2001 | Cell Biol. Toxicol. | pmid:11504446 |
| Chiba Y et al. | PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11511093 |
| Kozawa O et al. | Mechanism of prostaglandin D(2)-stimulated heat shock protein 27 induction in osteoblasts. | 2001 | Cell. Signal. | pmid:11483406 |
| Nakashiro KI et al. | Role of peroxisome proliferator-activated receptor gamma and its ligands in non-neoplastic and neoplastic human urothelial cells. | 2001 | Am. J. Pathol. | pmid:11485917 |
| Takashima T et al. | PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity. | 2001 | Int. J. Oncol. | pmid:11494023 |
| Rovin BH et al. | Cyclopentenone prostaglandins inhibit cytokine-induced nf-kappab activation and chemokine production by human mesangial cells. | 2001 | J. Am. Soc. Nephrol. | pmid:11461938 |
| Cernuda-Morollón E et al. | 15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit. | 2001 | J. Biol. Chem. | pmid:11466314 |