| MeSH term | MeSH ID | Detail |
|---|---|---|
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Landar A et al. | Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16387790 |
| Rehan VK et al. | In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17215434 |
| Joo M et al. | Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19181746 |
| Ferguson HE et al. | Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19734319 |
| O'Reilly KM et al. | Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15665045 |
| Reddy RC et al. | Deactivation of murine alveolar macrophages by peroxisome proliferator-activated receptor-gamma ligands. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:14617516 |
| Rehan VK et al. | A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17435078 |
| Kajekar R et al. | Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12618420 |
| Burgess HA et al. | PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15734787 |
| Nørregaard R et al. | Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20147610 |
| Finck BN and Johnson RW | Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11959686 |
| Mouihate A et al. | Fever suppression in near-term pregnant rats is dissociated from LPS-activated signaling pathways. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16037126 |
| Hu VY et al. | COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12388444 |
| Jelson GS et al. | Modulation of guinea pig intrinsic cardiac neurons by prostaglandins. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12791585 |
| Krall CM et al. | Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20393159 |
| Whigham LD et al. | Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11893615 |
| Romanovsky AA and Garami A | Prostaglandin riddles in energy metabolism: E is for excess, D is for depletion. Focus on "Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2". | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20410482 |
| Zhang A et al. | Prostaglandin D2 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in MDCK cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16896186 |
| Adachi H et al. | Molecular characterization of human and rat organic anion transporter OATP-D. | 2003 | Am. J. Physiol. Renal Physiol. | pmid:14631946 |
| Guan Y et al. | Peroxisome proliferator-activated receptor-gamma activity is associated with renal microvasculature. | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11704554 |
| Lehmann GM et al. | Novel anti-adipogenic activity produced by human fibroblasts. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20554910 |
| Hwang J et al. | Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15590897 |
| Simonin MA et al. | PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:11742805 |
| Kasai K et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11078701 |
| Tanaka A et al. | Mast cells function as an alternative modulator of adipogenesis through 15-deoxy-delta-12, 14-prostaglandin J2. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21865589 |
| Mujumdar VS et al. | Mechanism of constrictive vascular remodeling by homocysteine: role of PPAR. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:11940516 |
| Hunt MJ and Tyagi SC | Peroxisome proliferators compete and ameliorate Hcy-mediated endocardial endothelial cell activation. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:12225971 |
| Saito S et al. | Prostaglandin D2 and reproduction. | 2002 | Am. J. Reprod. Immunol. | pmid:12148545 |
| Longphre M et al. | PAF-induced airways hyperreactivity is modulated by mast cells in mice. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8624251 |
| Zhou Q et al. | Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26488390 |
| Sanchez Mejia RO et al. | Matrix-associated transforming growth factor-beta1 primes mouse bone marrow-derived mast cells for increased high-affinity Fc receptor for immunoglobulin E-dependent eicosanoid biosynthesis. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10783127 |
| Serhan CN and Devchand PR | Novel antiinflammatory targets for asthma. A role for PPARgamma? | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11415929 |
| Wang AC et al. | Peroxisome proliferator-activated receptor-gamma regulates airway epithelial cell activation. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11415933 |
| Kohyama T et al. | PGD(2) modulates fibroblast-mediated native collagen gel contraction. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:12204901 |
| Olsen KC et al. | Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24175906 |
| Mathew B et al. | Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17204585 |
| Sayers BC et al. | Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23642096 |
| Ferguson HE et al. | Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts. | 2009 | Am. J. Respir. Cell Mol. Biol. | pmid:19286977 |
| Levasseur-Acker GM et al. | Effect of furosemide on prostaglandin synthesis by human nasal and bronchial epithelial cells in culture. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8136154 |
| Ando M et al. | Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12707014 |
| Inase N et al. | Mitogen-inducible prostaglandin G/H synthase is expressed in canine mastocytoma cells. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8217194 |
| Parameswaran K et al. | Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17431098 |
| Yang X et al. | Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:12444028 |
| Reddy RC and Standiford TJ | Nrf2 and PPAR{gamma}: PPARtnering against oxidant-induced lung injury. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20634499 |
| Mochizuki M et al. | Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:15750045 |
| Balzar S et al. | Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:20813890 |
| Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
| Macfarlane AJ et al. | Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10806153 |
| Krawiec ME et al. | Persistent wheezing in very young children is associated with lower respiratory inflammation. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11371398 |
| Hartert TV et al. | Prostaglandin E(2) decreases allergen-stimulated release of prostaglandin D(2) in airways of subjects with asthma. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10934099 |
| Kowalski ML et al. | Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10673176 |
| Szczeklik A et al. | Salmeterol prevents aspirin-induced attacks of asthma and interferes with eicosanoid metabolism. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9769277 |
| Asada K et al. | Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:14563653 |
| Polosa R et al. | Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881647 |
| Cho HY et al. | Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20224069 |
| Hanks BC et al. | Evaluation of anti-inflammatory and chondroprotective effects of peroxisome proliferator-activated receptor gamma agonists in cartilage and synovial explants from dogs. | 2010 | Am. J. Vet. Res. | pmid:20919899 |
| Beasley R et al. | Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma. | 1987 | Am. Rev. Respir. Dis. | pmid:2960256 |
| Liu MC et al. | Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:2368958 |
| Ingenito EP et al. | Bronchoalveolar lavage cell and mediator responses to hyperpnea-induced bronchoconstriction in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2339838 |
| Naclerio RM et al. | Mediator release after nasal airway challenge with allergen. | 1983 | Am. Rev. Respir. Dis. | pmid:6354022 |
| Cohan VL et al. | Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin. | 1989 | Am. Rev. Respir. Dis. | pmid:2478059 |
| Picado C et al. | Release of peptide leukotriene into nasal secretions after local instillation of aspirin in aspirin-sensitive asthmatic patients. | 1992 | Am. Rev. Respir. Dis. | pmid:1309968 |
| Wang D et al. | Aminophylline reduces air-flow-induced constriction in the canine lung periphery. | 1988 | Am. Rev. Respir. Dis. | pmid:3422143 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Gray PR et al. | The role of cyclooxygenase products in the acute airway obstruction and airway hyperreactivity of ponies with heaves. | 1989 | Am. Rev. Respir. Dis. | pmid:2502051 |
| Eggleston PA et al. | Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells. | 1990 | Am. Rev. Respir. Dis. | pmid:1691604 |
| Jongejan RC et al. | Effects of inflammatory mediators on the responsiveness of isolated human airways to methacholine. | 1990 | Am. Rev. Respir. Dis. | pmid:2240835 |
| Holgate ST | Contribution of inflammatory mediators to the immediate asthmatic reaction. | 1987 | Am. Rev. Respir. Dis. | pmid:3473955 |
| Fuller RW et al. | Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine. | 1986 | Am. Rev. Respir. Dis. | pmid:3511806 |
| Gundel RH et al. | Antigen-induced mediator release in primates. | 1991 | Am. Rev. Respir. Dis. | pmid:1648317 |
| Wang D et al. | Terbutaline acts at multiple sites to inhibit bronchoconstriction induced by dry air in canine peripheral airways. | 1992 | Am. Rev. Respir. Dis. | pmid:1595994 |
| Broide DH et al. | Airway levels of mast cell-derived mediators in exercise-induced asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:1689974 |
| Kleeberger SR et al. | The role of mediators in the response of the canine peripheral lung to 1 ppm ozone. | 1988 | Am. Rev. Respir. Dis. | pmid:2829670 |
| Fernández PL | [Stress and inflammatory bowell disease (I.B.D). Therapeutic strategies]. | 2006 | An R Acad Nac Med (Madr) | pmid:17172222 |
| Koyama J et al. | Simultaneous determination of histamine and prostaglandin D2 using an LC-ESI-MS/MS method with positive/negative ion-switching ionization modes: application to the study of anti-allergic flavonoids on the degranulation of KU812 cells. | 2011 | Anal Bioanal Chem | pmid:21725829 |
| Hirano A et al. | Arachidonic acid-induced channel- and carrier-type ion transport across planar bilayer lipid membranes. | 2003 | Anal Sci | pmid:12608744 |
| Chen Q et al. | A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. | 2004 | Anal. Biochem. | pmid:15556564 |
| Zorrilla S et al. | Selective binding of the fluorescent dye 1-anilinonaphthalene-8-sulfonic acid to peroxisome proliferator-activated receptor gamma allows ligand identification and characterization. | 2010 | Anal. Biochem. | pmid:20025845 |
| Cao H et al. | An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids. | 2008 | Anal. Biochem. | pmid:17976507 |
| Welter H et al. | Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients. | 2013 | Andrology | pmid:23413143 |
| Araki M et al. | Isoflurane modulates phorbol myristate acetate-, prostaglandin D2-, and prostaglandin E2-induced alterations in hepatic flow and metabolism in the perfused liver in fasted rats. | 1994 | Anesth. Analg. | pmid:7639362 |
| Stellato C et al. | Human basophil/mast cell releasability. IX. Heterogeneity of the effects of opioids on mediator release. | 1992 | Anesthesiology | pmid:1280014 |
| Kashani IA et al. | Effects of prostaglandins on the pulmonary vascular bed of newborn rats with chronic hypoxia. | 1986 | Angiology | pmid:3511774 |
| Cichocka-Jarosz E et al. | Impact of Hymenoptera venom allergy and the effects of specific venom immunotherapy on mast cell metabolites in sensitized children. | 2014 | Ann Agric Environ Med | pmid:24959779 |
| Campbell AM et al. | Conjunctival provocation tests with codeine phosphate. Effect of disodium cromoglycate. | 1993 | Ann Allergy | pmid:7687104 |
| Naclerio RM | Effects of antihistamines on inflammatory mediators. | 1993 | Ann Allergy | pmid:7690526 |
| Campbell AM et al. | In vitro activation of bronchoalveolar lavage cells by house dust mite allergens. | 1992 | Ann Allergy | pmid:1371209 |
| Wasserman SI | Basic mechanisms in asthma. | 1988 | Ann Allergy | pmid:3163472 |
| Small P et al. | Effects of intensity of early response to allergen on the late phase of both the nose and skin. | 1994 | Ann Allergy | pmid:8092561 |
| Orfan N et al. | Systemic cold urticaria in a five-year-old boy. | 1991 | Ann Allergy | pmid:1867452 |
| Marone G et al. | Mechanisms of activation of human mast cells and basophils by general anesthetic drugs. | 1993 | Ann Fr Anesth Reanim | pmid:7690200 |
| Fujishima H et al. | Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. | 2013 | Ann. Allergy Asthma Immunol. | pmid:23886231 |
| Small P and Barrett D | Evaluation of dust and dust mite nasal provocation. | 1995 | Ann. Allergy Asthma Immunol. | pmid:8603280 |
| Rank MA et al. | Systemic reactions to allergen immunotherapy: a role for measuring a PGD2 metabolite? | 2013 | Ann. Allergy Asthma Immunol. | pmid:23244662 |
| Chiba T et al. | The opposing role of two prostaglandin D2 receptors, DP and CRTH2, in human eosinophil migration. | 2011 | Ann. Allergy Asthma Immunol. | pmid:21624751 |
| Leynadier F | [Mast cells and basophils in asthma]. | 1989 | Ann. Biol. Clin. (Paris) | pmid:2675683 |
| Liu JJ et al. | Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. | 2007 | Ann. Hematol. | pmid:17089125 |
| Polosa R et al. | [Mast cell mediator release after endobronchial challenge with adenosine 5'-monophosphate in asthmatic subjects]. | 1994 Apr-Jun | Ann. Ital. Med. Int. | pmid:7522500 |
| Figueiredo-Pereira ME et al. | Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. | 2016 | Ann. N. Y. Acad. Sci. | pmid:26748744 |
| Fukushima M et al. | Prostaglandin J2 and related compounds. Mode of action in G1 arrest and preclinical results. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825837 |