PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ahlquist DA et al. | Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa. | 1983 | Am. J. Physiol. | pmid:6401937 |
| Homma T and Malik KU | Effect of secretin and caerulein in canine pancreas: relation to prostaglandins. | 1983 | Am. J. Physiol. | pmid:6344655 |
| Feinstein MB et al. | Reversal of thrombin-induced myosin phosphorylation and the assembly of cytoskeletal structures in platelets by the adenylate cyclase stimulants prostaglandin D2 and forskolin. | 1983 | J. Biol. Chem. | pmid:6571835 |
| Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human neuroblastoma cells. | 1983 | Cancer Lett. | pmid:6572553 |
| Kootte AM et al. | The flush syndrome: an expression of systemic mastocytosis with increased prostaglandin D2 production. | 1983 | Neth J Med | pmid:6572798 |
| Abelson MB et al. | Aspirin therapy in vernal conjunctivitis. | 1983 | Am. J. Ophthalmol. | pmid:6573138 |
| Gerritsen ME | PGD2 formation in the vasculature: characteristics of rat tail vein prostaglandin endoperoxide-D isomerase. | 1983 | Prostaglandins | pmid:6573722 |
| Gaetani P et al. | [Prostaglandin D2 in subarachnoid hemorrhage. Biological and diagnostic implications]. | 1983 Jul-Aug | Riv Patol Nerv Ment | pmid:6598516 |
| Brus R et al. | Effect of prostaglandins on morphine-induced catalepsy in mice. | 1983 Sep-Dec | Acta Physiol Pol | pmid:6679984 |
| Bito LZ | Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. | 1984 | Exp. Eye Res. | pmid:6370708 |
| Barrow SE et al. | Measurement of prostaglandin D2 and identification of metabolites in human plasma during intravenous infusion. | 1984 | Prostaglandins | pmid:6441188 |
| Bertelé V et al. | Pharmacologic inhibition of thromboxane synthetase and platelet aggregation: modulatory role of cyclooxygenase products. | 1984 | Blood | pmid:6426554 |
| Peters SP et al. | Arachidonic acid metabolism in purified human lung mast cells. | 1984 | J. Immunol. | pmid:6199420 |
| Gresele P et al. | Serum albumin enhances the impairment of platelet aggregation with thromboxane synthase inhibition by increasing the formation of prostaglandin D2. | 1984 | Biochem. Pharmacol. | pmid:6430299 |
| Vicenzi E et al. | Human mononuclear phagocytes from different anatomical sites differ in their capacity to metabolize arachidonic acid. | 1984 | Clin. Exp. Immunol. | pmid:6432383 |
| Nishi S et al. | Different effects of prostaglandin E1, E2 and D2 on pancreatic somatostatin release. | 1984 | Horm. Metab. Res. | pmid:6152434 |
| Tynan SS et al. | On the multiplicity of platelet prostaglandin receptors. II. The use of N-0164 for distinguishing the loci of action for PGI2, PGD2, PGE2 and hydantoin analogs. | 1984 | Prostaglandins | pmid:6087417 |
| Neely SM et al. | Mechanism and characteristics of platelet activation by haematin. | 1984 | Br. J. Haematol. | pmid:6383458 |
| Uchizono K | [Studies of sleep inducing substance]. | 1984 | Nippon Rinsho | pmid:6384575 |
| Philips JB and Lyrene RK | Prostaglandins, related compounds, and the perinatal pulmonary circulation. | 1984 | Clin Perinatol | pmid:6386270 |
| Goetzl EJ | Asthma: new mediators and old problems. | 1984 | N. Engl. J. Med. | pmid:6330554 |
| Rao PS et al. | Prostaglandin D2 in canine endotoxic shock. Hemodynamic, hematologic, biochemical, and blood gas analyses. | 1984 | Am. J. Obstet. Gynecol. | pmid:6424477 |
| Schick B et al. | Activation of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1984 | J. Immunol. | pmid:6425408 |
| Dembinska-Kieć A et al. | Formation of leukotriene C4-like material by rat brain tissue. | 1984 | Eur. J. Pharmacol. | pmid:6426980 |
| Kawamura M and Koshihara Y | Prostaglandin D2 lowers nuclear DNA polymerase activity in cultured mastocytoma cells. | 1984 | Prostaglandins | pmid:6427850 |
| Vincent JE et al. | The effect of 5-(2-chlorobenzyl)-5,6,7,7a-tetrahydro 4H-thieno (3.2-C)-pyridine-2-one hydrochloride (PCR 3787), a metabolite of ticlopidine, on the aggregation of human platelets in vitro and on the aggregation inhibiting action of PGI2 and PGD2. | 1984 | Prostaglandins Leukot Med | pmid:6396655 |
| Weichman BM et al. | SK&F 88046: a unique pharmacologic antagonist of bronchoconstriction induced by leukotriene D4, thromboxane and prostaglandins F2 alpha and D2 in vitro. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6582266 |
| Higashida H et al. | Facilitation of synaptic transmission by prostaglandin D2 at synapses between NG108-15 hybrid and muscle cells. | 1984 | Brain Res. | pmid:6324947 |
| Bertelé V et al. | SQ 22536, an adenylate-cyclase inhibitor, prevents the antiplatelet effect of dazoxiben, a thromboxane-synthetase inhibitor. | 1984 | Thromb. Haemost. | pmid:6326343 |
| Chapnick BM | Divergent influences of leukotrienes C4, D4, and E4 on mesenteric and renal blood flow. | 1984 | Am. J. Physiol. | pmid:6326595 |
| Gardiner PJ and Browne JL | Tussive activity of inhaled PGD2 in the cat and characterisation of the receptor(s) involved. | 1984 | Prostaglandins Leukot Med | pmid:6328541 |
| Zavoico GB and Feinstein MB | Cytoplasmic Ca2+ in platelets is controlled by cyclic AMP: antagonism between stimulators and inhibitors of adenylate cyclase. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329175 |
| Imanishi J et al. | [Inhibition of the multiplication of human herpes virus I by prostaglandin D2 and the synergistic effect of human leukocyte interferon]. | 1984 | C. R. Seances Soc. Biol. Fil. | pmid:6100083 |
| Pan IQ et al. | Alteration of platelet responses to metabolites of arachidonic acid by oral contraceptives. | 1984 | Br. J. Haematol. | pmid:6089860 |
| Nilsson J and Olsson AG | Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor. | 1984 | Atherosclerosis | pmid:6093830 |
| Mitsuma T and Nogimori T | Effects of substance P, angiotensin II, oxotremorine and prostaglandin D2 on thyrotropin secretion in rats. | 1984 | Horm. Res. | pmid:6201427 |
| Ennis M et al. | Prostaglandin and histamine release from stimulated rat peritoneal mast cells. | 1984 | Agents Actions | pmid:6203356 |
| Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
| Ikai K et al. | Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice. | 1984 | Prostaglandins | pmid:6435183 |
| Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
| Erman A and Nasjletti A | Enhancement of renal medulla prostaglandin synthetase activity by dexamethasone treatment in the rat. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428405 |
| Holgate ST et al. | Anaphylactic- and calcium-dependent generation of prostaglandin D2 (PGD2), thromboxane B2, and other cyclooxygenase products of arachidonic acid by dispersed human lung cells and relationship to histamine release. | 1984 | J. Immunol. | pmid:6206153 |
| Schleimer RP et al. | Inflammatory mediators and mechanisms of release from purified human basophils and mast cells. | 1984 | J. Allergy Clin. Immunol. | pmid:6208229 |
| Inoué S et al. | Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6592612 |
| Inoué S et al. | Little sleep-promoting effect of three sleep substances diurnally infused in unrestrained rats. | 1984 | Neurosci. Lett. | pmid:6593603 |
| Peters SP et al. | Effect of prostaglandin D2 in modulating histamine release from human basophils. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6198512 |
| Marsden KA et al. | The effect of prostaglandin D2 (PGD2) on circulating eosinophils. | 1984 | Prostaglandins Leukot Med | pmid:6593748 |
| Uemura S et al. | Inotropic effects of prostaglandin D2 and E1 on the newborn rabbit heart. | 1984 | Pediatr. Res. | pmid:6596550 |
| Heavey DJ et al. | Effects of intravenous infusions of prostaglandin D2 in man. | 1984 | Prostaglandins | pmid:6596653 |
| Mahmud I et al. | On the identification and biological properties of prostaglandin J2. | 1984 | Prostaglandins Leukot Med | pmid:6597446 |
| Arisawa M et al. | Direct suppressive effect of prostaglandin D2 on growth hormone secretion from rat anterior pituitary. | 1984 | Asia Oceania J Obstet Gynaecol | pmid:6598030 |
| Newman JH and Sheller JR | Arachidonic acid metabolites in the healthy and diseased lung. | 1984 | Am. J. Med. Sci. | pmid:6091454 |
| Ogorochi T et al. | Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain. | 1984 | J. Neurochem. | pmid:6427411 |
| Abramovich DR et al. | The effect of prostaglandin D2 on the blood vessels of the perfused isolated cotyledon of the human placenta. | 1984 | Br. J. Pharmacol. | pmid:6584189 |
| Kikawa Y et al. | 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6584883 |
| Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human malignant tumor cells. | 1984 | Prostaglandins | pmid:6584941 |
| Imashuku S et al. | [Differentiation induction and potentiation of chemotherapy by PGE1 infusion in patients with neuroblastoma--effect of PGE1 on metastatic potential of neuroblastoma]. | 1984 | Gan To Kagaku Ryoho | pmid:6585182 |
| Nakajima M and Toda N | Neuroeffector actions of prostaglandin D2 on isolated dog mesenteric arteries. | 1984 | Prostaglandins | pmid:6587438 |
| Andersen NH and Hartzell CJ | High-field 1H NMR studies of prostaglandin H2 and its decomposition pathways. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6587849 |
| Gal D et al. | Effect of radiation on prostaglandin production by human bowel in vitro. | 1984 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:6588048 |
| Shimatsu A et al. | Prostaglandin D2 stimulates vasoactive intestinal polypeptide release into rat hypophysial portal blood. | 1984 Mar-Apr | Peptides | pmid:6591147 |
| Hall TJ et al. | Decreased natural killer cell activity in atopic eczema. | 1985 | Immunology | pmid:3876984 |
| Watanabe K et al. | Biosynthesis of prostaglandin F2 alpha from prostaglandins H2 and D2 by an apparently homogeneous enzyme. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936081 |
| Liston TE et al. | Prostaglandin D2 is metabolized in humans to 9 alpha,11 beta-prostaglandin F2, a novel biologically active prostaglandin. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936123 |
| Kimura H et al. | Modulatory effects of prostaglandin D2, E2 and F2 alpha on the postsynaptic actions of inhibitory and excitatory amino acids in cerebellar Purkinje cell dendrites in vitro. | 1985 | Brain Res. | pmid:2859088 |
| Toda N et al. | Neuroeffector actions of prostaglandins on isolated arteries. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936153 |
| Ueno R et al. | Prostaglandin D2: a cerebral sleep-regulating substance in rats. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936173 |
| Schick B and Austen KF | Pharmacological modulation of activation-secretion of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1985 | Immunology | pmid:3935569 |
| Fitscha P et al. | Platelet sensitivity to antiaggregatory prostaglandins (PGE1,D2,I2) in patients with peripheral vascular disease. | 1985 | Am. J. Hematol. | pmid:3885723 |
| Wong P et al. | Diminished sensitivity of platelet aggregation to prostaglandin D2 in patients with myeloproliferative disorders and in patients with acute leukemia. | 1985 | Nippon Ketsueki Gakkai Zasshi | pmid:3890456 |
| Cutler LS et al. | Cytochemical localization of adenylate cyclase in the dense tubule system of human blood platelets stimulated by forskolin, prostacyclin and prostaglandin D2. | 1985 | Biochim. Biophys. Acta | pmid:3890960 |
| Siegl PK and Wenger HC | Cardiovascular responses to an isosterically modified prostaglandin analog in the anesthetized dog. | 1985 | Eur. J. Pharmacol. | pmid:3899681 |
| Regulatory control and standardization of allergenic extracts. Clinical studies with "standardized" extracts. | 1985 | Arb Paul Ehrlich Inst Georg Speyer Haus Ferdinand Blum Inst Frankf A M | pmid:3901924 | |
| Kiyomiya K and Oh-ishi S | Involvement of arachidonic acid metabolites in acute inflammation: detection of 6-keto-PGF1 alpha, thromboxane B2 and PGD2 in rat pleurisy induced by phorbol myristate acetate. | 1985 | Jpn. J. Pharmacol. | pmid:3936958 |
| Majewska MD and Chuang DM | Benzodiazepines enhance the muscimol-dependent activation of phospholipase A2 in glioma C6 cells. | 1985 | J. Pharmacol. Exp. Ther. | pmid:2857784 |
| Schulman ES and Anderson CL | Lung hypersensitivity responses: dissociation of human lung mast cell leukotriene C4 (LTC4) from histamine release. | 1985 | Prog. Clin. Biol. Res. | pmid:2415994 |
| Creticos PS et al. | Nasal challenge with ragweed pollen in hay fever patients. Effect of immunotherapy. | 1985 | J. Clin. Invest. | pmid:2416777 |
| Holgate ST et al. | The release and role of inflammatory mediators in asthma. | 1985 | Clin Immunol Rev | pmid:2417772 |
| Beatty CH et al. | Metabolism of arachidonic acid by macaque platelets. Implications for studies on atherosclerosis. | 1985 | Atherosclerosis | pmid:3924062 |
| Baud L et al. | Lipoxygenase products mediate the attachment of rat macrophages to glomeruli in vitro. | 1985 | Kidney Int. | pmid:3927056 |
| Westcott JY and Murphy RC | Effect of alcohols on arachidonic acid metabolism in murine mastocytoma cells and human polymorphonuclear leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:2982416 |
| Bhattacharya SK et al. | Prostaglandin D2 mediated specific increase in rat brain serotonin. | 1985 | Proc. West. Pharmacol. Soc. | pmid:3865228 |
| Walenga RW et al. | Re-examination of the assay for plasma prostanoids by solid-phase extraction, and radioimmunoassay. | 1985 | Prostaglandins Leukot Med | pmid:3865240 |
| Okuyama S et al. | Redifferentiation of cancer cells: bestatin, estradiol, and prostaglandin D2. | 1985 | Ann. N. Y. Acad. Sci. | pmid:3868328 |
| Okuyama S and Mishina H | Principia of cancer therapy. X. Prostaglandin D2 triggers redifferentiation of the bestatin-treated breast cancer cells in vitro. | 1985 | Sci Rep Res Inst Tohoku Univ Med | pmid:3870142 |
| Arisawa M et al. | Suppressive effect of prostaglandin D2 on prolactin secretion from rat anterior pituitary. | 1985 | Asia Oceania J Obstet Gynaecol | pmid:3860198 |
| Spannhake EW et al. | Influence of mediators of anaphylaxis on collateral ventilation and the lung periphery of the dog. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3860642 |
| Liston TE and Roberts LJ | Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3862115 |
| Tanaka H et al. | The effects of PGD2 and 9-deoxy-delta 9-PGD2 on colony formation of murine osteosarcoma cells. | 1985 | Prostaglandins | pmid:3863195 |
| Liston TE and Roberts LJ | Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. | 1985 | J. Biol. Chem. | pmid:3863815 |
| Roberts LJ and Sweetman BJ | Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. | 1985 | Prostaglandins | pmid:3864190 |
| Nielsen JA and Sparber SB | Central administration of prostaglandin E2 facilitates while F2 alpha attenuates acute dependence upon morphine rats. | 1985 | Pharmacol. Biochem. Behav. | pmid:3860881 |
| Rajtar G et al. | Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors. | 1985 | Biochem. Pharmacol. | pmid:3918536 |
| Mendieta CF et al. | Biosynthesis of prostaglandins in gingiva of patients with chronic periodontitis. | 1985 | J. Periodontol. | pmid:3919173 |
| Robinson C and Holgate ST | Mast cell-dependent inflammatory mediators and their putative role in bronchial asthma. | 1985 | Clin. Sci. | pmid:2981650 |
| Pugliese G et al. | Hepatic transformation of prostaglandin D2 to a new prostanoid, 9 alpha,11 beta-prostaglandin F2, that inhibits platelet aggregation and constricts blood vessels. | 1985 | J. Biol. Chem. | pmid:3863819 |
| Bhattacharya SK and Parmar SS | Prostaglandin D2-induced potentiation of hexobarbitone hypnosis in rats: role of 5-hydroxytryptamine. | 1985 | J. Pharm. Pharmacol. | pmid:2868104 |
| Whittle BJ et al. | Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:2871707 |
| Gay SW and Kosher RA | Prostaglandin synthesis during the course of limb cartilage differentiation in vitro. | 1985 | J Embryol Exp Morphol | pmid:3867724 |
| Hollingsworth EB and Patrick GA | Involvement of the serotonergic system in the prolongation of pentobarbital sleeping time produced by prostaglandin D2. | 1985 | Pharmacol. Biochem. Behav. | pmid:2859604 |