PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang S et al. | Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23471341 |
| Welter H et al. | Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients. | 2013 | Andrology | pmid:23413143 |
| Moreira V et al. | A catalytically-inactive snake venom Lys49 phospholipase Aâ‚‚ homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages. | 2013 | Eur. J. Pharmacol. | pmid:23416211 |
| Heilmann S et al. | No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia. | 2013 | Br. J. Dermatol. | pmid:23448296 |
| Kanda H et al. | COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons. | 2013 | Glia | pmid:23505121 |
| Brose SA et al. | A fast one-step extraction and UPLC-MS/MS analysis for E2/D 2 series prostaglandins and isoprostanes. | 2013 | Lipids | pmid:23400687 |
| Li H and Narahara H | 15-Deoxy-Δ(12,14)-prostaglandin J(2) induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines. | 2013 | Int. J. Mol. Med. | pmid:23403520 |
| Murata T et al. | Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23479612 |
| Jabr S et al. | Quantification of major urinary metabolites of PGE2 and PGD2 in cystic fibrosis: correlation with disease severity. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23791427 |
| Rahman MS et al. | Cultured preadipocytes undergoing stable transfection with cyclooxygenase-1 in the antisense direction accelerate adipogenesis during the maturation phase of adipocytes. | 2013 | Appl. Biochem. Biotechnol. | pmid:23817787 |
| Aldrovandi M et al. | Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. | 2013 | J. Lipid Res. | pmid:23883581 |
| Fujishima H et al. | Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. | 2013 | Ann. Allergy Asthma Immunol. | pmid:23886231 |
| Lu Y et al. | 15-Deoxy-Δ(12,14)-prostaglandin J(2) modulates lipopolysaccharide-induced chemokine expression by blocking nuclear factor-κB activation via peroxisome proliferator activated receptor-γ-independent mechanism in renal tubular epithelial cells. | 2013 | Nephron Exp. Nephrol. | pmid:23887394 |
| Takayama F et al. | Possible involvement of aiPLA2 in the phosphatidylserine-containing liposomes induced production of PGE2 and PGD2 in microglia. | 2013 | J. Neuroimmunol. | pmid:23850486 |
| Nakagawa T et al. | A prostaglandin D2 metabolite is elevated in the urine of Duchenne muscular dystrophy patients and increases further from 8 years old. | 2013 | Clin. Chim. Acta | pmid:23603101 |
| Dave M and Amin AR | Yin-Yang regulation of prostaglandins and nitric oxide by PGD2 in human arthritis: reversal by celecoxib. | 2013 | Immunol. Lett. | pmid:23603366 |
| Nakamura M et al. | Tumor apoptosis in prostate cancer by PGD(2) and its metabolite 15d-PGJ(2) in murine model. | 2013 | Biomed. Pharmacother. | pmid:23206752 |
| Lewis A et al. | Heterogeneity in the responses of human lung mast cells to stem cell factor. | 2013 | Clin. Exp. Allergy | pmid:23278880 |
| Nozaki Y et al. | PPARγ ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis. | 2013 | Med Mol Morphol | pmid:23397546 |
| Carlson LM et al. | Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma. | 2013 | Carcinogenesis | pmid:23349014 |
| Doyle MC et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 inhibits IL-13 production in T cells via an NF-κB-dependent mechanism. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23333326 |
| Kobayashi K et al. | Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23307871 |
| Xu F et al. | Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury. | 2013 | PLoS ONE | pmid:23372817 |
| Sykes L et al. | The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour. | 2013 | Immunology | pmid:23374103 |
| Nelson AM et al. | Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. | 2013 | J. Invest. Dermatol. | pmid:23190891 |
| Kaikkonen S et al. | Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells. | 2013 | Mol. Endocrinol. | pmid:23192983 |
| Schmidt JA et al. | Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma. | 2013 | Br. J. Pharmacol. | pmid:23146091 |
| Aukema HM et al. | Dietary fish oil reduces glomerular injury and elevated renal hydroxyeicosatetraenoic acid levels in the JCR:LA-cp rat, a model of the metabolic syndrome. | 2013 | Br. J. Nutr. | pmid:23151363 |
| Frieri M et al. | Mast cell activation syndrome: a review. | 2013 | Curr Allergy Asthma Rep | pmid:23179866 |
| Shashni B et al. | Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPARγ in breast cancer pathophysiology. | 2013 | J Drug Target | pmid:23130662 |
| Moghaddami M et al. | Prostaglandin D(2) in inflammatory arthritis and its relation with synovial fluid dendritic cells. | 2013 | Mediators Inflamm. | pmid:23737645 |
| Labrecque P et al. | Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. | 2013 | PLoS ONE | pmid:23762421 |
| Lu Y et al. | Manassantin B isolated from Saururus chinensis inhibits cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Fyn-mediated nuclear factor-kappaB and mitogen activated protein kinase pathways in bone marrow derived-mast cells. | 2013 | Biol. Pharm. Bull. | pmid:23719635 |
| Yoo JM et al. | Inhibitory effect of N-Acyl dopamines on IgE-mediated allergic response in RBL-2H3 cells. | 2013 | Lipids | pmid:23377981 |
| Buckner MM et al. | 15-Deoxy-Δ12,14-prostaglandin J2 inhibits macrophage colonization by Salmonella enterica serovar Typhimurium. | 2013 | PLoS ONE | pmid:23922794 |
| Huisingh C and McGwin G | Change in prostaglandin expression levels and synthesizing activities. | 2013 | Ophthalmology | pmid:24001535 |
| Rim TH et al. | Author reply: To PMID 22858125. | 2013 | Ophthalmology | pmid:24001536 |
| Kaur R et al. | A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds. | 2013 | J Biomol Screen | pmid:23983232 |
| Liu H et al. | Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites. | 2013 | Neurotoxicology | pmid:23973622 |
| Bogacka I et al. | The involvement of peroxisome proliferator activated receptors (PPARs) in prostaglandin F2α production by porcine endometrium. | 2013 | Reprod Biol | pmid:24287039 |
| Mruwat R et al. | Phospholipase A2 in experimental allergic bronchitis: a lesson from mouse and rat models. | 2013 | PLoS ONE | pmid:24204651 |
| Fajt ML et al. | Prostaglandin Dâ‚‚ pathway upregulation: relation to asthma severity, control, and TH2 inflammation. | 2013 | J. Allergy Clin. Immunol. | pmid:23506843 |
| Cruse G et al. | A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells. | 2013 | Immunity | pmid:23643722 |
| Brose SA and Golovko MY | Eicosanoid post-mortem induction in kidney tissue is prevented by microwave irradiation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24113545 |
| Sayers BC et al. | Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23642096 |
| Tan BS et al. | 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). | 2013 | Cancer Lett. | pmid:23612072 |
| Yaacob NS et al. | Influence of 17β-estradiol on 15-deoxy-δ12,14 prostaglandin J2 -induced apoptosis in MCF-7 and MDA-MB-231 cells. | 2013 | Asian Pac. J. Cancer Prev. | pmid:24377602 |
| Chi Y et al. | [Effect of 15-deoxy-Δ(12), 14-prostaglandin J2 on the cytokines in the culture supernatant of bone marrow mesenchymal stem cells]. | 2013 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24370048 |
| Ramer R et al. | Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. | 2013 | J. Lipid Res. | pmid:23943857 |
| Penas F et al. | PPARγ ligand treatment inhibits cardiac inflammatory mediators induced by infection with different lethality strains of Trypanosoma cruzi. | 2013 | Biochim. Biophys. Acta | pmid:22917565 |