PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Seibert K et al. | 9 alpha, 11 beta-prostaglandin F2: formation and metabolism by human lung and contractile effects on human bronchial smooth muscle. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959045 |
| Roberts LJ et al. | PGD2 is transformed by human coronary arteries to 9 alpha, 11 beta-PGF2, which contracts human coronary artery rings. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959090 |
| Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and prostaglandin H2 to prostaglandin F2 alpha by PGF synthetase. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959094 |
| Wendelborn DF et al. | Isomeric prostaglandin F2 compounds: a new family of eicosanoids produced in vivo in humans. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959099 |
| Pugliese G et al. | 9 alpha, 11 beta-prostaglandin F2: a new prostanoid with selective biosynthesis and unique biological activity. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959104 |
| Narumiya S et al. | Site and mechanism of growth inhibition by prostaglandins. III. Distribution and binding of prostaglandin A2 and delta 12-prostaglandin J2 in nuclei. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3302206 |
| Robinson C et al. | Effects of inhaled 9 alpha, 11 beta-prostaglandin F2 on airway function in man. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960146 |
| Ruzicka T and Auböck J | Arachidonic acid metabolism in guinea pig Langerhans cells: studies on cyclooxygenase and lipoxygenase pathways. | 1987 | J. Immunol. | pmid:3098849 |
| Williams KA et al. | Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets. | 1987 | Biochem. J. | pmid:2444206 |
| Goto H | [Quantitative determination of prostaglandin D2 in the rat gastric mucosa by high performance liquid chromatography]. | 1987 | Nihon Shokakibyo Gakkai Zasshi | pmid:3473244 |
| Kariya T et al. | Platelet abnormality with no response to PGD2 in a patient with metastatic pancreas carcinoma and myeloproliferative disorder. | 1987 | Nippon Ketsueki Gakkai Zasshi | pmid:3473883 |
| Holgate ST | Contribution of inflammatory mediators to the immediate asthmatic reaction. | 1987 | Am. Rev. Respir. Dis. | pmid:3473955 |
| Hayashi H et al. | Determination of 9 alpha, 11 beta-prostaglandin F2 by stereospecific antibody in various rat tissues. | 1987 | Prostaglandins | pmid:3474704 |
| Maurice PD et al. | The effect of prostaglandin D2 on the response of human skin to histamine. | 1987 | J. Invest. Dermatol. | pmid:3476674 |
| Berryman GK et al. | Amniotic fluid prostaglandin D2 in spontaneous and augmented labor. | 1987 | Life Sci. | pmid:3476816 |
| Kempski O et al. | Postischemic production of eicosanoids in gerbil brain. | 1987 Jan-Feb | Stroke | pmid:3468670 |
| Mezawa A | [Nasal response to chemical mediators in nasal allergy]. | 1988 | Nippon Jibiinkoka Gakkai Kaiho | pmid:3199260 |
| Casteleijn E et al. | Endotoxin stimulates glycogenolysis in the liver by means of intercellular communication. | 1988 | J. Biol. Chem. | pmid:3284878 |
| Ikai K and Imamura S | Prostaglandin D2 in the skin. | 1988 | Int. J. Dermatol. | pmid:3286543 |
| Hardy CC et al. | Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma. | 1988 | J. Appl. Physiol. | pmid:3288608 |
| Pienkowski MM et al. | Prostaglandin D2 and histamine during the immediate and the late-phase components of allergic cutaneous responses. | 1988 | J. Allergy Clin. Immunol. | pmid:3292634 |
| Barr RM et al. | The in vitro 5-lipoxygenase and cyclo-oxygenase inhibitor L-652,343 does not inhibit 5-lipoxygenase in vivo in human skin. | 1988 | Br J Clin Pharmacol | pmid:2835975 |
| Ito S et al. | Problems in production of prostaglandin D2-specific antibody. | 1988 | Eicosanoids | pmid:3273218 |
| Saito K et al. | Blood components contribute to rise in gerbil brain levels of leukotriene-like immunoreactivity after ischemia and reperfusion. | 1988 | Stroke | pmid:3274043 |
| Giles H and Leff P | The biology and pharmacology of PGD2. | 1988 | Prostaglandins | pmid:3283848 |
| Featherstone RL et al. | Active sensitization of guinea-pig airways in vivo enhances in vivo and in vitro responsiveness. | 1988 | Eur. Respir. J. | pmid:3229483 |
| Petrini B et al. | Modulation of lymphocyte and monocyte responses in vitro by 9-deoxy-delta 9-prostaglandin D2 and 9-deoxy-delta 9-delta 12-prostaglandin D2. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3229858 |
| Hayaishi O | Sleep-wake regulation by prostaglandins D2 and E2. | 1988 | J. Biol. Chem. | pmid:3049580 |
| Beasley R et al. | Comparative vascular effects of histamine, prostaglandin (PG) D2 and its metabolite 9 alpha,11 beta-PGF2 in human skin. | 1988 | Clin. Allergy | pmid:3242978 |
| Ohishi K et al. | Increased level of salivary prostaglandins in patients with major depression. | 1988 | Biol. Psychiatry | pmid:3422573 |
| Casteleijn E et al. | Hormonal control of glycogenolysis in parenchymal liver cells by Kupffer and endothelial liver cells. | 1988 | J. Biol. Chem. | pmid:3422638 |
| Yamamoto K et al. | Muramyl dipeptide-elicited production of PGD2 from astrocytes in culture. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3056405 |
| Kuiper J et al. | Identification of prostaglandin D2 as the major eicosanoid from liver endothelial and Kupffer cells. | 1988 | Biochim. Biophys. Acta | pmid:3126817 |
| Hahn HL | [Inflammatory mediators in the pathogenesis of obstructive bronchial diseases: consequences for therapy]. | 1988 | Verh Dtsch Ges Inn Med | pmid:2905102 |
| Iwai M et al. | Potential role for prostaglandin F2 alpha, D2, E2 and thromboxane A2 in mediating the metabolic and hemodynamic actions of sympathetic nerves in perfused rat liver. | 1988 | Eur. J. Biochem. | pmid:3165341 |
| Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
| Koh T et al. | Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats. | 1988 | Eur. J. Pharmacol. | pmid:2969338 |
| Broide DH et al. | Functional and biochemical characterization of rat bone marrow derived mast cells. | 1988 | J. Immunol. | pmid:2974057 |
| Regal JF | Role of arachidonate metabolites in C5a-induced bronchoconstriction. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2841450 |
| Tran-Thi TA et al. | Net prostaglandin release by perfused rat liver after stimulation with phorbol 12-myristate 13-acetate. | 1988 | J. Hepatol. | pmid:3166024 |
| Kawata R et al. | Prostaglandin synthesis by the cochlea. | 1988 | Prostaglandins | pmid:3129756 |
| Heavey DJ et al. | Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells. | 1988 | J. Immunol. | pmid:2450136 |
| Parsons WG and Roberts LJ | Transformation of prostaglandin D2 to isomeric prostaglandin F2 compounds by human eosinophils. A potential mast cell-eosinophil interaction. | 1988 | J. Immunol. | pmid:3139758 |
| Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
| Nakagomi T et al. | Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries. | 1988 | J. Neurosurg. | pmid:2895803 |
| Negishi M et al. | Functional reconstitution of prostaglandin E receptor from bovine adrenal medulla with guanine nucleotide binding proteins. | 1988 | J. Biol. Chem. | pmid:2896200 |
| Fukui A et al. | Effects of prostaglandin D2 and omeprazole on indomethacin-induced gastric ulcers in rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3149561 |
| Vigano T et al. | Prostaglandin synthetase inhibition and formation of lipoxygenase products in immunologically challenged normal human lung parenchyma. | 1988 | Eicosanoids | pmid:3152489 |
| Casteleijn E et al. | Prostaglandin D2 mediates the stimulation of glycogenolysis in the liver by phorbol ester. | 1988 | Biochem. J. | pmid:3162673 |
| Ishioka C et al. | Inhibitory effects of prostaglandin A2 on c-myc expression and cell cycle progression in human leukemia cell line HL-60. | 1988 | Cancer Res. | pmid:3162825 |
| Miadonna A et al. | Mediators and allergic inflammation of human airways. | 1988 | Respiration | pmid:2466314 |
| Soifer SJ et al. | Effects of prostaglandin D2 on pulmonary arterial pressure and oxygenation in newborn infants with persistent pulmonary hypertension. | 1988 | J. Pediatr. | pmid:3162978 |
| Wasserman SI | Basic mechanisms in asthma. | 1988 | Ann Allergy | pmid:3163472 |
| Barr RM et al. | The release of prostaglandin D2 from human skin in vivo and in vitro during immediate allergic reactions. | 1988 | Br. J. Pharmacol. | pmid:2460180 |
| Lebel B et al. | Spontaneous and non-specific release of histamine and PGD2 by bronchoalveolar lavage cells from asthmatic and normal subjects: effect of nedocromil sodium. | 1988 | Clin. Allergy | pmid:2468432 |
| Sonoki H et al. | [Effects of 3,4-diaminopyridine on the contractions of guinea-pig tracheal smooth muscle induced by histamine and prostaglandin D2]. | 1988 | Nippon Yakurigaku Zasshi | pmid:3163668 |
| Ujihara M et al. | Biochemical and immunological demonstration of prostaglandin D2, E2, and F2 alpha formation from prostaglandin H2 by various rat glutathione S-transferase isozymes. | 1988 | Arch. Biochem. Biophys. | pmid:3041912 |
| Foreman D et al. | Anhydrolevuglandin D2 inhibits the uterotonic activity of prostaglandins F2 alpha and D2. | 1988 | Prostaglandins | pmid:3163807 |
| Moore PK et al. | Effect of fibrinopeptides A and B on human and rat platelet aggregation in vitro. | 1988 | Eur. J. Pharmacol. | pmid:3053211 |
| Hirata Y et al. | Occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin D2 in human urine. | 1988 | J. Biol. Chem. | pmid:3053696 |
| Yang CY et al. | Isolation and culture of two cell populations from chick calvaria by density gradient: prostaglandin synthesis by the cells in culture and coculture. | 1988 | Endocrinology | pmid:2844516 |
| Chock SP and Schmauder-Chock EA | Synthesis of prostaglandins and eicosanoids by the mast cell secretory granule. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3190706 |
| Rodriguez y Baena R et al. | A study on cisternal CSF levels of arachidonic acid metabolites after aneurysmal subarachnoid hemorrhage. | 1988 | J. Neurol. Sci. | pmid:3132538 |
| Casteleijn E et al. | Conditioned media of Kupffer and endothelial liver cells influence protein phosphorylation in parenchymal liver cells. Involvement of prostaglandins. | 1988 | Biochem. J. | pmid:3166374 |
| Hoult JR et al. | Organ selective conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and its subsequent metabolism in rat, rabbit and guinea pig. | 1988 | Biochem. Pharmacol. | pmid:3178873 |
| Nakamura O et al. | [Antineoplastic effect of prostaglandins on human glioma in athymic nude mice]. | 1988 | No To Shinkei | pmid:3179087 |
| Schulman ES et al. | Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release. | 1988 | J. Clin. Invest. | pmid:2449462 |
| Serio R and Daniel EE | Thromboxane effects on canine trachealis neuromuscular function. | 1988 | J. Appl. Physiol. | pmid:2839451 |
| Robinson C et al. | The immunoglobulin E- and calcium-dependent release of histamine and eicosanoids from human dispersed mastocytosis spleen cells. | 1988 | J. Invest. Dermatol. | pmid:2450144 |
| Undem BJ and Adams GK | An analysis of the functional interactions of selected contractile agonists in the guinea pig isolated trachea. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2839671 |
| Holgate ST et al. | The contribution of mast cell mediators to acute allergic reactions in human skin and airways. | 1988 | Allergy | pmid:2451448 |
| Schulman ES et al. | Density heterogeneity of human lung mast cells. | 1988 | J. Allergy Clin. Immunol. | pmid:2455745 |
| Rao PS et al. | The effect of prostaglandin D2 on angiotensin converting enzyme. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2845437 |
| Ormerod AD et al. | Prostaglandin D2 and histamine release in cold urticaria unaccompanied by evidence of platelet activation. | 1988 | J. Allergy Clin. Immunol. | pmid:2459177 |
| Keery RJ and Lumley P | AH6809, a prostaglandin DP-receptor blocking drug on human platelets. | 1988 | Br. J. Pharmacol. | pmid:2460179 |
| Michel L et al. | Prostaglandin D2 generation in mouse bone marrow-derived mast cells exposed to dexamethasone is associated with endogenous peroxidase activity. | 1988 | Lab. Invest. | pmid:2460694 |
| Undem BJ et al. | Isoproterenol-induced inhibition of immunoglobulin E-mediated release of histamine and arachidonic acid metabolites from the human lung mast cell. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2459368 |
| Lebel B et al. | Correlation between symptoms and the threshold for release of mediators in nasal secretions during nasal challenge with grass-pollen grains. | 1988 | J. Allergy Clin. Immunol. | pmid:2461405 |
| Bousquet J et al. | Antiallergic activity of H1-receptor antagonists assessed by nasal challenge. | 1988 | J. Allergy Clin. Immunol. | pmid:2461406 |
| Church MM et al. | The mediator and cellular basis of the allergic response. | 1988 | Allergy | pmid:2462372 |
| Takei M et al. | Role of cyclic AMP during histamine release. Histamine release is not directly related to increase in cyclic AMP levels in rat mast cells activated by concanavalin A, anti-IgE, antigen, prostaglandin D2 and isoproterenol. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:2463844 |
| Wang D et al. | Aminophylline reduces air-flow-induced constriction in the canine lung periphery. | 1988 | Am. Rev. Respir. Dis. | pmid:3422143 |
| Wendelborn DF et al. | Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3422430 |
| Ohno K et al. | Site and mechanism of growth inhibition by prostaglandins. IV. Effect of cyclopentenone prostaglandins on cell cycle progression of G1-enriched HeLa S3 cells. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3361448 |
| Goh Y et al. | Prostaglandin D2 reduces intraocular pressure. | 1988 | Br J Ophthalmol | pmid:3164634 |
| Yue TL and Mai K | [Effects of protein malnutrition on the metabolism of arachidonic acid in the rat stomach and spleen]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3142210 |
| Onoe H et al. | Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3163802 |
| Shohami E et al. | Experimental closed head injury in rats: prostaglandin production in a noninjured zone. | 1988 | Neurosurgery | pmid:3164097 |
| Dieter P et al. | Ca2+ requirement of prostanoid but not of superoxide production by rat Kupffer cells. | 1988 | Eur. J. Biochem. | pmid:2846298 |
| Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1988 | Prostaglandins | pmid:2847246 |
| Ujihara M et al. | Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats. | 1988 | Arch. Biochem. Biophys. | pmid:3124755 |
| Kashimura M et al. | Prostaglandin D2 diminishes transmucosal potential difference in rat colonic mucosa in vitro in contrast to the increasing effect of prostaglandin E1. | 1988 | Prostaglandins | pmid:2854645 |
| Lahoua Z et al. | Serum-induced arachidonic acid release and prostaglandin biosynthesis are potentiated by oxygenated sterols in NRK 49F cells. | 1988 | Biochim. Biophys. Acta | pmid:3124881 |
| Fukushima M | [Prostaglandin J2--anti-tumor activity and mechanism of action]. | 1988 | Nippon Rinsho | pmid:3043050 |
| Morimoto A et al. | Multiple control of fever production in the central nervous system of rabbits. | 1988 | J. Physiol. (Lond.) | pmid:3261794 |
| Kleeberger SR et al. | The role of mediators in the response of the canine peripheral lung to 1 ppm ozone. | 1988 | Am. Rev. Respir. Dis. | pmid:2829670 |
| Yokotani K et al. | Sympathoadrenomedullary system mediation of the prostaglandin E2-induced central inhibition of gastric acid output in rats. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3422095 |
| Robinson C et al. | The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men. | 1988 | Biochim. Biophys. Acta | pmid:3196723 |
| Miwa N et al. | Prostaglandin induces Ca2+ influx and cyclic GMP formation in mouse neuroblastoma X rat glioma hybrid NG108-15 cells in culture. | 1988 | J. Neurochem. | pmid:2834513 |
| Armour CL et al. | Prostaglandin F2 alpha augments the response to parasympathetic fibre stimulation in an isolated innervated preparation of rabbit trachea. | 1988 | J Auton Pharmacol | pmid:3198665 |