PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mondoro TH and Vostal JG | Cold temperatures reduce the sensitivity of stored platelets to disaggregating agents. | 2002 | Platelets | pmid:11918832 |
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| Schoppee PD et al. | Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells. | 2002 | Biol. Reprod. | pmid:11751282 |
| Fujitani Y et al. | Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. | 2002 | J. Immunol. | pmid:11751991 |
| Yagami T et al. | Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis. | 2002 | Mol. Pharmacol. | pmid:11752212 |
| Fu Y et al. | Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. | 2002 | Atherosclerosis | pmid:11755918 |
| Chen GG et al. | Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer. | 2002 | Life Sci. | pmid:12269390 |
| Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
| Kohyama T et al. | PGD(2) modulates fibroblast-mediated native collagen gel contraction. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:12204901 |
| Nencioni A et al. | Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor gamma. | 2002 | J. Immunol. | pmid:12133943 |
| Kudoh I et al. | [Prostanoids and acute lung injury]. | 2002 | Masui | pmid:12134647 |
| Meier CA et al. | Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activated receptor gamma. | 2002 | Cytokine | pmid:12160520 |
| Kwak BR et al. | PPARgamma but not PPARalpha ligands are potent repressors of major histocompatibility complex class II induction in atheroma-associated cells. | 2002 | Circ. Res. | pmid:11861426 |
| Shimada T et al. | Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. | 2002 | Gut | pmid:11950812 |
| Pestel S et al. | Inhibition by prostaglandin E(2) of anaphylatoxin C5a- but not zymosan-induced prostanoid release from rat Kupffer cells. | 2002 | Lab. Invest. | pmid:11950903 |
| Nishida K et al. | Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferator-activated receptor-gamma. | 2002 | Br. J. Cancer | pmid:11953889 |
| Finck BN and Johnson RW | Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11959686 |
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| Yu Y et al. | Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. | 2002 | Biochim. Biophys. Acta | pmid:12020636 |
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| Yagami T et al. | Group IB secretory phospholipase A2 induces neuronal cell death via apoptosis. | 2002 | J. Neurochem. | pmid:12065654 |
| Fujino T et al. | Effects of the prostanoids on the proliferation or hypertrophy of cultured murine aortic smooth muscle cells. | 2002 | Br. J. Pharmacol. | pmid:12055131 |
| Ward C et al. | Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. | 2002 | J. Immunol. | pmid:12055237 |
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| Fahmi H et al. | 15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes. | 2002 | Osteoarthr. Cartil. | pmid:12435328 |
| Vitzthum H et al. | Gene expression of prostanoid forming enzymes along the rat nephron. | 2002 | Kidney Int. | pmid:12371957 |
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| Li L et al. | 15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors. | 2001 | J. Biol. Chem. | pmid:11477100 |
| Ahluwalia P et al. | Nedocromil sodium and levocabastine reduce the symptoms of conjunctival allergen challenge by different mechanisms. | 2001 | J. Allergy Clin. Immunol. | pmid:11544467 |
| Nicolaidis S et al. | [Variations of hypothalamic and cortical prostaglandins and monoamines reveal transitions in arousal states: microdialysis study in the rat]. | 2001 | Rev. Neurol. (Paris) | pmid:11924034 |
| Pignatelli M et al. | The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells. | 2001 | J. Cell. Sci. | pmid:11739643 |
| Gervais FG et al. | Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. | 2001 | J. Allergy Clin. Immunol. | pmid:11742277 |
| Reilly TP et al. | A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. | 2001 | Chem. Res. Toxicol. | pmid:11743745 |
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| Tanaka T et al. | Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet. | 2001 | Life Sci. | pmid:11693274 |
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| Hirai H et al. | Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. | 2001 | J. Exp. Med. | pmid:11208866 |
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| Person EC et al. | Albumin regulates induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-delta(12-14)-prostaglandin J(2) in vitro and may be an important regulator of PPARgamma function in vivo. | 2001 | Endocrinology | pmid:11159824 |
| Reilly CM et al. | Prostaglandin J(2) inhibition of mesangial cell iNOS expression. | 2001 | Clin. Immunol. | pmid:11237557 |
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| Kadekaro M et al. | Central interactions between angiotensin II and PGD(2) in the regulation of vasopressin and oxytocin secretion in dehydrated rats. | 2001 | Brain Res. | pmid:11166690 |
| Szczeklik A et al. | Safety of a specific COX-2 inhibitor in aspirin-induced asthma. | 2001 | Clin. Exp. Allergy | pmid:11251623 |
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| Robbins IM et al. | Increased levels of prostaglandin D(2) suggest macrophage activation in patients with primary pulmonary hypertension. | 2001 | Chest | pmid:11713147 |
| Jozkowicz A et al. | Prostaglandin-J2 induces synthesis of interleukin-8 by endothelial cells in a PPAR-gamma-independent manner. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11577781 |
| Garcia Palacios V et al. | Expression of adipogenesis markers in a murine stromal cell line treated with 15-deoxy Delta(12,14)-prostaglandin J2, interleukin-11, 9-cis retinoic acid and vitamin K2. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728175 |
| Levine L | Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728177 |
| Tanimoto A et al. | Histamine increases the expression of LOX-1 via H2 receptor in human monocytic THP-1 cells. | 2001 | FEBS Lett. | pmid:11728449 |
| Yamamoto K et al. | Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes. | 2001 | Circulation | pmid:11581147 |
| Mizoguchi A et al. | Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11562489 |
| Inoue K et al. | Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11563856 |
| Clay CE et al. | Early de novo gene expression is required for 15-deoxy-Delta 12,14-prostaglandin J2-induced apoptosis in breast cancer cells. | 2001 | J. Biol. Chem. | pmid:11668172 |
| Cernuda-Morollón E et al. | 15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit. | 2001 | J. Biol. Chem. | pmid:11466314 |
| Boyault S et al. | 15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways. | 2001 | FEBS Lett. | pmid:11457450 |
| Nishimura H et al. | Acute effects of prostaglandin D2 to induce airflow obstruction and airway microvascular leakage in guinea pigs: role of thromboxane A2 receptors. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11519790 |
| Clay CE et al. | Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells. | 2001 | J. Investig. Med. | pmid:11523697 |
| Hunter JG et al. | Peroxisome proliferator-activated receptor gamma ligands differentially modulate muscle cell differentiation and MyoD gene expression via peroxisome proliferator-activated receptor gamma -dependent and -independent pathways. | 2001 | J. Biol. Chem. | pmid:11477074 |