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[Prostaglandin D2 in allergy: PGD2 has dual receptor systems]. |
2004 |
Nippon Yakurigaku Zasshi |
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Physiology and pharmacology of the prostaglandin J2 family. |
2004 |
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COX-2-mediated PGD2 synthesis regulates phosphatidylcholine biosynthesis in rat renal papillary tissue. |
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15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB. |
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Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats. |
2004 |
Kidney Int. |
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PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. |
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Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. |
2004 |
Clin. Immunol. |
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(S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model. |
2004 |
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Lysophosphatidic acid attenuates the cytotoxic effects and degree of peroxisome proliferator-activated receptor gamma activation induced by 15-deoxyDelta12,14-prostaglandin J2 in neuroblastoma cells. |
2004 |
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MITF is necessary for generation of prostaglandin D2 in mouse mast cells. |
2004 |
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15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells. |
2004 |
Tohoku J. Exp. Med. |
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The biphasic effects of cyclopentenone prostaglandins, prostaglandin J(2) and 15-deoxy-Delta(12,14)-prostaglandin J(2) on proliferation and apoptosis in rat basophilic leukemia (RBL-2H3) cells. |
2004 |
Biochem. Pharmacol. |
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Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion. |
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Am. J. Physiol. Endocrinol. Metab. |
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Peroxisome proliferator-activated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. |
2004 |
Cancer Epidemiol. Biomarkers Prev. |
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Differential peroxisome proliferator-activated receptor-gamma isoform expression and agonist effects in normal and malignant prostate cells. |
2004 |
Cancer Epidemiol. Biomarkers Prev. |
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Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. |
2004 |
Anticancer Drugs |
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Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts. |
2004 |
Prostaglandins Leukot. Essent. Fatty Acids |
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The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. |
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J. Immunol. |
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Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. |
2004 |
Arch Ital Biol |
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Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. |
2004 |
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Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510. |
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Expression and function of PPARgamma in rat placental development. |
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Mol. Pharmacol. |
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Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. |
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Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. |
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J Laryngol Otol |
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Curr Vasc Pharmacol |
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15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway. |
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15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. |
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15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity. |
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Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion. |
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Expression of prostaglandin D2 receptors DP1 and DP2 by human colorectal cancer cells. |
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Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway. |
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CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation. |
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Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells. |
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Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists. |
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BMC Pharmacol. |
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Physiological apoptotic agents have different effects upon human amnion epithelial and mesenchymal cells. |
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Placenta |
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Hematopoietic prostaglandin D synthase. |
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Prostaglandins Leukot. Essent. Fatty Acids |
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The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
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A novel PGD(2) receptor expressed in eosinophils. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895601
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The DP receptor, allergic inflammation and asthma. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
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Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. |
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PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes. |
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Hypertension |
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Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts. |
2003 |
Gastroenterology |
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Biochem. Biophys. Res. Commun. |
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Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cells. |
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Eur. J. Pharmacol. |
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First total synthesis of JS isoprostane. |
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Mol. Cell. Biochem. |
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Cytokines, prostaglandins and parturition--a review. |
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Placenta |
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15-Deoxy-delta12,14-prostaglandin J2, a ligand for peroxisome proliferators-activated receptor-gamma, induces apoptosis in human hepatoma cells. |
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Liver Int. |
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Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor. |
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Blood |
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Peroxisome proliferation-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis. |
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Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut. |
2003 |
Br. J. Pharmacol. |
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Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator. |
2003 |
Surgery |
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Peroxisome proliferator-activated receptor-gamma activated by ligands can inhibit human lung cancer cell growth through induction of apoptosis. |
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J. Huazhong Univ. Sci. Technol. Med. Sci. |
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15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product? |
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15d-PGJ2 inhibits cell growth and induces apoptosis of MCG-803 human gastric cancer cell line. |
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World J. Gastroenterol. |
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Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. |
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Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats. |
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J. Pharmacol. Exp. Ther. |
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Inducible cyclooxygenase-derived 15-deoxy(Delta)12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis. |
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FASEB J. |
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Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. |
2003 |
J. Allergy Clin. Immunol. |
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15-deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma. |
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Lab. Invest. |
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Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. |
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Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2. |
2003 |
Biochem. Biophys. Res. Commun. |
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Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1. |
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J. Immunol. |
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[Trend in chemical mediator research in asthma and its application for asthma treatment]. |
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Nihon Kokyuki Gakkai Zasshi |
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15-deoxy-delta(12,14)-prostaglandin J2 inhibits IFN-gamma-induced galectin-9 expression in cultured human umbilical vein endothelial cells. |
2003 |
Int. Arch. Allergy Immunol. |
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A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2. |
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Infect. Immun. |
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Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme. |
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Thioredoxin as a molecular target of cyclopentenone prostaglandins. |
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Regulation of heme oxygenase expression by cyclopentenone prostaglandins. |
2003 |
Exp. Biol. Med. (Maywood) |
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Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair. |
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J. Invest. Dermatol. |
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Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD). |
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Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis. |
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Prostaglandin J2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy. |
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Loss of microglial ramification in microglia-astrocyte cocultures: involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems. |
2003 |
Glia |
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Stimulation of proximal tubular cell apoptosis by albumin-bound fatty acids mediated by peroxisome proliferator activated receptor-gamma. |
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J. Am. Soc. Nephrol. |
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