PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Förstermann U et al. | Studies on the mechanism of central cardiovascular and temperature responses to prostaglandin D2. | 1985 | Prostaglandins Leukot Med | pmid:2991946 |
| Hamid S and Whittle BJ | Interaction of prostaglandin D2 with prostacyclin, carbacyclin and the hydantoin prostaglandin, BW245C, in guinea-pig platelets. | 1985 | Br. J. Pharmacol. | pmid:2992652 |
| Narumiya S and Toda N | Different responsiveness of prostaglandin D2-sensitive systems to prostaglandin D2 and its analogues. | 1985 | Br. J. Pharmacol. | pmid:2992661 |
| Bertelé V et al. | Refractoriness of platelets to prostaglandins after infusion in rabbits. | 1985 | J. Lab. Clin. Med. | pmid:2997353 |
| Thompson NT and Scrutton MC | Intracellular calcium fluxes in human platelets. | 1985 | Eur. J. Biochem. | pmid:3918866 |
| Urade Y et al. | Purification and characterization of rat brain prostaglandin D synthetase. | 1985 | J. Biol. Chem. | pmid:3930495 |
| Schick B and Austen KF | Pharmacological modulation of activation-secretion of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1985 | Immunology | pmid:3935569 |
| Fitscha P et al. | Platelet sensitivity to antiaggregatory prostaglandins (PGE1,D2,I2) in patients with peripheral vascular disease. | 1985 | Am. J. Hematol. | pmid:3885723 |
| Schleimer RP et al. | Role of human basophils and mast cells in the pathogenesis of allergic diseases. | 1985 | J. Allergy Clin. Immunol. | pmid:2410478 |
| Lad PM et al. | Receptor-specific threshold effects of cyclic AMP are involved in the regulation of enzyme release and superoxide production from human neutrophils. | 1985 | Biochim. Biophys. Acta | pmid:2411298 |
| Finney MJ et al. | Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. | 1985 | Br. J. Pharmacol. | pmid:2411319 |
| Fowler JC et al. | Prostaglandins block a Ca2+-dependent slow spike afterhyperpolarization independent of effects on Ca2+ influx in visceral afferent neurons. | 1985 | Brain Res. | pmid:2412652 |
| Levi-Schaffer F et al. | Fibroblasts maintain the phenotype and viability of the rat heparin-containing mast cell in vitro. | 1985 | J. Immunol. | pmid:2413121 |
| Forman MB et al. | Increased adventitial mast cells in a patient with coronary spasm. | 1985 | N. Engl. J. Med. | pmid:2413358 |
| Robin JL et al. | Regulation of mediator release from mouse bone marrow-derived mast cells by glucocorticoids. | 1985 | J. Immunol. | pmid:3161947 |
| Hollingsworth EB and Patrick GA | The effects produced by prostaglandin D2 on serotonin turnover and release and tryptophan uptake. | 1985 | Pharmacol. Biochem. Behav. | pmid:2581275 |
| Fox CC et al. | Isolation and characterization of human intestinal mucosal mast cells. | 1985 | J. Immunol. | pmid:2582045 |
| Naclerio RM et al. | Inflammatory mediators in late antigen-induced rhinitis. | 1985 | N. Engl. J. Med. | pmid:2582257 |
| Abbate R et al. | Decreased number of PGD2 binding sites on platelets from patients with type IIa hyperlipoproteinemia. | 1985 | Atherosclerosis | pmid:3857047 |
| Watanabe K et al. | Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung. | 1985 | J. Biol. Chem. | pmid:3858278 |
| Gause GE et al. | Hemodynamic effects of postpulmonary administration of prostaglandin D2 in fetal animals. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:3858885 |
| Seregi A et al. | The formation and regional distribution of prostaglandins D2 and F2 alpha in the brain of spontaneously convulsing gerbils. | 1985 | Brain Res. | pmid:3859353 |
| Ikai K et al. | Effect of ultraviolet irradiation on mast cell-deficient W/Wv mice. | 1985 | J. Invest. Dermatol. | pmid:3859552 |
| Arisawa M et al. | Suppressive effect of prostaglandin D2 on prolactin secretion from rat anterior pituitary. | 1985 | Asia Oceania J Obstet Gynaecol | pmid:3860198 |
| Spannhake EW et al. | Influence of mediators of anaphylaxis on collateral ventilation and the lung periphery of the dog. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3860642 |
| Ichikawa A et al. | Up-regulation of prostaglandin D2 receptors by agonist binding to beta-adrenoceptors in rabbit platelets. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004152 |
| Bhattacharya SK and Parmar SS | Prostaglandin D2-induced potentiation of hexobarbitone hypnosis in rats: role of 5-hydroxytryptamine. | 1985 | J. Pharm. Pharmacol. | pmid:2868104 |
| Shimatsu A et al. | Prostaglandin D2 stimulates vasoactive intestinal polypeptide release into rat hypophysial portal blood. | 1984 Mar-Apr | Peptides | pmid:6591147 |
| Neely SM et al. | Mechanism and characteristics of platelet activation by haematin. | 1984 | Br. J. Haematol. | pmid:6383458 |
| Uchizono K | [Studies of sleep inducing substance]. | 1984 | Nippon Rinsho | pmid:6384575 |
| Philips JB and Lyrene RK | Prostaglandins, related compounds, and the perinatal pulmonary circulation. | 1984 | Clin Perinatol | pmid:6386270 |
| Goetzl EJ | Asthma: new mediators and old problems. | 1984 | N. Engl. J. Med. | pmid:6330554 |
| Rao PS et al. | Prostaglandin D2 in canine endotoxic shock. Hemodynamic, hematologic, biochemical, and blood gas analyses. | 1984 | Am. J. Obstet. Gynecol. | pmid:6424477 |
| Schick B et al. | Activation of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1984 | J. Immunol. | pmid:6425408 |
| Imanishi J et al. | [Inhibition of the multiplication of human herpes virus I by prostaglandin D2 and the synergistic effect of human leukocyte interferon]. | 1984 | C. R. Seances Soc. Biol. Fil. | pmid:6100083 |
| Mitsuma T and Nogimori T | Effects of substance P, angiotensin II, oxotremorine and prostaglandin D2 on thyrotropin secretion in rats. | 1984 | Horm. Res. | pmid:6201427 |
| Ennis M et al. | Prostaglandin and histamine release from stimulated rat peritoneal mast cells. | 1984 | Agents Actions | pmid:6203356 |
| Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
| Ikai K et al. | Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice. | 1984 | Prostaglandins | pmid:6435183 |
| Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
| Erman A and Nasjletti A | Enhancement of renal medulla prostaglandin synthetase activity by dexamethasone treatment in the rat. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428405 |
| Holgate ST et al. | Anaphylactic- and calcium-dependent generation of prostaglandin D2 (PGD2), thromboxane B2, and other cyclooxygenase products of arachidonic acid by dispersed human lung cells and relationship to histamine release. | 1984 | J. Immunol. | pmid:6206153 |
| Schleimer RP et al. | Inflammatory mediators and mechanisms of release from purified human basophils and mast cells. | 1984 | J. Allergy Clin. Immunol. | pmid:6208229 |
| Inoué S et al. | Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6592612 |
| Inoué S et al. | Little sleep-promoting effect of three sleep substances diurnally infused in unrestrained rats. | 1984 | Neurosci. Lett. | pmid:6593603 |
| Marsden KA et al. | The effect of prostaglandin D2 (PGD2) on circulating eosinophils. | 1984 | Prostaglandins Leukot Med | pmid:6593748 |
| Abramovich DR et al. | The effect of prostaglandin D2 on the blood vessels of the perfused isolated cotyledon of the human placenta. | 1984 | Br. J. Pharmacol. | pmid:6584189 |
| Kikawa Y et al. | 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6584883 |
| Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human malignant tumor cells. | 1984 | Prostaglandins | pmid:6584941 |
| Imashuku S et al. | [Differentiation induction and potentiation of chemotherapy by PGE1 infusion in patients with neuroblastoma--effect of PGE1 on metastatic potential of neuroblastoma]. | 1984 | Gan To Kagaku Ryoho | pmid:6585182 |