PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Sneezing D012912 6 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Helicobacter Infections D016481 21 associated lipids
Coronary Restenosis D023903 10 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Imamura Y et al. Mechanism of phospholipase D activation induced by prostaglandin D2 in osteoblast-like cells: function of Ca2+/calmodulin. 1995 Cell. Signal. pmid:7756110
Xu X et al. Effect of Salusin-β on Peroxisome Proliferator-Activated Receptor Gamma Gene Expression in Vascular Smooth Muscle Cells and its Possible Mechanism. 2015 Cell. Physiol. Biochem. pmid:26279448
Meng Y et al. Angiotensin II-induced Egr-1 expression is suppressed by peroxisome proliferator-activated receptor-γ ligand 15d-PGJ₂ in macrophages. 2015 Cell. Physiol. Biochem. pmid:25591955
Niemoeller OM et al. Ciglitazone and 15d-PGJ2 induced suicidal erythrocyte death. 2008 Cell. Physiol. Biochem. pmid:18769050
Ye F et al. Quantitative characterization of 15-deoxy-delta(12,14)-prostaglandin J2 in regulating EGFPSmad2 translocation in CHO cells through PPARgamma/TGFbeta/Smad2 pathway. 2006 Cell. Physiol. Biochem. pmid:16914899
Muñoz U et al. On the mechanism of inhibition of p27 degradation by 15-deoxy-Delta12,14-prostaglandin J2 in lymphoblasts of Alzheimer's disease patients. 2008 Cell. Mol. Life Sci. pmid:18818877
Olmos G et al. 15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. 2009 Cell. Mol. Life Sci. pmid:19458911
Lahaye DH et al. Effect of bradykinin on loss of density-dependent growth inhibition of normal rat kidney cells. 1994 Cell. Mol. Biol. (Noisy-le-grand) pmid:7981625
Gualde N et al. Stimulation of prostaglandin synthesis by the serum factor (FTS). 1982 Cell. Immunol. pmid:6957270
Mulkins MA et al. Mycophenolic acid inhibits the degranulation of rat peritoneal mast cells. 1992 Cell. Immunol. pmid:1349511
Burke SJ and Collier JJ The gene encoding cyclooxygenase-2 is regulated by IL-1β and prostaglandins in 832/13 rat insulinoma cells. 2011 Cell. Immunol. pmid:21885043
Bancos S et al. Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2. 2010 Cell. Immunol. pmid:20064636
Parker CW et al. Modulation of IL-4 production in murine spleen cells by prostaglandins. 1995 Cell. Immunol. pmid:7720090
Moon TC et al. Regulation of cyclooxygenase-2 and endogenous cytokine expression by bacterial lipopolysaccharide that acts in synergy with c-kit ligand and Fc epsilon receptor I crosslinking in cultured mast cells. 1998 Cell. Immunol. pmid:9636692
Farnesi-de-Assunção TS et al. PPAR-γ agonists, mainly 15d-PGJ(2), reduce eosinophil recruitment following allergen challenge. 2012 Cell. Immunol. pmid:22192475
Merwald H et al. Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2. 2006 Cell Stress Chaperones pmid:16572732
Hamel L et al. Induction of heat shock protein 70 by herbimycin A and cyclopentenone prostaglandins in smooth muscle cells. 2000 Cell Stress Chaperones pmid:11147963
Hennersdorf F et al. Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation. 2005 Cell Res. pmid:15916720
Austin S et al. Induction of the nuclear orphan receptor RORgamma during adipocyte differentiation of D1 and 3T3-L1 cells. 1998 Cell Growth Differ. pmid:9543393
Butler R et al. Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferator-activated receptor gamma ligand, 15-deoxy-delta12,14-prostaglandin J2. 2000 Cell Growth Differ. pmid:10672903
Campo PA et al. Translational regulation of cyclin D1 by 15-deoxy-delta(12,14)-prostaglandin J(2). 2002 Cell Growth Differ. pmid:12354750
Zhu F et al. Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases. 2010 Cell Death Differ. pmid:20150912
Lalier L et al. Prostaglandins antagonistically control Bax activation during apoptosis. 2011 Cell Death Differ. pmid:20966963
Figarella K et al. Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form. 2005 Cell Death Differ. pmid:15678148
Figarella K et al. Prostaglandin-induced programmed cell death in Trypanosoma brucei involves oxidative stress. 2006 Cell Death Differ. pmid:16456581
Akrishnan VR and Menon VP Potential role of antioxidants during ethanol-induced changes in the fatty acid composition and arachidonic acid metabolites in male Wistar rats. 2001 Cell Biol. Toxicol. pmid:11504446
Torii SI et al. Thiazolidinedione induces the adipose differentiation of fibroblast-like cells resident within bovine skeletal muscle. 1998 Cell Biol. Int. pmid:10328850
Wang JJ and Mak OT Induction of apoptosis in non-small cell lung carcinoma A549 cells by PGDâ‚‚ metabolite, 15d-PGJâ‚‚. 2011 Cell Biol. Int. pmid:21999315
Maggiora M et al. Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells. 2010 Cell Biochem. Funct. pmid:20862655
Rehan V and Torday J Hyperoxia augments pulmonary lipofibroblast-to-myofibroblast transdifferentiation. 2003 Cell Biochem. Biophys. pmid:12794266
Makino N et al. Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia. 2006 Cell Biochem. Biophys. pmid:16456235
Kanaoka Y et al. Cloning and crystal structure of hematopoietic prostaglandin D synthase. 1997 Cell pmid:9323136
Nagy L et al. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. 1998 Cell pmid:9568715
Forman BM et al. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. 1995 Cell pmid:8521497
Kliewer SA et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. 1995 Cell pmid:8521498
Tontonoz P et al. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. 1998 Cell pmid:9568716
Takai T et al. FcR gamma chain deletion results in pleiotrophic effector cell defects. 1994 Cell pmid:8313472
Viñals M et al. Aspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages. 2005 Cardiovasc. Res. pmid:15769457
Yuan Z et al. Peroxisome proliferation-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis. 2003 Cardiovasc. Res. pmid:14499870
Chintalgattu V et al. PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts. 2007 Cardiovasc. Res. pmid:17320065
Ramji DP Growth hormone-releasing peptides, CD36, and stimulation of cholesterol efflux: cyclooxygenase-2 is the link. 2009 Cardiovasc. Res. pmid:19520704
Tomita H et al. Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells. 2005 Cardiovasc. Res. pmid:15949477
Bujold K et al. CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages. 2009 Cardiovasc. Res. pmid:19377069
Qiu H et al. Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia. 2012 Cardiovasc. Res. pmid:22707158
Chatterjee PK et al. The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure. 2004 Cardiovasc. Res. pmid:14962493
Carlson LM et al. Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma. 2013 Carcinogenesis pmid:23349014
Millán O et al. Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. 2006 Carcinogenesis pmid:16113051
Pavan L et al. Human invasive trophoblasts transformed with simian virus 40 provide a new tool to study the role of PPARgamma in cell invasion process. 2003 Carcinogenesis pmid:12807721
Kim DH et al. 15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS. 2009 Carcinogenesis pmid:19136476
Clay CE et al. Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells. 1999 Carcinogenesis pmid:10506103
Kim EH et al. 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. 2008 Carcinogenesis pmid:18192694
Kobayashi Y et al. Syntheses of 2,6-dideoxy-6-fluoro-2-[(3R and 3S)-3- hydroxytetradecanamido]-3-O-[(3R)-3-(tetradecanoyloxy)tetra decanoyl]-D- glucopyranose 4-(dihydrogen phosphate) and 2-deoxy-2-[(3R and 3S)-3- hydroxytetradecanamido]-3-O-[(3R)-3-(tetradecanoyloxy)tetra decanoyl]- alpha-D-glucopyranosyl fluoride 4-(dihydrogen phosphate): fluorosugar analogues of GLA-60. 1991 Carbohydr. Res. pmid:1813114
Chen F Endogenous inhibitors of nuclear factor-kappaB, an opportunity for cancer control. 2004 Cancer Res. pmid:15548674
Atsmon J et al. Conjugation of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 with intracellular glutathione and enhancement of its antiproliferative activity by glutathione depletion. 1990 Cancer Res. pmid:2306739
Sakai T et al. Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or delta 12-prostaglandin J2 on human osteosarcoma cells. 1989 Cancer Res. pmid:2917351
Chiabrando C et al. Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. 1987 Cancer Res. pmid:3100032
McClay EF et al. delta 12-Prostaglandin-J2 is cytotoxic in human malignancies and synergizes with both cisplatin and radiation. 1996 Cancer Res. pmid:8752147
Rubin GL et al. Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy. 2000 Cancer Res. pmid:10749129
Houston KD et al. Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. 2003 Cancer Res. pmid:12649180
Yang VW et al. Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis. 1998 Cancer Res. pmid:9563494
Vanaja DK et al. Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14-prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells. 2000 Cancer Res. pmid:10987274
Abdel-Malek ZA et al. In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins. 1987 Cancer Res. pmid:2438034
Ishioka C et al. Inhibitory effects of prostaglandin A2 on c-myc expression and cell cycle progression in human leukemia cell line HL-60. 1988 Cancer Res. pmid:3162825
Iwanaga K et al. Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. 2014 Cancer Res. pmid:24879565
Kim J et al. Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived products. 2005 Cancer Res. pmid:16024620
Park JM et al. Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. 2007 Cancer Res. pmid:17283118
Kim HJ et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain. 2007 Cancer Res. pmid:17363578
Bregman MD et al. Inhibition of human melanoma growth by prostaglandin A, D, and J analogues. 1986 Cancer Res. pmid:3698005
Kato T et al. Antitumor activity of delta 7-prostaglandin A1 and delta 12-prostaglandin J2 in vitro and in vivo. 1986 Cancer Res. pmid:3708585
Shimakura S and Boland CR Eicosanoid production by the human gastric cancer cell line AGS and its relation to cell growth. 1992 Cancer Res. pmid:1551103
Badawi AF et al. Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma. 2004 Cancer Res. pmid:14871855
Bhuyan BK et al. Cell cycle effects of prostaglandins A1, A2, and D2 in human and murine melanoma cells in culture. 1986 Cancer Res. pmid:3456266
Kikuchi Y et al. Inhibition of human ovarian cancer cell growth in vitro and in nude mice by prostaglandin D2. 1986 Cancer Res. pmid:3458525
Avis I et al. Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition. 2005 Cancer Res. pmid:15899809
Grau R et al. Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. 2004 Cancer Res. pmid:15289320
Chinery R et al. Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. 1999 Cancer Res. pmid:10364000
Desmond JC et al. The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs. 2003 Cancer Res. pmid:12543809
Zimmer M et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. 2010 Cancer Res. pmid:20354189
Qin C et al. Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. 2003 Cancer Res. pmid:12615709
Davies NJ et al. AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. 2009 Cancer Res. pmid:19487289
Park EY et al. Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer. 2004 Cancer Res. pmid:15150131
Tippin BL et al. Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR. 2014 Cancer Med pmid:24729479
Fu YG et al. Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J2 through the downregulation of angiopoietin-1. 2006 Cancer Lett. pmid:16412567
Cesario RM et al. Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer. 2006 Cancer Lett. pmid:16271436
Qiao L et al. Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. 2008 Cancer Lett. pmid:18477501
Tan BS et al. 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). 2013 Cancer Lett. pmid:23612072
Núñez NP et al. PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. 2006 Cancer Lett. pmid:15979236
Sakai T et al. Prostaglandin D2 inhibits the proliferation of human neuroblastoma cells. 1983 Cancer Lett. pmid:6572553
Siavash H et al. Targeting of epidermal growth factor receptor by cyclopentenone prostaglandin 15-Deoxy-Delta12,14-prostaglandin J2 in human oral squamous carcinoma cells. 2004 Cancer Lett. pmid:15194221
Hawcroft G et al. Expression of prostaglandin D2 receptors DP1 and DP2 by human colorectal cancer cells. 2004 Cancer Lett. pmid:15172124
Sabichi AL et al. Peroxisome proliferator-activated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. 2004 Cancer Epidemiol. Biomarkers Prev. pmid:15533896
Subbarayan V et al. Differential peroxisome proliferator-activated receptor-gamma isoform expression and agonist effects in normal and malignant prostate cells. 2004 Cancer Epidemiol. Biomarkers Prev. pmid:15533897
Nagata D et al. Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer. 2008 Cancer Detect. Prev. pmid:18789607
Liu J et al. Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells. 2005 Cancer Chemother. Pharmacol. pmid:15838654
Liao CH et al. Antiplatelet effect of demethyldiisoeugenol. 1996 Can. J. Physiol. Pharmacol. pmid:9022830
Coe JY et al. A fetal-instrumented model to study age-specific responses to leukotriene D4 and prostaglandin D2 in unsedated newborn lambs. 1989 Can. J. Physiol. Pharmacol. pmid:2776077
Larsen P et al. Calcium-stimulated short-circuit currents in the canine proximal colonic epithelium: effects of DK-PGD2, a metabolite of prostaglandin D2. 2002 Can. J. Physiol. Pharmacol. pmid:12489928
Sato T et al. Decreased hypothalamic prostaglandin D2 and prostaglandin E2 contents during isoflurane anaesthesia in rats. 1995 Can J Anaesth pmid:8590493
Takagi T et al. Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats. 1993 Calcif. Tissue Int. pmid:8369992
Maurin AC et al. Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. 2005 Calcif. Tissue Int. pmid:15868283