| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asthma | D001249 | 52 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Blister | D001768 | 16 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Damage, Chronic | D001925 | 6 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yuan J et al. | Ligands for peroxisome proliferator-activated receptor gamma have potent antitumor effect against human renal cell carcinoma. | 2005 | Urology | pmid:15780399 |
| Park JM | Role of prostaglandins in bladder smooth muscle cell gene expression. | 2001 | Urology | pmid:11378068 |
| Jerde TJ et al. | Celecoxib inhibits ureteral contractility and prostanoid release. | 2005 | Urology | pmid:15667901 |
| Masuda H et al. | 15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats. | 2006 | Urology | pmid:16461118 |
| Lee JJ et al. | Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. | 2006 | Vascul. Pharmacol. | pmid:16916624 |
| Hahn HL | [Inflammatory mediators in the pathogenesis of obstructive bronchial diseases: consequences for therapy]. | 1988 | Verh Dtsch Ges Inn Med | pmid:2905102 |
| BrazÃs P et al. | Dermal microdialysis in the dog: in vivo assessment of the effect of cyclosporin A on cutaneous histamine and prostaglandin D2 release. | 2006 | Vet. Dermatol. | pmid:16674731 |
| Gueck T et al. | Influence of vitamin E on mast cell mediator release. | 2002 | Vet. Dermatol. | pmid:12464062 |
| Lin TY and London CA | Characterization and modulation of canine mast cell derived eicosanoids. | 2010 | Vet. Immunol. Immunopathol. | pmid:20036014 |
| Cerrato S et al. | Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFalpha release from canine skin mast cells. | 2010 | Vet. Immunol. Immunopathol. | pmid:19625089 |
| Liu Y et al. | Increased expression of the peroxisome proliferator-activated receptor gamma in the immune system of weaned pigs after Escherichia coli lipopolysaccharide injection. | 2008 | Vet. Immunol. Immunopathol. | pmid:18394717 |
| Yoshitake R et al. | Molecular investigation of the direct anti-tumour effects of nonsteroidal anti-inflammatory drugs in a panel of canine cancer cell lines. | 2017 | Vet. J. | pmid:28283079 |
| Arnold R and König W | Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. | 2006 | Virology | pmid:16616290 |
| Arnold R and König W | Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. | 2006 | Virology | pmid:16330064 |
| Boisvert M et al. | PGJ2 antagonizes NF-kappaB-induced HIV-1 LTR activation in colonic epithelial cells. | 2008 | Virology | pmid:18755491 |
| Urade Y and Hayaishi O | Prostaglandin D synthase: structure and function. | 2000 | Vitam. Horm. | pmid:10668396 |
| Jović N et al. | Do prostaglandins E2, F2 alpha and D2 have a role in the development of idiopathic trigeminal neuralgia? | 1996 May-Jun | Vojnosanit Pregl | pmid:9174396 |
| Ma XM et al. | Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma. | 2009 | World J. Gastroenterol. | pmid:19701967 |
| Dong YW et al. | Suppression of pancreatic carcinoma growth by activating peroxisome proliferator-activated receptor gamma involves angiogenesis inhibition. | 2009 | World J. Gastroenterol. | pmid:19152448 |
| Chen YX et al. | 15d-PGJ2 inhibits cell growth and induces apoptosis of MCG-803 human gastric cancer cell line. | 2003 | World J. Gastroenterol. | pmid:14562367 |