| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stroke | D020521 | 32 associated lipids |
| Multiple Sclerosis, Relapsing-Remitting | D020529 | 7 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Coronary Restenosis | D023903 | 10 associated lipids |
| Tauopathies | D024801 | 6 associated lipids |
| Mastocytosis, Systemic | D034721 | 1 associated lipids |
| Decapitation | D049248 | 2 associated lipids |
| Graves Ophthalmopathy | D049970 | 3 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Frölich JC et al. | Advances in the analysis of eicosanoids by ELISA and GC/MS/MS. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949561 |
| Barnea A et al. | Evidence that a short-lived effect of copper leads to amplification of prostaglandin E2 stimulation of the release of gonadotropin-releasing hormone from median eminence explants. | 1986 | Endocrinology | pmid:3525128 |
| Nordlund JJ et al. | Prostaglandin E2 and D2 but not MSH stimulate the proliferation of pigment cells in the pinnal epidermis of the DBA/2 mouse. | 1986 | J. Invest. Dermatol. | pmid:3528310 |
| Hattori Y and Levi R | Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3012066 |
| Tsao CJ et al. | In-vitro effects of antineoplastic prostaglandins on human leukemic cell growth and normal myelopoiesis. | 1986 | Leuk. Res. | pmid:3012210 |
| Halenda SP et al. | Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets. | 1986 | FEBS Lett. | pmid:3015684 |
| Todo S et al. | Cell kinetic studies of PGD2 cytotoxicity on the in vitro growth of human neuroblastoma. | 1986 | Prostaglandins Leukot Med | pmid:3016753 |
| Bhattacharya SK | The antinociceptive effect of intracerebroventricularly administered prostaglandin D2 in the rat. | 1986 | Psychopharmacology (Berl.) | pmid:3016786 |
| Hamid-Bloomfield S and Whittle BJ | Prostaglandin D2 interacts at thromboxane receptor-sites on guinea-pig platelets. | 1986 | Br. J. Pharmacol. | pmid:3017497 |
| Shalit M et al. | New role for heparan sulfate: regulator of leukotriene generation in mouse E-mast cells. | 1986 | Life Sci. | pmid:3018403 |
| Kuno S et al. | Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3010301 |
| Ohno K et al. | Metabolic dehydration of prostaglandin E2 and cellular uptake of the dehydration product: correlation with prostaglandin E2-induced growth inhibition. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3464277 |
| Wells E et al. | Characterization of primate bronchoalveolar mast cells. I. IgE-dependent release of histamine, leukotrienes, and prostaglandins. | 1986 | J. Immunol. | pmid:2431048 |
| Eling TE et al. | Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase. | 1986 | J. Biol. Chem. | pmid:3007487 |
| Narumiya S and Fukushima M | Site and mechanism of growth inhibition by prostaglandins. I. Active transport and intracellular accumulation of cyclopentenone prostaglandins, a reaction leading to growth inhibition. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3772804 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Peters SP et al. | The pharmacologic control of mediator release from human basophils and mast cells. | 1986 | Respiration | pmid:3494282 |
| Bhuyan BK et al. | Cell cycle effects of prostaglandins A1, A2, and D2 in human and murine melanoma cells in culture. | 1986 | Cancer Res. | pmid:3456266 |
| Brooks DP et al. | Role of brain prostaglandins in the control of vasopressin secretion in the conscious rat. | 1986 | Endocrinology | pmid:3456303 |
| Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3456602 |
| Maclouf J et al. | Development of a radioimmunoassay for prostaglandin D2 using an antiserum against 11-methoxime prostaglandin D2. | 1986 | Prostaglandins | pmid:3456623 |
| Ruzicka T et al. | Skin levels of arachidonic acid-derived inflammatory mediators and histamine in atopic dermatitis and psoriasis. | 1986 | J. Invest. Dermatol. | pmid:3018086 |
| Kuno S et al. | Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3458226 |
| Ikai K et al. | Ear swelling in response to UVB irradiation. | 1986 | Arch. Dermatol. Res. | pmid:3466577 |
| Rees MC and Kelly RW | Prostaglandin D2 release by endometrium and myometrium. | 1986 | Br J Obstet Gynaecol | pmid:3466645 |
| Hardy CC et al. | Evidence against the formation of 13,14-dihydro-15-keto-prostaglandin F2 alpha following inhalation of prostaglandin D2 in man. | 1986 | Br. J. Pharmacol. | pmid:3467804 |
| Inoué S | Multifactorial humoral regulation of sleep. | 1986 | Clin Neuropharmacol | pmid:3471328 |
| Bhuyan BK et al. | Cytotoxicity of combinations of prostaglandin D2 (PGD2) and antitumor drugs for B16 melanoma cells in culture. | 1986 | Invest New Drugs | pmid:3473056 |
| Tokumoto H et al. | Specificity of prostaglandin D2 binding to synaptic membrane fraction of rat brain. | 1986 | Brain Res. | pmid:2867812 |
| Honn KV et al. | Possible strategies for antimetastastic therapy. | 1986 | Prog. Clin. Biol. Res. | pmid:3520578 |
| Watanabe Y et al. | Modulation by prostaglandin D2 of mitral cell responses to odor stimulation in rabbit olfactory bulb. | 1986 | Brain Res. | pmid:2873871 |
| Huddleston KW et al. | Influence of prostaglandin D2 on hemodynamic effects of group B streptococcus in neonatal lambs. | 1986 | Dev Pharmacol Ther | pmid:3530674 |
| Hiroshima O et al. | Basal level of prostaglandin D2 in rat brain by a solid-phase enzyme immunoassay. | 1986 | Prostaglandins | pmid:3532208 |
| Strobl-Jäger E et al. | Influence of type IIa, IIb and IV-hyperlipoproteinemia on platelet prostaglandin sensitivity, plasma thromboxane B2 and platelet half-life. | 1986 | Prostaglandins Leukot Med | pmid:3540998 |
| Haxhiu MA et al. | [Bronchial response to prostaglandins (F2 alpha and D2) and leukotrienes in patients with bronchial asthma]. | 1986 Jan-Mar | Plucne Bolesti | pmid:3466189 |
| Zijlstra FJ et al. | Formation of prostaglandins and leukotrienes by human lung tissue in vitro after activation by the calcium ionophore A23187. | 1987 | Eur. J. Clin. Invest. | pmid:2822430 |
| Pugliese G et al. | 9 alpha, 11 beta-prostaglandin F2: a new prostanoid with selective biosynthesis and unique biological activity. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959104 |
| Narumiya S et al. | Site and mechanism of growth inhibition by prostaglandins. III. Distribution and binding of prostaglandin A2 and delta 12-prostaglandin J2 in nuclei. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3302206 |
| Robinson C et al. | Effects of inhaled 9 alpha, 11 beta-prostaglandin F2 on airway function in man. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960146 |
| Roberts LJ | Recent metabolic findings bring into question the reliability of existing methods for quantification of PGF2 alpha and its metabolites in human biological fluids. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960165 |
| Jacobsen S et al. | Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [14C]arachidonic acid and histamine from rat peritoneal mast cells. | 1987 | Biochem. Pharmacol. | pmid:2435291 |
| Prakash C et al. | Synthesis of putative prostaglandin D2 metabolites. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960191 |
| Kawabe H et al. | Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2436614 |
| Watanabe Y et al. | Synthesis of 11C-labeled prostaglandins and positron emission tomography studies using the rhesus monkey. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960207 |
| Hayaishi O et al. | Prostaglandin D2 induces sleep when infused into the cerebral ventricle of conscious monkeys. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960208 |
| Narumiya S and Fukushima M | Active transport and cellular accumulation of cyclopentenone prostaglandins: a mechanism of prostaglandin-induced growth inhibition. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960214 |
| Ono K et al. | Suppressive effects of various antitumor prostaglandin derivatives on the activity levels of DNA polymerases in human cultured tumor cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960215 |
| Beasley R et al. | Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma. | 1987 | Am. Rev. Respir. Dis. | pmid:2960256 |
| Saito R et al. | The effect of neurotransmitters on cataleptic behavior induced by PG D2 in rats. | 1987 | Pharmacol. Biochem. Behav. | pmid:2883669 |
| Westcott JY et al. | Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. | 1987 | Prostaglandins | pmid:2835791 |
| Goh Y et al. | Content and formation of prostaglandins and distribution of prostaglandin-related enzyme activities in the rat ocular system. | 1987 | Biochim. Biophys. Acta | pmid:3477292 |
| Chiabrando C et al. | Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. | 1987 | Cancer Res. | pmid:3100032 |
| Bhattacharya SK and Parmar SS | Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism. | 1987 | Pharm. Res. | pmid:2977646 |
| Santoro MG et al. | PGJ2, a new antiviral prostaglandin: inhibition of Sendai virus replication and alteration of virus protein synthesis. | 1987 | J. Gen. Virol. | pmid:3033130 |
| Levi-Schaffer F et al. | Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. | 1987 | J. Immunol. | pmid:2445814 |
| Kozuka T et al. | Prostaglandin D2 release by guinea pig skin during in vitro anaphylaxis induced by antigen and compound 48/80. | 1987 | J. Invest. Dermatol. | pmid:2433354 |
| Church MK and Hiroi J | Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. | 1987 | Br. J. Pharmacol. | pmid:2435353 |
| Pearce FL et al. | Some studies on human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymic dissociation of whole lung tissue. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:2437052 |
| Weinreich D and Undem BJ | Immunological regulation of synaptic transmission in isolated guinea pig autonomic ganglia. | 1987 | J. Clin. Invest. | pmid:2437156 |
| Abdel-Malek ZA et al. | In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins. | 1987 | Cancer Res. | pmid:2438034 |
| Bushfield M et al. | Effects of protein kinase C activation on human platelet cyclic AMP metabolism. | 1987 | FEBS Lett. | pmid:2820806 |
| Williams KA et al. | Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets. | 1987 | Biochem. J. | pmid:2444206 |
| Lawrence ID et al. | Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity. | 1987 | J. Immunol. | pmid:2444649 |
| Benyon RC et al. | Prostaglandin D2 release from human skin mast cells in response to ionophore A23187. | 1987 | Br. J. Pharmacol. | pmid:2447989 |
| Underwood DC et al. | Blockade of thromboxane responses in the airway of the cat by SQ 29,548. | 1987 | J. Appl. Physiol. | pmid:2440845 |
| Levi-Schaffer F et al. | Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes. | 1987 | J. Immunol. | pmid:2439587 |
| Leung KB et al. | Some further properties of human pulmonary mast cells recovered by bronchoalveolar lavage and enzymic dispersion of lung tissue. | 1987 | Agents Actions | pmid:2440274 |
| Church MK et al. | Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. | 1987 | Clin. Allergy | pmid:2441900 |
| Kosaka Y et al. | Oxatomide inhibits the release of bronchoconstrictor arachidonic acid metabolites (iLTC4 and PGD2) from rat mast cells and guinea-pig lung. | 1987 | Agents Actions | pmid:2442981 |
| Pipkorn U et al. | Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge. | 1987 | J. Clin. Invest. | pmid:2443539 |
| Rodriguez R et al. | Effect of nimodipine on arachidonic acid metabolites after subarachnoid hemorrhage. | 1987 | Acta Neurol. Scand. | pmid:3120489 |
| Namima M and Okamoto K | Modulatory action of prostaglandin D2 on the release of 3H-norepinephrine from rat cerebellar slices. | 1987 | Jpn. J. Pharmacol. | pmid:2883337 |
| Tilden SJ et al. | Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2. | 1987 | J. Appl. Physiol. | pmid:2954941 |
| Foreman D et al. | Effects of E2 levuglandins on the contractile activity of the rat uterus. | 1987 | Prostaglandins | pmid:3317517 |
| Suzuki F et al. | Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. | 1987 | Biochim. Biophys. Acta | pmid:3467795 |
| Richelsen B | Relationship between binding and action of different prostaglandins in rat adipocytes with special reference to PGE2 and PGI2. | 1987 | Biochem. Pharmacol. | pmid:2825710 |
| Hayashi H et al. | Metabolism of prostaglandin D2 in isolated rat lung: the stereospecific formation of 9 alpha,11 beta-prostaglandin F2 from prostaglandin D2. | 1987 | Biochim. Biophys. Acta | pmid:3467796 |
| Dieter P et al. | Prostaglandin release but not superoxide production by rat Kupffer cells stimulated in vitro depends on Na+/H+ exchange. | 1987 | Eur. J. Biochem. | pmid:2826152 |
| Drummond WH and Carter RL | Cardiac depressant and circulatory effects of prostaglandin D2 in developing lambs. | 1987 | Am. J. Physiol. | pmid:3468806 |
| Burgess JR et al. | Enzymatic transformation of PGH2 to PGF2 alpha catalyzed by glutathione S-transferases. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3468949 |
| Beasley CR et al. | 9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. | 1987 | J. Clin. Invest. | pmid:3469218 |
| Maurice PD et al. | The effect of prostaglandin D2 on the response of human skin to histamine. | 1987 | J. Invest. Dermatol. | pmid:3476674 |
| Berryman GK et al. | Amniotic fluid prostaglandin D2 in spontaneous and augmented labor. | 1987 | Life Sci. | pmid:3476816 |
| Kikuchi Y et al. | Inhibitory effects of neuroendocrine hormones on human ovarian cancer cell proliferation in vitro. | 1987 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:3479504 |
| Tran-Thi TA et al. | Studies on synthesis and degradation of eicosanoids by rat hepatocytes in primary culture. | 1987 | J. Hepatol. | pmid:2828463 |
| Stier CT et al. | Renal response to 9 alpha, 11 beta-prostaglandin F2 in the rat. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3479549 |
| Amano N | [Effects of anesthesia and various types of stress on prostaglandin D2 (PGD2) contents in brain and plasma levels of stress hormones in rats]. | 1987 | Masui | pmid:3480360 |
| Brunelli G et al. | PGD2 induces pulmonary hyperresponsiveness to acetylcholine in vivo in the guinea-pig. | 1987 | J Auton Pharmacol | pmid:3480891 |
| Weinreich D and Wonderlin WF | Inhibition of calcium-dependent spike after-hyperpolarization increases excitability of rabbit visceral sensory neurones. | 1987 | J. Physiol. (Lond.) | pmid:3481834 |
| Nakamura M et al. | In vivo effects of prostaglandins on human retinoblastoma cells in nude mice. | 1987 | Jpn. J. Ophthalmol. | pmid:3482290 |
| Yatomi A et al. | Prostaglandins affect the central nervous system to produce hyperglycemia in rats. | 1987 | Endocrinology | pmid:3474143 |
| Hanasaki K et al. | Beta 2-adrenergic regulation of prostaglandin D2 receptor in rabbit platelets. | 1987 | Biochim. Biophys. Acta | pmid:2880608 |
| Holgate ST et al. | Primary and secondary effector cells in the pathogenesis of bronchial asthma. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3553030 |
| Rao PS et al. | Dose-dependent effects of prostaglandin D2 on hemodynamics, renal function, and blood gas analyses. | 1987 | Am. J. Obstet. Gynecol. | pmid:3555078 |
| Kinoshita T et al. | Predominance of prostaglandin D2 and I2 in the rat gastric mucosa--analysis by high-performance liquid chromatography. | 1987 | Biochem. Int. | pmid:3555501 |
| Matsuura H and Imaya H | [Effect of prostaglandin (delta 12-PGJ2) on host immunity--an experimental study]. | 1987 | Gan To Kagaku Ryoho | pmid:3592721 |
| Yamamoto N et al. | Mechanism of inhibition of herpes simplex virus replication by delta 7-prostaglandin A1 and delta 12-prostaglandin J2. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3040001 |
| Bhattacharya SK and Rao PJ | Prostaglandin D2-induced catalepsy in rats: role of 5-hydroxytryptamine. | 1987 | J. Pharm. Pharmacol. | pmid:2890744 |
| Tamaoki J et al. | Cholinergic neuromodulation by prostaglandin D2 in canine airway smooth muscle. | 1987 | J. Appl. Physiol. | pmid:2891674 |
| Shimojima T et al. | [Effects of prostaglandins on superoxide production by human polymorphonuclear leukocytes]. | 1987 | Nihon Shishubyo Gakkai Kaishi | pmid:2851629 |