PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Cystitis, Interstitial D018856 2 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Optic Neuropathy, Ischemic D018917 2 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Airway Remodeling D056151 3 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Decapitation D049248 2 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Schuligoi R et al. PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors. 2007 Biochem. Pharmacol. pmid:17452035
Taniguchi H et al. Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. 2007 J. Neurosci. pmid:17442814
Tanaka H et al. Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-delta(12,14)-PGJ2 derivatives. 2006 Chem Asian J pmid:17441107
Vunta H et al. The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. 2007 J. Biol. Chem. pmid:17439952
Vinall SL et al. A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes. 2007 Immunology pmid:17437532
Rehan VK et al. A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17435078
Parameswaran K et al. Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines. 2007 Am. J. Respir. Cell Mol. Biol. pmid:17431098
Li SJ et al. [Effects of peroxisome proliferator-activated receptor gamma and its ligands on cytotrophoblast invasion in first trimester of pregnancy and mechanism thereof]. 2007 Zhonghua Yi Xue Za Zhi pmid:17425848
Arnold R et al. Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. 2007 Immunology pmid:17425601
Hwang J et al. 15-deoxy-Delta12,14-prostaglandin J2-induced down-regulation of endothelial nitric oxide synthase in association with HSP70 induction. 2007 Biochem. Biophys. Res. Commun. pmid:17418102
Gayarre J et al. Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro. 2007 Ann. N. Y. Acad. Sci. pmid:17405918
Pettipher R et al. Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. 2007 Nat Rev Drug Discov pmid:17396136
Kim EH et al. Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. 2006 Ann. N. Y. Acad. Sci. pmid:17384282
Fionda C et al. 15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors. 2007 J. Immunol. pmid:17371958
Yamada K et al. Nose-to-brain delivery of TS-002, prostaglandin D2 analogue. 2007 J Drug Target pmid:17365274
Kim HJ et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain. 2007 Cancer Res. pmid:17363578
Yang WZ et al. [The effect of ligand of peroxisome proliferators-activated receptor gamma 15d-PGJ2 on the proliferation and activation of hepatic stellate cells]. 2007 Zhonghua Gan Zang Bing Za Zhi pmid:17362636
Ito W et al. Hepatocyte growth factor attenuates eotaxin and PGD2-induced chemotaxis of human eosinophils. 2007 Allergy pmid:17362253
Takaoka A et al. Role of scratch-induced cutaneous prostaglandin D production on atopic-like scratching behaviour in mice. 2007 Exp. Dermatol. pmid:17359340
Takeda K et al. Neuroendocrine functions of melanocytes: beyond the skin-deep melanin maker. 2007 Tohoku J. Exp. Med. pmid:17347546
Sugimoto M et al. The anti-pruritic efficacy of TS-022, a prostanoid DP1 receptor agonist, is dependent on the endogenous prostaglandin D2 level in the skin of NC/Nga mice. 2007 Eur. J. Pharmacol. pmid:17328887
Fournier T et al. Involvement of PPARgamma in human trophoblast invasion. 2007 Placenta pmid:17321592
Chintalgattu V et al. PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts. 2007 Cardiovasc. Res. pmid:17320065
Satoh T [Cysteine-mediated signaling pathway by a novel electrophilic compound, NEPP11]. 2007 Seikagaku pmid:17319510
Hirano Y et al. Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells. 2007 Eur. J. Pharmacol. pmid:17307163
Li CF et al. [Effect of peroxisome proliferators-activated receptor-gamma in the mechanisms of sulindac against large intestine carcinoma]. 2007 Beijing Da Xue Xue Bao pmid:17304332
Schäffler A et al. Regulation and function of collagenous repeat containing sequence of 26-kDa protein gene product "cartonectin". 2007 Obesity (Silver Spring) pmid:17299102
Aldini G et al. Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement. 2007 Biochemistry pmid:17297918
Reyes-Martin P et al. Cyclooxygenase-independent inhibition of H2O2-induced cell death by S-ketoprofen in renal cells. 2007 Pharmacol. Res. pmid:17291778
Nitta N et al. Quantitative analysis of eosinophil chemotaxis tracked using a novel optical device -- TAXIScan. 2007 J. Immunol. Methods pmid:17289072
Hammad H et al. Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. 2007 J. Exp. Med. pmid:17283205
Park JM et al. Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. 2007 Cancer Res. pmid:17283118
Wilhelm D et al. SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. 2007 J. Biol. Chem. pmid:17277314
Misawa M and Kanai Y Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs. 1991 Arzneimittelforschung pmid:1725697
Yang C et al. Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. 2007 Am. J. Pathol. pmid:17255338
Li X et al. Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells. 2007 Nephrol. Dial. Transplant. pmid:17255125
Sugimoto M et al. Putative mechanism of the itch-scratch circle: repeated scratching decreases the cutaneous level of prostaglandin D2, a mediator that inhibits itching. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17250998
Butchers PR et al. Salmeterol: a potent and long-acting inhibitor of inflammatory mediator release from human lung. 1991 Br. J. Pharmacol. pmid:1724629
Hagens WI et al. Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated. 2007 Pharm. Res. pmid:17245650
Tinfo N and Komar C Potential role for peroxisome proliferator-activated receptor gamma in regulating luteal lifespan in the rat. 2007 Reproduction pmid:17244745
Liu M et al. Focal cerebral ischemia/reperfusion injury in mice induces hematopoietic prostaglandin D synthase in microglia and macrophages. 2007 Neuroscience pmid:17241746
Moreira V et al. Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2, and expression of cyclooxygenases. 2007 Toxicon pmid:17241651
Walmrath D et al. Intravascular anti-IgE challenge in perfused lungs: mediator release and vascular pressor response. 1991 J. Appl. Physiol. pmid:1723406
Ruano D et al. Family-based and case-control studies reveal no association of lipocalin-type prostaglandin D2 synthase with schizophrenia. 2007 Am. J. Med. Genet. B Neuropsychiatr. Genet. pmid:17230501
Stellato C et al. General anaesthetics induce only histamine release selectively from human mast cells. 1991 Br J Anaesth pmid:1722691
Myers AC et al. Influence of antigen on membrane properties of guinea pig bronchial ganglion neurons. 1991 J. Appl. Physiol. pmid:1721906
Murakami M et al. Group II phospholipase A2 inhibitors suppressed lysophosphatidylserine-dependent degranulation of rat peritoneal mast cells. 1991 Biochem. Biophys. Res. Commun. pmid:1721808
Rehan VK et al. In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17215434
Gallant MA et al. Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2. 2007 Eur. J. Pharmacol. pmid:17207480
Mathew B et al. Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages. 2007 Am. J. Respir. Cell Mol. Biol. pmid:17204585
Van Hecken A et al. The effect of MK-0524, a prostaglandin D(2) receptor antagonist, on prostaglandin D (2)-induced nasal airway obstruction in healthy volunteers. 2007 Eur. J. Clin. Pharmacol. pmid:17200838
Xue L et al. Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2). 2007 Biochem. Pharmacol. pmid:17196174
van der Donk EM et al. Leukotriene C4 formation by enriched human basophil preparations from normal and asthmatic subjects. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1719566
Perreault T and De Marte J Endothelin-1 has a dilator effect on neonatal pig pulmonary vasculature. 1991 J. Cardiovasc. Pharmacol. pmid:1719291
Watanabe T et al. Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01s. 1991 Blood pmid:1718495
Zhang YF et al. Peroxisome proliferator-activated receptor-gamma is expressed by rat peritoneal mesothelial cells: its potential role in peritoneal cavity local defense. 2006 Am. J. Nephrol. pmid:17183189
Castellani ML et al. Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. 2006 Oct-Dec Int. J. Biol. Markers pmid:17177158
Fernández PL [Stress and inflammatory bowell disease (I.B.D). Therapeutic strategies]. 2006 An R Acad Nac Med (Madr) pmid:17172222
Sánchez-Gómez FJ et al. Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival. 2007 Arch. Biochem. Biophys. pmid:17169324
Arai I [Role of cutaneous prostaglandin D2 production on scratching dermatitis in mice]. 2006 Nippon Yakurigaku Zasshi pmid:17167214
Kang MA et al. Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. 2007 Life Sci. pmid:17161435
Hortobágyi L et al. Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids. 2007 Brain Res. pmid:17161389
Fulzele SV et al. 15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. 2007 Anticancer Drugs pmid:17159504
Massey WA et al. Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology. 1991 J. Immunol. pmid:1715365
Rousseaux C and Desreumaux P [The peroxisome-proliferator-activated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD)]. 2006 J. Soc. Biol. pmid:17151549
Tanaka Y et al. Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. 2007 Mol. Pharmacol. pmid:17151289
Mazid MA et al. Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. 2006 FEBS Lett. pmid:17150216
Chambers KT et al. PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17148750
Berruyer C et al. Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. 2006 J. Exp. Med. pmid:17145956
Arai I et al. Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. 2007 Eur. J. Pharmacol. pmid:17141215
Kim HY and Kim HS Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages. 2007 Immunol. Cell Biol. pmid:17130903
Ishimura M et al. Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. 2006 Allergol Int pmid:17130683
Akabane H et al. Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. 2006 Allergol Int pmid:17130681
Huang ZL et al. Prostaglandins and adenosine in the regulation of sleep and wakefulness. 2007 Curr Opin Pharmacol pmid:17129762
White MV et al. Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE. 1991 J. Immunol. pmid:1712816
Raphael GD et al. The pathophysiology of rhinitis. V. Sources of protein in allergen-induced nasal secretions. 1991 J. Allergy Clin. Immunol. pmid:1712803
Kim SJ et al. Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. 2006 Arch. Pharm. Res. pmid:17121182
García-Bueno B et al. Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats. 2007 Neuropsychopharmacology pmid:17119541
Rahman A et al. Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats. 2007 Eur. J. Pharmacol. pmid:17112500
Nicoll-Griffith DA et al. In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites. 2007 Bioorg. Med. Chem. Lett. pmid:17095220
Qu WM et al. Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:17093043
Jin YR et al. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. 2007 Atherosclerosis pmid:17092506
Liu JJ et al. Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. 2007 Ann. Hematol. pmid:17089125
Phulwani NK et al. 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. 2006 J. Neurochem. pmid:17074064
Gulliksson M et al. Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. 2006 Allergy pmid:17073880
Gyles SL et al. A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants. 2006 Immunology pmid:17067313
Qin S et al. Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. 2006 Invest. Ophthalmol. Vis. Sci. pmid:17065531
Diaz BL et al. Group V secretory phospholipase A2 amplifies the induction of cyclooxygenase 2 and delayed prostaglandin D2 generation in mouse bone marrow culture-derived mast cells in a strain-dependent manner. 2006 Biochim. Biophys. Acta pmid:17064958
Okuda-Ashitaka E et al. Cyclic AMP-mediated inhibition of cell growth by prostaglandin D2 in a fibroblastic cell line (EBTr). 1990 Eicosanoids pmid:1705811
Sandig H et al. Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function. 2007 J. Leukoc. Biol. pmid:17043246
Cossette C et al. Agonist and antagonist effects of 15R-prostaglandin (PG) D2 and 11-methylene-PGD2 on human eosinophils and basophils. 2007 J. Pharmacol. Exp. Ther. pmid:17041009
Fox CC et al. Modulation of mediator release from human intestinal mast cells by sulfasalazine and 5-aminosalicylic acid. 1991 Dig. Dis. Sci. pmid:1703070
Kamagata C et al. 15-deoxy-Delta(12,14)-prostaglandin J2 inhibits G2-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivin expression. 2007 Breast Cancer Res. Treat. pmid:17028981
Marriott DR et al. Substance P-induced release of prostaglandins from astrocytes: regional specialisation and correlation with phosphoinositol metabolism. 1991 J. Neurochem. pmid:1702831
Ray DM et al. The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. 2006 J. Immunol. pmid:17015690
Knapp HR Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor. 1990 N. Engl. J. Med. pmid:1701029
Maciejewski-Lenoir D et al. Langerhans cells release prostaglandin D2 in response to nicotinic acid. 2006 J. Invest. Dermatol. pmid:17008871
Payne SG et al. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. 2007 Blood pmid:17008548
Cho WH et al. 15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells. 2006 Neurochem. Res. pmid:17006759
Feldon SE et al. Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. 2006 Am. J. Pathol. pmid:17003477