| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypotension | D007022 | 41 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Parker J et al. | Antiviral effect of cyclopentenone prostaglandins on vesicular stomatitis virus replication. | 1995 | Antiviral Res. | pmid:7537950 |
| Caito S et al. | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages. | 2008 | Antioxid. Redox Signal. | pmid:17970647 |
| Gong P et al. | Activation of the mouse heme oxygenase-1 gene by 15-deoxy-Delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2. | 2002 | Antioxid. Redox Signal. | pmid:12006176 |
| Jozkowicz A et al. | Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1. | 2002 | Antioxid. Redox Signal. | pmid:12230869 |
| Jozkowicz A et al. | 15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress. | 2008 | Antioxid. Redox Signal. | pmid:18665800 |
| Pica F et al. | Delta(12)-prostaglandin J(2) is a potent inhibitor of influenza A virus replication. | 2000 | Antimicrob. Agents Chemother. | pmid:10602750 |
| Conti C et al. | Inhibition of poliovirus replication by prostaglandins A and J in human cells. | 1996 | Antimicrob. Agents Chemother. | pmid:8834882 |
| Conti C et al. | Antiviral effect of hyperthermic treatment in rhinovirus infection. | 1999 | Antimicrob. Agents Chemother. | pmid:10103186 |
| Dionne S et al. | PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. | 2010 | Anticancer Res. | pmid:20150631 |
| el Attar TM and Virji AS | Effects of indomethacin, cisplatin and delta 12-prostaglandin J2 on growth of oral squamous carcinoma cells. | 1997 Nov-Dec | Anticancer Res. | pmid:9494540 |
| Tejedor M et al. | Potentiation of radiation toxicity in C-6 glioma cells by prostaglandin D2. | 1989 Jul-Aug | Anticancer Res. | pmid:2817802 |
| Conde B et al. | Modulation of cell growth and differentiation induced by prostaglandin D2 in the glioma cell line C6. | 1991 Jan-Feb | Anticancer Res. | pmid:1902073 |
| Chen SY et al. | 15-Deoxy-delta12,14-prostaglandin J2 induces apoptosis of a thyroid papillary cancer cell line (CG3 cells) through increasing intracellular iron and oxidative stress. | 2002 | Anticancer Drugs | pmid:12187333 |
| Eucker J et al. | Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. | 2004 | Anticancer Drugs | pmid:15514564 |
| Fulzele SV et al. | 15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. | 2007 | Anticancer Drugs | pmid:17159504 |
| Eucker J et al. | Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. | 2006 | Anticancer Drugs | pmid:16926626 |
| Austen KF | Doing what I like. | 2008 | Annu. Rev. Immunol. | pmid:17877459 |
| Shimizu T et al. | A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage. | 2006 | Ann. Surg. | pmid:16794398 |
| Scott HW et al. | Hazards in operative management of patients with systemic mastocytosis. | 1983 | Ann. Surg. | pmid:6189461 |
| Brodsky L et al. | Arachidonic acid metabolites in middle ear effusions of children. | 1991 | Ann. Otol. Rhinol. Laryngol. | pmid:1648326 |
| Liu JJ et al. | Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro. | 2005 | Ann. Oncol. | pmid:15642706 |
| Zhao X et al. | Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. | 2007 | Ann. Neurol. | pmid:17457822 |
| Zhuang H et al. | Prostaglandins of J series control heme oxygenase expression: potential significance in modulating neuroinflammation. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12853315 |
| Figueiredo-Pereira ME et al. | Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. | 2016 | Ann. N. Y. Acad. Sci. | pmid:26748744 |
| Padilla J et al. | PPAR-gamma-mediated regulation of normal and malignant B lineage cells. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818446 |
| Padilla J et al. | Effects of 15-deoxy-delta 12,14-PGJ2 on B lineage cells. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818475 |
| Wolfe LS and Pellerin L | Arachidonic acid metabolites in the rat and human brain. New findings on the metabolism of prostaglandin D2 and lipoxygenase products. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2570544 |
| Fukushima M et al. | Prostaglandin J2 and related compounds. Mode of action in G1 arrest and preclinical results. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825837 |
| Barrett KE | Effect of histamine and other mast cell mediators on T84 epithelial cells. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456653 |
| Gayarre J et al. | Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17405918 |
| Okuyama S et al. | Redifferentiation of cancer cells: bestatin, estradiol, and prostaglandin D2. | 1985 | Ann. N. Y. Acad. Sci. | pmid:3868328 |
| Kim DH et al. | Effects of 15-deoxy-delta 12, 14-prostaglandin J2 on the expression of p53 in MCF-7 cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723057 |
| Song NY et al. | 15-Deoxy-delta 12, 14-prostaglandin J2 induces upregulation of multidrug resistance-associated protein 1 via Nrf2 activation in human breast cancer cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723058 |
| Cha B et al. | 15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723089 |
| Norman P et al. | BAY u3405 is a potent and competitive antagonist of U46619, PGD2 and 9 alpha, 11 beta PGF2 alpha-induced contractions of airway smooth muscle. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952564 |
| Nowak D et al. | Comparison of airway responsiveness to prostaglandin D2 and histamine, methacholine or exercise in healthy and asthmatic subjects. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952573 |
| Kim EH et al. | Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. | 2006 | Ann. N. Y. Acad. Sci. | pmid:17384282 |
| Rangachari PK | Concerning prostaglandin D2: forgotten, promiscuous, capricious. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456655 |
| Hayaishi O | Prostaglandin D2 and sleep. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2774407 |
| Francis HP et al. | The thromboxane receptor antagonist BAY u3405 reverses prostaglandin D2 (PGD2)-induced bronchoconstriction in the anaesthetised guinea pig. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1835329 |
| Polosa R et al. | [Mast cell mediator release after endobronchial challenge with adenosine 5'-monophosphate in asthmatic subjects]. | 1994 Apr-Jun | Ann. Ital. Med. Int. | pmid:7522500 |
| Liu JJ et al. | Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. | 2007 | Ann. Hematol. | pmid:17089125 |
| Leynadier F | [Mast cells and basophils in asthma]. | 1989 | Ann. Biol. Clin. (Paris) | pmid:2675683 |
| Fujishima H et al. | Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. | 2013 | Ann. Allergy Asthma Immunol. | pmid:23886231 |
| Small P and Barrett D | Evaluation of dust and dust mite nasal provocation. | 1995 | Ann. Allergy Asthma Immunol. | pmid:8603280 |
| Rank MA et al. | Systemic reactions to allergen immunotherapy: a role for measuring a PGD2 metabolite? | 2013 | Ann. Allergy Asthma Immunol. | pmid:23244662 |
| Chiba T et al. | The opposing role of two prostaglandin D2 receptors, DP and CRTH2, in human eosinophil migration. | 2011 | Ann. Allergy Asthma Immunol. | pmid:21624751 |
| Marone G et al. | Mechanisms of activation of human mast cells and basophils by general anesthetic drugs. | 1993 | Ann Fr Anesth Reanim | pmid:7690200 |
| Campbell AM et al. | Conjunctival provocation tests with codeine phosphate. Effect of disodium cromoglycate. | 1993 | Ann Allergy | pmid:7687104 |
| Naclerio RM | Effects of antihistamines on inflammatory mediators. | 1993 | Ann Allergy | pmid:7690526 |
| Campbell AM et al. | In vitro activation of bronchoalveolar lavage cells by house dust mite allergens. | 1992 | Ann Allergy | pmid:1371209 |
| Wasserman SI | Basic mechanisms in asthma. | 1988 | Ann Allergy | pmid:3163472 |
| Small P et al. | Effects of intensity of early response to allergen on the late phase of both the nose and skin. | 1994 | Ann Allergy | pmid:8092561 |
| Orfan N et al. | Systemic cold urticaria in a five-year-old boy. | 1991 | Ann Allergy | pmid:1867452 |
| Cichocka-Jarosz E et al. | Impact of Hymenoptera venom allergy and the effects of specific venom immunotherapy on mast cell metabolites in sensitized children. | 2014 | Ann Agric Environ Med | pmid:24959779 |
| Kashani IA et al. | Effects of prostaglandins on the pulmonary vascular bed of newborn rats with chronic hypoxia. | 1986 | Angiology | pmid:3511774 |
| Stellato C et al. | Human basophil/mast cell releasability. IX. Heterogeneity of the effects of opioids on mediator release. | 1992 | Anesthesiology | pmid:1280014 |
| Araki M et al. | Isoflurane modulates phorbol myristate acetate-, prostaglandin D2-, and prostaglandin E2-induced alterations in hepatic flow and metabolism in the perfused liver in fasted rats. | 1994 | Anesth. Analg. | pmid:7639362 |
| Welter H et al. | Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients. | 2013 | Andrology | pmid:23413143 |
| Chen Q et al. | A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. | 2004 | Anal. Biochem. | pmid:15556564 |
| Zorrilla S et al. | Selective binding of the fluorescent dye 1-anilinonaphthalene-8-sulfonic acid to peroxisome proliferator-activated receptor gamma allows ligand identification and characterization. | 2010 | Anal. Biochem. | pmid:20025845 |
| Cao H et al. | An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids. | 2008 | Anal. Biochem. | pmid:17976507 |
| Hirano A et al. | Arachidonic acid-induced channel- and carrier-type ion transport across planar bilayer lipid membranes. | 2003 | Anal Sci | pmid:12608744 |
| Koyama J et al. | Simultaneous determination of histamine and prostaglandin D2 using an LC-ESI-MS/MS method with positive/negative ion-switching ionization modes: application to the study of anti-allergic flavonoids on the degranulation of KU812 cells. | 2011 | Anal Bioanal Chem | pmid:21725829 |
| Fernández PL | [Stress and inflammatory bowell disease (I.B.D). Therapeutic strategies]. | 2006 | An R Acad Nac Med (Madr) | pmid:17172222 |
| Beasley R et al. | Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma. | 1987 | Am. Rev. Respir. Dis. | pmid:2960256 |
| Liu MC et al. | Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:2368958 |
| Ingenito EP et al. | Bronchoalveolar lavage cell and mediator responses to hyperpnea-induced bronchoconstriction in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2339838 |
| Naclerio RM et al. | Mediator release after nasal airway challenge with allergen. | 1983 | Am. Rev. Respir. Dis. | pmid:6354022 |
| Cohan VL et al. | Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin. | 1989 | Am. Rev. Respir. Dis. | pmid:2478059 |
| Picado C et al. | Release of peptide leukotriene into nasal secretions after local instillation of aspirin in aspirin-sensitive asthmatic patients. | 1992 | Am. Rev. Respir. Dis. | pmid:1309968 |
| Wang D et al. | Aminophylline reduces air-flow-induced constriction in the canine lung periphery. | 1988 | Am. Rev. Respir. Dis. | pmid:3422143 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Gray PR et al. | The role of cyclooxygenase products in the acute airway obstruction and airway hyperreactivity of ponies with heaves. | 1989 | Am. Rev. Respir. Dis. | pmid:2502051 |
| Eggleston PA et al. | Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells. | 1990 | Am. Rev. Respir. Dis. | pmid:1691604 |
| Jongejan RC et al. | Effects of inflammatory mediators on the responsiveness of isolated human airways to methacholine. | 1990 | Am. Rev. Respir. Dis. | pmid:2240835 |
| Holgate ST | Contribution of inflammatory mediators to the immediate asthmatic reaction. | 1987 | Am. Rev. Respir. Dis. | pmid:3473955 |
| Fuller RW et al. | Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine. | 1986 | Am. Rev. Respir. Dis. | pmid:3511806 |
| Gundel RH et al. | Antigen-induced mediator release in primates. | 1991 | Am. Rev. Respir. Dis. | pmid:1648317 |
| Wang D et al. | Terbutaline acts at multiple sites to inhibit bronchoconstriction induced by dry air in canine peripheral airways. | 1992 | Am. Rev. Respir. Dis. | pmid:1595994 |
| Broide DH et al. | Airway levels of mast cell-derived mediators in exercise-induced asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:1689974 |
| Kleeberger SR et al. | The role of mediators in the response of the canine peripheral lung to 1 ppm ozone. | 1988 | Am. Rev. Respir. Dis. | pmid:2829670 |
| Hanks BC et al. | Evaluation of anti-inflammatory and chondroprotective effects of peroxisome proliferator-activated receptor gamma agonists in cartilage and synovial explants from dogs. | 2010 | Am. J. Vet. Res. | pmid:20919899 |
| Reddy RC and Standiford TJ | Nrf2 and PPAR{gamma}: PPARtnering against oxidant-induced lung injury. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20634499 |
| Mochizuki M et al. | Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:15750045 |
| Balzar S et al. | Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:20813890 |
| Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
| Macfarlane AJ et al. | Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10806153 |
| Krawiec ME et al. | Persistent wheezing in very young children is associated with lower respiratory inflammation. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11371398 |
| Hartert TV et al. | Prostaglandin E(2) decreases allergen-stimulated release of prostaglandin D(2) in airways of subjects with asthma. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10934099 |
| Kowalski ML et al. | Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10673176 |
| Szczeklik A et al. | Salmeterol prevents aspirin-induced attacks of asthma and interferes with eicosanoid metabolism. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9769277 |
| Asada K et al. | Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:14563653 |
| Polosa R et al. | Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881647 |
| Cho HY et al. | Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20224069 |
| Longphre M et al. | PAF-induced airways hyperreactivity is modulated by mast cells in mice. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8624251 |
| Zhou Q et al. | Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26488390 |
| Serhan CN and Devchand PR | Novel antiinflammatory targets for asthma. A role for PPARgamma? | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11415929 |
| Wang AC et al. | Peroxisome proliferator-activated receptor-gamma regulates airway epithelial cell activation. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11415933 |
| Mathew B et al. | Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17204585 |