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Human invasive trophoblasts transformed with simian virus 40 provide a new tool to study the role of PPARgamma in cell invasion process. |
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Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. |
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Shock |
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Oncogene |
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The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. |
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Neurology |
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The effect of PPARgamma ligands on the proliferation and apoptosis of human melanoma cells. |
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15-Deoxy-delta 12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide. |
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Prostaglandins Other Lipid Mediat. |
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Differential expression of c-fos and c-myc protooncogenes by estrogens, xenobiotics and other growth-stimulatory agents in primary rat hepatocytes. |
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Arch. Toxicol. |
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The effect of peroxisome proliferator-activated receptor-gamma ligand on urological cancer cells. |
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Hyperoxia augments pulmonary lipofibroblast-to-myofibroblast transdifferentiation. |
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Cell Biochem. Biophys. |
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Invest. Ophthalmol. Vis. Sci. |
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An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. |
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Mol. Pharmacol. |
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[Sleep substances]. |
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Biochemistry |
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PPARgamma ligands and ATRA inhibit the invasion of human breast cancer cells in vitro. |
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Breast Cancer Res. Treat. |
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DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand. |
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Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. |
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BMC Ophthalmol |
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Inverse relationship between the expression of messenger ribonucleic acid for peroxisome proliferator-activated receptor gamma and P450 side chain cleavage in the rat ovary. |
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Biol. Reprod. |
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Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. |
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A controlled study of 9alpha,11beta-PGF2 (a prostaglandin D2 metabolite) in plasma and urine of patients with bronchial asthma and healthy controls after aspirin challenge. |
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15-deoxy-delta12,14 prostaglandin J2 synergizes with phorbol ester to induce proliferation in Swiss 3T3 cells independently of peroxisome proliferator-activated receptor gamma and PGD2 receptors. |
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J. Cell. Physiol. |
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2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB. |
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Effect of 15-deoxy-delta12,14-prostaglandin J2 on IL-1beta-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells. |
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Prostaglandins Leukot. Essent. Fatty Acids |
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The cyclopentenone-type prostaglandin 15-deoxy-delta 12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T lymphocytes: interference with promoter activation via peroxisome proliferator-activated receptor-gamma-independent mechanisms. |
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J. Immunol. |
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Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways. |
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Eur. J. Immunol. |
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Hematopoietic prostaglandin D synthase is expressed in microglia in the developing postnatal mouse brain. |
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Glia |
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Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation. |
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Involvement of c-jun N-terminal kinase activation in 15-deoxy-delta12,14-prostaglandin J2-and prostaglandin A1-induced apoptosis in AGS gastric epithelial cells. |
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Mol. Carcinog. |
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Expression and molecular pharmacology of the mouse CRTH2 receptor. |
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J. Pharmacol. Exp. Ther. |
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The antiproliferative effects of PPARgamma ligands in normal human mammary epithelial cells. |
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Breast Cancer Res. Treat. |
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The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. |
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Proc. Natl. Acad. Sci. U.S.A. |
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The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs. |
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Cancer Res. |
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Possible involvement of prostaglandins F(2alpha) and D(2) in acetylcholine-induced positive inotropy in isolated mouse left atria. |
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Pharmacology |
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Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures. |
2003 |
Biochim. Biophys. Acta |
pmid:12573447
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Hypothermia suppresses inducible nitric oxide synthase and stimulates cyclooxygenase-2 in lipopolysaccharide stimulated BV-2 cells. |
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Brain Res. Mol. Brain Res. |
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Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. |
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PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. |
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The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. |
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Br. J. Pharmacol. |
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Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages. |
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Mol. Cell. Biol. |
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Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. |
2003 |
Biochem. Biophys. Res. Commun. |
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15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. |
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15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. |
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Biochem. Biophys. Res. Commun. |
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Activation of p38 mitogen-activated protein kinase and activator protein-1 during the promotion of neurite extension of PC-12 cells by 15-deoxy-delta12,14-prostaglandin J2. |
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Mol. Pharmacol. |
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GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. |
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Arterioscler. Thromb. Vasc. Biol. |
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Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. |
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Cancer Res. |
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Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons. |
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Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:12618420
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Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells. |
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Fertil. Steril. |
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Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. |
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Am. J. Physiol. Endocrinol. Metab. |
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Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. |
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Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. |
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Biochem. J. |
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Arachidonic acid-induced channel- and carrier-type ion transport across planar bilayer lipid membranes. |
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Anal Sci |
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Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells. |
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Arterioscler. Thromb. Vasc. Biol. |
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Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs. |
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J Ocul Pharmacol Ther |
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Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. |
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Biochem. Biophys. Res. Commun. |
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Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin. |
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BioTechniques |
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