PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Airway Remodeling D056151 3 associated lipids
HTLV-I Infections D015490 3 associated lipids
Respiratory Sounds D012135 3 associated lipids
Ascariasis D001196 3 associated lipids
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Goiter D006042 4 associated lipids
Headache D006261 4 associated lipids
Actinobacillus Infections D000189 4 associated lipids
Urticaria Pigmentosa D014582 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Halenda SP et al. Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets. 1986 FEBS Lett. pmid:3015684
Murakami M et al. Detection of secretory phospholipase A2s related but not identical to type IIA isozyme in cultured mast cells. 1997 FEBS Lett. pmid:9280291
Toyomoto M et al. Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures. 2004 FEBS Lett. pmid:15044028
Faveeuw C et al. Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells. 2000 FEBS Lett. pmid:11119715
Gayarre J et al. Differential selectivity of protein modification by the cyclopentenone prostaglandins PGA1 and 15-deoxy-Delta12,14-PGJ2: role of glutathione. 2005 FEBS Lett. pmid:16223487
Na HK et al. ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells. 2005 FEBS Lett. pmid:16253239
Bushfield M et al. Effects of protein kinase C activation on human platelet cyclic AMP metabolism. 1987 FEBS Lett. pmid:2820806
Ianaro A et al. 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB. 2003 FEBS Lett. pmid:14550540
Lee JH et al. Induction of p53 and apoptosis by delta 12-PGJ2 in human hepatocarcinoma SK-HEP-1 cells. 1995 FEBS Lett. pmid:7628635
Boyault S et al. 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway. 2004 FEBS Lett. pmid:15304320
Ianaro A et al. Role of cyclopentenone prostaglandins in rat carrageenin pleurisy. 2001 FEBS Lett. pmid:11707269
Murakami M et al. Eicosanoid generation from antigen-primed mast cells by extracellular mammalian 14-kDa group II phospholipase A2. 1991 FEBS Lett. pmid:1756867
Tanimoto A et al. Histamine increases the expression of LOX-1 via H2 receptor in human monocytic THP-1 cells. 2001 FEBS Lett. pmid:11728449
Boyault S et al. 15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways. 2001 FEBS Lett. pmid:11457450
Pritts EA et al. Peroxisome proliferator-activated receptor-gamma ligand inhibition of RANTES production by human endometriotic stromal cells is mediated through an upstream promoter element. 2003 Fertil. Steril. pmid:12909507
Sharma I et al. In vitro effects of peroxisome proliferator-activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells. 2011 Fertil. Steril. pmid:20970133
Bennegård B et al. Luteotropic effects of prostaglandins I2 and D2 on isolated human corpora luteum. 1990 Fertil. Steril. pmid:2168845
Wanichkul T et al. Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells. 2003 Fertil. Steril. pmid:12620489
Lu Y et al. Anti-inflammatory activity of hexane extracts from bones and internal organs of Anguilla japonica suppresses cyclooxygenase-2-dependent prostaglandin Dâ‚‚ generation in mast cells and anaphylaxis in mice. 2013 Food Chem. Toxicol. pmid:23562928
Lu Y et al. Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells. 2012 Food Chem. Toxicol. pmid:22154852
Pizzimenti S et al. Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation. 2002 Free Radic. Biol. Med. pmid:11827749
Kim YS et al. Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity. 2005 Free Radic. Biol. Med. pmid:15589375
Erttmann SF et al. PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2. 2011 Free Radic. Biol. Med. pmid:21651978
Kitz K et al. 15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. 2011 Free Radic. Biol. Med. pmid:21236332
Kim KH et al. Nrf2 is essential for the expression of lipocalin-prostaglandin D synthase induced by prostaglandin D2. 2013 Free Radic. Biol. Med. pmid:24029383
Jeng JH et al. Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. 2002 Free Radic. Biol. Med. pmid:11978487
Moon TC and Befus AD Exogenous nitric oxide regulates cyclooxygenase-2 expression and prostaglandin D(2) generation through p38 MAPK in mouse bone marrow-derived mast cells. 2008 Free Radic. Biol. Med. pmid:18598759
Masini E et al. Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic. 2005 Free Radic. Biol. Med. pmid:16043023
Ishii T Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation. 2015 Free Radic. Biol. Med. pmid:25968070
Cerbone A et al. 4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells. 2007 Free Radic. Biol. Med. pmid:17462534
Higdon AN et al. Methods for imaging and detecting modification of proteins by reactive lipid species. 2009 Free Radic. Biol. Med. pmid:19446632
Brechbuhl HM et al. Select cyclopentenone prostaglandins trigger glutathione efflux and the role of ABCG2 transport. 2009 Free Radic. Biol. Med. pmid:19520157
Lee E et al. 15-Deoxy-Δ12,14-prostaglandin J₂ modulates manganese-induced activation of the NF-κB, Nrf2, and PI3K pathways in astrocytes. 2012 Free Radic. Biol. Med. pmid:22245093
Niki E Lipid peroxidation: physiological levels and dual biological effects. 2009 Free Radic. Biol. Med. pmid:19500666
Kansanen E et al. Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2. 2009 Free Radic. Biol. Med. pmid:19573595
Lin YC et al. The glutathionylation of p65 modulates NF-κB activity in 15-deoxy-Δ¹²,¹⁴-prostaglandin J₂-treated endothelial cells. 2012 Free Radic. Biol. Med. pmid:22387200
Kang ES et al. 15-Deoxy-Δ(12,14)-prostaglandin J2 prevents oxidative injury by upregulating the expression of aldose reductase in vascular smooth muscle cells. 2014 Free Radic. Res. pmid:24180671
Bolton C et al. N-Methyl-D-aspartate (NMDA) receptor involvement in central nervous system prostaglandin production during the relapse phase of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE). 2013 Fundam Clin Pharmacol pmid:22742874
Fukushima M et al. [Antineoplastic action of prostaglandin D2--effect of PGD2 on proliferation of L1210 leukemic cells in culture]. 1982 Gan To Kagaku Ryoho pmid:6964030
Ishikawa H et al. [Changes of protein and RNA content in accumulated G1 cells by delta12-PGJ2]. 1989 Gan To Kagaku Ryoho pmid:2930205
Nakagawa Y et al. [Effect of prostaglandin D2 on the growth of mouse glioma]. 1986 Gan To Kagaku Ryoho pmid:3459395
Honda C and Tabuchi K [Effects of prostaglandin D2 on cultured glioma cells]. 1986 Gan To Kagaku Ryoho pmid:3463248
Fukushima M [Development of antineoplastic prostaglandins]. 1983 Gan To Kagaku Ryoho pmid:6577812
Imashuku S et al. [Differentiation induction and potentiation of chemotherapy by PGE1 infusion in patients with neuroblastoma--effect of PGE1 on metastatic potential of neuroblastoma]. 1984 Gan To Kagaku Ryoho pmid:6585182
Matsuura H and Imaya H [Effect of prostaglandin (delta 12-PGJ2) on host immunity--an experimental study]. 1987 Gan To Kagaku Ryoho pmid:3592721
Koyama Y et al. Prostaglandin production by isolated Kupffer cells. 1990 Gastroenterol. Jpn. pmid:2227259
Fox CC et al. Enhancement of human intestinal mast cell mediator release in active ulcerative colitis. 1990 Gastroenterology pmid:1693122
Li L et al. Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts. 2003 Gastroenterology pmid:12891549
Santos J et al. Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropin-releasing hormone in rats. 1996 Gastroenterology pmid:8942724
Goerg KJ et al. Inhibition of neuronally mediated secretion in rat colonic mucosa by prostaglandin D2. 1992 Gastroenterology pmid:1379954
Marra F et al. Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. 2000 Gastroenterology pmid:10930382
Ponferrada A et al. The role of PPARgamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction. 2007 Gastroenterology pmid:17484875
Kawada N et al. Possible induction of fatty acid cyclo-oxygenase in lipopolysaccharide-stimulated rat Kupffer cells. 1992 Gastroenterology pmid:1499903
Reddy PS et al. The synthesis and effects of prostaglandins on the ovary of the crab Oziotelphusa senex senex. 2004 Gen. Comp. Endocrinol. pmid:14644642
Matzkin ME et al. Exploring the cyclooxygenase 2 (COX2)/15d-Δ(12,14)PGJ(2) system in hamster Sertoli cells: regulation by FSH/testosterone and relevance to glucose uptake. 2012 Gen. Comp. Endocrinol. pmid:22974512
Suzuki K et al. Inhibition of human gingival carcinoma cell growth by prostaglandins. 1988 Gen. Pharmacol. pmid:3162424
Fujimori K et al. Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. 2008 Gene pmid:18817855
Hossain MS et al. Prostaglandin J2 series induces the gene expression of monocyte chemoattractant protein-1 during the maturation phase of cultured adipocytes. 2012 Gene pmid:22561694
Quinkler M et al. Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis. 2006 Gene pmid:16842938
Fujimori K et al. Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways. 2012 Gene pmid:22664386
Tsujita T et al. Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish. 2011 Genes Cells pmid:21143560
Kobayashi M et al. ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. 2006 Genes Cells pmid:16824197
Natarajan C and Bright JJ Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. 2002 Genes Immun. pmid:11960303
Li XY et al. 15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation. 2015 Genet. Mol. Res. pmid:26535717
Kanda H et al. COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons. 2013 Glia pmid:23505121
Ito S et al. Type-1 and type-2 astrocytes are distinct targets for prostaglandins D2, E2, and F2 alpha. 1992 Glia pmid:1324890
Mohri I et al. Hematopoietic prostaglandin D synthase is expressed in microglia in the developing postnatal mouse brain. 2003 Glia pmid:12673832
Kerr BJ et al. The protective effects of 15-deoxy-delta-(12,14)-prostaglandin J2 in spinal cord injury. 2008 Glia pmid:18205174
Kalla R et al. Loss of microglial ramification in microglia-astrocyte cocultures: involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems. 2003 Glia pmid:12465045
Nakajima M et al. Effects of prostaglandin D2 and its analogue, BW245C, on intraocular pressure in humans. 1991 Graefes Arch. Clin. Exp. Ophthalmol. pmid:1937072
Shimada T et al. Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. 2002 Gut pmid:11950812
Zamuner SR et al. Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction. 2003 Gut pmid:14633948
Santos J et al. Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy. 1999 Gut pmid:10486364
Preclik G et al. Alimentary tract and pancreas. Stimulation of mucosal prostaglandin synthesis in human stomach and duodenum by antacid treatment. 1989 Gut pmid:2703138
Lanas AI et al. Non-steroidal anti-inflammatory drugs and prostaglandin effects on pepsinogen secretion by dispersed human peptic cells. 1995 Gut pmid:7797113
Leung WK et al. Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. 2004 Gut pmid:14960510
Sasaki H et al. Human ovarian cancer cell lines resistant to cisplatin, doxorubicin, and L-phenylalanine mustard are sensitive to delta 7-prostaglandin A1 and delta 12-prostaglandin J2. 1991 Gynecol. Oncol. pmid:2026357
Gensini GF et al. Ticlopidine activity on platelet function in patients with enhanced platelet aggregation. A short-term crossover study. 1983 Haemostasis pmid:6228500
Egan K and FitzGerald GA Eicosanoids and the vascular endothelium. 2006 Handb Exp Pharmacol pmid:16999220
Yuan Z et al. Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. 2005 Heart pmid:15774612
Johnston DE and Kroening C Stimulation of prostaglandin synthesis in cultured liver cells by CCl4. 1996 Hepatology pmid:8781342
Galli A et al. Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells. 2000 Hepatology pmid:10613734
Fennekohl A et al. Induction by interleukin 6 of G(s)-coupled prostaglandin E(2) receptors in rat hepatocytes mediating a prostaglandin E(2)-dependent inhibition of the hepatocyte's acute phase response. 2000 Hepatology pmid:10796889
Wettstein M and Häussinger D Cytoprotection by the osmolytes betaine and taurine in ischemia-reoxygenation injury in the perfused rat liver. 1997 Hepatology pmid:9397998
Hashimoto N et al. Prostanoid secretion by rat hepatic sinusoidal endothelial cells and its regulation by exogenous adenosine triphosphate. 1995 Hepatology pmid:7768516
Püschel GP et al. Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a. 1993 Hepatology pmid:8244278
Hespeling U et al. Feedback-inhibition of glucagon-stimulated glycogenolysis in hepatocyte/Kupffer cell cocultures by glucagon-elicited prostaglandin production in Kupffer cells. 1995 Hepatology pmid:7590678
You Q et al. Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. 2008 Hepatology pmid:18712788
Kuboki S et al. Peroxisome proliferator-activated receptor-gamma protects against hepatic ischemia/reperfusion injury in mice. 2008 Hepatology pmid:18085707
Beckh K et al. Direct regulation of bile secretion by prostaglandins in perfused rat liver. 1994 Hepatology pmid:8175143
Athari A et al. Prostaglandin F2 alpha and D2 release from primary Ito cell cultures after stimulation with noradrenaline and ATP but not adenosine. 1994 Hepatology pmid:8020883
Tzung SP et al. Suppression of hepatic lymphokine-activated killer cell induction by murine Kupffer cells and hepatocytes. 1990 Hepatology pmid:2210667
Akerboom T et al. Cholestasis and changes of portal pressure caused by chlorpromazine in the perfused rat liver. 1991 Hepatology pmid:1899850
Han Z et al. 15-deoxy-Δ12,14 -prostaglandin J2 reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury in mice. 2012 Hepatology pmid:22371273
González-Utor AL et al. Cytochemical localization of K(+)-dependent p-nitrophenyl phosphatase and adenylate cyclase by using one-step method in human washed platelets. 1992 Histochemistry pmid:1330994
Nishi S et al. Different effects of prostaglandin E1, E2 and D2 on pancreatic somatostatin release. 1984 Horm. Metab. Res. pmid:6152434
Mitsuma T and Nogimori T Effects of substance P, angiotensin II, oxotremorine and prostaglandin D2 on thyrotropin secretion in rats. 1984 Horm. Res. pmid:6201427
Kawamoto K [Flow cytometric analysis of cell cycle for the action mechanism of antineoplastic agents]. 1995 Hum. Cell pmid:8652450
Yokoyama Y et al. Synergistic antiproliferative effect of delta 12-prostaglandin J2 (delta 12-PGJ2) and hyperthermia on human esophageal cancer cell lines. 2000 Hum. Cell pmid:10937344
Philibert P et al. Unilateral cryptorchidism in mice mutant for Ptgds. 2013 Hum. Mutat. pmid:23076868