| MeSH term | MeSH ID | Detail |
|---|---|---|
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
| Viganò T et al. | Stimulus-related difference in the formation of leukotrienes and PGD2 after immunological and non-immunological challenge of human lung parenchyma "in vitro". | 1986 | Prostaglandins Leukot Med | pmid:3020580 |
| Burrall B and Ziboh VA | Increased biosynthesis of lipoxygenase products by UVB-irradiated guinea pig epidermis: evidence of a cyclooxygenase inhibitor. | 1986 | J. Invest. Dermatol. | pmid:3086462 |
| Koshihara Y and Kawamura M | Inhibitory effect of prostaglandin D2 on DNA synthesis in nuclei. | 1986 | Prostaglandins Leukot Med | pmid:3020589 |
| Jaschonek K et al. | The binding of 6-oxo-prostaglandin E1 to platelet prostanoid receptors. | 1986 | Prostaglandins Leukot Med | pmid:3020591 |
| Inokuchi A and Oomura Y | Effects of prostaglandin D2 on the activity of hypothalamic neurons in the rat. | 1986 | Jpn. J. Physiol. | pmid:3022048 |
| Saito H et al. | Bio-synthesis of PGD2 and TXB2 by rabbit blood monocytes. | 1986 | Prostaglandins | pmid:3086936 |
| Hickok NJ et al. | Characterization of prostaglandin endoperoxide synthase from a human cell line. | 1986 | Biochim. Biophys. Acta | pmid:3087430 |
| MacIntyre DE et al. | Receptors and receptor mechanisms of endogenous platelet stimulatory and inhibitory mediators. | 1986 | Agents Actions Suppl. | pmid:3028106 |
| Tanaka A et al. | Antiherpetic action of prostaglandin D2. | 1986 | Prostaglandins Leukot Med | pmid:3029784 |
| Watanabe K | [PGF synthetase]. | 1986 | Seikagaku | pmid:3084680 |
| Blomgren H et al. | Prostaglandin sensitivity of the PHA-response of blood lymphocytes following radiation therapy for breast cancer. | 1986 | Radiother Oncol | pmid:3466235 |
| Kriseman T et al. | Analysis of airway responses to A23187 in the cat. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3095538 |
| Shimizu Y et al. | Cycloheximide reduces PGD2 or delta 12-PGJ2 cytotoxicity on NCG cells. | 1986 | Prostaglandins | pmid:3099333 |
| Bregman MD et al. | Inhibition of human melanoma growth by prostaglandin A, D, and J analogues. | 1986 | Cancer Res. | pmid:3698005 |
| Kato T et al. | Antitumor activity of delta 7-prostaglandin A1 and delta 12-prostaglandin J2 in vitro and in vivo. | 1986 | Cancer Res. | pmid:3708585 |
| Horiguchi S et al. | Alterations in nociception after intracisternal administration of prostaglandin D2, E2 or F2 alpha to conscious mice. | 1986 | Eur. J. Pharmacol. | pmid:3458588 |
| Zavoico GB et al. | Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs. | 1986 | J. Biol. Chem. | pmid:3020026 |
| Gaetani P et al. | Prostaglandin D2 monitoring in human CSF after subarachnoid hemorrhage: the possible role of prostaglandin D2 in the genesis of cerebral vasospasm. | 1986 | Ital J Neurol Sci | pmid:3456998 |
| Sugiyama T et al. | Platelet prostaglandin D2 dehydrogenase in patients with myeloproliferative disorders. | 1986 | Prostaglandins Leukot Med | pmid:3457389 |
| Omini C et al. | Prostaglandin D2 (PGD2) potentiates cholinergic responsiveness in guinea-pig trachea. | 1986 | J Auton Pharmacol | pmid:3464602 |
| Kikuchi Y et al. | Inhibition of human ovarian cancer cell growth in vitro and in nude mice by prostaglandin D2. | 1986 | Cancer Res. | pmid:3458525 |
| Hamilton RG et al. | Dirofilaria immitis: diethylcarbamazine-induced anaphylactoid reactions in infected dogs. | 1986 | Exp. Parasitol. | pmid:3458592 |
| Nakagawa Y et al. | [Effect of prostaglandin D2 on the growth of mouse glioma]. | 1986 | Gan To Kagaku Ryoho | pmid:3459395 |
| Naclerio R et al. | The role of inflammatory mediators in allergic rhinitis. | 1986 | Ear Nose Throat J | pmid:3459645 |
| Wogensen L and Warberg J | Effect of prostaglandin D2 on the release of luteinizing hormone and prolactin in castrated and intact male rats. | 1986 | Acta Endocrinol. | pmid:3461657 |
| Murray JJ et al. | Release of prostaglandin D2 into human airways during acute antigen challenge. | 1986 | N. Engl. J. Med. | pmid:3462506 |
| Honda C and Tabuchi K | [Effects of prostaglandin D2 on cultured glioma cells]. | 1986 | Gan To Kagaku Ryoho | pmid:3463248 |
| Nelson CA and Seamon KB | Binding of [3H]forskolin to human platelet membranes. Regulation by guanyl-5'-yl imidodiphosphate, NaF, and prostaglandins E1 and D2. | 1986 | J. Biol. Chem. | pmid:3463564 |
| Black JL et al. | A comparison of the contractile activity of PGD2 and PGF2 alpha on human isolated bronchus. | 1986 | Prostaglandins | pmid:3464041 |
| Sago T et al. | Metabolism of prostaglandins D2 and F2 alpha in primary cultures of rat hepatocytes. | 1986 | Biochim. Biophys. Acta | pmid:3465372 |
| Suzuki F et al. | Transport of prostaglandin D2 into brain. | 1986 | Brain Res. | pmid:3465420 |
| Makhoul RG and Gewertz BL | Renal prostaglandins. | 1986 | J. Surg. Res. | pmid:3511324 |
| Dutta-Roy AK et al. | Prostacyclin stimulation of the activation of blood coagulation factor X by platelets. | 1986 | Science | pmid:3001935 |
| Kashani IA et al. | Effects of prostaglandins on the pulmonary vascular bed of newborn rats with chronic hypoxia. | 1986 | Angiology | pmid:3511774 |
| Fuller RW et al. | Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine. | 1986 | Am. Rev. Respir. Dis. | pmid:3511806 |
| Blockmans D et al. | Heparin-induced thrombocytopenia platelet aggregation studies in the presence of heparin fractions or semi-synthetic analogues of various molecular weights and anticoagulant activities. | 1986 | Thromb. Haemost. | pmid:3518134 |
| Lumsden MA et al. | Changes in the concentration of prostaglandins in preovulatory human follicles after administration of hCG. | 1986 | J. Reprod. Fertil. | pmid:3459888 |
| Holgate ST | The role of mast cells in the pathogenesis of asthma. | 1985 Sep-Oct | Bull Eur Physiopathol Respir | pmid:2415192 |
| Korbut R and Gryglewski RJ | Anti-aggregatory prostanoids. Part I. | 1985 Sep-Dec | Acta Physiol Pol | pmid:3915631 |
| Nolan PN et al. | Participation of prostanoids in chemical activation of the pericardial pressor reflex in dogs. | 1985 Jan-Feb | Clin. Exp. Pharmacol. Physiol. | pmid:3924453 |
| Schick B and Austen KF | Pharmacological modulation of activation-secretion of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1985 | Immunology | pmid:3935569 |
| Fitscha P et al. | Platelet sensitivity to antiaggregatory prostaglandins (PGE1,D2,I2) in patients with peripheral vascular disease. | 1985 | Am. J. Hematol. | pmid:3885723 |
| Schulman ES and Anderson CL | Lung hypersensitivity responses: dissociation of human lung mast cell leukotriene C4 (LTC4) from histamine release. | 1985 | Prog. Clin. Biol. Res. | pmid:2415994 |
| Creticos PS et al. | Nasal challenge with ragweed pollen in hay fever patients. Effect of immunotherapy. | 1985 | J. Clin. Invest. | pmid:2416777 |
| Beatty CH et al. | Metabolism of arachidonic acid by macaque platelets. Implications for studies on atherosclerosis. | 1985 | Atherosclerosis | pmid:3924062 |
| Arisawa M et al. | Suppressive effect of prostaglandin D2 on prolactin secretion from rat anterior pituitary. | 1985 | Asia Oceania J Obstet Gynaecol | pmid:3860198 |
| Spannhake EW et al. | Influence of mediators of anaphylaxis on collateral ventilation and the lung periphery of the dog. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3860642 |
| Nielsen JA and Sparber SB | Central administration of prostaglandin E2 facilitates while F2 alpha attenuates acute dependence upon morphine rats. | 1985 | Pharmacol. Biochem. Behav. | pmid:3860881 |
| Bhattacharya SK and Parmar SS | Prostaglandin D2-induced potentiation of hexobarbitone hypnosis in rats: role of 5-hydroxytryptamine. | 1985 | J. Pharm. Pharmacol. | pmid:2868104 |