| MeSH term | MeSH ID | Detail |
|---|---|---|
| Angioedemas, Hereditary | D054179 | 2 associated lipids |
| Idiopathic Pulmonary Fibrosis | D054990 | 4 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Pulmonary Aspergillosis | D055732 | 1 associated lipids |
| Asthma, Aspirin-Induced | D055963 | 2 associated lipids |
| Airway Remodeling | D056151 | 3 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
| Fetal Alcohol Spectrum Disorders | D063647 | 6 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Murakami M et al. | Cyclooxygenase-2-dependent delayed prostaglandin D2 generation is initiated by nerve growth factor in rat peritoneal mast cells: its augmentation by extracellular type II secretory phospholipase A2. | 1997 | J. Immunol. | pmid:9200484 |
| ElAttar TM and Virji AS | Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins: comparison with chemotherapeutic agents. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9223658 |
| Sampson SE et al. | Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4. | 1997 | Thorax | pmid:9227716 |
| Werman A et al. | Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin. | 1997 | J. Biol. Chem. | pmid:9242701 |
| Blom HM et al. | Intranasal capsaicin is efficacious in non-allergic, non-infectious perennial rhinitis. A placebo-controlled study. | 1997 | Clin. Exp. Allergy | pmid:9249272 |
| Murakami M et al. | Detection of secretory phospholipase A2s related but not identical to type IIA isozyme in cultured mast cells. | 1997 | FEBS Lett. | pmid:9280291 |
| Kiriyama M et al. | Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. | 1997 | Br. J. Pharmacol. | pmid:9313928 |
| Kanaoka Y et al. | Cloning and crystal structure of hematopoietic prostaglandin D synthase. | 1997 | Cell | pmid:9323136 |
| Mahmud I et al. | Prostaglandin D synthase in human megakaryoblastic cells. | 1997 | J. Biol. Chem. | pmid:9353279 |
| Howarth PH | Mediators of nasal blockage in allergic rhinitis. | 1997 | Allergy | pmid:9353555 |
| Tsuri T et al. | Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: orally active, potent, and selective prostaglandin D2 receptor antagonists. | 1997 | J. Med. Chem. | pmid:9357516 |
| Liakos P et al. | ANG II AT1 and AT2 receptors both inhibit bFGF-induced proliferation of bovine adrenocortical cells. | 1997 | Am. J. Physiol. | pmid:9357777 |
| Minami T et al. | Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. | 1997 | Br. J. Pharmacol. | pmid:9375954 |
| Li Y et al. | Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes. | 1997 | Prostaglandins | pmid:9380795 |
| Fournier T et al. | Tumor necrosis factor-alpha inversely regulates prostaglandin D2 and prostaglandin E2 production in murine macrophages. Synergistic action of cyclic AMP on cyclooxygenase-2 expression and prostaglandin E2 synthesis. | 1997 | J. Biol. Chem. | pmid:9388257 |
| Wettstein M and Häussinger D | Cytoprotection by the osmolytes betaine and taurine in ischemia-reoxygenation injury in the perfused rat liver. | 1997 | Hepatology | pmid:9397998 |
| Adams M et al. | Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation. | 1997 | J. Clin. Invest. | pmid:9399962 |
| Ricote M et al. | The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. | 1998 | Nature | pmid:9422508 |
| Jiang C et al. | PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. | 1998 | Nature | pmid:9422509 |
| McGowan SE et al. | Peroxisome proliferators alter lipid acquisition and elastin gene expression in neonatal rat lung fibroblasts. | 1997 | Am. J. Physiol. | pmid:9435581 |