| MeSH term | MeSH ID | Detail |
|---|---|---|
| Angioedemas, Hereditary | D054179 | 2 associated lipids |
| Idiopathic Pulmonary Fibrosis | D054990 | 4 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Pulmonary Aspergillosis | D055732 | 1 associated lipids |
| Asthma, Aspirin-Induced | D055963 | 2 associated lipids |
| Airway Remodeling | D056151 | 3 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
| Fetal Alcohol Spectrum Disorders | D063647 | 6 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ikai K and Imamura S | Prostaglandin D2 in the skin. | 1988 | Int. J. Dermatol. | pmid:3286543 |
| Hardy CC et al. | Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma. | 1988 | J. Appl. Physiol. | pmid:3288608 |
| Pienkowski MM et al. | Prostaglandin D2 and histamine during the immediate and the late-phase components of allergic cutaneous responses. | 1988 | J. Allergy Clin. Immunol. | pmid:3292634 |
| Ito S et al. | Problems in production of prostaglandin D2-specific antibody. | 1988 | Eicosanoids | pmid:3273218 |
| Saito K et al. | Blood components contribute to rise in gerbil brain levels of leukotriene-like immunoreactivity after ischemia and reperfusion. | 1988 | Stroke | pmid:3274043 |
| Giles H and Leff P | The biology and pharmacology of PGD2. | 1988 | Prostaglandins | pmid:3283848 |
| Featherstone RL et al. | Active sensitization of guinea-pig airways in vivo enhances in vivo and in vitro responsiveness. | 1988 | Eur. Respir. J. | pmid:3229483 |
| Petrini B et al. | Modulation of lymphocyte and monocyte responses in vitro by 9-deoxy-delta 9-prostaglandin D2 and 9-deoxy-delta 9-delta 12-prostaglandin D2. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3229858 |
| Beasley R et al. | Comparative vascular effects of histamine, prostaglandin (PG) D2 and its metabolite 9 alpha,11 beta-PGF2 in human skin. | 1988 | Clin. Allergy | pmid:3242978 |
| Koh T et al. | Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats. | 1988 | Eur. J. Pharmacol. | pmid:2969338 |
| Broide DH et al. | Functional and biochemical characterization of rat bone marrow derived mast cells. | 1988 | J. Immunol. | pmid:2974057 |
| Parsons WG and Roberts LJ | Transformation of prostaglandin D2 to isomeric prostaglandin F2 compounds by human eosinophils. A potential mast cell-eosinophil interaction. | 1988 | J. Immunol. | pmid:3139758 |
| Ujihara M et al. | Biochemical and immunological demonstration of prostaglandin D2, E2, and F2 alpha formation from prostaglandin H2 by various rat glutathione S-transferase isozymes. | 1988 | Arch. Biochem. Biophys. | pmid:3041912 |
| Schulman ES et al. | Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release. | 1988 | J. Clin. Invest. | pmid:2449462 |
| Robinson C et al. | The immunoglobulin E- and calcium-dependent release of histamine and eicosanoids from human dispersed mastocytosis spleen cells. | 1988 | J. Invest. Dermatol. | pmid:2450144 |
| Undem BJ and Adams GK | An analysis of the functional interactions of selected contractile agonists in the guinea pig isolated trachea. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2839671 |
| Holgate ST et al. | The contribution of mast cell mediators to acute allergic reactions in human skin and airways. | 1988 | Allergy | pmid:2451448 |
| Schulman ES et al. | Density heterogeneity of human lung mast cells. | 1988 | J. Allergy Clin. Immunol. | pmid:2455745 |
| Bousquet J et al. | Antiallergic activity of H1-receptor antagonists assessed by nasal challenge. | 1988 | J. Allergy Clin. Immunol. | pmid:2461406 |
| Church MM et al. | The mediator and cellular basis of the allergic response. | 1988 | Allergy | pmid:2462372 |
| Takei M et al. | Role of cyclic AMP during histamine release. Histamine release is not directly related to increase in cyclic AMP levels in rat mast cells activated by concanavalin A, anti-IgE, antigen, prostaglandin D2 and isoproterenol. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:2463844 |
| Yue TL and Mai K | [Effects of protein malnutrition on the metabolism of arachidonic acid in the rat stomach and spleen]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3142210 |
| Kempski O et al. | Postischemic production of eicosanoids in gerbil brain. | 1987 Jan-Feb | Stroke | pmid:3468670 |
| Jacobsen S et al. | Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [14C]arachidonic acid and histamine from rat peritoneal mast cells. | 1987 | Biochem. Pharmacol. | pmid:2435291 |
| Chiabrando C et al. | Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. | 1987 | Cancer Res. | pmid:3100032 |
| Kozuka T et al. | Prostaglandin D2 release by guinea pig skin during in vitro anaphylaxis induced by antigen and compound 48/80. | 1987 | J. Invest. Dermatol. | pmid:2433354 |
| Abdel-Malek ZA et al. | In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins. | 1987 | Cancer Res. | pmid:2438034 |
| Bushfield M et al. | Effects of protein kinase C activation on human platelet cyclic AMP metabolism. | 1987 | FEBS Lett. | pmid:2820806 |
| Levi-Schaffer F et al. | Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes. | 1987 | J. Immunol. | pmid:2439587 |
| Leung KB et al. | Some further properties of human pulmonary mast cells recovered by bronchoalveolar lavage and enzymic dispersion of lung tissue. | 1987 | Agents Actions | pmid:2440274 |
| Church MK et al. | Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. | 1987 | Clin. Allergy | pmid:2441900 |
| Kosaka Y et al. | Oxatomide inhibits the release of bronchoconstrictor arachidonic acid metabolites (iLTC4 and PGD2) from rat mast cells and guinea-pig lung. | 1987 | Agents Actions | pmid:2442981 |
| Pipkorn U et al. | Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge. | 1987 | J. Clin. Invest. | pmid:2443539 |
| Namima M and Okamoto K | Modulatory action of prostaglandin D2 on the release of 3H-norepinephrine from rat cerebellar slices. | 1987 | Jpn. J. Pharmacol. | pmid:2883337 |
| Omini C et al. | Prostaglandin D2 and the cholinergic system in guinea pig airways. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823557 |
| Suzuki F et al. | Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. | 1987 | Biochim. Biophys. Acta | pmid:3467795 |
| Hayashi H et al. | Metabolism of prostaglandin D2 in isolated rat lung: the stereospecific formation of 9 alpha,11 beta-prostaglandin F2 from prostaglandin D2. | 1987 | Biochim. Biophys. Acta | pmid:3467796 |
| Dieter P et al. | Prostaglandin release but not superoxide production by rat Kupffer cells stimulated in vitro depends on Na+/H+ exchange. | 1987 | Eur. J. Biochem. | pmid:2826152 |
| Drummond WH and Carter RL | Cardiac depressant and circulatory effects of prostaglandin D2 in developing lambs. | 1987 | Am. J. Physiol. | pmid:3468806 |
| Burgess JR et al. | Enzymatic transformation of PGH2 to PGF2 alpha catalyzed by glutathione S-transferases. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3468949 |
| Beasley CR et al. | 9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. | 1987 | J. Clin. Invest. | pmid:3469218 |
| Tran-Thi TA et al. | Studies on synthesis and degradation of eicosanoids by rat hepatocytes in primary culture. | 1987 | J. Hepatol. | pmid:2828463 |
| Hanasaki K et al. | Beta 2-adrenergic regulation of prostaglandin D2 receptor in rabbit platelets. | 1987 | Biochim. Biophys. Acta | pmid:2880608 |
| Holgate ST et al. | Primary and secondary effector cells in the pathogenesis of bronchial asthma. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3553030 |
| Rao PS et al. | Dose-dependent effects of prostaglandin D2 on hemodynamics, renal function, and blood gas analyses. | 1987 | Am. J. Obstet. Gynecol. | pmid:3555078 |
| Kinoshita T et al. | Predominance of prostaglandin D2 and I2 in the rat gastric mucosa--analysis by high-performance liquid chromatography. | 1987 | Biochem. Int. | pmid:3555501 |
| Matsuura H and Imaya H | [Effect of prostaglandin (delta 12-PGJ2) on host immunity--an experimental study]. | 1987 | Gan To Kagaku Ryoho | pmid:3592721 |
| Yamamoto N et al. | Mechanism of inhibition of herpes simplex virus replication by delta 7-prostaglandin A1 and delta 12-prostaglandin J2. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3040001 |
| Bhattacharya SK and Rao PJ | Prostaglandin D2-induced catalepsy in rats: role of 5-hydroxytryptamine. | 1987 | J. Pharm. Pharmacol. | pmid:2890744 |
| Tamaoki J et al. | Cholinergic neuromodulation by prostaglandin D2 in canine airway smooth muscle. | 1987 | J. Appl. Physiol. | pmid:2891674 |