PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Brain Ischemia D002545 89 associated lipids
Seizures D012640 87 associated lipids
Arteriosclerosis D001161 86 associated lipids
Atherosclerosis D050197 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Masuko-Hongo K [Role of prostaglandins in rheumatoid arthritis]. 2005 Nippon Rinsho pmid:15799333
Yuan J et al. Ligands for peroxisome proliferator-activated receptor gamma have potent antitumor effect against human renal cell carcinoma. 2005 Urology pmid:15780399
Kim S et al. Synthesis of 15R-PGD2: a potential DP2 receptor agonist. 2005 Bioorg. Med. Chem. Lett. pmid:15780624
Marshall JC Modeling MODS: what can be learned from animal models of the multiple-organ dysfunction syndrome? 2005 Intensive Care Med pmid:15782317
Gazi L et al. Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes. 2005 Prostaglandins Other Lipid Mediat. pmid:15789622
Fowler CJ and Tiger G Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. 2005 Biochem. Pharmacol. pmid:15794945
Dore-Duffy P et al. The CNS pericyte response to low oxygen: early synthesis of cyclopentenone prostaglandins of the J-series. 2005 Microvasc. Res. pmid:15797264
Liu J et al. Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells. 2005 Cancer Chemother. Pharmacol. pmid:15838654
Ji JD et al. Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2. 2005 Rheumatology (Oxford) pmid:15840591
Sanchez-Rodriguez J et al. The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells. 2005 Biochem. J. pmid:15819613
Kim YS et al. Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity. 2005 Free Radic. Biol. Med. pmid:15589375
Almishri W et al. Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. 2005 J. Pharmacol. Exp. Ther. pmid:15590767
Hwang J et al. Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. 2005 Am. J. Physiol., Cell Physiol. pmid:15590897
López-Parra M et al. The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin. 2005 J. Hepatol. pmid:15629510
Scher JU and Pillinger MH 15d-PGJ2: the anti-inflammatory prostaglandin? 2005 Clin. Immunol. pmid:15639643
Hata AN et al. Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. 2005 Mol. Pharmacol. pmid:15563582
Chou YH et al. The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1. 2005 Int. J. Biochem. Cell Biol. pmid:15618017
Farrajota K et al. Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. 2005 Arthritis Rheum. pmid:15641079
Liu JJ et al. Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro. 2005 Ann. Oncol. pmid:15642706
Wu CC et al. 2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a direct thrombin inhibitor with a suppressive effect on thromboxane formation in platelets. 2005 Eur. J. Pharmacol. pmid:16313903
Coyle AT et al. 15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells. 2005 FEBS J. pmid:16156795
Chen WC et al. Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor gamma activation up-regulating PTEN and inhibiting PI3K activity. 2005 Chin. Med. J. pmid:16157051
Uehara Y [Prostaglandin D2]. 2005 Nippon Rinsho pmid:16149440
Negoro H et al. Endogenous prostaglandin D(2) synthesis decreases vascular cell adhesion molecule-1 expression in human umbilical vein endothelial cells. 2005 Life Sci. pmid:16154157
O'Flaherty JT et al. 5-Oxo-ETE analogs and the proliferation of cancer cells. 2005 Biochim. Biophys. Acta pmid:16154383
Schmidt R et al. LC-MS/MS-analysis of prostaglandin E2 and D2 in microdialysis samples of rats. 2005 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16172029
Wilhelm D et al. Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. 2005 Dev. Biol. pmid:16185683
Armer RE et al. Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. 2005 J. Med. Chem. pmid:16190744
Koh SH et al. 15-Deoxy-delta12,14-prostaglandin J2, a neuroprotectant or a neurotoxicant? 2005 Toxicology pmid:16191461
Soares AF et al. Covalent binding of 15-deoxy-delta12,14-prostaglandin J2 to PPARgamma. 2005 Biochem. Biophys. Res. Commun. pmid:16198309
Xue L et al. Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. 2005 J. Immunol. pmid:16272307
Yuhas Y et al. Involvement of prostaglandins in an animal model of Shigella-related seizures. 2005 J. Neuroimmunol. pmid:16139898
Gayarre J et al. Differential selectivity of protein modification by the cyclopentenone prostaglandins PGA1 and 15-deoxy-Delta12,14-PGJ2: role of glutathione. 2005 FEBS Lett. pmid:16223487
Hatoum OA et al. Novel mechanism of vasodilation in inflammatory bowel disease. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:16141408
Noguchi J et al. Strain difference of murine bone marrow-derived mast cell functions. 2005 J. Leukoc. Biol. pmid:16126842
Marone G et al. Role of human mast cells and basophils in bronchial asthma. 2005 Adv. Immunol. pmid:16227089
Jin YR et al. An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. 2005 Basic Clin. Pharmacol. Toxicol. pmid:16128910
Fujishima H et al. Prostaglandin D2 induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitis. 2005 Cornea pmid:16227827
Kobayashi Y et al. Physiological levels of 15-deoxy-Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation. 2005 J. Immunol. pmid:16237065
Na HK et al. ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells. 2005 FEBS Lett. pmid:16253239
Sugimoto H et al. CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. 2005 Eur. J. Pharmacol. pmid:16256979
Iwata C et al. Augmentation of lipogenesis by 15-deoxy-Delta12,14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12,14-prostaglandin J2 production. 2005 J. Invest. Dermatol. pmid:16297182
Thomas RK et al. Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. 2005 Clin. Cancer Res. pmid:16299251
Sugimoto M et al. Increased scratching counts depend on a decrease in ability of cutaneous prostaglandin D2 biosynthesis in NC/Nga mice with atopic dermatitis. 2005 Exp. Dermatol. pmid:16274457
Shiraki T et al. [Activation mechanism of PPARgamma by its endogenous ligands]. 2005 Tanpakushitsu Kakusan Koso pmid:16277244
Bianchi A et al. Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14prostaglandin J2. 2005 Arthritis Res. Ther. pmid:16277686
Shibata T and Uchida K [Current opinions on prostaglandin J2]. 2005 Seikagaku pmid:16241007
Shiraishi Y et al. Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. 2005 J. Pharmacol. Exp. Ther. pmid:15528449
Monneret G et al. Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophils. 2005 J. Pharmacol. Exp. Ther. pmid:15388786
Muñoz U et al. The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients. 2005 Exp. Neurol. pmid:16061222
Chen ZY and Tseng CC 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells. 2005 Mol. Pharmacol. pmid:16077033
Chevalier E et al. Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. 2005 J. Immunol. pmid:16081770
Polikandriotis JA et al. Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:16020752
Kim J et al. Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived products. 2005 Cancer Res. pmid:16024620
Choi YH et al. New anti-inflammatory formulation containing Synurus deltoides extract. 2005 Arch. Pharm. Res. pmid:16114500
Kim KA et al. 15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16098720
Chen C and Bazan NG Lipid signaling: sleep, synaptic plasticity, and neuroprotection. 2005 Prostaglandins Other Lipid Mediat. pmid:16099392
Mouihate A et al. Fever suppression in near-term pregnant rats is dissociated from LPS-activated signaling pathways. 2005 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:16037126
Nakae K et al. Functional role of prostacyclin receptor in rat dorsal root ganglion neurons. 2005 Neurosci. Lett. pmid:16039053
Gelir E et al. Effect of rapid-eye-movement sleep deprivation on rat hypothalamic prostaglandins. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16039105
Masini E et al. Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic. 2005 Free Radic. Biol. Med. pmid:16043023
Stahlschmidt J et al. Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease. 2005 Kidney Int. pmid:16105033
Appel S et al. PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. 2005 Blood pmid:16105976
Boyce JA Eicosanoid mediators of mast cells: receptors, regulation of synthesis, and pathobiologic implications. 2005 Chem Immunol Allergy pmid:16107763
Hata AN et al. Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2. 2005 J. Biol. Chem. pmid:16030019
Motilva V et al. COX expression and PGE(2) and PGD(2) production in experimental acute and chronic gastric lesions. 2005 Int. Immunopharmacol. pmid:15652766
Martínez B et al. The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action. 2005 J. Lipid Res. pmid:15654126
Liang X et al. Prostaglandin D2 mediates neuronal protection via the DP1 receptor. 2005 J. Neurochem. pmid:15659218
Jerde TJ et al. Celecoxib inhibits ureteral contractility and prostanoid release. 2005 Urology pmid:15667901
Figarella K et al. Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form. 2005 Cell Death Differ. pmid:15678148
Tanaka T et al. Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. 2005 Eur. J. Pharmacol. pmid:15680279
Genovese T et al. Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury. 2005 Eur. Respir. J. pmid:15684285
Artwohl M et al. Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. 2005 Thromb. Haemost. pmid:15886792
Malki S et al. Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. 2005 EMBO J. pmid:15889150
Wang Z and Figueiredo-Pereira ME Inhibition of sequestosome 1/p62 up-regulation prevents aggregation of ubiquitinated proteins induced by prostaglandin J2 without reducing its neurotoxicity. 2005 Mol. Cell. Neurosci. pmid:15911346
Ishida A et al. Characterization of cAMP-dependent proteolysis of GATA-6. 2005 Biochem. Biophys. Res. Commun. pmid:15913546
Hennersdorf F et al. Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation. 2005 Cell Res. pmid:15916720
Hosoya T et al. Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. 2005 J. Biol. Chem. pmid:15917255
Andrews WJ et al. Aromatase inhibition by 15-deoxy-prostaglandin J(2) (15-dPGJ(2)) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production. 2005 J. Steroid Biochem. Mol. Biol. pmid:15862961
Allred CD and Kilgore MW Selective activation of PPARgamma in breast, colon, and lung cancer cell lines. 2005 Mol. Cell. Endocrinol. pmid:15866424
Marzocco S et al. The cyclopentenone prostaglandin 15-deoxydelta(12,14)-prostaglandin J2 attenuates the development of zymosan-induced shock. 2005 Intensive Care Med pmid:15868139
Yoshida M et al. Methotrexate suppresses inflammatory agonist induced interleukin 6 synthesis in osteoblasts. 2005 J. Rheumatol. pmid:15868610
Li X et al. Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. 2005 J. Rheumatol. pmid:15868626
De Oliveira C et al. Insulin alters nuclear factor-lambdaB and peroxisome proliferator-activated receptor-gamma protein expression induced by glycated bovine serum albumin in vascular smooth-muscle cells. 2005 J. Lab. Clin. Med. pmid:15871306
Planagumà A et al. The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. 2005 FASEB J. pmid:15876570
Kim HY et al. Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages. 2005 Immunol. Cell Biol. pmid:15877607
Gallant MA et al. Production of prostaglandin D(2) by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors. 2005 J. Bone Miner. Res. pmid:15765187
Capobianco E et al. 15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. 2005 Reprod. Fertil. Dev. pmid:15899154
Avis I et al. Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition. 2005 Cancer Res. pmid:15899809
Costello DA et al. Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro. 2005 Neuropharmacology pmid:15993441
Patel KM et al. Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma). 2005 Cell. Signal. pmid:15993751
Zurich MG et al. Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. 2005 Neuroscience pmid:15994020
Chacón P et al. Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. 2005 Eur. J. Immunol. pmid:15997464
Honma Y et al. Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice. 2005 Eur. J. Pharmacol. pmid:16000196
Atkins KB et al. Effects of PPAR-gamma ligands on vascular smooth muscle marker expression in hypertensive and normal arteries. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:15345487
Burgess HA et al. PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:15734787
Inoue K et al. Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide. 2005 Clin. Exp. Pharmacol. Physiol. pmid:15743408
Berry EB et al. Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B. 2005 Mol. Pharmacol. pmid:15821150
Lindström TM and Bennett PR 15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications. 2005 J. Clin. Endocrinol. Metab. pmid:15755849
Takashima T et al. Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma. 2005 Oncol. Rep. pmid:15756430