| MeSH term | MeSH ID | Detail |
|---|---|---|
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim YI et al. | Effects of 15-deoxy-∆¹²,¹â´-prostaglandin Jâ‚‚ on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide. | 2011 | Mol. Biol. Rep. | pmid:20174873 |
| Mor A et al. | Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. | 2011 | Inflammation | pmid:20706780 |
| Balzar S et al. | Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:20813890 |
| Mathurin K et al. | An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production. | 2011 | J. Biol. Chem. | pmid:21112970 |
| Wingard CJ et al. | Mast cells contribute to altered vascular reactivity and ischemia-reperfusion injury following cerium oxide nanoparticle instillation. | 2011 | Nanotoxicology | pmid:21043986 |
| Joachim A and Ruttkowski B | Prostaglandin D(2) synthesis in Oesophagostomum dentatum is mediated by cytosolic glutathione S-transferase. | 2011 | Exp. Parasitol. | pmid:21056037 |
| Afrin LB | Polycythemia from mast cell activation syndrome: lessons learned. | 2011 | Am. J. Med. Sci. | pmid:21642812 |
| Kajiwara D et al. | Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis. | 2011 | Eur. J. Pharmacol. | pmid:21645503 |
| Erttmann SF et al. | PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2. | 2011 | Free Radic. Biol. Med. | pmid:21651978 |
| Chiba T et al. | The opposing role of two prostaglandin D2 receptors, DP and CRTH2, in human eosinophil migration. | 2011 | Ann. Allergy Asthma Immunol. | pmid:21624751 |
| Liu TY et al. | [Advances in the study of histaminergic systems and sleep-wake regulation]. | 2011 | Yao Xue Xue Bao | pmid:21626776 |
| Zhang Y et al. | Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers. | 2011 | J Mass Spectrom | pmid:21706677 |
| Ugajin T et al. | FcεRI, but not FcγR, signals induce prostaglandin D2 and E2 production from basophils. | 2011 | Am. J. Pathol. | pmid:21712025 |
| Tobiasova Z et al. | Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells. | 2011 | Circulation | pmid:21690493 |
| Menon R et al. | Amniotic fluid eicosanoids in preterm and term births: effects of risk factors for spontaneous preterm labor. | 2011 | Obstet Gynecol | pmid:21691170 |
| Chowdhury AA et al. | 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21699992 |
| Yamamoto Y et al. | Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. | 2011 | Am. J. Pathol. | pmid:21703412 |
| Ebersberger A et al. | Effects of prostaglandin D2 on tetrodotoxin-resistant Na+ currents in DRG neurons of adult rat. | 2011 | Pain | pmid:21345590 |
| Ulivi V et al. | Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway. | 2011 | Arthritis Res. Ther. | pmid:21682897 |
| Farhat A et al. | Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology. | 2011 | J Ovarian Res | pmid:21352547 |
| Yamamoto Y et al. | 15-Deoxy-Δ12,14-prostaglandin J2 enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPARγ pathways. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21683069 |
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| Ayoub SS et al. | Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). | 2011 | Inflamm. Res. | pmid:21667309 |
| Matsumoto T et al. | Lipocalin-type prostaglandin D synthase is associated with coronary vasospasm and vasomotor reactivity in response to acetylcholine. | 2011 | Circ. J. | pmid:21325722 |
| Cha B et al. | 15-deoxy-D12,14-prostaglandin J2 suppresses RANTES expression by inhibiting NADPH oxidase activation in Helicobacter pylori-infected gastric epithelial cells. | 2011 | J. Physiol. Pharmacol. | pmid:21673364 |
| Wang P et al. | Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2. | 2011 | PLoS ONE | pmid:22096605 |
| Maekawa N et al. | High-performance affinity purification for identification of 15-deoxy-Δ 12,14 -PGJ₂ interacting factors using magnetic nanobeads. | 2011 | Biomed. Chromatogr. | pmid:21374648 |
| Kane CJ et al. | Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists. | 2011 | Brain Behav. Immun. | pmid:21376806 |
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| MartÃnez-Gras I et al. | The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia. | 2011 | Schizophr. Res. | pmid:21334179 |
| Zhao J et al. | Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. | 2011 | J. Clin. Invest. | pmid:22105170 |
| Chbicheb S et al. | EGR1 expression: a calcium and ERK1/2 mediated PPARγ-independent event involved in the antiproliferative effect of 15-deoxy-Δ12,14-prostaglandin J2 and thiazolidinediones in breast cancer cells. | 2011 | Biochem. Pharmacol. | pmid:21338579 |
| Braciale TJ and Kim TS | Slowing down with age: lung DCs do it too. | 2011 | J. Clin. Invest. | pmid:22105176 |
| Qiu Z et al. | Cough reflex sensitivity and airway inflammation in patients with chronic cough due to non-acid gastro-oesophageal reflux. | 2011 | Respirology | pmid:21342332 |
| Wang JJ and Mak OT | Induction of apoptosis by 15d-PGJ2 via ROS formation: an alternative pathway without PPARγ activation in non-small cell lung carcinoma A549 cells. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21396480 |
| Murata T et al. | Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106279 |
| Yamamoto Y et al. | Proteomic identification of protein targets for 15-deoxy-Δ(12,14)-prostaglandin J2 in neuronal plasma membrane. | 2011 | PLoS ONE | pmid:21445266 |
| Mackay GA and Stewart AG | R2D(2) for C(4)Eo: an 'alliance' of PGD(2) receptors is required for LTC(4) production by human eosinophils. | 2011 | Br. J. Pharmacol. | pmid:21426314 |
| Huang ZL et al. | The role of adenosine in the regulation of sleep. | 2011 | Curr Top Med Chem | pmid:21401496 |
| Osanai T and Okumura K | Lipocalin-type PGD synthase as a novel biomarker for coronary vasospasm. | 2011 | Circ. J. | pmid:21378446 |
| Kamauchi S and Urade Y | [Hematopoietic prostaglandin D synthase inhibitors for the treatment of duchenne muscular dystrophy]. | 2011 | Brain Nerve | pmid:22068479 |
| Flachs P et al. | Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. | 2011 | Diabetologia | pmid:21779874 |
| Leamy AW et al. | Curcumin ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1. | 2011 | Neurosci. Lett. | pmid:21855605 |
| Sharma I et al. | In vitro effects of peroxisome proliferator-activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells. | 2011 | Fertil. Steril. | pmid:20970133 |
| Mesquita-Santos FP et al. | Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils. | 2011 | Br. J. Pharmacol. | pmid:20973774 |
| Wienecke T et al. | Discrepancy between strong cephalic arterial dilatation and mild headache caused by prostaglandin Dâ‚‚ (PGDâ‚‚). | 2011 | Cephalalgia | pmid:20974593 |
| El-Shazly AE et al. | IFN-γ and TNF-α potentiate prostaglandin D2-induced human eosinophil chemotaxis through up-regulation of CRTH2 surface receptor. | 2011 | Int. Immunopharmacol. | pmid:21835268 |
| Kuehn HS et al. | Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release. | 2011 | J. Biol. Chem. | pmid:20980255 |
| Surh YJ et al. | 15-Deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling. | 2011 | Biochem. Pharmacol. | pmid:21843512 |
| Bräutigam K et al. | Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines. | 2011 | J. Cancer Res. Clin. Oncol. | pmid:20878528 |
| Alves C et al. | Effects of 15d-PGJâ‚‚-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation. | 2011 | Br. J. Pharmacol. | pmid:20883476 |
| Lu Y et al. | Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. | 2011 | Biochem. Pharmacol. | pmid:21907188 |
| Kanda N et al. | The antimycotic drugs itraconazole and terbinafine hydrochloride induce the production of human β-defensin-3 in human keratinocytes. | 2011 | Immunobiology | pmid:20875690 |
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| Crosignani S et al. | Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. | 2011 | J. Med. Chem. | pmid:21916510 |
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| Aung G et al. | Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. | 2011 | Immunology | pmid:21214543 |
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| Lotz C et al. | Activation of peroxisome-proliferator-activated receptors α and γ mediates remote ischemic preconditioning against myocardial infarction in vivo. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21163821 |
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| Eguchi M et al. | Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor (DP)-dependent pathway. | 2011 | Clin. Exp. Immunol. | pmid:21166666 |
| Oh YC et al. | Anti-allergic effects of sinomenine by inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ in mouse bone marrow-derived mast cells. | 2011 | Immunopharmacol Immunotoxicol | pmid:21080779 |
| Cichocka-Jarosz E et al. | Serum tryptase level is a better predictor of systemic side effects than prostaglandin D2 metabolites during venom immunotherapy in children. | 2011 | J Investig Allergol Clin Immunol | pmid:21721371 |
| Nabe T et al. | Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21601002 |
| Joos H et al. | Single impact trauma in human early-stage osteoarthritic cartilage: implication of prostaglandin D2 but no additive effect of IL-1β on cell survival. | 2011 | Int. J. Mol. Med. | pmid:21567074 |
| Wang JJ and Mak OT | Induction of apoptosis in non-small cell lung carcinoma A549 cells by PGDâ‚‚ metabolite, 15d-PGJâ‚‚. | 2011 | Cell Biol. Int. | pmid:21999315 |
| Seno T et al. | 15-Deoxy-Δ¹²,¹ⴠprostaglandin J₂ reduces the formation of atherosclerotic lesions in apolipoprotein E knockout mice. | 2011 | PLoS ONE | pmid:22003398 |
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| Shinozawa T et al. | Tetranor PGDM analyses for the amyotrophic lateral sclerosis: positive and simple diagnosis and evaluation of drug effect. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22027143 |
| Chang MC et al. | Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. | 2011 | Atherosclerosis | pmid:21993412 |
| de Jong E et al. | Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. | 2011 | PLoS ONE | pmid:21957481 |
| Jin M et al. | Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ production in mouse bone marrow-derived mast cells. | 2011 | Arch. Pharm. Res. | pmid:21975811 |
| Urade Y and Hayaishi O | Prostaglandin D2 and sleep/wake regulation. | 2011 | Sleep Med Rev | pmid:22024172 |
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| Sykes L et al. | Chemoattractant receptor homologous to the T helper 2 cell (CRTH2) is not expressed in human amniocytes and myocytes. | 2012 | PLoS ONE | pmid:23226366 |
| Yamaura K et al. | Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D2 production of mast cells in a murine model of allergic contact dermatitis. | 2012 | J Toxicol Sci | pmid:23208428 |
| Bardelli C et al. | Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPARγ ligands. | 2012 | Br. J. Pharmacol. | pmid:21745193 |
| Chae HS and Chin YW | Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells. | 2012 | Immunopharmacol Immunotoxicol | pmid:21854102 |
| Kanakasabai S et al. | PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes. | 2012 | PLoS ONE | pmid:23185633 |
| Ito H et al. | PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis. | 2012 | J. Am. Soc. Nephrol. | pmid:22997255 |
| Wu CC et al. | Involvement of the prostaglandin D2 signal pathway in retinoid-inducible gene 1 (RIG1)-mediated suppression of cell invasion in testis cancer cells. | 2012 | Biochim. Biophys. Acta | pmid:22960220 |
| Song HH et al. | Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells. | 2012 | Am. J. Chin. Med. | pmid:22928836 |
| Tachikawa M et al. | A clearance system for prostaglandin D2, a sleep-promoting factor, in cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22931759 |
| Fredman G et al. | Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. | 2012 | Sci Rep | pmid:22957142 |
| Cloutier A et al. | The prostanoid 15-deoxy-Δ12,14-prostaglandin-j2 reduces lung inflammation and protects mice against lethal influenza infection. | 2012 | J. Infect. Dis. | pmid:22219346 |
| Sykes L et al. | Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2. | 2012 | Mediators Inflamm. | pmid:22690041 |
| Raman P et al. | 15-Deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor γ ligand, modulates nuclear factor of activated T cells. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22700433 |