| MeSH term | MeSH ID | Detail |
|---|---|---|
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sirén AL | Central cardiovascular and thermal effects of prostaglandin D2 in rats. | 1982 | Prostaglandins Leukot Med | pmid:6955803 |
| Mitchell MD et al. | The human placenta: a major source of prostaglandin D2. | 1982 | Prostaglandins Leukot Med | pmid:6955806 |
| Koshihara Y and Kawamura M | Inhibitory effect of prostaglandin D2 on DNA synthesis in nuclei. | 1986 | Prostaglandins Leukot Med | pmid:3020589 |
| Förstermann U et al. | Studies on the mechanism of central cardiovascular and temperature responses to prostaglandin D2. | 1985 | Prostaglandins Leukot Med | pmid:2991946 |
| Jaschonek K et al. | The binding of 6-oxo-prostaglandin E1 to platelet prostanoid receptors. | 1986 | Prostaglandins Leukot Med | pmid:3020591 |
| Vincent JE et al. | The effect of 5-(2-chlorobenzyl)-5,6,7,7a-tetrahydro 4H-thieno (3.2-C)-pyridine-2-one hydrochloride (PCR 3787), a metabolite of ticlopidine, on the aggregation of human platelets in vitro and on the aggregation inhibiting action of PGI2 and PGD2. | 1984 | Prostaglandins Leukot Med | pmid:6396655 |
| Gardiner PJ and Browne JL | Tussive activity of inhaled PGD2 in the cat and characterisation of the receptor(s) involved. | 1984 | Prostaglandins Leukot Med | pmid:6328541 |
| Strobl-Jäger E et al. | Influence of type IIa, IIb and IV-hyperlipoproteinemia on platelet prostaglandin sensitivity, plasma thromboxane B2 and platelet half-life. | 1986 | Prostaglandins Leukot Med | pmid:3540998 |
| Okamatsu S and Lefer AM | Cardiac effects of prostaglandins during global ischemia in isolated perfused cat hearts. | 1982 | Prostaglandins Leukot Med | pmid:6952273 |
| Giles H and Leff P | The biology and pharmacology of PGD2. | 1988 | Prostaglandins | pmid:3283848 |
| Ishizawa M and Minowa T | Effects of PGD2 and PGF2 alpha on longitudinal and circular muscles of guinea-pig isolated proximal colon. | 1982 | Prostaglandins | pmid:6962973 |
| Wendling MG and DuCharme DW | Cardiovascular effects of prostaglandin D3 and D2 in anesthetized dogs. | 1981 | Prostaglandins | pmid:6945633 |
| Toda N | Different responsiveness of a variety of isolated dog arteries to prostaglandin D2. | 1982 | Prostaglandins | pmid:6950464 |
| Barrow SE et al. | Measurement of prostaglandin D2 and identification of metabolites in human plasma during intravenous infusion. | 1984 | Prostaglandins | pmid:6441188 |
| Saito H et al. | Bio-synthesis of PGD2 and TXB2 by rabbit blood monocytes. | 1986 | Prostaglandins | pmid:3086936 |
| Li Y et al. | Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes. | 1997 | Prostaglandins | pmid:9380795 |
| Okumura T and Saito K | Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver. | 1990 | Prostaglandins | pmid:2353117 |
| Norwitz ER et al. | Prostaglandin production by human peripheral blood monocytes changes with in vitro differentiation. | 1996 | Prostaglandins | pmid:8792444 |
| Mitsuoka S et al. | Inhibitory effect of prostaglandin delta 12-PGJ2 on cell proliferation and alpha-fetoprotein expression in HuH-7 human hepatoma cells. | 1992 | Prostaglandins | pmid:1371888 |
| Taber DF et al. | A nomenclature system for the isoprostanes. | 1997 | Prostaglandins | pmid:9112285 |
| Westcott JY and Murphy RC | The interaction of ethanol and exogenous arachidonic acid in the formation of leukotrienes and prostaglandin D2 in mastocytoma cells. | 1983 | Prostaglandins | pmid:6316419 |
| McGuire JC et al. | Production of prostaglandin D2 by murine macrophage cell lines. | 1985 | Prostaglandins | pmid:3937182 |
| Huttemeier PC et al. | Microdialysis measurements of PGD2, TXB2 and 6-KETO-PGF1 alpha in rat CA1 hippocampus during transient cerebral ischemia. | 1993 | Prostaglandins | pmid:8430228 |
| Town MH et al. | Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors. | 1983 | Prostaglandins | pmid:6302737 |
| Tynan SS et al. | On the multiplicity of platelet prostaglandin receptors. II. The use of N-0164 for distinguishing the loci of action for PGI2, PGD2, PGE2 and hydantoin analogs. | 1984 | Prostaglandins | pmid:6087417 |
| Tasaki Y et al. | Prostaglandin D2 metabolite stimulates collagen synthesis by human osteoblasts during calcification. | 1991 | Prostaglandins | pmid:1871375 |
| Whittle BJ et al. | Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue. | 1983 | Prostaglandins | pmid:6344147 |
| Kawamura M and Koshihara Y | Prostaglandin D2 lowers nuclear DNA polymerase activity in cultured mastocytoma cells. | 1984 | Prostaglandins | pmid:6427850 |
| Ramis I et al. | In vivo release of 15-HETE and other arachidonic acid metabolites in nasal secretions during early allergic reactions. | 1991 | Prostaglandins | pmid:1662405 |
| Hata Y et al. | Primary colonic epithelial cell culture of the rabbit producing prostaglandins. | 1993 | Prostaglandins | pmid:8430223 |
| Gimeno AL et al. | Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats. | 1983 | Prostaglandins | pmid:6361911 |
| Gerritsen ME and Printz MP | Prostaglandin D synthase in microvessels from the rat cerebral cortex. | 1981 | Prostaglandins | pmid:6119739 |
| Shimizu Y et al. | Selective synthesis and retention of 66k protein in a human neuroblastoma cell line (NCG) treated with a cytotoxic dosage of delta 12-prostaglandin J2. | 1987 | Prostaglandins | pmid:3449899 |
| Maclouf J et al. | Development of a radioimmunoassay for prostaglandin D2 using an antiserum against 11-methoxime prostaglandin D2. | 1986 | Prostaglandins | pmid:3456623 |
| Seiler S et al. | SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors. | 1990 | Prostaglandins | pmid:2171039 |
| Ikai K et al. | Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice. | 1984 | Prostaglandins | pmid:6435183 |
| Alvarez R et al. | Stimulation of prostaglandin D2 receptors on human platelets by analogs of prostacyclin. | 1991 | Prostaglandins | pmid:1775633 |
| Ashida Y et al. | A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | 1989 | Prostaglandins | pmid:2748922 |
| Raisz LG and Woodiel FN | Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. | 1989 | Prostaglandins | pmid:2727307 |
| Lysz TW et al. | Kupffer cell-hepatocyte interactions and the changes in 1-14C-arachidonate incorporation in response to endotoxin in vitro. | 1990 | Prostaglandins | pmid:2112770 |
| Bulbena O et al. | Mast cells in the rat gastric mucosa are not primarily responsible for PGD2 generation. | 1991 | Prostaglandins | pmid:1871377 |
| Heavey DJ et al. | Effects of intravenous infusions of prostaglandin D2 in man. | 1984 | Prostaglandins | pmid:6596653 |
| Hayashi H et al. | Determination of 9 alpha, 11 beta-prostaglandin F2 by stereospecific antibody in various rat tissues. | 1987 | Prostaglandins | pmid:3474704 |
| Nakahata N et al. | PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells. | 1990 | Prostaglandins | pmid:2177901 |
| Ishizawa M | Contractile effects of PGD2 and PGF2 alpha on mechanical and electrical activities in longitudinal and circular muscles of the guinea-pig colon. | 1983 | Prostaglandins | pmid:6580679 |
| Bregman MD and Meyskens FL | In vitro modulation of human and murine melanoma growth by prostanoid analogues. | 1983 | Prostaglandins | pmid:6581509 |
| Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human malignant tumor cells. | 1984 | Prostaglandins | pmid:6584941 |
| Nakajima M and Toda N | Neuroeffector actions of prostaglandin D2 on isolated dog mesenteric arteries. | 1984 | Prostaglandins | pmid:6587438 |
| Smith GS et al. | Adaptive cytoprotection against alcohol injury in the rat stomach is not due to increased prostanoid synthesis. | 1991 | Prostaglandins | pmid:1906621 |
| Xu L et al. | Effect of culture conditions on mast cell eicosanoid synthesis. | 1993 | Prostaglandins | pmid:8493360 |