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PPAR activators and gastroenterology. |
2004 |
Drug News Perspect. |
pmid:15801147
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Ray DM et al. |
Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. |
2004 |
Clin. Immunol. |
pmid:15451478
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Abdelrahman M et al. |
The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. |
2004 |
Shock |
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Endogenous inhibitors of nuclear factor-kappaB, an opportunity for cancer control. |
2004 |
Cancer Res. |
pmid:15548674
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Inoue K et al. |
Effects of 15-deoxy-delta12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide. |
2004 |
Arzneimittelforschung |
pmid:15612612
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Mitsumori S |
Recent progress in work on PGD2 antagonists for drugs targeting allergic diseases. |
2004 |
Curr. Pharm. Des. |
pmid:15579050
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Kumagai M et al. |
15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells. |
2004 |
Tohoku J. Exp. Med. |
pmid:14998300
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Emi M and Maeyama K |
The biphasic effects of cyclopentenone prostaglandins, prostaglandin J(2) and 15-deoxy-Delta(12,14)-prostaglandin J(2) on proliferation and apoptosis in rat basophilic leukemia (RBL-2H3) cells. |
2004 |
Biochem. Pharmacol. |
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Nociceptin/orphanin FQ modulates human T cell function in vitro. |
2004 |
J. Neuroimmunol. |
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Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1. |
2004 |
J. Pharmacol. Sci. |
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Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis. |
2004 |
J. Neuroimmunol. |
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Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2). |
2004 |
Biochemistry |
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Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2. |
2004 |
Immunol. Cell Biol. |
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Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. |
2004 |
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15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. |
2004 |
J. Biol. Chem. |
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The human heart as a shock organ in anaphylaxis. |
2004 |
Novartis Found. Symp. |
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A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. |
2004 |
Mol. Cancer Ther. |
pmid:15026545
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Hashimoto K et al. |
Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. |
2004 |
Pancreas |
pmid:15028947
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Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures. |
2004 |
FEBS Lett. |
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Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling. |
2004 |
Mol. Pharmacol. |
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Peroxisome proliferator-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis associated with inhibition of self-sensitive T cells. |
2004 |
J. Cardiovasc. Pharmacol. |
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Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g. |
2004 |
Exp. Mol. Med. |
pmid:15665586
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Monitoring mast cell activation by prostaglandin D2 in vivo. |
2004 |
Thorax |
pmid:15170020
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Bochenek G et al. |
Plasma 9alpha,11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma. |
2004 |
Thorax |
pmid:15170023
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15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process. |
2004 |
J. Immunol. |
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15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes. |
2004 |
Toxicol. Sci. |
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Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. |
2004 |
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Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells. |
2004 |
Kidney Int. |
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PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose. |
2004 |
Kidney Int. |
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Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma. |
2004 |
Cancer Res. |
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Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages. |
2004 |
Am. J. Respir. Crit. Care Med. |
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The synthesis and effects of prostaglandins on the ovary of the crab Oziotelphusa senex senex. |
2004 |
Gen. Comp. Endocrinol. |
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15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway. |
2004 |
FEBS Lett. |
pmid:15304320
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15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. |
2004 |
Biochem. Biophys. Res. Commun. |
pmid:15369766
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Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2. |
2004 |
J. Immunol. |
pmid:15322177
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15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications. |
2004 |
J. Immunol. |
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Peroxisome proliferator-activated receptor gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2, and ciglitazone, induce growth inhibition and cell cycle arrest in hepatic oval cells. |
2004 |
Biochem. Biophys. Res. Commun. |
pmid:15325252
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T-cell trafficking in asthma: lipid mediators grease the way. |
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Nat. Rev. Immunol. |
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p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis. |
2004 |
Biochem. Biophys. Res. Commun. |
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Ciglitizone and 15d PGJ2 induce apoptosis in Jurkat and Raji cells. |
2004 |
Int. Immunopharmacol. |
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Differential effects of serum constituents on apoptosis induced by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in WISH epithelial cells. |
2004 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:15253890
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The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. |
2004 |
Int. J. Oncol. |
pmid:15254749
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Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells. |
2004 |
Arterioscler. Thromb. Vasc. Biol. |
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Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. |
2004 |
Exp. Cell Res. |
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A potential role of 15-deoxy-delta(12,14)-prostaglandin J2 for induction of human articular chondrocyte apoptosis in arthritis. |
2004 |
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Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists. |
2004 |
Kidney Int. |
pmid:15149321
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Garg TK and Chang JY |
15-deoxy-delta 12, 14-Prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress. |
2004 |
BMC Pharmacol. |
pmid:15149553
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Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer. |
2004 |
Cancer Res. |
pmid:15150131
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Akbiyik F et al. |
Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. |
2004 |
Blood |
pmid:15130939
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Han S et al. |
Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression. |
2004 |
Chest |
pmid:15136464
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Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin. |
2004 |
Crit. Care Med. |
pmid:15090969
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Baolin L et al. |
Resveratrol inhibits the release of mediators from bone marrow-derived mouse mast cells in vitro. |
2004 |
Planta Med. |
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Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. |
2004 |
Leuk. Res. |
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Chondrogenesis of expanded adult human articular chondrocytes is enhanced by specific prostaglandins. |
2004 |
Rheumatology (Oxford) |
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PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase. |
2004 |
Circ. Res. |
pmid:15117825
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Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. |
2004 |
Gut |
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A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain. |
2004 |
J. Neurosci. |
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The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure. |
2004 |
Cardiovasc. Res. |
pmid:14962493
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Brummond KM et al. |
The first total synthesis of 15-deoxy-Delta12,14-prostaglandin J2 and the unambiguous assignment of the C14 stereochemistry. |
2004 |
Org. Lett. |
pmid:14723515
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Moore RM et al. |
Physiological apoptotic agents have different effects upon human amnion epithelial and mesenchymal cells. |
2003 Feb-Mar |
Placenta |
pmid:12566244
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Kanaoka Y and Urade Y |
Hematopoietic prostaglandin D synthase. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895599
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Nagata K and Hirai H |
The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895600
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Powell WS |
A novel PGD(2) receptor expressed in eosinophils. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895601
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Kabashima K and Narumiya S |
The DP receptor, allergic inflammation and asthma. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895602
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Khan E and Abu-Amer Y |
Activation of peroxisome proliferator-activated receptor-gamma inhibits differentiation of preosteoblasts. |
2003 |
J. Lab. Clin. Med. |
pmid:12878983
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[Peroxisome proliferation-activated receptor-gamma ligands ameliorate autoimmune myocarditis associated with inhibition of T cell immunity]. |
2003 |
Zhonghua Yi Xue Za Zhi |
pmid:14703419
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Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells. |
2003 |
Int. Arch. Allergy Immunol. |
pmid:14707465
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Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress. |
2003 |
Eur. J. Neurosci. |
pmid:12814358
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Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response. |
2003 |
Mol. Pharmacol. |
pmid:12815164
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Hashimoto K et al. |
The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. |
2003 |
Pancreas |
pmid:12826907
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Montuschi P et al. |
Exhaled leukotrienes and prostaglandins in COPD. |
2003 |
Thorax |
pmid:12832671
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Taba Y et al. |
15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells. |
2003 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:12623786
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Fukuchi K et al. |
Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone. |
2003 |
J. Dent. Res. |
pmid:14514760
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Józkowicz A et al. |
Prostaglandin-J(2) upregulates expression of matrix metalloproteinase-1 independently of activation of peroxisome proliferator-activated receptor-gamma. |
2003 |
Acta Biochim. Pol. |
pmid:14515149
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Imaizumi T et al. |
15-Deoxy-delta 12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide. |
2003 |
Prostaglandins Other Lipid Mediat. |
pmid:14518569
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Lee CH and Edwards AM |
Differential expression of c-fos and c-myc protooncogenes by estrogens, xenobiotics and other growth-stimulatory agents in primary rat hepatocytes. |
2003 |
Arch. Toxicol. |
pmid:12632255
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Yoshimura R et al. |
The effect of peroxisome proliferator-activated receptor-gamma ligand on urological cancer cells. |
2003 |
Int. J. Mol. Med. |
pmid:14612958
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Okano H et al. |
The PPARgamma ligand, 15-Deoxy-Delta12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells. |
2003 |
Int. J. Mol. Med. |
pmid:14612959
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Ajmone-Cat MA et al. |
Prolonged exposure of microglia to lipopolysaccharide modifies the intracellular signaling pathways and selectively promotes prostaglandin E2 synthesis. |
2003 |
J. Neurochem. |
pmid:14622099
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Komar CM and Curry TE |
Inverse relationship between the expression of messenger ribonucleic acid for peroxisome proliferator-activated receptor gamma and P450 side chain cleavage in the rat ovary. |
2003 |
Biol. Reprod. |
pmid:12700202
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Bochenek G et al. |
A controlled study of 9alpha,11beta-PGF2 (a prostaglandin D2 metabolite) in plasma and urine of patients with bronchial asthma and healthy controls after aspirin challenge. |
2003 |
J. Allergy Clin. Immunol. |
pmid:12704352
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Castaño E and Gil J |
15-deoxy-delta12,14 prostaglandin J2 synergizes with phorbol ester to induce proliferation in Swiss 3T3 cells independently of peroxisome proliferator-activated receptor gamma and PGD2 receptors. |
2003 |
J. Cell. Physiol. |
pmid:12704651
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2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB. |
2003 |
FEBS Lett. |
pmid:14550540
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Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin. |
2003 |
Am. J. Respir. Cell Mol. Biol. |
pmid:12707014
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Imaizumi T et al. |
Effect of 15-deoxy-delta12,14-prostaglandin J2 on IL-1beta-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells. |
2003 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:14580366
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Cippitelli M et al. |
The cyclopentenone-type prostaglandin 15-deoxy-delta 12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T lymphocytes: interference with promoter activation via peroxisome proliferator-activated receptor-gamma-independent mechanisms. |
2003 |
J. Immunol. |
pmid:12707336
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Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis. |
2003 |
J. Immunol. |
pmid:12707356
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Patel HJ et al. |
Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. |
2003 |
J. Immunol. |
pmid:12594295
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PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. |
2003 |
J. Am. Soc. Nephrol. |
pmid:12595494
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The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. |
2003 |
Br. J. Pharmacol. |
pmid:12598422
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Castrillo A et al. |
Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages. |
2003 |
Mol. Cell. Biol. |
pmid:12556480
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Farrow B and Evers BM |
Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. |
2003 |
Biochem. Biophys. Res. Commun. |
pmid:12535639
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Park EJ et al. |
15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. |
2003 |
J. Biol. Chem. |
pmid:12584205
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Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. |
2003 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:12517740
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Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. |
2003 |
J. Immunol. |
pmid:12517972
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Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. |
2003 |
Biochem. J. |
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Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells. |
2003 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:12524224
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Hashimoto T et al. |
Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs. |
2003 |
J Ocul Pharmacol Ther |
pmid:14733714
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Hirai H et al. |
Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. |
2003 |
Biochem. Biophys. Res. Commun. |
pmid:12878180
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Zhang X et al. |
Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin. |
2003 |
BioTechniques |
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