PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Osteoarthritis, Knee D020370 13 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Thrombophilia D019851 6 associated lipids
Endotoxemia D019446 27 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Optic Neuropathy, Ischemic D018917 2 associated lipids
Cystitis, Interstitial D018856 2 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Vasculitis, Leukocytoclastic, Cutaneous D018366 5 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Coronavirus Infections D018352 4 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Helicobacter Infections D016481 21 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Wang P et al. The antagonistic actions of endogenous interleukin-1β and 15-deoxy-Δ12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. 2012 J. Biol. Chem. pmid:22829602
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Yamaura K et al. Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D2 production of mast cells in a murine model of allergic contact dermatitis. 2012 J Toxicol Sci pmid:23208428
Alba G et al. Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils. 2012 PLoS ONE pmid:23115616
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Kaneko K et al. Novel orexigenic pathway prostaglandin D2-NPY system--involvement in orally active orexigenic δ opioid peptide. 2012 Neuropeptides pmid:23141054
Springstead JR et al. Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function. 2012 J. Lipid Res. pmid:22550136
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Wu CC et al. Involvement of the prostaglandin D2 signal pathway in retinoid-inducible gene 1 (RIG1)-mediated suppression of cell invasion in testis cancer cells. 2012 Biochim. Biophys. Acta pmid:22960220
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Shim J et al. Change in prostaglandin expression levels and synthesizing activities in dry eye disease. 2012 Ophthalmology pmid:22858125
Chae HS et al. Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells. 2012 Immunopharmacol Immunotoxicol pmid:22229445
Nakahigashi K et al. PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis. 2012 J. Allergy Clin. Immunol. pmid:22206772
Lu Y et al. Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells. 2012 Food Chem. Toxicol. pmid:22154852
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Mantel A et al. Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. 2012 J. Invest. Dermatol. pmid:22170488
Farnesi-de-Assunção TS et al. PPAR-γ agonists, mainly 15d-PGJ(2), reduce eosinophil recruitment following allergen challenge. 2012 Cell. Immunol. pmid:22192475
Ji Y et al. Activation of rat intestinal mucosal mast cells by fat absorption. 2012 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:22461027
Kim SE et al. 15-deoxy-Δ¹²,¹⁴ -prostaglandin J₂ inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-activated receptor-γ and heme oxygenase-1 in rat hippocampal slices. 2012 J. Neurosci. Res. pmid:22487967
Garza LA et al. Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. 2012 Sci Transl Med pmid:22440736
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Cao DS et al. Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. 2012 PLoS ONE pmid:22701540
Yue L et al. Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway. 2012 Bone pmid:22705147
Napimoga MH et al. Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. 2012 J. Immunol. pmid:22706081
Qiu H et al. Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia. 2012 Cardiovasc. Res. pmid:22707158
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Fujimori K et al. Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways. 2012 Gene pmid:22664386
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Cha B et al. 15-deoxy-D12,14-prostaglandin J2 suppresses RANTES expression by inhibiting NADPH oxidase activation in Helicobacter pylori-infected gastric epithelial cells. 2011 J. Physiol. Pharmacol. pmid:21673364
Wang P et al. Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2. 2011 PLoS ONE pmid:22096605
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Kitz K et al. 15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. 2011 Free Radic. Biol. Med. pmid:21236332
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Eguchi M et al. Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor (DP)-dependent pathway. 2011 Clin. Exp. Immunol. pmid:21166666
Cichocka-Jarosz E et al. Serum tryptase level is a better predictor of systemic side effects than prostaglandin D2 metabolites during venom immunotherapy in children. 2011 J Investig Allergol Clin Immunol pmid:21721371
Wang JJ and Mak OT Induction of apoptosis in non-small cell lung carcinoma A549 cells by PGDâ‚‚ metabolite, 15d-PGJâ‚‚. 2011 Cell Biol. Int. pmid:21999315
Seno T et al. 15-Deoxy-Δ¹²,¹⁴ prostaglandin J₂ reduces the formation of atherosclerotic lesions in apolipoprotein E knockout mice. 2011 PLoS ONE pmid:22003398
Matsushima Y et al. Distinct roles of prostaglandin D2 receptors in chronic skin inflammation. 2011 Mol. Immunol. pmid:21943706
Shinozawa T et al. Tetranor PGDM analyses for the amyotrophic lateral sclerosis: positive and simple diagnosis and evaluation of drug effect. 2011 Biochem. Biophys. Res. Commun. pmid:22027143
Chang MC et al. Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. 2011 Atherosclerosis pmid:21993412
de Jong E et al. Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. 2011 PLoS ONE pmid:21957481
Jin M et al. Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ production in mouse bone marrow-derived mast cells. 2011 Arch. Pharm. Res. pmid:21975811
Urade Y and Hayaishi O Prostaglandin D2 and sleep/wake regulation. 2011 Sleep Med Rev pmid:22024172
Birbian N et al. No association of PTGDR -441C/T polymorphism with asthma in a North Indian population. 2011 Dis. Markers pmid:22182808
Wan CJ et al. [PPARgamma agonists against respiratory syncytial virus infection in vitro study]. 2011 Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi pmid:22734242