Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li P et al. | [Effect of peroxisome proliferator-activated receptor-γ on endothelial cells oxidative stress induced by Porphyromonas gingivalis]. | 2015 | Beijing Da Xue Xue Bao | pmid:26679661 |
Meng Y et al. | Angiotensin II-induced Egr-1 expression is suppressed by peroxisome proliferator-activated receptor-γ ligand 15d-PGJ₂ in macrophages. | 2015 | Cell. Physiol. Biochem. | pmid:25591955 |
Penas F et al. | Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice. | 2015 | Biochim. Biophys. Acta | pmid:25557389 |
Oishi Y et al. | The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep. | 2015 | Brain Behav. Immun. | pmid:25532785 |
Fukuoka T et al. | Prostaglandin D synthase is a potential novel therapeutic agent for the treatment of gastric carcinomas expressing PPARγ. | 2015 | Int. J. Cancer | pmid:25516376 |
Säfholm J et al. | Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor. | 2015 | J. Allergy Clin. Immunol. | pmid:25962903 |
Wallert M et al. | α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages. | 2015 | Mol Nutr Food Res | pmid:25943249 |
Ott D et al. | Prostaglandin D2 modulates calcium signals induced by prostaglandin E2 in neurons of rat dorsal root ganglia. | 2015 | Neurosci. Lett. | pmid:25912777 |
Willenberg I et al. | Determining cyclooxygenase-2 activity in three different test systems utilizing online-solid phase extraction-liquid chromatography-mass spectrometry for parallel quantification of prostaglandin E(2), D(2) and thromboxane B(2). | 2015 | J Chromatogr A | pmid:25777050 |
Gonzalez-Rodriguez PJ et al. | Dexamethasone protects neonatal hypoxic-ischemic brain injury via L-PGDS-dependent PGD2-DP1-pERK signaling pathway. | 2014 | PLoS ONE | pmid:25474649 |
Kurzynska A et al. | Peroxisome proliferator activated receptor ligands affect progesterone and 17β-estradiol secretion by porcine corpus luteum during early pregnancy. | 2014 | J. Physiol. Pharmacol. | pmid:25371531 |
Reddy PH | Inhibitors of mitochondrial fission as a therapeutic strategy for diseases with oxidative stress and mitochondrial dysfunction. | 2014 | J. Alzheimers Dis. | pmid:24413616 |
Zhang S et al. | Prostaglandin D2 receptor D-type prostanoid receptor 2 mediates eosinophil trafficking into the esophagus. | 2014 | Dis. Esophagus | pmid:24165271 |
Kaplan J et al. | Pioglitazone reduces inflammation through inhibition of NF-κB in polymicrobial sepsis. | 2014 | Innate Immun | pmid:24029145 |
Filep JG | Glucocorticoid protection against myocardial ischemia-reperfusion injury: central role for the PGD2-Nrf2 pathway. | 2014 | Hypertension | pmid:24101660 |
Katsumata Y et al. | Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2. | 2014 | Hypertension | pmid:24101662 |
Mello CF and Oliveira MS | Commentary on Kaushik et al.: Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Novel evidence supporting a role for prostanoid receptors in seizure control. | 2014 | Exp. Neurol. | pmid:24814715 |
Chen S et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) promotes apoptosis of HBx-positive liver cells. | 2014 | Chem. Biol. Interact. | pmid:24582817 |
Brugha RE et al. | Carbon in airway macrophages from children with asthma. | 2014 | Thorax | pmid:24567296 |
Takeshima Y | [Development of novel therapeutic approaches for Duchenne muscular dystrophy]. | 2014 | No To Hattatsu | pmid:24738186 |