| MeSH term | MeSH ID | Detail |
|---|---|---|
| Graves Ophthalmopathy | D049970 | 3 associated lipids |
| Cryptococcosis | D003453 | 3 associated lipids |
| Cholangitis | D002761 | 3 associated lipids |
| Leukemia, B-Cell | D015448 | 3 associated lipids |
| Dirofilariasis | D004184 | 3 associated lipids |
| Urticaria Pigmentosa | D014582 | 4 associated lipids |
| Meningoencephalitis | D008590 | 4 associated lipids |
| Coronavirus Infections | D018352 | 4 associated lipids |
| Nasal Obstruction | D015508 | 4 associated lipids |
| Idiopathic Pulmonary Fibrosis | D054990 | 4 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Itoh K et al. | Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). | 2004 | Mol. Cell. Biol. | pmid:14673141 |
| Kasim-Karakas SE et al. | Metabolic and endocrine effects of a polyunsaturated fatty acid-rich diet in polycystic ovary syndrome. | 2004 | J. Clin. Endocrinol. Metab. | pmid:14764771 |
| Hirai H | [Prostaglandin D2 in allergy: PGD2 has dual receptor systems]. | 2004 | Nippon Yakurigaku Zasshi | pmid:14695454 |
| Uehara Y | [PGD(2)/L-PGDS system in hypertension and renal injury]. | 2004 | Nippon Yakurigaku Zasshi | pmid:14695455 |
| Miwa Y et al. | Physiology and pharmacology of the prostaglandin J2 family. | 2004 | Nippon Yakurigaku Zasshi | pmid:14695456 |
| Fernández-Tome M et al. | COX-2-mediated PGD2 synthesis regulates phosphatidylcholine biosynthesis in rat renal papillary tissue. | 2004 | Biochem. Pharmacol. | pmid:14698037 |
| Matsuo T et al. | 15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14741709 |
| Józkowicz A et al. | Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14715242 |
| Neuhofer W et al. | Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats. | 2004 | Kidney Int. | pmid:14717913 |
| Ward JE et al. | PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. | 2004 | Br. J. Pharmacol. | pmid:14718259 |
| Ray DM et al. | Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. | 2004 | Clin. Immunol. | pmid:15451478 |
| Abraha D et al. | (S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model. | 2004 | Int. Arch. Allergy Immunol. | pmid:15031612 |
| Rodway HA et al. | Lysophosphatidic acid attenuates the cytotoxic effects and degree of peroxisome proliferator-activated receptor gamma activation induced by 15-deoxyDelta12,14-prostaglandin J2 in neuroblastoma cells. | 2004 | Biochem. J. | pmid:15171682 |
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| Weber SM et al. | PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:14600076 |
| Grau R et al. | Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. | 2004 | Cancer Res. | pmid:15289320 |
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| Szczeklik W et al. | Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma. | 2004 | J. Allergy Clin. Immunol. | pmid:15316498 |
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| Shahab R et al. | Prostaglandins, leukotrienes and perennial rhinitis. | 2004 | J Laryngol Otol | pmid:15318955 |
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| Sommer A et al. | A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2. | 2003 | Infect. Immun. | pmid:12761146 |
| Irikura D et al. | Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme. | 2003 | J. Biochem. | pmid:12761195 |
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| Zhuang H et al. | Regulation of heme oxygenase expression by cyclopentenone prostaglandins. | 2003 | Exp. Biol. Med. (Maywood) | pmid:12709576 |
| Kämpfer H et al. | Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair. | 2003 | J. Invest. Dermatol. | pmid:12713596 |
| Brown JR et al. | Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD). | 2003 | J. Leukoc. Biol. | pmid:12714573 |
| Tautenhahn A et al. | Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis. | 2003 | J. Leukoc. Biol. | pmid:12714582 |
| Winnett G et al. | Prostaglandin J2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy. | 2003 | Int. J. Cancer | pmid:12494466 |
| Kalla R et al. | Loss of microglial ramification in microglia-astrocyte cocultures: involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems. | 2003 | Glia | pmid:12465045 |
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