PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jović N et al. | Do prostaglandins E2, F2 alpha and D2 have a role in the development of idiopathic trigeminal neuralgia? | 1996 May-Jun | Vojnosanit Pregl | pmid:9174396 |
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| Teixeira MM et al. | Characterization of the prostanoid receptors mediating inhibition of PAF-induced aggregation of guinea-pig eosinophils. | 1997 | Br. J. Pharmacol. | pmid:9146890 |
| AL-Hader AA et al. | Novel expression of functional luteinizing hormone/chorionic gonadotropin receptors in cultured glial cells from neonatal rat brains. | 1997 | Biol. Reprod. | pmid:9116153 |
| Minami T et al. | Absence of prostaglandin E2-induced hyperalgesia in NMDA receptor epsilon subunit knockout mice. | 1997 | Br. J. Pharmacol. | pmid:9113374 |
| Taber DF et al. | A nomenclature system for the isoprostanes. | 1997 | Prostaglandins | pmid:9112285 |
| Ram A et al. | CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats. | 1997 | Brain Res. | pmid:9098570 |
| Kanamori Y et al. | Migration of neutrophils from blood to tissue: alteration of modulatory effects of prostanoid on superoxide generation in rabbits and humans. | 1997 | Life Sci. | pmid:9096262 |
| Franzese O et al. | Functional antagonism between IL-2 and PGA1 or PGJ2 in the control of proliferation of human cord blood-derived mononuclear cells. | 1996 | Int. J. Immunopharmacol. | pmid:9089005 |
| Abran D et al. | Regulation of prostanoid vasomotor effects and receptors in choroidal vessels of newborn pigs. | 1997 | Am. J. Physiol. | pmid:9087666 |
| Bogaards JJ et al. | Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1. | 1997 | Chem. Res. Toxicol. | pmid:9084911 |
| Ito H et al. | Prostaglandins stimulate the stress-induced synthesis of hsp27 and alpha B crystallin. | 1997 | J. Cell. Physiol. | pmid:9066782 |
| Nasushita R et al. | A comparative study of adrenocorticotropin-releasing activity of prostaglandins E1, E2, F2 alpha and D2 in the rat. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051727 |
| Hutchinson SM et al. | Effects of eicosanoids on parameters in isolated rat hepatocytes and isolated rat hepatocyte couplets: protective effects of eicosanoid receptor antagonists. | 1997 | J Lipid Mediat Cell Signal | pmid:9041475 |
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| Matsumoto H et al. | Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9020023 |
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| Santos J et al. | Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropin-releasing hormone in rats. | 1996 | Gastroenterology | pmid:8942724 |
| Vedin I et al. | Stimulation of tumor necrosis factor-alpha release from lipopolysaccharide-activated human blood monocytes by prostaglandin J2 and metabolites of prostaglandin J2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931117 |
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| Ishimoto T et al. | Importance of the phospholipase D-initiated sequential pathway for arachidonic acid release and prostaglandin D2 generation by rat peritoneal mast cells. | 1996 | J. Biochem. | pmid:8902628 |
| Lydford SJ et al. | Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein. | 1996 | Prostaglandins | pmid:8880898 |
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| Knol EF et al. | The role of basophils in allergic disease. | 1996 | Eur Respir J Suppl | pmid:8871057 |
| Woodiel FN et al. | Anabolic effects of prostaglandins in cultured fetal rat calvariae: structure-activity relations and signal transduction pathway. | 1996 | J. Bone Miner. Res. | pmid:8864899 |
| Conti C et al. | Inhibition of poliovirus replication by prostaglandins A and J in human cells. | 1996 | Antimicrob. Agents Chemother. | pmid:8834882 |
| Chung HS et al. | Heat contact urticaria--a case report. | 1996 | Yonsei Med. J. | pmid:8826790 |
| Bingham CO et al. | A heparin-sensitive phospholipase A2 and prostaglandin endoperoxide synthase-2 are functionally linked in the delayed phase of prostaglandin D2 generation in mouse bone marrow-derived mast cells. | 1996 | J. Biol. Chem. | pmid:8824228 |
| Wang DY et al. | Prostaglandin D2 measurement in nasal secretions is not a reliable marker for mast cell activation in atopic patients. | 1995 | Clin. Exp. Allergy | pmid:8821304 |
| Sharif NA et al. | Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819509 |
| Minami T et al. | Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819497 |
| Westcott JY et al. | Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase. | 1996 | Biochim. Biophys. Acta | pmid:8816855 |
| Ko FN et al. | Mechanism of action of p-chlorobiphenyl on the inhibition of platelet aggregation. | 1996 | J. Pharm. Pharmacol. | pmid:8794990 |
| Norwitz ER et al. | Prostaglandin production by human peripheral blood monocytes changes with in vitro differentiation. | 1996 | Prostaglandins | pmid:8792444 |
| Johnston DE and Kroening C | Stimulation of prostaglandin synthesis in cultured liver cells by CCl4. | 1996 | Hepatology | pmid:8781342 |
| Obata T et al. | IgE-anti-IgE-induced prostaglandin D2 release from cultured human mast cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780726 |
| Negishi M et al. | Biological actions of delta 12-prostaglandin J2. | 1995 | J Lipid Mediat Cell Signal | pmid:8777585 |
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| Casimir DA et al. | Preadipocyte differentiation blocked by prostaglandin stimulation of prostanoid FP2 receptor in murine 3T3-L1 cells. | 1996 | Differentiation | pmid:8765050 |
| Patella V et al. | Eosinophil granule proteins activate human heart mast cells. | 1996 | J. Immunol. | pmid:8757629 |
| O'Sullivan S et al. | Increased urinary excretion of the prostaglandin D2 metabolite 9 alpha, 11 beta-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. | 1996 | J. Allergy Clin. Immunol. | pmid:8757220 |
| Patella V et al. | Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8753840 |
| McClay EF et al. | delta 12-Prostaglandin-J2 is cytotoxic in human malignancies and synergizes with both cisplatin and radiation. | 1996 | Cancer Res. | pmid:8752147 |
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| Hallbrucker C et al. | Hydroperoxide metabolism in rat liver. K+ channel activation, cell volume changes and eicosanoid formation. | 1993 | Eur. J. Biochem. | pmid:8436107 |
| Matsuo T and Cynader MS | The EP2 receptor is the predominant prostanoid receptor in the human ciliary muscle. | 1993 | Br J Ophthalmol | pmid:8435410 |
| Huttemeier PC et al. | Microdialysis measurements of PGD2, TXB2 and 6-KETO-PGF1 alpha in rat CA1 hippocampus during transient cerebral ischemia. | 1993 | Prostaglandins | pmid:8430228 |
| Hata Y et al. | Primary colonic epithelial cell culture of the rabbit producing prostaglandins. | 1993 | Prostaglandins | pmid:8430223 |
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