PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Neuroblastoma D009447 66 associated lipids
Pain D010146 64 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Parkinson Disease D010300 53 associated lipids
Peptic Ulcer D010437 19 associated lipids
Peritonitis D010538 38 associated lipids
Persistent Fetal Circulation Syndrome D010547 1 associated lipids
Pleurisy D010998 20 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Respiratory Sounds D012135 3 associated lipids
Retinopathy of Prematurity D012178 9 associated lipids
Rhinitis D012220 10 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Sarcoidosis D012507 13 associated lipids
Sarcoma 180 D012510 21 associated lipids
Osteosarcoma D012516 50 associated lipids
Seizures D012640 87 associated lipids
Sleep Wake Disorders D012893 7 associated lipids
Sneezing D012912 6 associated lipids
Stomach Ulcer D013276 75 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thrombosis D013927 49 associated lipids
Thyroid Diseases D013959 8 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Translocation, Genetic D014178 20 associated lipids
Trigeminal Neuralgia D014277 1 associated lipids
Uremia D014511 33 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Urticaria D014581 13 associated lipids
Urticaria Pigmentosa D014582 4 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Wounds, Stab D014951 3 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Zollinger-Ellison Syndrome D015043 1 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Loss D015431 56 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
HTLV-I Infections D015490 3 associated lipids
Nasal Obstruction D015508 4 associated lipids
Choroid Diseases D015862 2 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Helicobacter Infections D016481 21 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Coronavirus Infections D018352 4 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Vasculitis, Leukocytoclastic, Cutaneous D018366 5 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Cystitis, Interstitial D018856 2 associated lipids
Optic Neuropathy, Ischemic D018917 2 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Endotoxemia D019446 27 associated lipids
Thrombophilia D019851 6 associated lipids
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Stroke D020521 32 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Fetal Weight D020567 12 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Coronary Restenosis D023903 10 associated lipids
Tauopathies D024801 6 associated lipids
Mastocytosis, Systemic D034721 1 associated lipids
Decapitation D049248 2 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Angioedemas, Hereditary D054179 2 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Acute Lung Injury D055371 33 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Airway Remodeling D056151 3 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Arai I et al. Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. 2007 Eur. J. Pharmacol. pmid:17141215
Chambers KT et al. PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17148750
Liu JJ et al. Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. 2007 Ann. Hematol. pmid:17089125
Skogvall S et al. Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. 2007 Pulm Pharmacol Ther pmid:16731017
Rehan VK et al. In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17215434
Mathew B et al. Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages. 2007 Am. J. Respir. Cell Mol. Biol. pmid:17204585
Gallant MA et al. Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2. 2007 Eur. J. Pharmacol. pmid:17207480
Xue L et al. Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2). 2007 Biochem. Pharmacol. pmid:17196174
Jin YR et al. Antiplatelet effect of NQ12: a possible mechanism through the arachidonic acid cascade. 2007 J. Pharmacol. Sci. pmid:17951980
Fionda C et al. 15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors. 2007 J. Immunol. pmid:17371958
Saleem S et al. PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury. 2007 Eur. J. Neurosci. pmid:17573924
Wu L et al. Divergent effects of prostaglandin receptor signaling on neuronal survival. 2007 Neurosci. Lett. pmid:17574754
Hasegawa H et al. A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production. 2007 Blood pmid:17551094
Ueki S et al. Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. 2007 Int. Arch. Allergy Immunol. pmid:17541271
Lim HJ et al. 15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells. 2007 Toxicol. Appl. Pharmacol. pmid:17631927
Olmos G et al. Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism. 2007 Cell. Signal. pmid:17658243
Xiang Z et al. 15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells. 2007 J Neuroinflammation pmid:17634127
Ye Y et al. Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. 2007 Prostaglandins Other Lipid Mediat. pmid:17643887
Desmarais JA et al. The peroxisome proliferator-activated receptor gamma regulates trophoblast cell differentiation in mink (Mustela vison). 2007 Biol. Reprod. pmid:17615406
Chen Y et al. Prostaglandin D2 suppresses human NK cell function via signaling through D prostanoid receptor. 2007 J. Immunol. pmid:17709490
Li Y et al. Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist. 2007 J. Am. Chem. Soc. pmid:17691773
Parameswaran K et al. Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines. 2007 Am. J. Respir. Cell Mol. Biol. pmid:17431098
Rehan VK et al. A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17435078
Vinall SL et al. A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes. 2007 Immunology pmid:17437532
Rollins MD et al. Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. 2006 Sep-Oct J. Gastrointest. Surg. pmid:16966031
Goya K et al. The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells. 2006 Sep-Oct J. Diabetes Complicat. pmid:16949522
Castellani ML et al. Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. 2006 Oct-Dec Int. J. Biol. Markers pmid:17177158
Lappas M et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. 2006 Nov-Dec Placenta pmid:16434095
Urade Y Twenty-fifth anniversary of the discovery of somnogenic activity of prostaglandin D2: sleep research directed by Osamu Hayaishi. 2006 May-Jun IUBMB Life pmid:16754308
Okano M et al. Presence and characterization of prostaglandin D2-related molecules in nasal mucosa of patients with allergic rhinitis. 2006 May-Jun Am J Rhinol pmid:16871941
Guyer BJ et al. Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis. 2006 May-Jun Allergy Asthma Proc pmid:16913263
Qu WM et al. Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:17093043
Arai I [Role of cutaneous prostaglandin D2 production on scratching dermatitis in mice]. 2006 Nippon Yakurigaku Zasshi pmid:17167214
Akabane H et al. Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. 2006 Allergol Int pmid:17130681
Ishimura M et al. Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. 2006 Allergol Int pmid:17130683
Mazid MA et al. Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. 2006 FEBS Lett. pmid:17150216
Rousseaux C and Desreumaux P [The peroxisome-proliferator-activated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD)]. 2006 J. Soc. Biol. pmid:17151549
Lee SJ et al. Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: role for Zf9 dephosphorylation. 2006 Mol. Pharmacol. pmid:16611854
Herlong JL and Scott TR Positioning prostanoids of the D and J series in the immunopathogenic scheme. 2006 Immunol. Lett. pmid:16310861
Rockwell CE et al. Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. 2006 Mol. Pharmacol. pmid:16611855
Arnold R and König W Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. 2006 Virology pmid:16616290
Merwald H et al. Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2. 2006 Cell Stress Chaperones pmid:16572732
Sato TA and Mitchell MD Preferential production of prostaglandin D2 by lipopolysaccharide stimulated human choriodecidual explants. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16380246
Cheng K et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16617107
Arnold R and König W Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. 2006 Virology pmid:16330064
Sheddan NA and Mulzer J Cross metathesis as a general strategy for the synthesis of prostacyclin and prostaglandin analogues. 2006 Org. Lett. pmid:16805562
Kohno S et al. Inhibition of skin sclerosis by 15deoxy delta12,14-prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma. 2006 Biomed. Pharmacother. pmid:16337105
Chiang PC et al. Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells. 2006 Eur. J. Pharmacol. pmid:16806159
Xie Y et al. Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins. 2006 Diabetes Obes Metab pmid:16367886
Ogburn KD et al. Prostaglandin J2 reduces catechol-O-methyltransferase activity and enhances dopamine toxicity in neuronal cells. 2006 Neurobiol. Dis. pmid:16406650
Honma Y et al. Effects of indomethacin and dexamethasone on mechanical scratching-induced cutaneous barrier disruption in mice. 2006 Exp. Dermatol. pmid:16761958
El Mezayen R et al. Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. 2006 Immunol. Lett. pmid:16762422
Lin TN et al. 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:16385084
Kobayashi M et al. ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. 2006 Genes Cells pmid:16824197
Ding J et al. Cyclooxygenase isozymes are expressed in human myeloma cells but not involved in anti-proliferative effect of cyclooxygenase inhibitors. 2006 Mol. Carcinog. pmid:16385588
Ogburn KD and Figueiredo-Pereira ME Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates. 2006 J. Biol. Chem. pmid:16774923
Landar A et al. Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16387790
Zhang M et al. Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. 2006 Int. Immunopharmacol. pmid:16782535
Cuzzocrea S Peroxisome proliferator-activated receptors and acute lung injury. 2006 Curr Opin Pharmacol pmid:16580256
Brannan JD et al. Inhibition of mast cell PGD2 release protects against mannitol-induced airway narrowing. 2006 Eur. Respir. J. pmid:16707393
Suzuki T et al. Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions. 2006 Endocr. Relat. Cancer pmid:16601291
Bate C et al. Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells. 2006 Neuropharmacology pmid:16289250
Bellows CF et al. Modulation of macrophage nitric oxide production by prostaglandin D2. 2006 J. Surg. Res. pmid:16289592
Helliwell RJ et al. Gestational age-dependent up-regulation of prostaglandin D synthase (PGDS) and production of PGDS-derived antiinflammatory prostaglandins in human placenta. 2006 J. Clin. Endocrinol. Metab. pmid:16291703
Grill M et al. Systemic inflammation induces COX-2 mediated prostaglandin D2 biosynthesis in mice spinal cord. 2006 Neuropharmacology pmid:16182321
Stamatakis K et al. Identification of novel protein targets for modification by 15-deoxy-Delta12,14-prostaglandin J2 in mesangial cells reveals multiple interactions with the cytoskeleton. 2006 J. Am. Soc. Nephrol. pmid:16291835
Zhao X et al. 15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. 2006 J. Cereb. Blood Flow Metab. pmid:16208315
Landar A et al. Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria. 2006 Biochem. J. pmid:16268779
Cho WH et al. 15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells. 2006 Neurochem. Res. pmid:17006759
Maciejewski-Lenoir D et al. Langerhans cells release prostaglandin D2 in response to nicotinic acid. 2006 J. Invest. Dermatol. pmid:17008871
Wilson RJ et al. GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. 2006 Br. J. Pharmacol. pmid:16604093
Pereira MP et al. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. 2006 J. Cereb. Blood Flow Metab. pmid:16034372
Tanaka H et al. Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-delta(12,14)-PGJ2 derivatives. 2006 Chem Asian J pmid:17441107
Gulliksson M et al. Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. 2006 Allergy pmid:17073880
Phulwani NK et al. 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. 2006 J. Neurochem. pmid:17074064
Kim EH et al. Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. 2006 Ann. N. Y. Acad. Sci. pmid:17384282
Aquila S et al. Peroxisome proliferator-activated receptor (PPAR)gamma is expressed by human spermatozoa: its potential role on the sperm physiology. 2006 J. Cell. Physiol. pmid:16972250
Gayarre J et al. Addition of electrophilic lipids to actin alters filament structure. 2006 Biochem. Biophys. Res. Commun. pmid:16979589
Zhang YJ et al. Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2). 2006 Am. J. Nephrol. pmid:16864989
Schratl P et al. Hierarchy of eosinophil chemoattractants: role of p38 mitogen-activated protein kinase. 2006 Eur. J. Immunol. pmid:16906532
Ciucci A et al. Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. 2006 Mol. Pharmacol. pmid:16908599
Egan K and FitzGerald GA Eicosanoids and the vascular endothelium. 2006 Handb Exp Pharmacol pmid:16999220
Sugimoto M et al. Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Nga mice. 2006 Exp. Dermatol. pmid:17002684
Feldon SE et al. Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. 2006 Am. J. Pathol. pmid:17003477
Peeraully MR et al. Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. 2006 Pflugers Arch. pmid:16924534
Eucker J et al. Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. 2006 Anticancer Drugs pmid:16926626
Satoh T et al. Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. 2006 J. Immunol. pmid:16888024
Sugimoto M et al. COX-1 inhibition enhances scratching behaviour in NC/Nga mice with atopic dermatitis. 2006 Exp. Dermatol. pmid:16842596
Quinkler M et al. Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis. 2006 Gene pmid:16842938
Raikwar HP et al. PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. 2006 J. Neuroimmunol. pmid:16844232
Mesquita-Santos FP et al. Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. 2006 J. Immunol. pmid:16424158
Martín AR et al. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. 2006 Br. J. Pharmacol. pmid:16474422
Kang HY et al. Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis. 2006 Arch. Dermatol. Res. pmid:16474974
Schröder O et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells. 2006 J. Lipid Res. pmid:16495511
King VL et al. Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:16514081
Ray DM et al. The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. 2006 J. Immunol. pmid:17015690
Takai S et al. Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16876988
Piraino G et al. Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. 2006 Shock pmid:16878022
Moulin D et al. Effect of peroxisome proliferator activated receptor (PPAR)gamma agonists on prostaglandins cascade in joint cells. 2006 Biorheology pmid:16912428
Yeh CH et al. Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. 2006 Shock pmid:16912651