PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Equils O et al. | Bacterial lipopolysaccharide activates HIV long terminal repeat through Toll-like receptor 4. | 2001 | J. Immunol. | pmid:11160291 |
| Kitamura Y et al. | Effects of 15-deoxy-delta(12,14) prostaglandin J(2) and interleukin-4 in Toll-like receptor-4-mutant glial cells. | 2001 | Eur. J. Pharmacol. | pmid:11164379 |
| Kadekaro M et al. | Central interactions between angiotensin II and PGD(2) in the regulation of vasopressin and oxytocin secretion in dehydrated rats. | 2001 | Brain Res. | pmid:11166690 |
| Wilmer WA et al. | A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11178960 |
| Åazarewicz JW et al. | NMDA receptors and nitric oxide regulate prostaglandin D2 synthesis in the rabbit hippocampus in vivo. | 2000 | Acta Neurobiol Exp (Wars) | pmid:11200170 |
| Inoue T et al. | Serum prostaglandin D synthase level after coronary angioplasty may predict occurrence of restenosis. | 2001 | Thromb. Haemost. | pmid:11204569 |
| Hirai H et al. | Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. | 2001 | J. Exp. Med. | pmid:11208866 |
| Tunaz H et al. | Prostaglandin biosynthesis by fat body from true armyworms, Pseudaletia unipuncta. | 2001 | Insect Biochem. Mol. Biol. | pmid:11222953 |
| Reilly CM et al. | Prostaglandin J(2) inhibition of mesangial cell iNOS expression. | 2001 | Clin. Immunol. | pmid:11237557 |
| Szczeklik A et al. | Safety of a specific COX-2 inhibitor in aspirin-induced asthma. | 2001 | Clin. Exp. Allergy | pmid:11251623 |
| Kang SS et al. | Cyclooxygenase-2 inhibitory cerebrosides from phytolaccae radix. | 2001 | Chem. Pharm. Bull. | pmid:11253924 |
| Okayama Y et al. | A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI. | 2001 | J. Immunol. | pmid:11254731 |
| Fahmi H et al. | Peroxisome proliferator--activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes. | 2001 | Arthritis Rheum. | pmid:11263774 |
| Thévenon C et al. | Gas chromatographic-mass spectrometric measurement of 15-deoxy-delta(12,14)-prostaglandin J(2), the peroxisome proliferator-activated receptor gamma ligand, in urine. | 2001 | Clin. Chem. | pmid:11274037 |
| Rohn TT et al. | 15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis. | 2001 | Neuroreport | pmid:11277593 |
| Satoh T et al. | Neurotrophic actions of novel compounds designed from cyclopentenone prostaglandins. | 2001 | J. Neurochem. | pmid:11279261 |
| Drew PD and Chavis JA | The cyclopentone prostaglandin 15-deoxy-Delta(12,14) prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells. | 2001 | J. Neuroimmunol. | pmid:11282151 |
| Wang C et al. | Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1. | 2001 | Mol. Cell. Biol. | pmid:11287611 |
| Jiang JG et al. | Peroxisome proliferator-activated receptor gamma-mediated transcriptional up-regulation of the hepatocyte growth factor gene promoter via a novel composite cis-acting element. | 2001 | J. Biol. Chem. | pmid:11292834 |
| Niyonsaba F et al. | Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. | 2001 | Eur. J. Immunol. | pmid:11298331 |