| MeSH term | MeSH ID | Detail |
|---|---|---|
| Angioedemas, Hereditary | D054179 | 2 associated lipids |
| Idiopathic Pulmonary Fibrosis | D054990 | 4 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Pulmonary Aspergillosis | D055732 | 1 associated lipids |
| Asthma, Aspirin-Induced | D055963 | 2 associated lipids |
| Airway Remodeling | D056151 | 3 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
| Fetal Alcohol Spectrum Disorders | D063647 | 6 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| O'Sullivan S et al. | Increased urinary excretion of the prostaglandin D2 metabolite 9 alpha, 11 beta-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. | 1996 | J. Allergy Clin. Immunol. | pmid:8757220 |
| Patella V et al. | Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8753840 |
| McClay EF et al. | delta 12-Prostaglandin-J2 is cytotoxic in human malignancies and synergizes with both cisplatin and radiation. | 1996 | Cancer Res. | pmid:8752147 |
| Shiroma T et al. | [Production and metabolism of prostaglandin D2 by cultured chick retinal pigment epithelial cells]. | 1996 | Nippon Ganka Gakkai Zasshi | pmid:8741332 |
| Wagenmann M et al. | Unilateral nasal allergen challenge leads to bilateral release of prostaglandin D2. | 1996 | Clin. Exp. Allergy | pmid:8732233 |
| Sakai T | [Molecular cancer epidemiology--the present status and future possibilities]. | 1996 | Nihon Eiseigaku Zasshi | pmid:8720930 |
| Spannhake EW | Down-regulation of canine airway mast cell function following exposure to ozone in vivo. | 1996 Mar-Apr | Exp. Lung Res. | pmid:8706634 |
| Yang KD et al. | A higher production of platelet activating factor in ex vivo heterologously secondary dengue-2 virus infections. | 1995 | Acta Microbiol Immunol Hung | pmid:8689093 |
| de Paulis A et al. | Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization. | 1996 | Arthritis Rheum. | pmid:8670335 |
| Shalev A and Meier CA | Peroxisome proliferator-activated receptors: a nuclear hormone receptor involved in adipocyte differentiation and lipid homeostasis. | 1996 | Eur. J. Endocrinol. | pmid:8664970 |
| Odani N et al. | Regulation of BiP gene expression by cyclopentenone prostaglandins through unfolded protein response element. | 1996 | J. Biol. Chem. | pmid:8663202 |
| Kawamoto K | [Flow cytometric analysis of cell cycle for the action mechanism of antineoplastic agents]. | 1995 | Hum. Cell | pmid:8652450 |
| Satoh S et al. | Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8650205 |
| Weidenbach H et al. | Reduction of bile secretion by prostaglandins in the rat in vivo. | 1996 | Life Sci. | pmid:8649182 |
| Genovese A et al. | Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645973 |
| Odani N et al. | Induction of protein disulfide isomerase mRNA by delta 12-prostaglandin J2. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8645293 |
| Chilton FH et al. | Antigen-induced generation of lyso-phospholipids in human airways. | 1996 | J. Exp. Med. | pmid:8642333 |
| Longphre M et al. | PAF-induced airways hyperreactivity is modulated by mast cells in mice. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8624251 |
| Seghaye MC et al. | Histamine liberation related to cardiopulmonary bypass in children: possible relation to transient postoperative arrhythmias. | 1996 | J. Thorac. Cardiovasc. Surg. | pmid:8622322 |
| Rozera C et al. | Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block. | 1996 | J. Clin. Invest. | pmid:8621762 |
| Small P and Barrett D | Evaluation of dust and dust mite nasal provocation. | 1995 | Ann. Allergy Asthma Immunol. | pmid:8603280 |
| Vesin MF et al. | Biosynthesis of prostaglandin D2 by motoneurons and dorsal horn microneurons: a biochemical and high resolution immunocytochemical study in chick spinal cord. | 1995 | Neuroscience | pmid:8596663 |
| Pandey HP et al. | Concentration of prostaglandin D2 in cerebrospinal fluid exhibits a circadian alteration in conscious rats. | 1995 | Biochem. Mol. Biol. Int. | pmid:8595382 |
| Usatiuk PV et al. | [Content of prostaglandins E2 and F1alpha in small intestine epithelium in cattle as a function of age and pathology in non-infectious diarrhea]. | 1995 Mar-Apr | Ukr. Biokhim. Zh. | pmid:8592776 |
| Sato T et al. | Decreased hypothalamic prostaglandin D2 and prostaglandin E2 contents during isoflurane anaesthesia in rats. | 1995 | Can J Anaesth | pmid:8590493 |
| Kane GC et al. | Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. | 1995 | Prostaglandins | pmid:8588068 |
| Radziszewski W et al. | Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins. | 1995 | Int. J. Cardiol. | pmid:8586470 |
| Kanamori S et al. | Effects of dietary fibre on dimethylhydrazine-induced changes in prostanoid concentrations in rat colonic mucosa. | 1995 | Clin. Exp. Pharmacol. Physiol. | pmid:8575110 |
| Naffah-Mazzacoratti MG et al. | Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy. | 1995 | Neurochem. Int. | pmid:8574174 |
| Cummings JJ | Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep. | 1995 | J. Appl. Physiol. | pmid:8567564 |
| Hardy E et al. | Magnesium modifies the responses of platelets to inhibitory agents which act via cAMP. | 1995 | Thromb. Haemost. | pmid:8560425 |
| Osaka T and Hayaishi O | Prostaglandin D2 modulates sleep-related and noradrenaline-induced activity of preoptic and basal forebrain neurons in the rat. | 1995 | Neurosci. Res. | pmid:8545074 |
| Daugschies A | Oesophagostomum dentatum: population dynamics and synthesis of prostanoids by histotropic stages cultured in vitro. | 1995 | Exp. Parasitol. | pmid:8542999 |
| Kliewer SA et al. | A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. | 1995 | Cell | pmid:8521498 |
| Forman BM et al. | 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. | 1995 | Cell | pmid:8521497 |
| Itabashi S et al. | Late asthmatic response causes peripheral airway hyperresponsiveness in dogs treated with metopirone. | 1993 | Int. Arch. Allergy Immunol. | pmid:8508057 |
| Rangachari PK and Betti PA | Biological activity of metabolites of PGD2 on canine proximal colon. | 1993 | Am. J. Physiol. | pmid:8498516 |
| Xu L et al. | Effect of culture conditions on mast cell eicosanoid synthesis. | 1993 | Prostaglandins | pmid:8493360 |
| Fredberg JJ et al. | Tissue resistance and the contractile state of lung parenchyma. | 1993 | J. Appl. Physiol. | pmid:8482682 |
| Kim IK et al. | Prostaglandin A2 and delta 12-prostaglandin J2 induce apoptosis in L1210 cells. | 1993 | FEBS Lett. | pmid:8477853 |
| Wegner CD et al. | The role of 5-lipoxygenase products in preclinical models of asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8473681 |
| Johnston SL et al. | The effect of BAY u 3405, a thromboxane receptor antagonist, on prostaglandin D2-induced nasal blockage. | 1993 | J. Allergy Clin. Immunol. | pmid:8473679 |
| Morrow JD and Minton TA | Improved assay for the quantification of 11-dehydrothromboxane B2 by gas chromatography-mass spectrometry. | 1993 | J. Chromatogr. | pmid:8468374 |
| Barski OA and Watanabe K | Kinetic mechanism of ketoreductase activity of prostaglandin F synthase from bovine lung. | 1993 | FEBS Lett. | pmid:8458424 |
| Woodward DF et al. | Further studies on ocular responses to DP receptor stimulation. | 1993 | Eur. J. Pharmacol. | pmid:8440310 |
| Hallbrucker C et al. | Hydroperoxide metabolism in rat liver. K+ channel activation, cell volume changes and eicosanoid formation. | 1993 | Eur. J. Biochem. | pmid:8436107 |
| Matsuo T and Cynader MS | The EP2 receptor is the predominant prostanoid receptor in the human ciliary muscle. | 1993 | Br J Ophthalmol | pmid:8435410 |
| Huttemeier PC et al. | Microdialysis measurements of PGD2, TXB2 and 6-KETO-PGF1 alpha in rat CA1 hippocampus during transient cerebral ischemia. | 1993 | Prostaglandins | pmid:8430228 |
| Hata Y et al. | Primary colonic epithelial cell culture of the rabbit producing prostaglandins. | 1993 | Prostaglandins | pmid:8430223 |
| Neuschäfer-Rube F et al. | Characterization of prostaglandin-F2 alpha-binding sites on rat hepatocyte plasma membranes. | 1993 | Eur. J. Biochem. | pmid:8425526 |