PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Neuroblastoma D009447 66 associated lipids
Pain D010146 64 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Parkinson Disease D010300 53 associated lipids
Peptic Ulcer D010437 19 associated lipids
Peritonitis D010538 38 associated lipids
Persistent Fetal Circulation Syndrome D010547 1 associated lipids
Pleurisy D010998 20 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Respiratory Sounds D012135 3 associated lipids
Retinopathy of Prematurity D012178 9 associated lipids
Rhinitis D012220 10 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Sarcoidosis D012507 13 associated lipids
Sarcoma 180 D012510 21 associated lipids
Osteosarcoma D012516 50 associated lipids
Seizures D012640 87 associated lipids
Sleep Wake Disorders D012893 7 associated lipids
Sneezing D012912 6 associated lipids
Stomach Ulcer D013276 75 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thrombosis D013927 49 associated lipids
Thyroid Diseases D013959 8 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Translocation, Genetic D014178 20 associated lipids
Trigeminal Neuralgia D014277 1 associated lipids
Uremia D014511 33 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Urticaria D014581 13 associated lipids
Urticaria Pigmentosa D014582 4 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Wounds, Stab D014951 3 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Zollinger-Ellison Syndrome D015043 1 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Loss D015431 56 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
HTLV-I Infections D015490 3 associated lipids
Nasal Obstruction D015508 4 associated lipids
Choroid Diseases D015862 2 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Helicobacter Infections D016481 21 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Coronavirus Infections D018352 4 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Vasculitis, Leukocytoclastic, Cutaneous D018366 5 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Cystitis, Interstitial D018856 2 associated lipids
Optic Neuropathy, Ischemic D018917 2 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Endotoxemia D019446 27 associated lipids
Thrombophilia D019851 6 associated lipids
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Stroke D020521 32 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Fetal Weight D020567 12 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Coronary Restenosis D023903 10 associated lipids
Tauopathies D024801 6 associated lipids
Mastocytosis, Systemic D034721 1 associated lipids
Decapitation D049248 2 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Angioedemas, Hereditary D054179 2 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Acute Lung Injury D055371 33 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Airway Remodeling D056151 3 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Mutalithas K et al. CRTH2 expression on T cells in asthma. 2010 Clin. Exp. Immunol. pmid:20491797
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Norman P DP(2) receptor antagonists in development. 2010 Expert Opin Investig Drugs pmid:20615077
Pedersen PJ et al. Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties. 2010 Bioorg. Med. Chem. Lett. pmid:20591667
Bai YJ et al. A LC-MS-based method for quantification of biomarkers from serum of allergic rats. 2010 Molecules pmid:20657485
Reddy RC and Standiford TJ Nrf2 and PPAR{gamma}: PPARtnering against oxidant-induced lung injury. 2010 Am. J. Respir. Crit. Care Med. pmid:20634499
Ahmad AS et al. Prostaglandin D2 DP1 receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice. 2010 Age (Dordr) pmid:20640551
Shah S et al. Efficacy and safety of extended-release niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia. 2010 Int. J. Clin. Pract. pmid:20518948
Genovese A et al. Human cardiac mast cells in anaphylaxis. 2010 Chem Immunol Allergy pmid:20519884
Diers AR et al. Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy. 2010 Biochem. J. pmid:20536428
Vong L et al. A pro-resolution mediator, prostaglandin D(2), is specifically up-regulated in individuals in long-term remission from ulcerative colitis. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20547854
van den Brule S et al. The D prostanoid receptor agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice. 2010 J. Pharmacol. Exp. Ther. pmid:20719937
Kar R et al. Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1. 2010 Biochem. Biophys. Res. Commun. pmid:20678484
Satoh T et al. Indomethacin-induced reduction in CRTH2 in eosinophilic pustular folliculitis (Ofuji's disease): a proposed mechanism of action. 2010 Acta Derm. Venereol. pmid:20107720
Akin C et al. Mast cell activation syndrome: Proposed diagnostic criteria. 2010 J. Allergy Clin. Immunol. pmid:21035176
Veliça P et al. Prostaglandin D2 inhibits C2C12 myogenesis. 2010 Mol. Cell. Endocrinol. pmid:20109525
Gallant MA et al. Increased concentrations of prostaglandin D2 during post-fracture bone remodeling. 2010 J. Rheumatol. pmid:20080921
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Katura T et al. 15-Deoxy-delta 12,14-prostaglandin J2 biphasically regulates the proliferation of mouse hippocampal neural progenitor cells by modulating the redox state. 2010 Mol. Pharmacol. pmid:20086036
Buga GM et al. L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965777
Roy SJ et al. Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif. 2010 Eur. J. Pharmacol. pmid:20035740
Lin TY and London CA Characterization and modulation of canine mast cell derived eicosanoids. 2010 Vet. Immunol. Immunopathol. pmid:20036014
Byrns MC et al. Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. 2010 J. Steroid Biochem. Mol. Biol. pmid:20036328
Templeton DJ et al. Purification of reversibly oxidized proteins (PROP) reveals a redox switch controlling p38 MAP kinase activity. 2010 PLoS ONE pmid:21085594
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Subra C et al. Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. 2010 J. Lipid Res. pmid:20424270
Hatanaka M et al. 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. 2010 J. Pharmacol. Sci. pmid:20424389
Maggiora M et al. Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells. 2010 Cell Biochem. Funct. pmid:20862655
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Hanks BC et al. Evaluation of anti-inflammatory and chondroprotective effects of peroxisome proliferator-activated receptor gamma agonists in cartilage and synovial explants from dogs. 2010 Am. J. Vet. Res. pmid:20919899
Kim NJ et al. Concise and enantioselective total synthesis of 15-deoxy-Δ-(12,14)-prostaglandin J(2). 2010 J. Org. Chem. pmid:20929274
Bancos S et al. Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2. 2010 Cell. Immunol. pmid:20064636
Koyama M et al. Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. 2010 Clin. Cancer Res. pmid:20371690
Kim DH et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue. 2010 Oncogene pmid:20208557
Cho HY et al. Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. 2010 Am. J. Respir. Crit. Care Med. pmid:20224069
Krall CM et al. Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20393159
Lee JJ et al. The protective effects of paclitaxel on platelet aggregation through the inhibition of thromboxane A2 synthase. 2010 Arch. Pharm. Res. pmid:20361303
Pérez-Novo CA et al. CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue. 2010 Allergy pmid:19839971
Mo C et al. PPARgamma regulates LIF-induced growth and self-renewal of mouse ES cells through Tyk2-Stat3 pathway. 2010 Cell. Signal. pmid:19922793
Kanda N et al. Prostaglandin D2 induces the production of human beta-defensin-3 in human keratinocytes. 2010 Biochem. Pharmacol. pmid:19925780
Biburger M et al. Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity. 2010 J. Leukoc. Biol. pmid:19797297
Toaldo C et al. PPARgamma ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells. 2010 J. Cell. Mol. Med. pmid:19912441
Diers AR et al. Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. 2010 Biochem. J. pmid:19916962
Hilliard M et al. The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export. 2010 J. Biol. Chem. pmid:20457605
Yokoyama Y et al. 15-Deoxy-Delta12,14-prostaglandin J2 inhibits angiotensin II-induced fibronectin expression via hepatocyte growth factor induction in human peritoneal mesothelial cells. 2010 Ther Apher Dial pmid:20438519
Romanovsky AA and Garami A Prostaglandin riddles in energy metabolism: E is for excess, D is for depletion. Focus on "Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2". 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20410482
Shiraya K et al. A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. 2010 J. Biol. Chem. pmid:20448048
Mishra N et al. Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2. 2010 Biochem. Biophys. Res. Commun. pmid:20307494
Guo N et al. Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. 2010 J. Biol. Chem. pmid:20308056
Poncin S et al. N-acetylcysteine and 15 deoxy-{delta}12,14-prostaglandin J2 exert a protective effect against autoimmune thyroid destruction in vivo but not against interleukin-1{alpha}/interferon {gamma}-induced inhibitory effects in thyrocytes in vitro. 2010 Am. J. Pathol. pmid:20489149
Kolaczkowska E et al. Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation. 2009 Nov-Dec Arch. Immunol. Ther. Exp. (Warsz.) pmid:19885646
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Hayden RE et al. Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. 2009 Leukemia pmid:18923439
Yuan ZB et al. Temporal expression of cyclooxygenase-2 in peritoneal macrophages of rats and effects of panax notoginseng saponins. 2009 Inflamm. Res. pmid:19184357
Whelan CJ Evidence that 13-14 di-hydro, 15-keto prostaglandin D(2)-induced airway eosinophilia in guinea-pigs is independent of interleukin-5. 2009 Inflamm. Res. pmid:19184361
Liu J et al. Peroxisome proliferator-activated receptor-gamma ligands 15-deoxy-delta(12,14)-prostaglandin J2 and pioglitazone inhibit hydroxyl peroxide-induced TNF-alpha and lipopolysaccharide-induced CXC chemokine expression in neonatal rat cardiac myocytes. 2009 Shock pmid:19174742
Kolaczkowska E et al. Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9. 2009 Immunology pmid:19175797
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Wang Y et al. Peroxisome proliferator-activated receptor gamma agonists enhance lung maturation in a neonatal rat model. 2009 Pediatr. Res. pmid:19262292
Yamamoto M et al. Expression and characterization of PGD2 receptors in chronic rhinosinusitis: modulation of DP and CRTH2 by PGD2. 2009 Int. Arch. Allergy Immunol. pmid:18802357
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Cha B et al. 15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells. 2009 Ann. N. Y. Acad. Sci. pmid:19723089
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Zhang GY et al. Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro. 2009 Arch. Dermatol. Res. pmid:19466435
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Wang X et al. Potential effects of peroxisome proliferator-activated receptor activator on LPS-induced lung injury in rats. 2009 Pulm Pharmacol Ther pmid:19489131
Tokudome S et al. Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. 2009 J. Clin. Invest. pmid:19451694
Pierre SR et al. Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice. 2009 J Neuroinflammation pmid:19630993
Pena-dos-Santos DR et al. Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint. 2009 Neuroscience pmid:19647045
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Butterfield JH Survey of aspirin administration in systemic mastocytosis. 2009 Prostaglandins Other Lipid Mediat. pmid:19429499
Moniot B et al. The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. 2009 Development pmid:19429785
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Jung WK et al. The 15-deoxy-Delta12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-kappaB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1. 2009 Life Sci. pmid:19409914
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Bujold K et al. CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages. 2009 Cardiovasc. Res. pmid:19377069
Mrabet-Dahbi S et al. Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands. 2009 Exp. Dermatol. pmid:19382314
Davies NJ et al. AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. 2009 Cancer Res. pmid:19487289
Prakash J et al. Albumin-binding and tumor vasculature determine the antitumor effect of 15-deoxy-Delta-(12,14)-prostaglandin-J(2) in vivo. 2009 Neoplasia pmid:20019843
Khanim FL et al. Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. 2009 PLoS ONE pmid:19997560
Pustovrh MC et al. MMP/ TIMP balance is modulated in vitro by 15dPGJ(2) in fetuses and placentas from diabetic rats. 2009 Eur. J. Clin. Invest. pmid:19811527
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