PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chiabrando C et al. | Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. | 1987 | Cancer Res. | pmid:3100032 |
| Kozuka T et al. | Prostaglandin D2 release by guinea pig skin during in vitro anaphylaxis induced by antigen and compound 48/80. | 1987 | J. Invest. Dermatol. | pmid:2433354 |
| Abdel-Malek ZA et al. | In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins. | 1987 | Cancer Res. | pmid:2438034 |
| Haxhiu MA et al. | [Bronchial response to prostaglandins (F2 alpha and D2) and leukotrienes in patients with bronchial asthma]. | 1986 Jan-Mar | Plucne Bolesti | pmid:3466189 |
| Frölich JC et al. | Advances in the analysis of eicosanoids by ELISA and GC/MS/MS. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949561 |
| Nordlund JJ et al. | Prostaglandin E2 and D2 but not MSH stimulate the proliferation of pigment cells in the pinnal epidermis of the DBA/2 mouse. | 1986 | J. Invest. Dermatol. | pmid:3528310 |
| Burrall B and Ziboh VA | Increased biosynthesis of lipoxygenase products by UVB-irradiated guinea pig epidermis: evidence of a cyclooxygenase inhibitor. | 1986 | J. Invest. Dermatol. | pmid:3086462 |
| Inokuchi A and Oomura Y | Effects of prostaglandin D2 on the activity of hypothalamic neurons in the rat. | 1986 | Jpn. J. Physiol. | pmid:3022048 |
| Hattori Y and Levi R | Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3012066 |
| Tsao CJ et al. | In-vitro effects of antineoplastic prostaglandins on human leukemic cell growth and normal myelopoiesis. | 1986 | Leuk. Res. | pmid:3012210 |
| Halenda SP et al. | Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets. | 1986 | FEBS Lett. | pmid:3015684 |
| Todo S et al. | Cell kinetic studies of PGD2 cytotoxicity on the in vitro growth of human neuroblastoma. | 1986 | Prostaglandins Leukot Med | pmid:3016753 |
| Bhattacharya SK | The antinociceptive effect of intracerebroventricularly administered prostaglandin D2 in the rat. | 1986 | Psychopharmacology (Berl.) | pmid:3016786 |
| Hamid-Bloomfield S and Whittle BJ | Prostaglandin D2 interacts at thromboxane receptor-sites on guinea-pig platelets. | 1986 | Br. J. Pharmacol. | pmid:3017497 |
| Shalit M et al. | New role for heparan sulfate: regulator of leukotriene generation in mouse E-mast cells. | 1986 | Life Sci. | pmid:3018403 |
| Kuno S et al. | Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3010301 |
| Peters SP et al. | Mediator release from human lung under conditions of reduced oxygen tension. | 1986 | J. Pharmacol. Exp. Ther. | pmid:2425080 |
| Wells E et al. | Characterization of primate bronchoalveolar mast cells. I. IgE-dependent release of histamine, leukotrienes, and prostaglandins. | 1986 | J. Immunol. | pmid:2431048 |
| MacDermot J | Desensitization of prostacyclin responsiveness in platelets. Apparent differences in the mechanism in vitro or in vivo. | 1986 | Biochem. Pharmacol. | pmid:2427086 |
| Heavey DJ et al. | Prostaglandin D2 and histamine release in cold urticaria. | 1986 | J. Allergy Clin. Immunol. | pmid:2428856 |
| Eady RP | The pharmacology of nedocromil sodium. | 1986 | Eur J Respir Dis Suppl | pmid:2429854 |
| Kleeberger SR et al. | Central role of cyclooxygenase in the response of canine peripheral airways to antigen. | 1986 | J. Appl. Physiol. | pmid:2430928 |
| Eling TE et al. | Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase. | 1986 | J. Biol. Chem. | pmid:3007487 |
| Zavoico GB et al. | Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs. | 1986 | J. Biol. Chem. | pmid:3020026 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Peters SP et al. | The pharmacologic control of mediator release from human basophils and mast cells. | 1986 | Respiration | pmid:3494282 |
| Bhuyan BK et al. | Cell cycle effects of prostaglandins A1, A2, and D2 in human and murine melanoma cells in culture. | 1986 | Cancer Res. | pmid:3456266 |
| Brooks DP et al. | Role of brain prostaglandins in the control of vasopressin secretion in the conscious rat. | 1986 | Endocrinology | pmid:3456303 |
| Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3456602 |
| Ruzicka T et al. | Skin levels of arachidonic acid-derived inflammatory mediators and histamine in atopic dermatitis and psoriasis. | 1986 | J. Invest. Dermatol. | pmid:3018086 |
| Nelson CA and Seamon KB | Binding of [3H]forskolin to human platelet membranes. Regulation by guanyl-5'-yl imidodiphosphate, NaF, and prostaglandins E1 and D2. | 1986 | J. Biol. Chem. | pmid:3463564 |
| Black JL et al. | A comparison of the contractile activity of PGD2 and PGF2 alpha on human isolated bronchus. | 1986 | Prostaglandins | pmid:3464041 |
| Sago T et al. | Metabolism of prostaglandins D2 and F2 alpha in primary cultures of rat hepatocytes. | 1986 | Biochim. Biophys. Acta | pmid:3465372 |
| Suzuki F et al. | Transport of prostaglandin D2 into brain. | 1986 | Brain Res. | pmid:3465420 |
| Kuno S et al. | Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3458226 |
| Ikai K et al. | Ear swelling in response to UVB irradiation. | 1986 | Arch. Dermatol. Res. | pmid:3466577 |
| Rees MC and Kelly RW | Prostaglandin D2 release by endometrium and myometrium. | 1986 | Br J Obstet Gynaecol | pmid:3466645 |
| Hardy CC et al. | Evidence against the formation of 13,14-dihydro-15-keto-prostaglandin F2 alpha following inhalation of prostaglandin D2 in man. | 1986 | Br. J. Pharmacol. | pmid:3467804 |
| Inoué S | Multifactorial humoral regulation of sleep. | 1986 | Clin Neuropharmacol | pmid:3471328 |
| Bhuyan BK et al. | Cytotoxicity of combinations of prostaglandin D2 (PGD2) and antitumor drugs for B16 melanoma cells in culture. | 1986 | Invest New Drugs | pmid:3473056 |
| Kashani IA et al. | Effects of prostaglandins on the pulmonary vascular bed of newborn rats with chronic hypoxia. | 1986 | Angiology | pmid:3511774 |
| Fuller RW et al. | Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine. | 1986 | Am. Rev. Respir. Dis. | pmid:3511806 |
| Blockmans D et al. | Heparin-induced thrombocytopenia platelet aggregation studies in the presence of heparin fractions or semi-synthetic analogues of various molecular weights and anticoagulant activities. | 1986 | Thromb. Haemost. | pmid:3518134 |
| Tokumoto H et al. | Specificity of prostaglandin D2 binding to synaptic membrane fraction of rat brain. | 1986 | Brain Res. | pmid:2867812 |
| Honn KV et al. | Possible strategies for antimetastastic therapy. | 1986 | Prog. Clin. Biol. Res. | pmid:3520578 |
| Lumsden MA et al. | Changes in the concentration of prostaglandins in preovulatory human follicles after administration of hCG. | 1986 | J. Reprod. Fertil. | pmid:3459888 |
| Watanabe Y et al. | Modulation by prostaglandin D2 of mitral cell responses to odor stimulation in rabbit olfactory bulb. | 1986 | Brain Res. | pmid:2873871 |
| Huddleston KW et al. | Influence of prostaglandin D2 on hemodynamic effects of group B streptococcus in neonatal lambs. | 1986 | Dev Pharmacol Ther | pmid:3530674 |
| Hiroshima O et al. | Basal level of prostaglandin D2 in rat brain by a solid-phase enzyme immunoassay. | 1986 | Prostaglandins | pmid:3532208 |
| Strobl-Jäger E et al. | Influence of type IIa, IIb and IV-hyperlipoproteinemia on platelet prostaglandin sensitivity, plasma thromboxane B2 and platelet half-life. | 1986 | Prostaglandins Leukot Med | pmid:3540998 |