Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sawada H et al. | Regulation of type V phospholipase A2 expression and function by proinflammatory stimuli. | 1999 | Eur. J. Biochem. | pmid:10469147 |
Keelan JA et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10471366 |
Jackson SM et al. | Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10479650 |
Furutani K et al. | Substance P- and antigen-induced release of leukotriene B4, prostaglandin D2 and histamine from guinea pig skin by different mechanisms in vitro. | 1999 Jul-Aug | Arch. Dermatol. Res. | pmid:10482019 |
Pucci ML et al. | Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. | 1999 | Am. J. Physiol. | pmid:10484490 |
Santos J et al. | Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy. | 1999 | Gut | pmid:10486364 |
Alvarez-Dolado M et al. | Retinoic acid and 1,25-dihydroxyvitamin D3 inhibit tenascin-C expression in rat glioma C6 cells. | 1999 | J. Neurosci. Res. | pmid:10502285 |
Anderson LE et al. | Prostaglandin moieties that determine receptor binding specificity in the bovine corpus luteum. | 1999 | J. Reprod. Fertil. | pmid:10505064 |
Clay CE et al. | Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells. | 1999 | Carcinogenesis | pmid:10506103 |
Valmaseda A et al. | Opposite regulation of PPAR-alpha and -gamma gene expression by both their ligands and retinoic acid in brown adipocytes. | 1999 | Mol. Cell. Endocrinol. | pmid:10509805 |