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PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation. |
2007 |
Am. J. Physiol. Endocrinol. Metab. |
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Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. |
2007 |
Ann. Hematol. |
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Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. |
2007 |
Atherosclerosis |
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In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites. |
2007 |
Bioorg. Med. Chem. Lett. |
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Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids. |
2007 |
Brain Res. |
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Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. |
2007 |
Arthritis Res. Ther. |
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Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2. |
2007 |
Eur. J. Pharmacol. |
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Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2). |
2007 |
Biochem. Pharmacol. |
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The effect of MK-0524, a prostaglandin D(2) receptor antagonist, on prostaglandin D (2)-induced nasal airway obstruction in healthy volunteers. |
2007 |
Eur. J. Clin. Pharmacol. |
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Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2, and expression of cyclooxygenases. |
2007 |
Toxicon |
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Liu M et al. |
Focal cerebral ischemia/reperfusion injury in mice induces hematopoietic prostaglandin D synthase in microglia and macrophages. |
2007 |
Neuroscience |
pmid:17241746
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Tinfo N and Komar C |
Potential role for peroxisome proliferator-activated receptor gamma in regulating luteal lifespan in the rat. |
2007 |
Reproduction |
pmid:17244745
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Ueki S et al. |
Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. |
2007 |
Int. Arch. Allergy Immunol. |
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Possible novel receptor for PGD2 on human bronchial epithelial cells. |
2007 |
Int. Arch. Allergy Immunol. |
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15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) mediates repression of TNF-alpha by decreasing levels of acetylated histone H3 and H4 at its promoter. |
2007 |
Biochem. Biophys. Res. Commun. |
pmid:17532302
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Lin MS et al. |
Activation of peroxisome proliferator-activated receptor gamma inhibits cell growth via apoptosis and arrest of the cell cycle in human colorectal cancer. |
2007 |
J Dig Dis |
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Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. |
2007 |
Prostaglandins Other Lipid Mediat. |
pmid:17643887
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Desmarais JA et al. |
The peroxisome proliferator-activated receptor gamma regulates trophoblast cell differentiation in mink (Mustela vison). |
2007 |
Biol. Reprod. |
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[The role of lipid mediators in allergic diseases]. |
2007 |
Arerugi |
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Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells. |
2007 |
Shock |
pmid:17621259
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Deficiency of cyclooxygenases transcripts in cultured primary bronchial epithelial cells of aspirin-sensitive asthmatics. |
2007 |
J. Physiol. Pharmacol. |
pmid:17622692
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PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. |
2007 |
Bone |
pmid:17669705
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A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung. |
2007 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes. |
2007 |
Immunology |
pmid:17437532
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Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. |
2006 Sep-Oct |
J. Gastrointest. Surg. |
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The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells. |
2006 Sep-Oct |
J. Diabetes Complicat. |
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Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. |
2006 Oct-Dec |
Int. J. Biol. Markers |
pmid:17177158
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Lappas M et al. |
15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. |
2006 Nov-Dec |
Placenta |
pmid:16434095
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Urade Y |
Twenty-fifth anniversary of the discovery of somnogenic activity of prostaglandin D2: sleep research directed by Osamu Hayaishi. |
2006 May-Jun |
IUBMB Life |
pmid:16754308
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Okano M et al. |
Presence and characterization of prostaglandin D2-related molecules in nasal mucosa of patients with allergic rhinitis. |
2006 May-Jun |
Am J Rhinol |
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Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis. |
2006 May-Jun |
Allergy Asthma Proc |
pmid:16913263
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Arai I |
[Role of cutaneous prostaglandin D2 production on scratching dermatitis in mice]. |
2006 |
Nippon Yakurigaku Zasshi |
pmid:17167214
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Akabane H et al. |
Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. |
2006 |
Allergol Int |
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Ishimura M et al. |
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. |
2006 |
Allergol Int |
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Mazid MA et al. |
Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. |
2006 |
FEBS Lett. |
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[The peroxisome-proliferator-activated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD)]. |
2006 |
J. Soc. Biol. |
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Kang DS et al. |
15-deoxy-Delta12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism. |
2006 |
Toxicol. Appl. Pharmacol. |
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15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis. |
2006 |
Mol. Cancer Ther. |
pmid:16891469
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Wang XS and Lau HY |
Beta-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells. |
2006 |
Clin. Exp. Pharmacol. Physiol. |
pmid:16895550
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Merwald H et al. |
Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2. |
2006 |
Cell Stress Chaperones |
pmid:16572732
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Arnold R and König W |
Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. |
2006 |
Virology |
pmid:16330064
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Sheddan NA and Mulzer J |
Cross metathesis as a general strategy for the synthesis of prostacyclin and prostaglandin analogues. |
2006 |
Org. Lett. |
pmid:16805562
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Kohno S et al. |
Inhibition of skin sclerosis by 15deoxy delta12,14-prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma. |
2006 |
Biomed. Pharmacother. |
pmid:16337105
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Chiang PC et al. |
Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells. |
2006 |
Eur. J. Pharmacol. |
pmid:16806159
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Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins. |
2006 |
Diabetes Obes Metab |
pmid:16367886
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Prostaglandin J2 reduces catechol-O-methyltransferase activity and enhances dopamine toxicity in neuronal cells. |
2006 |
Neurobiol. Dis. |
pmid:16406650
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Honma Y et al. |
Effects of indomethacin and dexamethasone on mechanical scratching-induced cutaneous barrier disruption in mice. |
2006 |
Exp. Dermatol. |
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Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. |
2006 |
Immunol. Lett. |
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15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. |
2006 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:16385084
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Kobayashi M et al. |
ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. |
2006 |
Genes Cells |
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Cyclooxygenase isozymes are expressed in human myeloma cells but not involved in anti-proliferative effect of cyclooxygenase inhibitors. |
2006 |
Mol. Carcinog. |
pmid:16385588
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Ogburn KD and Figueiredo-Pereira ME |
Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates. |
2006 |
J. Biol. Chem. |
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Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. |
2006 |
Am. J. Physiol. Heart Circ. Physiol. |
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Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. |
2006 |
Int. Immunopharmacol. |
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Shimizu T et al. |
A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage. |
2006 |
Ann. Surg. |
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Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. |
2006 |
J. Cell. Biochem. |
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Yucel-Lindberg T et al. |
Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. |
2006 |
Cell. Signal. |
pmid:16766159
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Peroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis. |
2006 |
J. Biol. Chem. |
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Sugimoto M et al. |
Role of COX-1 and COX-2 on skin PGs biosynthesis by mechanical scratching in mice. |
2006 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:16815697
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Bate C et al. |
Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells. |
2006 |
Neuropharmacology |
pmid:16289250
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Bellows CF et al. |
Modulation of macrophage nitric oxide production by prostaglandin D2. |
2006 |
J. Surg. Res. |
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Helliwell RJ et al. |
Gestational age-dependent up-regulation of prostaglandin D synthase (PGDS) and production of PGDS-derived antiinflammatory prostaglandins in human placenta. |
2006 |
J. Clin. Endocrinol. Metab. |
pmid:16291703
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Systemic inflammation induces COX-2 mediated prostaglandin D2 biosynthesis in mice spinal cord. |
2006 |
Neuropharmacology |
pmid:16182321
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Stamatakis K et al. |
Identification of novel protein targets for modification by 15-deoxy-Delta12,14-prostaglandin J2 in mesangial cells reveals multiple interactions with the cytoskeleton. |
2006 |
J. Am. Soc. Nephrol. |
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15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. |
2006 |
J. Cereb. Blood Flow Metab. |
pmid:16208315
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Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria. |
2006 |
Biochem. J. |
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Cesario RM et al. |
Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer. |
2006 |
Cancer Lett. |
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Garg TK and Chang JY |
Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. |
2006 |
J. Neuroimmunol. |
pmid:16225932
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Cho WH et al. |
15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells. |
2006 |
Neurochem. Res. |
pmid:17006759
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Maciejewski-Lenoir D et al. |
Langerhans cells release prostaglandin D2 in response to nicotinic acid. |
2006 |
J. Invest. Dermatol. |
pmid:17008871
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Wilson RJ et al. |
GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. |
2006 |
Br. J. Pharmacol. |
pmid:16604093
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Tanaka H et al. |
Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-delta(12,14)-PGJ2 derivatives. |
2006 |
Chem Asian J |
pmid:17441107
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Gulliksson M et al. |
Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. |
2006 |
Allergy |
pmid:17073880
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Phulwani NK et al. |
15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. |
2006 |
J. Neurochem. |
pmid:17074064
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Kim EH et al. |
Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. |
2006 |
Ann. N. Y. Acad. Sci. |
pmid:17384282
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Ciucci A et al. |
Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. |
2006 |
Mol. Pharmacol. |
pmid:16908599
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Egan K and FitzGerald GA |
Eicosanoids and the vascular endothelium. |
2006 |
Handb Exp Pharmacol |
pmid:16999220
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Sugimoto M et al. |
Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Nga mice. |
2006 |
Exp. Dermatol. |
pmid:17002684
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Feldon SE et al. |
Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. |
2006 |
Am. J. Pathol. |
pmid:17003477
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Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. |
2006 |
Pflugers Arch. |
pmid:16924534
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Eucker J et al. |
Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. |
2006 |
Anticancer Drugs |
pmid:16926626
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Satoh T et al. |
Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. |
2006 |
J. Immunol. |
pmid:16888024
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Sugimoto M et al. |
COX-1 inhibition enhances scratching behaviour in NC/Nga mice with atopic dermatitis. |
2006 |
Exp. Dermatol. |
pmid:16842596
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Quinkler M et al. |
Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis. |
2006 |
Gene |
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Raikwar HP et al. |
PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. |
2006 |
J. Neuroimmunol. |
pmid:16844232
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Willermain F et al. |
15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. |
2006 |
Prostaglandins Other Lipid Mediat. |
pmid:16939878
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Lim HJ et al. |
PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. |
2006 |
Prostaglandins Other Lipid Mediat. |
pmid:16939881
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Chiba T et al. |
Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway. |
2006 |
Int. Arch. Allergy Immunol. |
pmid:16940740
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Yu X et al. |
Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. |
2006 |
J. Biol. Chem. |
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Chen ZH et al. |
Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta(12,14)-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms. |
2006 |
J. Biol. Chem. |
pmid:16565077
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King VL et al. |
Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. |
2006 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:16514081
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Ray DM et al. |
The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. |
2006 |
J. Immunol. |
pmid:17015690
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Takai S et al. |
Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily. |
2006 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:16876988
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Piraino G et al. |
Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. |
2006 |
Shock |
pmid:16878022
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Moulin D et al. |
Effect of peroxisome proliferator activated receptor (PPAR)gamma agonists on prostaglandins cascade in joint cells. |
2006 |
Biorheology |
pmid:16912428
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Yeh CH et al. |
Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. |
2006 |
Shock |
pmid:16912651
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Ye F et al. |
Quantitative characterization of 15-deoxy-delta(12,14)-prostaglandin J2 in regulating EGFPSmad2 translocation in CHO cells through PPARgamma/TGFbeta/Smad2 pathway. |
2006 |
Cell. Physiol. Biochem. |
pmid:16914899
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Lee JJ et al. |
Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. |
2006 |
Vascul. Pharmacol. |
pmid:16916624
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Ulven T and Kostenis E |
Targeting the prostaglandin D2 receptors DP and CRTH2 for treatment of inflammation. |
2006 |
Curr Top Med Chem |
pmid:16918458
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Theiner G et al. |
The mast cell mediator PGD2 suppresses IL-12 release by dendritic cells leading to Th2 polarized immune responses in vivo. |
2006 |
Immunobiology |
pmid:16920486
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