Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Arai I et al. | Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. | 2007 | Eur. J. Pharmacol. | pmid:17141215 |
Chambers KT et al. | PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17148750 |
Liu JJ et al. | Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. | 2007 | Ann. Hematol. | pmid:17089125 |
Jin YR et al. | Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. | 2007 | Atherosclerosis | pmid:17092506 |
Nicoll-Griffith DA et al. | In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17095220 |
Hortobágyi L et al. | Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids. | 2007 | Brain Res. | pmid:17161389 |
Kang MA et al. | Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. | 2007 | Life Sci. | pmid:17161435 |
Sánchez-Gómez FJ et al. | Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival. | 2007 | Arch. Biochem. Biophys. | pmid:17169324 |
Huang ZL et al. | Prostaglandins and adenosine in the regulation of sleep and wakefulness. | 2007 | Curr Opin Pharmacol | pmid:17129762 |
Kim HY and Kim HS | Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages. | 2007 | Immunol. Cell Biol. | pmid:17130903 |
Tanaka Y et al. | Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. | 2007 | Mol. Pharmacol. | pmid:17151289 |
Rahman A et al. | Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats. | 2007 | Eur. J. Pharmacol. | pmid:17112500 |
Suwaki N et al. | Expression and potential role of peroxisome proliferator-activated receptor gamma in the placenta of diabetic pregnancy. | 2007 | Placenta | pmid:16753211 |
Skogvall S et al. | Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. | 2007 | Pulm Pharmacol Ther | pmid:16731017 |
Rehan VK et al. | In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17215434 |
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Jin YR et al. | Antiplatelet effect of NQ12: a possible mechanism through the arachidonic acid cascade. | 2007 | J. Pharmacol. Sci. | pmid:17951980 |
Van Hecken A et al. | The effect of MK-0524, a prostaglandin D(2) receptor antagonist, on prostaglandin D (2)-induced nasal airway obstruction in healthy volunteers. | 2007 | Eur. J. Clin. Pharmacol. | pmid:17200838 |
Moreira V et al. | Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2, and expression of cyclooxygenases. | 2007 | Toxicon | pmid:17241651 |
Liu M et al. | Focal cerebral ischemia/reperfusion injury in mice induces hematopoietic prostaglandin D synthase in microglia and macrophages. | 2007 | Neuroscience | pmid:17241746 |
Tinfo N and Komar C | Potential role for peroxisome proliferator-activated receptor gamma in regulating luteal lifespan in the rat. | 2007 | Reproduction | pmid:17244745 |
Payne SG et al. | The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. | 2007 | Blood | pmid:17008548 |
Aldini G et al. | Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement. | 2007 | Biochemistry | pmid:17297918 |
Pettipher R et al. | Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. | 2007 | Nat Rev Drug Discov | pmid:17396136 |
Gayarre J et al. | Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17405918 |
Hagens WI et al. | Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated. | 2007 | Pharm. Res. | pmid:17245650 |
Sugimoto M et al. | Putative mechanism of the itch-scratch circle: repeated scratching decreases the cutaneous level of prostaglandin D2, a mediator that inhibits itching. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17250998 |
Li X et al. | Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells. | 2007 | Nephrol. Dial. Transplant. | pmid:17255125 |
Yang C et al. | Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. | 2007 | Am. J. Pathol. | pmid:17255338 |
Schäffler A et al. | Regulation and function of collagenous repeat containing sequence of 26-kDa protein gene product "cartonectin". | 2007 | Obesity (Silver Spring) | pmid:17299102 |
Petrova LN et al. | Effect of prostaglandins E2 and D2 on presynaptic NMDA receptors in rat cerebral cortex. | 2007 | Bull. Exp. Biol. Med. | pmid:18457019 |
Li CF et al. | [Effect of peroxisome proliferators-activated receptor-gamma in the mechanisms of sulindac against large intestine carcinoma]. | 2007 | Beijing Da Xue Xue Bao | pmid:17304332 |
Hirano Y et al. | Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells. | 2007 | Eur. J. Pharmacol. | pmid:17307163 |
Takaoka A et al. | Role of scratch-induced cutaneous prostaglandin D production on atopic-like scratching behaviour in mice. | 2007 | Exp. Dermatol. | pmid:17359340 |
Ito W et al. | Hepatocyte growth factor attenuates eotaxin and PGD2-induced chemotaxis of human eosinophils. | 2007 | Allergy | pmid:17362253 |
Yang WZ et al. | [The effect of ligand of peroxisome proliferators-activated receptor gamma 15d-PGJ2 on the proliferation and activation of hepatic stellate cells]. | 2007 | Zhonghua Gan Zang Bing Za Zhi | pmid:17362636 |
Wilhelm D et al. | SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. | 2007 | J. Biol. Chem. | pmid:17277314 |
Park JM et al. | Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. | 2007 | Cancer Res. | pmid:17283118 |
Hammad H et al. | Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. | 2007 | J. Exp. Med. | pmid:17283205 |
Kim HJ et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain. | 2007 | Cancer Res. | pmid:17363578 |
Yamada K et al. | Nose-to-brain delivery of TS-002, prostaglandin D2 analogue. | 2007 | J Drug Target | pmid:17365274 |
Fionda C et al. | 15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors. | 2007 | J. Immunol. | pmid:17371958 |
Saleem S et al. | PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury. | 2007 | Eur. J. Neurosci. | pmid:17573924 |
Wu L et al. | Divergent effects of prostaglandin receptor signaling on neuronal survival. | 2007 | Neurosci. Lett. | pmid:17574754 |
Hasegawa H et al. | A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production. | 2007 | Blood | pmid:17551094 |
Ueki S et al. | Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. | 2007 | Int. Arch. Allergy Immunol. | pmid:17541271 |
Zingarelli B et al. | Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. | 2007 | Shock | pmid:17589386 |
Vunta H et al. | The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. | 2007 | J. Biol. Chem. | pmid:17439952 |
Taniguchi H et al. | Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. | 2007 | J. Neurosci. | pmid:17442814 |
Zhang XC et al. | Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17483291 |
Ponferrada A et al. | The role of PPARgamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction. | 2007 | Gastroenterology | pmid:17484875 |
Renedo M et al. | Modification and activation of Ras proteins by electrophilic prostanoids with different structure are site-selective. | 2007 | Biochemistry | pmid:17489560 |
Cerbone A et al. | 4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells. | 2007 | Free Radic. Biol. Med. | pmid:17462534 |
Yano M et al. | Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages. | 2007 | Circ. Res. | pmid:17463321 |
Hwang J et al. | 15-deoxy-Delta12,14-prostaglandin J2-induced down-regulation of endothelial nitric oxide synthase in association with HSP70 induction. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17418102 |
Fulzele SV et al. | 15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. | 2007 | Anticancer Drugs | pmid:17159504 |
Arnold R et al. | Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. | 2007 | Immunology | pmid:17425601 |
Li SJ et al. | [Effects of peroxisome proliferator-activated receptor gamma and its ligands on cytotrophoblast invasion in first trimester of pregnancy and mechanism thereof]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17425848 |
Schuligoi R et al. | PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors. | 2007 | Biochem. Pharmacol. | pmid:17452035 |
Richman JG et al. | Nicotinic acid receptor agonists differentially activate downstream effectors. | 2007 | J. Biol. Chem. | pmid:17452318 |
Schütz TC et al. | Effects of COX-2 inhibitor in temporomandibular joint acute inflammation. | 2007 | J. Dent. Res. | pmid:17452571 |
Zhao X et al. | Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. | 2007 | Ann. Neurol. | pmid:17457822 |
Berry A et al. | IL-13 induces expression of CD36 in human monocytes through PPARgamma activation. | 2007 | Eur. J. Immunol. | pmid:17458857 |
Takeda K et al. | Neuroendocrine functions of melanocytes: beyond the skin-deep melanin maker. | 2007 | Tohoku J. Exp. Med. | pmid:17347546 |
Mazid MA et al. | Development of enzyme-linked immunosorbent assay for prostaglandin D2 using the stable isosteric analogue as a hapten mimic and its application. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17481559 |
Lim HJ et al. | 15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17631927 |
Olmos G et al. | Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism. | 2007 | Cell. Signal. | pmid:17658243 |
Xiang Z et al. | 15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells. | 2007 | J Neuroinflammation | pmid:17634127 |
Ye Y et al. | Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17643887 |
Desmarais JA et al. | The peroxisome proliferator-activated receptor gamma regulates trophoblast cell differentiation in mink (Mustela vison). | 2007 | Biol. Reprod. | pmid:17615406 |
Rajakariar R et al. | Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077391 |
Moulin D et al. | Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells. | 2007 | Cytokine | pmid:18023358 |
Mizutani N et al. | Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. | 2007 | J. Immunol. | pmid:18025192 |
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Kim WJ et al. | Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A. | 2007 | EMBO J. | pmid:18034160 |
Haworth O and Buckley CD | Resolving the problem of persistence in the switch from acute to chronic inflammation. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18093938 |
Wang LH et al. | Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP. | 2007 | Blood | pmid:17785586 |
Han H et al. | 15-Deoxy-delta 12,14-prostaglandin J2 (15d-PGJ 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation. | 2007 | Apoptosis | pmid:17786557 |
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Kershaw EE et al. | PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17848638 |
Brunoldi EM et al. | Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione. | 2007 | Chem. Res. Toxicol. | pmid:17854155 |
Siddhivarn C et al. | Mechanical loading and delta12prostaglandin J2 induce bone morphogenetic protein-2, peroxisome proliferator-activated receptor gamma-1, and bone nodule formation in an osteoblastic cell line. | 2007 | J. Periodont. Res. | pmid:17760815 |
Wu P et al. | Inflammation pro-resolving potential of 3,4-dihydroxyacetophenone through 15-deoxy-delta12,14-prostaglandin J2 in murine macrophages. | 2007 | Int. Immunopharmacol. | pmid:17761349 |
Saito Y et al. | Protective effects of 15-deoxy-Delta12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione. | 2007 | J. Neurochem. | pmid:17697048 |
Iikura M et al. | IL-33 can promote survival, adhesion and cytokine production in human mast cells. | 2007 | Lab. Invest. | pmid:17700564 |
Kondoh K et al. | Inhibition of estrogen receptor beta-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Delta(12,14)-prostaglandin J(2)-induced apoptosis in cancer cells. | 2007 | Exp. Cell Res. | pmid:17706193 |
Richard CL et al. | 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways. | 2007 | Exp. Cell Res. | pmid:17707368 |
Chen Y et al. | Prostaglandin D2 suppresses human NK cell function via signaling through D prostanoid receptor. | 2007 | J. Immunol. | pmid:17709490 |
Li Y et al. | Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist. | 2007 | J. Am. Chem. Soc. | pmid:17691773 |
Parameswaran K et al. | Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17431098 |
Rehan VK et al. | A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17435078 |
Vinall SL et al. | A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes. | 2007 | Immunology | pmid:17437532 |
Cossette C et al. | Agonist and antagonist effects of 15R-prostaglandin (PG) D2 and 11-methylene-PGD2 on human eosinophils and basophils. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17041009 |
Sandig H et al. | Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function. | 2007 | J. Leukoc. Biol. | pmid:17043246 |
Kamagata C et al. | 15-deoxy-Delta(12,14)-prostaglandin J2 inhibits G2-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivin expression. | 2007 | Breast Cancer Res. Treat. | pmid:17028981 |
GarcÃa-Bueno B et al. | Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats. | 2007 | Neuropsychopharmacology | pmid:17119541 |