PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Colville-Nash PR et al. | Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1. | 1998 | J. Immunol. | pmid:9670978 |
| Palea S et al. | Pharmacological characterization of thromboxane and prostanoid receptors in human isolated urinary bladder. | 1998 | Br. J. Pharmacol. | pmid:9692770 |
| Yoshida T et al. | Inhibitory effects of prostaglandin D2 against the proliferation of human colon cancer cell lines and hepatic metastasis from colorectal cancer. | 1998 | Surg. Today | pmid:9697269 |
| Terao A et al. | Interleukin-1 induces slow-wave sleep at the prostaglandin D2-sensitive sleep-promoting zone in the rat brain. | 1998 | J. Neurosci. | pmid:9698346 |
| Rosenbaum SE and Greenberg AS | The short- and long-term effects of tumor necrosis factor-alpha and BRL 49653 on peroxisome proliferator-activated receptor (PPAR)gamma2 gene expression and other adipocyte genes. | 1998 | Mol. Endocrinol. | pmid:9717841 |
| Christman BW | Lipid mediator dysregulation in primary pulmonary hypertension. | 1998 | Chest | pmid:9741570 |
| Takahashi S et al. | Localization of a cyclopentenone prostaglandin to the endoplasmic reticulum and induction of BiP mRNA. | 1998 | Biochem. J. | pmid:9742210 |
| Csala M et al. | Prostaglandin-independent stimulation of interleukin-6 production by fibrinogen degradation product D in perfused murine liver. | 1998 | Scand. J. Immunol. | pmid:9743211 |
| Kilunga Kubata B et al. | Plasmodium falciparum produces prostaglandins that are pyrogenic, somnogenic, and immunosuppressive substances in humans. | 1998 | J. Exp. Med. | pmid:9743538 |
| Crider JY et al. | Use of a semi-automated, robotic radioimmunoassay to measure cAMP generated by activation of DP-, EP2-, and IP-prostaglandin receptors in human ocular and other cell types. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758211 |
| Szczeklik A et al. | Salmeterol prevents aspirin-induced attacks of asthma and interferes with eicosanoid metabolism. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9769277 |
| Ohtani-Fujita N et al. | p53-Independent activation of the gadd45 promoter by Delta12-prostaglandin J2. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9792828 |
| Tada K et al. | Induction of cyclooxygenase-2 by secretory phospholipases A2 in nerve growth factor-stimulated rat serosal mast cells is facilitated by interaction with fibroblasts and mediated by a mechanism independent of their enzymatic functions. | 1998 | J. Immunol. | pmid:9794438 |
| Huszár E et al. | Elevated circulating adenosine level potentiates antigen-induced immediate bronchospasm and bronchoconstrictor mediator release in sensitized guinea pigs. | 1998 | J. Allergy Clin. Immunol. | pmid:9802380 |
| Matsushita N et al. | Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. | 1998 | Jpn. J. Pharmacol. | pmid:9804057 |
| Ma H et al. | Estrogen-induced production of a peroxisome proliferator-activated receptor (PPAR) ligand in a PPARgamma-expressing tissue. | 1998 | J. Biol. Chem. | pmid:9804768 |
| Arakida Y et al. | In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808690 |
| Madhu C et al. | Penetration of natural prostaglandins and their ester prodrugs and analogs across human ocular tissues in vitro. | 1998 | J Ocul Pharmacol Ther | pmid:9811228 |
| Takafuji S et al. | Release of granule proteins from human eosinophils stimulated with mast-cell mediators. | 1998 | Allergy | pmid:9821474 |
| Shichijo M et al. | The effects of anti-asthma drugs on mediator release from cultured human mast cells. | 1998 | Clin. Exp. Allergy | pmid:9824389 |
| Ahn SG et al. | The role of c-Myc and heat shock protein 70 in human hepatocarcinoma Hep3B cells during apoptosis induced by prostaglandin A2/Delta12-prostaglandin J2. | 1998 | Biochim. Biophys. Acta | pmid:9824682 |
| Molderings GJ et al. | Modulation of noradrenaline release from the sympathetic nerves of human right atrial appendages by presynaptic EP3- and DP-receptors. | 1998 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9826066 |
| Marx N et al. | Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. | 1998 | Circ. Res. | pmid:9831704 |
| Löhrke B et al. | Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells. | 1998 | J. Endocrinol. | pmid:9834460 |
| Haberl C et al. | Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity. | 1998 | Mediators Inflamm. | pmid:9836493 |
| Longo WE et al. | The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation. | 1998 | Mediators Inflamm. | pmid:9836494 |
| Fiebich BL et al. | Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer's disease. | 1998 | J. Neural Transm. Suppl. | pmid:9850935 |
| Hwang GS et al. | Effects of Brazilin on the phospholipase A2 activity and changes of intracellular free calcium concentration in rat platelets. | 1998 | Arch. Pharm. Res. | pmid:9868555 |
| Sutarmo Setiadji V et al. | Actions of prostaglandin E2 on rat supraoptic neurones. | 1998 | J. Neuroendocrinol. | pmid:9870750 |
| Terao A et al. | Enhancement of slow-wave sleep by tumor necrosis factor-alpha is mediated by cyclooxygenase-2 in rats. | 1998 | Neuroreport | pmid:9875706 |
| Gambero A and Gomes JC | Pharmacological antagonism of Anchietia salutaris extracts on the contraction induced by prostaglandin D2 and U46619 in guinea-pig lung parenchymal strips. | 1998 | J. Pharm. Pharmacol. | pmid:9877316 |
| Sakamoto H et al. | Effect of intracellular glutathione on the production of prostaglandin D2 in RBL-2H3 cells oxidized by tert-butyl hydroperoxide. | 1999 | J. Biochem. | pmid:9880802 |
| Lin Q et al. | Ligand selectivity of the peroxisome proliferator-activated receptor alpha. | 1999 | Biochemistry | pmid:9890897 |
| Eguchi N et al. | Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9892701 |
| Gao T et al. | Arachidonic acid metabolism to prostaglandin E2, D2, F2alpha, and I2 in the plerocercoid of Spirometra erinaceieuropaei. | 1998 | J. Parasitol. | pmid:9920298 |
| Satoh H et al. | Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function. | 1999 | Biochem. Biophys. Res. Commun. | pmid:9920814 |
| Urade Y and Hayaishi O | Prostaglandin D2 and sleep regulation. | 1999 | Biochim. Biophys. Acta | pmid:9989291 |
| Longo WE et al. | Contribution of cyclooxygenase-1 and cyclooxygenase-2 to prostanoid formation by human enterocytes stimulated by calcium ionophore and inflammatory agents. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990676 |