PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Liver Cirrhosis, Experimental D008106 36 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukodystrophy, Globoid Cell D007965 6 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia, Megakaryoblastic, Acute D007947 7 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukemia P388 D007941 43 associated lipids
Leukemia D007938 74 associated lipids
Leiomyoma D007889 8 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Inflammation D007249 119 associated lipids
Hypothermia D007035 19 associated lipids
Hypotension D007022 41 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypersensitivity D006967 22 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hyperemia D006940 25 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypercalcemia D006934 13 associated lipids
Hyperalgesia D006930 42 associated lipids
HIV Seropositivity D006679 15 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Hemolysis D006461 131 associated lipids
Hematoma D006406 5 associated lipids
Headache D006261 4 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Goiter D006042 4 associated lipids
Glioma D005910 112 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Folliculitis D005499 7 associated lipids
Fibrosis D005355 23 associated lipids
Fever D005334 35 associated lipids
Erythema D004890 22 associated lipids
Epilepsy, Tonic-Clonic D004830 2 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Encephalitis D004660 15 associated lipids
Edema D004487 152 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Down Syndrome D004314 18 associated lipids
Dirofilariasis D004184 3 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Drug Eruptions D003875 30 associated lipids
Dehydration D003681 11 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cryptorchidism D003456 2 associated lipids
Cryptococcosis D003453 3 associated lipids
Cough D003371 19 associated lipids
Coronary Disease D003327 70 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Colitis D003092 69 associated lipids
Chondrosarcoma D002813 9 associated lipids
Cholangitis D002761 3 associated lipids
Brain Ischemia D002545 89 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Cataract D002386 34 associated lipids
Catalepsy D002375 30 associated lipids
Carotid Artery Thrombosis D002341 7 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Bronchial Spasm D001986 18 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Body Weight D001835 333 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Blister D001768 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Astrocytoma D001254 15 associated lipids
Asthma D001249 52 associated lipids
Ascariasis D001196 3 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Arthritis D001168 41 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Anaphylaxis D000707 35 associated lipids
Anal Gland Neoplasms D000694 1 associated lipids
Alzheimer Disease D000544 76 associated lipids
Adenocarcinoma D000230 166 associated lipids
Actinobacillus Infections D000189 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Ward JE et al. PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. 2004 Br. J. Pharmacol. pmid:14718259
Ray DM et al. Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. 2004 Clin. Immunol. pmid:15451478
Abdelrahman M et al. The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. 2004 Shock pmid:15545828
Chen F Endogenous inhibitors of nuclear factor-kappaB, an opportunity for cancer control. 2004 Cancer Res. pmid:15548674
Inoue K et al. Effects of 15-deoxy-delta12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide. 2004 Arzneimittelforschung pmid:15612612
Mitsumori S Recent progress in work on PGD2 antagonists for drugs targeting allergic diseases. 2004 Curr. Pharm. Des. pmid:15579050
Kumagai M et al. 15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells. 2004 Tohoku J. Exp. Med. pmid:14998300
Emi M and Maeyama K The biphasic effects of cyclopentenone prostaglandins, prostaglandin J(2) and 15-deoxy-Delta(12,14)-prostaglandin J(2) on proliferation and apoptosis in rat basophilic leukemia (RBL-2H3) cells. 2004 Biochem. Pharmacol. pmid:15013841
Waits PS et al. Nociceptin/orphanin FQ modulates human T cell function in vitro. 2004 J. Neuroimmunol. pmid:15020071
Azuma Y et al. Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1. 2004 J. Pharmacol. Sci. pmid:15037811
Diab A et al. Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis. 2004 J. Neuroimmunol. pmid:14975592
Paumi CM et al. Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2). 2004 Biochemistry pmid:14979731
Fogel-Petrovic M et al. Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2. 2004 Immunol. Cell Biol. pmid:14984594
Cheng S et al. Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. 2004 J. Biol. Chem. pmid:15023995
Alvarez-Maqueda M et al. 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. 2004 J. Biol. Chem. pmid:15024026
Marone G et al. The human heart as a shock organ in anaphylaxis. 2004 Novartis Found. Symp. pmid:15025396
Qin C et al. A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. 2004 Mol. Cancer Ther. pmid:15026545
Asami-Miyagishi R et al. Expression and function of PPARgamma in rat placental development. 2004 Biochem. Biophys. Res. Commun. pmid:14766236
Mix KS et al. Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling. 2004 Mol. Pharmacol. pmid:14742672
Trottein F et al. Role of the D prostanoid receptor 1 in the modulation of immune and inflammatory responses. 2004 Crit. Rev. Immunol. pmid:15663363
Yuan Z et al. Peroxisome proliferator-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis associated with inhibition of self-sensitive T cells. 2004 J. Cardiovasc. Pharmacol. pmid:15167281
Lee KJ et al. Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g. 2004 Exp. Mol. Med. pmid:15665586
Dahlén SE and Kumlin M Monitoring mast cell activation by prostaglandin D2 in vivo. 2004 Thorax pmid:15170020
Bochenek G et al. Plasma 9alpha,11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma. 2004 Thorax pmid:15170023
Cheron A et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process. 2004 J. Immunol. pmid:15187150
Maddox JF et al. 15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes. 2004 Toxicol. Sci. pmid:14657518
Baek SJ et al. Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. 2004 J. Biol. Chem. pmid:14662774
Zhang X et al. Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells. 2004 Kidney Int. pmid:14871400
Ueta M et al. PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose. 2004 Kidney Int. pmid:14871416
Badawi AF et al. Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma. 2004 Cancer Res. pmid:14871855
Weber SM et al. PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells. 2004 Am. J. Physiol. Endocrinol. Metab. pmid:14600076
Asada K et al. Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages. 2004 Am. J. Respir. Crit. Care Med. pmid:14563653
Reddy PS et al. The synthesis and effects of prostaglandins on the ovary of the crab Oziotelphusa senex senex. 2004 Gen. Comp. Endocrinol. pmid:14644642
Servidei T et al. The cellular response to PPARgamma ligands is related to the phenotype of neuroblastoma cell lines. 2004 Oncol. Res. pmid:15301425
Boyault S et al. 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway. 2004 FEBS Lett. pmid:15304320
Ichiki T et al. 15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. 2004 Biochem. Biophys. Res. Commun. pmid:15369766
Schlezinger JJ et al. Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2. 2004 J. Immunol. pmid:15322177
Si Q et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications. 2004 J. Immunol. pmid:15322215
Cheng J et al. Peroxisome proliferator-activated receptor gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2, and ciglitazone, induce growth inhibition and cell cycle arrest in hepatic oval cells. 2004 Biochem. Biophys. Res. Commun. pmid:15325252
Luster AD and Tager AM T-cell trafficking in asthma: lipid mediators grease the way. 2004 Nat. Rev. Immunol. pmid:15343370
Fernández-Tome M et al. p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis. 2004 Biochem. Biophys. Res. Commun. pmid:15249196
Kanunfre CC et al. Ciglitizone and 15d PGJ2 induce apoptosis in Jurkat and Raji cells. 2004 Int. Immunopharmacol. pmid:15251113
Berry EB et al. Differential effects of serum constituents on apoptosis induced by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in WISH epithelial cells. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15253890
Morosetti R et al. The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. 2004 Int. J. Oncol. pmid:15254749
Hofnagel O et al. Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15271788
Hsu MF et al. Inhibition of the arachidonic acid cascade by norathyriol via blockade of cyclooxygenase and lipoxygenase activity in neutrophils. 2004 Naunyn Schmiedebergs Arch. Pharmacol. pmid:15083266
Karimi K et al. Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells. 2004 Eur. J. Pharmacol. pmid:15063154
Chana RS et al. Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists. 2004 Kidney Int. pmid:15149321
Garg TK and Chang JY 15-deoxy-delta 12, 14-Prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress. 2004 BMC Pharmacol. pmid:15149553
Park EY et al. Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer. 2004 Cancer Res. pmid:15150131
Akbiyik F et al. Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. 2004 Blood pmid:15130939
Han S et al. Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression. 2004 Chest pmid:15136464
Collin M et al. Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin. 2004 Crit. Care Med. pmid:15090969
Baolin L et al. Resveratrol inhibits the release of mediators from bone marrow-derived mouse mast cells in vitro. 2004 Planta Med. pmid:15095144
Zang C et al. Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. 2004 Leuk. Res. pmid:15109539
Jakob M et al. Chondrogenesis of expanded adult human articular chondrocytes is enhanced by specific prostaglandins. 2004 Rheumatology (Oxford) pmid:15113997
Verrier E et al. PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase. 2004 Circ. Res. pmid:15117825
Leung WK et al. Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. 2004 Gut pmid:14960510
Mouihate A et al. A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain. 2004 J. Neurosci. pmid:14960602
Moore RM et al. Physiological apoptotic agents have different effects upon human amnion epithelial and mesenchymal cells. 2003 Feb-Mar Placenta pmid:12566244
Kanaoka Y and Urade Y Hematopoietic prostaglandin D synthase. 2003 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12895599
Nagata K and Hirai H The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes. 2003 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12895600
Powell WS A novel PGD(2) receptor expressed in eosinophils. 2003 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12895601
Kabashima K and Narumiya S The DP receptor, allergic inflammation and asthma. 2003 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12895602
Yuan ZY et al. [Peroxisome proliferation-activated receptor-gamma ligands ameliorate autoimmune myocarditis associated with inhibition of T cell immunity]. 2003 Zhonghua Yi Xue Za Zhi pmid:14703419
Guyton K et al. Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. 2003 Shock pmid:12813370
Burgermeister E et al. Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. 2003 Oncogene pmid:12813462
Satoh T et al. Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress. 2003 Eur. J. Neurosci. pmid:12814358
Ianaro A et al. Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response. 2003 Mol. Pharmacol. pmid:12815164
Hashimoto K et al. The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. 2003 Pancreas pmid:12826907
Urade Y et al. Sleep regulation in adenosine A2A receptor-deficient mice. 2003 Neurology pmid:14663019
Montuschi P et al. Exhaled leukotrienes and prostaglandins in COPD. 2003 Thorax pmid:12832671
Placha W et al. The effect of PPARgamma ligands on the proliferation and apoptosis of human melanoma cells. 2003 Melanoma Res. pmid:14512786
Taba Y et al. 15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12623786
Fukuchi K et al. Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone. 2003 J. Dent. Res. pmid:14514760
Józkowicz A et al. Prostaglandin-J(2) upregulates expression of matrix metalloproteinase-1 independently of activation of peroxisome proliferator-activated receptor-gamma. 2003 Acta Biochim. Pol. pmid:14515149
Imaizumi T et al. 15-Deoxy-delta 12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide. 2003 Prostaglandins Other Lipid Mediat. pmid:14518569
Yoshimura R et al. The effect of peroxisome proliferator-activated receptor-gamma ligand on urological cancer cells. 2003 Int. J. Mol. Med. pmid:14612958
Okano H et al. The PPARgamma ligand, 15-Deoxy-Delta12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells. 2003 Int. J. Mol. Med. pmid:14612959
Garg TK and Chang JY Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. 2003 BMC Ophthalmol pmid:12659653
Komar CM and Curry TE Inverse relationship between the expression of messenger ribonucleic acid for peroxisome proliferator-activated receptor gamma and P450 side chain cleavage in the rat ovary. 2003 Biol. Reprod. pmid:12700202
Worley JR et al. Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. 2003 J. Biol. Chem. pmid:14534304
Bochenek G et al. A controlled study of 9alpha,11beta-PGF2 (a prostaglandin D2 metabolite) in plasma and urine of patients with bronchial asthma and healthy controls after aspirin challenge. 2003 J. Allergy Clin. Immunol. pmid:12704352
Bernardo A et al. 15-deoxy-delta12,14-prostaglandin J2 regulates the functional state and the survival of microglial cells through multiple molecular mechanisms. 2003 J. Neurochem. pmid:14535956
Castaño E and Gil J 15-deoxy-delta12,14 prostaglandin J2 synergizes with phorbol ester to induce proliferation in Swiss 3T3 cells independently of peroxisome proliferator-activated receptor gamma and PGD2 receptors. 2003 J. Cell. Physiol. pmid:12704651
Ianaro A et al. 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB. 2003 FEBS Lett. pmid:14550540
Ando M et al. Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12707014
Imaizumi T et al. Effect of 15-deoxy-delta12,14-prostaglandin J2 on IL-1beta-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:14580366
Söderström M et al. Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures. 2003 Biochim. Biophys. Acta pmid:12573447
Gibbons H et al. Hypothermia suppresses inducible nitric oxide synthase and stimulates cyclooxygenase-2 in lipopolysaccharide stimulated BV-2 cells. 2003 Brain Res. Mol. Brain Res. pmid:12573534
Patel HJ et al. Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. 2003 J. Immunol. pmid:12594295
Ruan XZ et al. PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. 2003 J. Am. Soc. Nephrol. pmid:12595494
Cuzzocrea S et al. The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. 2003 Br. J. Pharmacol. pmid:12598422
Castrillo A et al. Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages. 2003 Mol. Cell. Biol. pmid:12556480
Weber SM et al. Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12517740
Pang L et al. Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. 2003 J. Immunol. pmid:12517972
Neuschäfer-Rube F et al. Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. 2003 Biochem. J. pmid:12519077
Calnek DS et al. Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12524224
Hashimoto T et al. Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs. 2003 J Ocul Pharmacol Ther pmid:14733714
Zhang X et al. Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin. 2003 BioTechniques pmid:14682047