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Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. |
2007 |
Atherosclerosis |
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In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites. |
2007 |
Bioorg. Med. Chem. Lett. |
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Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids. |
2007 |
Brain Res. |
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Kang MA et al. |
Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. |
2007 |
Life Sci. |
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The effect of MK-0524, a prostaglandin D(2) receptor antagonist, on prostaglandin D (2)-induced nasal airway obstruction in healthy volunteers. |
2007 |
Eur. J. Clin. Pharmacol. |
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Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2, and expression of cyclooxygenases. |
2007 |
Toxicon |
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Focal cerebral ischemia/reperfusion injury in mice induces hematopoietic prostaglandin D synthase in microglia and macrophages. |
2007 |
Neuroscience |
pmid:17241746
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Tinfo N and Komar C |
Potential role for peroxisome proliferator-activated receptor gamma in regulating luteal lifespan in the rat. |
2007 |
Reproduction |
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Payne SG et al. |
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. |
2007 |
Blood |
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Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells. |
2007 |
Nephrol. Dial. Transplant. |
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Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. |
2007 |
Am. J. Pathol. |
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Regulation and function of collagenous repeat containing sequence of 26-kDa protein gene product "cartonectin". |
2007 |
Obesity (Silver Spring) |
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[Effect of peroxisome proliferators-activated receptor-gamma in the mechanisms of sulindac against large intestine carcinoma]. |
2007 |
Beijing Da Xue Xue Bao |
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Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells. |
2007 |
Eur. J. Pharmacol. |
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Takaoka A et al. |
Role of scratch-induced cutaneous prostaglandin D production on atopic-like scratching behaviour in mice. |
2007 |
Exp. Dermatol. |
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4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells. |
2007 |
Free Radic. Biol. Med. |
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Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages. |
2007 |
Circ. Res. |
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Hwang J et al. |
15-deoxy-Delta12,14-prostaglandin J2-induced down-regulation of endothelial nitric oxide synthase in association with HSP70 induction. |
2007 |
Biochem. Biophys. Res. Commun. |
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Arnold R et al. |
Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. |
2007 |
Immunology |
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[Effects of peroxisome proliferator-activated receptor gamma and its ligands on cytotrophoblast invasion in first trimester of pregnancy and mechanism thereof]. |
2007 |
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[Synthesis of chemical probes based on combinatorial chemistry and lab automation]. |
2007 |
Tanpakushitsu Kakusan Koso |
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Kushikata T et al. |
[Sleep and anesthesia--Part 1, Recent findings in research]. |
2007 |
Masui |
pmid:17877045
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PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. |
2007 |
Am. J. Physiol. Endocrinol. Metab. |
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Brunoldi EM et al. |
Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione. |
2007 |
Chem. Res. Toxicol. |
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Rollins MD et al. |
Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. |
2006 Sep-Oct |
J. Gastrointest. Surg. |
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The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells. |
2006 Sep-Oct |
J. Diabetes Complicat. |
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Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. |
2006 Oct-Dec |
Int. J. Biol. Markers |
pmid:17177158
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Lappas M et al. |
15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. |
2006 Nov-Dec |
Placenta |
pmid:16434095
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Urade Y |
Twenty-fifth anniversary of the discovery of somnogenic activity of prostaglandin D2: sleep research directed by Osamu Hayaishi. |
2006 May-Jun |
IUBMB Life |
pmid:16754308
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Okano M et al. |
Presence and characterization of prostaglandin D2-related molecules in nasal mucosa of patients with allergic rhinitis. |
2006 May-Jun |
Am J Rhinol |
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Guyer BJ et al. |
Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis. |
2006 May-Jun |
Allergy Asthma Proc |
pmid:16913263
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Akabane H et al. |
Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. |
2006 |
Allergol Int |
pmid:17130681
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Ishimura M et al. |
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. |
2006 |
Allergol Int |
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Mazid MA et al. |
Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. |
2006 |
FEBS Lett. |
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[The peroxisome-proliferator-activated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD)]. |
2006 |
J. Soc. Biol. |
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Kang DS et al. |
15-deoxy-Delta12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism. |
2006 |
Toxicol. Appl. Pharmacol. |
pmid:16890972
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Nakata S et al. |
15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis. |
2006 |
Mol. Cancer Ther. |
pmid:16891469
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Wang XS and Lau HY |
Beta-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells. |
2006 |
Clin. Exp. Pharmacol. Physiol. |
pmid:16895550
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Zhang A et al. |
Prostaglandin D2 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in MDCK cells. |
2006 |
Am. J. Physiol. Renal Physiol. |
pmid:16896186
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Chaffer CL et al. |
PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. |
2006 |
BMC Cancer |
pmid:16519808
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Pérez S et al. |
The 2-series prostaglandins suppress VLDL secretion in an inflammatory condition-dependent manner in primary rat hepatocytes. |
2006 |
Biochim. Biophys. Acta |
pmid:16545597
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Wise H |
Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells. |
2006 |
Eur. J. Pharmacol. |
pmid:16545798
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Wang XS et al. |
Functional characterization of human mast cells cultured from adult peripheral blood. |
2006 |
Int. Immunopharmacol. |
pmid:16546715
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Sawai H et al. |
Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. |
2006 |
Mol. Cancer Res. |
pmid:16547153
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Herlong JL and Scott TR |
Positioning prostanoids of the D and J series in the immunopathogenic scheme. |
2006 |
Immunol. Lett. |
pmid:16310861
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Merwald H et al. |
Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2. |
2006 |
Cell Stress Chaperones |
pmid:16572732
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Sato TA and Mitchell MD |
Preferential production of prostaglandin D2 by lipopolysaccharide stimulated human choriodecidual explants. |
2006 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:16380246
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Chiang PC et al. |
Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells. |
2006 |
Eur. J. Pharmacol. |
pmid:16806159
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Honma Y et al. |
Effects of indomethacin and dexamethasone on mechanical scratching-induced cutaneous barrier disruption in mice. |
2006 |
Exp. Dermatol. |
pmid:16761958
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El Mezayen R et al. |
Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. |
2006 |
Immunol. Lett. |
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Kobayashi M et al. |
ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. |
2006 |
Genes Cells |
pmid:16824197
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Ogburn KD and Figueiredo-Pereira ME |
Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates. |
2006 |
J. Biol. Chem. |
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Zhang M et al. |
Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. |
2006 |
Int. Immunopharmacol. |
pmid:16782535
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Shimizu T et al. |
A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage. |
2006 |
Ann. Surg. |
pmid:16794398
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Chen Y et al. |
Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. |
2006 |
J. Cell. Biochem. |
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Yucel-Lindberg T et al. |
Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. |
2006 |
Cell. Signal. |
pmid:16766159
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Peroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis. |
2006 |
J. Biol. Chem. |
pmid:16766531
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Sugimoto M et al. |
Role of COX-1 and COX-2 on skin PGs biosynthesis by mechanical scratching in mice. |
2006 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:16815697
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Schwartz MS et al. |
Determination of a prostaglandin D2 antagonist and its acyl glucuronide metabolite in human plasma by high performance liquid chromatography with tandem mass spectrometric detection--a lack of MS/MS selectivity between a glucuronide conjugate and a phase I metabolite. |
2006 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:16716772
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Na HK and Surh YJ |
Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection. |
2006 |
Mol. Carcinog. |
pmid:16673384
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BrazÃs P et al. |
Dermal microdialysis in the dog: in vivo assessment of the effect of cyclosporin A on cutaneous histamine and prostaglandin D2 release. |
2006 |
Vet. Dermatol. |
pmid:16674731
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Hickson-Bick DL et al. |
The response of neonatal rat ventricular myocytes to lipopolysaccharide-induced stress. |
2006 |
Shock |
pmid:16680021
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Son MJ et al. |
Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. |
2006 |
Arch. Pharm. Res. |
pmid:16681032
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Grill M et al. |
Systemic inflammation induces COX-2 mediated prostaglandin D2 biosynthesis in mice spinal cord. |
2006 |
Neuropharmacology |
pmid:16182321
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Zhao X et al. |
15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. |
2006 |
J. Cereb. Blood Flow Metab. |
pmid:16208315
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[The role of peroxisome proliferator-activated receptor gamma in proliferation of cardiac non myocytes]. |
2006 |
Zhongguo Ying Yong Sheng Li Xue Za Zhi |
pmid:21162229
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Shiraki T et al. |
Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting. |
2006 |
Biochem. J. |
pmid:16236024
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Maciejewski-Lenoir D et al. |
Langerhans cells release prostaglandin D2 in response to nicotinic acid. |
2006 |
J. Invest. Dermatol. |
pmid:17008871
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Wilson RJ et al. |
GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. |
2006 |
Br. J. Pharmacol. |
pmid:16604093
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Millán O et al. |
Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. |
2006 |
Carcinogenesis |
pmid:16113051
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Pereira MP et al. |
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. |
2006 |
J. Cereb. Blood Flow Metab. |
pmid:16034372
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Kim EH et al. |
Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. |
2006 |
Ann. N. Y. Acad. Sci. |
pmid:17384282
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Sugimoto M et al. |
Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Nga mice. |
2006 |
Exp. Dermatol. |
pmid:17002684
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Feldon SE et al. |
Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. |
2006 |
Am. J. Pathol. |
pmid:17003477
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Peeraully MR et al. |
Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. |
2006 |
Pflugers Arch. |
pmid:16924534
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Eucker J et al. |
Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. |
2006 |
Anticancer Drugs |
pmid:16926626
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Satoh T et al. |
Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. |
2006 |
J. Immunol. |
pmid:16888024
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Sugimoto M et al. |
COX-1 inhibition enhances scratching behaviour in NC/Nga mice with atopic dermatitis. |
2006 |
Exp. Dermatol. |
pmid:16842596
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Quinkler M et al. |
Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis. |
2006 |
Gene |
pmid:16842938
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Raikwar HP et al. |
PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. |
2006 |
J. Neuroimmunol. |
pmid:16844232
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Willermain F et al. |
15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. |
2006 |
Prostaglandins Other Lipid Mediat. |
pmid:16939878
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Lim HJ et al. |
PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. |
2006 |
Prostaglandins Other Lipid Mediat. |
pmid:16939881
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Chiba T et al. |
Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway. |
2006 |
Int. Arch. Allergy Immunol. |
pmid:16940740
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Yu X et al. |
Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. |
2006 |
J. Biol. Chem. |
pmid:16857669
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Chen ZH et al. |
Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta(12,14)-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms. |
2006 |
J. Biol. Chem. |
pmid:16565077
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Horiguchi T et al. |
Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. |
2006 |
Neuroscience |
pmid:16567054
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Siddhivarn C et al. |
Prostaglandin D2 pathway and peroxisome proliferator-activated receptor gamma-1 expression are induced by mechanical loading in an osteoblastic cell line. |
2006 |
J. Periodont. Res. |
pmid:16499711
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Coyle AT and Kinsella BT |
Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells. |
2006 |
Biochem. Pharmacol. |
pmid:16499875
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Makino N et al. |
Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia. |
2006 |
Cell Biochem. Biophys. |
pmid:16456235
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Figarella K et al. |
Prostaglandin-induced programmed cell death in Trypanosoma brucei involves oxidative stress. |
2006 |
Cell Death Differ. |
pmid:16456581
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Takai S et al. |
Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily. |
2006 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:16876988
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Piraino G et al. |
Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. |
2006 |
Shock |
pmid:16878022
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Moulin D et al. |
Effect of peroxisome proliferator activated receptor (PPAR)gamma agonists on prostaglandins cascade in joint cells. |
2006 |
Biorheology |
pmid:16912428
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Yeh CH et al. |
Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. |
2006 |
Shock |
pmid:16912651
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Ye F et al. |
Quantitative characterization of 15-deoxy-delta(12,14)-prostaglandin J2 in regulating EGFPSmad2 translocation in CHO cells through PPARgamma/TGFbeta/Smad2 pathway. |
2006 |
Cell. Physiol. Biochem. |
pmid:16914899
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Lee JJ et al. |
Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. |
2006 |
Vascul. Pharmacol. |
pmid:16916624
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Ulven T and Kostenis E |
Targeting the prostaglandin D2 receptors DP and CRTH2 for treatment of inflammation. |
2006 |
Curr Top Med Chem |
pmid:16918458
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Theiner G et al. |
The mast cell mediator PGD2 suppresses IL-12 release by dendritic cells leading to Th2 polarized immune responses in vivo. |
2006 |
Immunobiology |
pmid:16920486
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Urade Y and Mohri I |
[Sleep and brain function]. |
2006 |
No To Hattatsu |
pmid:16986732
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Kim EH and Surh YJ |
15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors. |
2006 |
Biochem. Pharmacol. |
pmid:16987499
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