PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Angioedemas, Hereditary D054179 2 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Acute Lung Injury D055371 33 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Airway Remodeling D056151 3 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Jabr S et al. Quantification of major urinary metabolites of PGE2 and PGD2 in cystic fibrosis: correlation with disease severity. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23791427
Thornhill J and Asselin J Temperature and hemodynamic changes associated with increased neural damage to global hemispheric hypoxic ischemia by prior prostaglandin E2, D2 and F2alpha administration. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10574644
Tokuda H et al. Prostaglandin D2 induces interleukin-6 synthesis via Ca2+ mobilization in osteoblasts: regulation by protein kinase C. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10582659
ElAttar TM and Virji AS Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins: comparison with chemotherapeutic agents. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9223658
Kuroyanagi G et al. Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts. 2014 Prostaglandins Leukot. Essent. Fatty Acids pmid:24813642
Takahata R et al. Seasonal variation in levels of prostaglandins D2, E2 and F2(alpha) in the brain of a mammalian hibernator, the Asian chipmunk. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8992498
Yamauchi J et al. (-)-epigallocatechin gallate inhibits prostaglandin D2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in osteoblasts. 2007 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:17949962
Moussard C et al. Effect of chronic REM sleep deprivation on pituitary, hypothalamus and hippocampus PGE2 and PGD2 biosynthesis in the mouse. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846109
Brose SA and Golovko MY Eicosanoid post-mortem induction in kidney tissue is prevented by microwave irradiation. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24113545
Kim KA et al. 15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16098720
Crider JY et al. Use of a semi-automated, robotic radioimmunoassay to measure cAMP generated by activation of DP-, EP2-, and IP-prostaglandin receptors in human ocular and other cell types. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758211
Gelir E et al. Effect of rapid-eye-movement sleep deprivation on rat hypothalamic prostaglandins. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16039105
Rao PS et al. The effect of prostaglandin D2 on angiotensin converting enzyme. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:2845437
Mita H et al. Generation of thromboxane A2 from highly purified human sinus mast cells after immunological stimulation. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10359019
van der Donk EM et al. Leukotriene C4 formation by enriched human basophil preparations from normal and asthmatic subjects. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1719566
Imaizumi T et al. Effect of 15-deoxy-delta12,14-prostaglandin J2 on IL-1beta-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:14580366
Berry EB et al. Differential effects of serum constituents on apoptosis induced by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in WISH epithelial cells. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15253890
Garcia Palacios V et al. Expression of adipogenesis markers in a murine stromal cell line treated with 15-deoxy Delta(12,14)-prostaglandin J2, interleukin-11, 9-cis retinoic acid and vitamin K2. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11728175
Levine L Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11728177
Takai S et al. Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16876988