Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Laidlaw TM and Boyce JA | Aspirin-Exacerbated Respiratory Disease--New Prime Suspects. | 2016 | N. Engl. J. Med. | pmid:26840139 |
Buchheit KM et al. | Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. | 2016 | J. Allergy Clin. Immunol. | pmid:26691435 |
Fernando MR et al. | Bidirectional crosstalk via IL-6, PGE2 and PGD2 between murine myofibroblasts and alternatively activated macrophages enhances anti-inflammatory phenotype in both cells. | 2016 | Br. J. Pharmacol. | pmid:26676587 |
Nelson SM et al. | Selenoprotein Expression in Macrophages Is Critical for Optimal Clearance of Parasitic Helminth Nippostrongylus brasiliensis. | 2016 | J. Biol. Chem. | pmid:26644468 |
Wang M et al. | The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice. | 2016 | Life Sci. | pmid:26808090 |
Carregaro V et al. | Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 (15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25-FOXP3+ Cells. | 2016 | Mediators Inflamm. | pmid:27872515 |
Suganami A et al. | Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands. | 2016 | FEBS J. | pmid:27636113 |
Kong D et al. | PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation. | 2016 | J. Exp. Med. | pmid:27621415 |
de Melo NF et al. | 15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation. | 2016 | PLoS ONE | pmid:27575486 |
Li WY et al. | Effect of 15-Deoxy-â–³(12,14)-prostaglandin J2 on Expression of Macrophage Migration Inhibitory Factor in Mouse Monocyte/macrophage Cell Line J774A.1. | 2016 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:27544994 |
Kim HJ et al. | ROSics: chemistry and proteomics of cysteine modifications in redox biology. | 2015 Mar-Apr | Mass Spectrom Rev | pmid:24916017 |
Le Loupp AG et al. | [Dual role for prostaglandin D2 in intestinal epithelial homeostasis]. | 2015 Jun-Jul | Med Sci (Paris) | pmid:26152165 |
Le Loupp AG et al. | Activation of the prostaglandin D2 metabolic pathway in Crohn's disease: involvement of the enteric nervous system. | 2015 | BMC Gastroenterol | pmid:26338799 |
Xu X et al. | Effect of Salusin-β on Peroxisome Proliferator-Activated Receptor Gamma Gene Expression in Vascular Smooth Muscle Cells and its Possible Mechanism. | 2015 | Cell. Physiol. Biochem. | pmid:26279448 |
Busse WW et al. | Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control. | 2015 | Chest | pmid:26226215 |
Tsutsumi S et al. | Cerebrospinal fluid drainage through the diploic and spinal epidural veins. | 2015 | J. Anat. | pmid:26184099 |
Jeon KI et al. | Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts. | 2015 | Exp. Eye Res. | pmid:26142957 |
Maher SA et al. | Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events. | 2015 | Eur. Respir. J. | pmid:25323233 |
Rossitto M et al. | Multiple roles of the prostaglandin D2 signaling pathway in reproduction. | 2015 | Reproduction | pmid:25269616 |
Hyun J et al. | Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. | 2015 | J Innate Immun | pmid:25171731 |