Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yoshitake R et al. | Molecular investigation of the direct anti-tumour effects of nonsteroidal anti-inflammatory drugs in a panel of canine cancer cell lines. | 2017 | Vet. J. | pmid:28283079 |
Kutyrev IA et al. | Prostaglandins E2 and D2-regulators of host immunity in the model parasite Diphyllobothrium dendriticum: An immunocytochemical and biochemical study. | 2017 | Mol. Biochem. Parasitol. | pmid:28137629 |
Giménez-Bastida JA et al. | Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes. | 2017 | FASEB J. | pmid:28096231 |
El-Shazly AE et al. | Tyrosine kinase inhibition is an important factor for gene expression of CRTH2 in human eosinophils and lymphocytes: A novel mechanism for explaining eosinophils recruitment by the neuro-immune axis in allergic rhinitis. | 2017 | Int. Immunopharmacol. | pmid:28222358 |
Salimi M et al. | Cysteinyl leukotriene E4 activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D2 and epithelial cytokines. | 2017 | J. Allergy Clin. Immunol. | pmid:28115217 |
Yuan J et al. | M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPARγ signaling pathway. | 2017 | Oncotarget | pmid:28423639 |
Nagata N et al. | Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2. | 2017 | PLoS ONE | pmid:28394950 |
Tang Q et al. | Effect of 15-Deoxy-Δ12,14-prostaglandin J2Nanocapsules on Inflammation and Bone Regeneration in a Rat Bone Defect Model. | 2017 | Chin. Med. J. | pmid:28139520 |
Guan NN et al. | Prostaglandin D2 effects and DP1 /DP2 receptor distribution in guinea pig urinary bladder out-flow region. | 2017 | J. Cell. Mol. Med. | pmid:27664012 |
Muhammad SN et al. | 15d-PGJ2 Induces Apoptosis of MCF-7 and MDA-MB-231 Cells via Increased Intracellular Calcium and Activation of Caspases, Independent of ERα and ERβ. | 2016 | Asian Pac. J. Cancer Prev. | pmid:27509924 |
Murata T and Maehara T | Discovery of anti-inflammatory role of prostaglandin D2. | 2016 | J. Vet. Med. Sci. | pmid:27498997 |
Tsujimoto S et al. | Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ. | 2016 | Int. J. Mol. Med. | pmid:27431935 |
Feng X et al. | Eosinophil production of prostaglandin D2 in patients with aspirin-exacerbated respiratory disease. | 2016 | J. Allergy Clin. Immunol. | pmid:27423494 |
Abbasi S et al. | Elimination of the biphasic pharmacodynamics of 15d-PGJ2 by controlling its release from a nanoemulsion. | 2016 | Int J Nanomedicine | pmid:27354798 |
Phillips JE et al. | Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma. | 2016 | J Aerosol Med Pulm Drug Deliv | pmid:27111445 |
Kanai K et al. | Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts. | 2016 | Allergol Int | pmid:27091669 |
Ma J et al. | Effect of the PGD2-DP signaling pathway on primary cultured rat hippocampal neuron injury caused by aluminum overload. | 2016 | Sci Rep | pmid:27089935 |
Zhou Q et al. | Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26488390 |
Doig CL et al. | Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:26429394 |
Martinez-Cengotitabengoa M et al. | BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. | 2016 | Schizophr Bull | pmid:26130821 |