PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Angioedemas, Hereditary D054179 2 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Acute Lung Injury D055371 33 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Airway Remodeling D056151 3 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Haack M et al. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. 2007 Sleep pmid:17910386
Abdelrahman M et al. The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. 2004 Shock pmid:15545828
Hickson-Bick DL et al. The response of neonatal rat ventricular myocytes to lipopolysaccharide-induced stress. 2006 Shock pmid:16680021
Liu J et al. Peroxisome proliferator-activated receptor-gamma ligands 15-deoxy-delta(12,14)-prostaglandin J2 and pioglitazone inhibit hydroxyl peroxide-induced TNF-alpha and lipopolysaccharide-induced CXC chemokine expression in neonatal rat cardiac myocytes. 2009 Shock pmid:19174742
Genovese T et al. Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury. 2008 Shock pmid:18628687
Monroy MA et al. THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma model. 2007 Shock pmid:17510607
Zingarelli B et al. Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. 2007 Shock pmid:17589386
Piraino G et al. Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. 2006 Shock pmid:16878022
Hovsepian E et al. 15-deoxy-Delta12,14 prostaglandin GJ2 but not rosiglitazone regulates metalloproteinase 9, NOS-2, and cyclooxygenase 2 expression and functions by peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms in cardiac cells. 2010 Shock pmid:19997048
Yeh CH et al. Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. 2006 Shock pmid:16912651