PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Leukemia D007938 74 associated lipids
Hyperlipidemias D006949 73 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Coronary Disease D003327 70 associated lipids
Colitis D003092 69 associated lipids
Melanoma D008545 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Neuroblastoma D009447 66 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Houston KD et al. Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. 2003 Cancer Res. pmid:12649180
Mueller C et al. Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma. 2003 Arch. Biochem. Biophys. pmid:14522590
Rehan V and Torday J Hyperoxia augments pulmonary lipofibroblast-to-myofibroblast transdifferentiation. 2003 Cell Biochem. Biophys. pmid:12794266
Aoun P et al. Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12824244
Sugimoto H et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. 2003 J. Pharmacol. Exp. Ther. pmid:12649388
Saito S et al. 15-Deoxy-Delta(12,14)-prostaglandin J2 induces apoptosis through activation of the CHOP gene in HeLa cells. 2003 Biochem. Biophys. Res. Commun. pmid:14575689
Zamuner SR et al. Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction. 2003 Gut pmid:14633948
Shibata T et al. An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome. 2003 Biochemistry pmid:14636064
Mohri I et al. Hematopoietic prostaglandin D synthase is expressed in microglia in the developing postnatal mouse brain. 2003 Glia pmid:12673832
Takata K et al. Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation. 2003 J. Pharmacol. Sci. pmid:12719662
Liu JD et al. Involvement of c-jun N-terminal kinase activation in 15-deoxy-delta12,14-prostaglandin J2-and prostaglandin A1-induced apoptosis in AGS gastric epithelial cells. 2003 Mol. Carcinog. pmid:12720296
Jung KM et al. Activation of p38 mitogen-activated protein kinase and activator protein-1 during the promotion of neurite extension of PC-12 cells by 15-deoxy-delta12,14-prostaglandin J2. 2003 Mol. Pharmacol. pmid:12606768
Abe M et al. GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12615657
Qin C et al. Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. 2003 Cancer Res. pmid:12615709
Hirano A et al. Arachidonic acid-induced channel- and carrier-type ion transport across planar bilayer lipid membranes. 2003 Anal Sci pmid:12608744
Takano H and Komuro I Roles of peroxisome proliferator-activated receptor gamma in cardiovascular disease. 2002 Jan-Feb J. Diabetes Complicat. pmid:11872377
Harris SG et al. Prostaglandins as modulators of immunity. 2002 Trends Immunol. pmid:11864843
Fahmi H et al. Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the activator protein 1. 2002 Osteoarthr. Cartil. pmid:11869069
Pizzimenti S et al. Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation. 2002 Free Radic. Biol. Med. pmid:11827749
Büyükgüzel K et al. Prostaglandin biosynthesis by midgut tissue isolated from the tobacco hornworm, Manduca sexta. 2002 Insect Biochem. Mol. Biol. pmid:11886778
González E et al. Streptozotocin-pancreatic damage in the rat: modulatory effect of 15-deoxy delta12,14-prostaglandin j(2) on nitridergic and prostanoid pathway. 2002 Nitric Oxide pmid:11890746
Monneret G et al. 15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophils. 2002 J. Immunol. pmid:11907120
Hayaishi O and Urade Y Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives. 2002 Neuroscientist pmid:11843094
Harris SG and Phipps RP Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells. 2002 Immunology pmid:11849312
Masamune A et al. Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells. 2002 Pancreas pmid:11854617
Diab A et al. Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis. 2002 J. Immunol. pmid:11859145
Adams IR and McLaren A Sexually dimorphic development of mouse primordial germ cells: switching from oogenesis to spermatogenesis. 2002 Development pmid:11874911
Mellor EA et al. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. 2002 J. Exp. Med. pmid:11877481
Xie S et al. 15 deoxy delta12,14 PGJ2 induces procoagulant activity in cultured human endothelial cells. 2002 Thromb. Haemost. pmid:11916086
Rovin BH et al. 15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death. 2002 Kidney Int. pmid:11918736
Mondoro TH and Vostal JG Cold temperatures reduce the sensitivity of stored platelets to disaggregating agents. 2002 Platelets pmid:11918832
Noverr MC et al. Production of prostaglandins and leukotrienes by pathogenic fungi. 2002 Infect. Immun. pmid:11748207
Schoppee PD et al. Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells. 2002 Biol. Reprod. pmid:11751282
Chen GG et al. Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer. 2002 Life Sci. pmid:12269390
Harris SG et al. 15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway. 2002 J. Immunol. pmid:11801678
Diaz BL et al. Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids. 2002 J. Immunol. pmid:11801681
Cheuk BL et al. Cyclooxygenase-2 regulates apoptosis in rat epididymis through prostaglandin D2. 2002 Biol. Reprod. pmid:11804951
Hayaishi O Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D(2) system. 2002 J. Appl. Physiol. pmid:11796702
Dieter P et al. Lipopolysaccharide-induced release of arachidonic acid and prostaglandins in liver macrophages: regulation by Group IV cytosolic phospholipase A2, but not by Group V and Group IIA secretory phospholipase A2. 2002 Cell. Signal. pmid:11812647
Michimata T et al. Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D(2)-mediated manner. 2002 Mol. Hum. Reprod. pmid:11818521
Masamune A et al. Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells. 2002 J. Biol. Chem. pmid:11606585
Chen SY et al. 15-Deoxy-delta12,14-prostaglandin J2 induces apoptosis of a thyroid papillary cancer cell line (CG3 cells) through increasing intracellular iron and oxidative stress. 2002 Anticancer Drugs pmid:12187333
Yamamoto S et al. Agents that elevate cyclic AMP induce receptor phosphorylation primarily at serine 331 in HEK 293 cells overexpressing human thromboxane receptor alpha. 2002 Biochem. Pharmacol. pmid:12147288
Sakurai S et al. Retinal capillary pericyte proliferation and c-Fos mRNA induction by prostaglandin D2 through the cAMP response element. 2002 Invest. Ophthalmol. Vis. Sci. pmid:12147615
Saito S et al. Prostaglandin D2 and reproduction. 2002 Am. J. Reprod. Immunol. pmid:12148545
Miyazaki Y et al. Inhibitory effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39. 2002 Biochem. Biophys. Res. Commun. pmid:12150985
Fernández-Tomé Mdel C et al. Phospholipase C inhibitors and prostaglandins differentially regulate phosphatidylcholine synthesis in rat renal papilla. Evidence of compartmental regulation of CTP:phosphocholine cytidylyltransferase and CDP-choline:1,2-diacylglycerol cholinephosphotransferase. 2002 Biochim. Biophys. Acta pmid:12117562
Kohyama T et al. PGD(2) modulates fibroblast-mediated native collagen gel contraction. 2002 Am. J. Respir. Cell Mol. Biol. pmid:12204901
Nencioni A et al. Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor gamma. 2002 J. Immunol. pmid:12133943
Kudoh I et al. [Prostanoids and acute lung injury]. 2002 Masui pmid:12134647
Meier CA et al. Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activated receptor gamma. 2002 Cytokine pmid:12160520
Ushikubi F and Narumiya S [The roles of the prostanoids played in the body]. 2002 Nippon Yakurigaku Zasshi pmid:11979724
Quraishi O et al. Inhibition of inducible prostaglandin E(2) synthase by 15-deoxy-Delta(12,14)-prostaglandin J(2) and polyunsaturated fatty acids. 2002 Biochem. Pharmacol. pmid:11931852
Cao J et al. In vitro pharmacological characterization of the prostanoid receptor population in the non-pregnant porcine myometrium. 2002 Eur. J. Pharmacol. pmid:12020689
Gong P et al. Activation of the mouse heme oxygenase-1 gene by 15-deoxy-Delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2. 2002 Antioxid. Redox Signal. pmid:12006176
Hong JT et al. Inhibitory effect of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells. 2002 J. Toxicol. Environ. Health Part A pmid:11936221
Mujumdar VS et al. Mechanism of constrictive vascular remodeling by homocysteine: role of PPAR. 2002 Am. J. Physiol., Cell Physiol. pmid:11940516
Padilla J et al. Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists. 2002 Clin. Immunol. pmid:11987982
Natarajan C and Bright JJ Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. 2002 Genes Immun. pmid:11960303
Cuzzocrea S et al. The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation. 2002 Mol. Pharmacol. pmid:11961117
Kojima K et al. Effect of PPARgamma ligands on the viability of gastric epithelial cells. 2002 Aliment. Pharmacol. Ther. pmid:11966526
Lee B et al. Prostaglandin D synthase in the prenatal ovine brain and effects of its inhibition with selenium chloride on fetal sleep/wake activity in utero. 2002 J. Neurosci. pmid:12097519
Wang YL et al. Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival. 2002 J. Biol. Chem. pmid:12082115
Huang WC et al. Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. 2002 Exp. Cell Res. pmid:12083801
Kondo M et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12032289
Krishnaswamy G et al. Regulation of eosinophil-active cytokine production from human cord blood-derived mast cells. 2002 J. Interferon Cytokine Res. pmid:12034046
Sawano H et al. 15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. 2002 Kidney Int. pmid:12028436
Zander T et al. Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. 2002 J. Neurochem. pmid:12065618
Yagami T et al. Group IB secretory phospholipase A2 induces neuronal cell death via apoptosis. 2002 J. Neurochem. pmid:12065654
Fujino T et al. Effects of the prostanoids on the proliferation or hypertrophy of cultured murine aortic smooth muscle cells. 2002 Br. J. Pharmacol. pmid:12055131
Marx N PPARgamma and vascular inflammation: adding another piece to the puzzle. 2002 Circ. Res. pmid:12215484
Takata Y et al. Vascular inflammation is negatively autoregulated by interaction between CCAAT/enhancer-binding protein-delta and peroxisome proliferator-activated receptor-gamma. 2002 Circ. Res. pmid:12215492
Ahn SG et al. Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2). 2002 Exp. Mol. Med. pmid:12216117
Mössner R et al. Agonists of peroxisome proliferator-activated receptor gamma inhibit cell growth in malignant melanoma. 2002 J. Invest. Dermatol. pmid:12230498
Iwasaki M et al. Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. 2002 J. Invest. Dermatol. pmid:12230502
Jozkowicz A et al. Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1. 2002 Antioxid. Redox Signal. pmid:12230869
Haslmayer P et al. The peroxisome proliferator-activated receptor gamma ligand 15-deoxy-Delta12,14-prostaglandin J2 induces vascular endothelial growth factor in the hormone-independent prostate cancer cell line PC 3 and the urinary bladder carcinoma cell line 5637. 2002 Int. J. Oncol. pmid:12239635
Clay CE et al. 15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells. 2002 J. Lipid Res. pmid:12401880
Imaizumi T et al. 15-Deoxy-D12,14-prostaglandin J2 inhibits CX3CL1/fractalkine expression in human endothelial cells. 2002 Immunol. Cell Biol. pmid:12406386
Kim SY et al. Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. 2002 Phytother Res pmid:12410540
Jawerbaum A et al. Modulation of nitric oxide concentration and lipid metabolism by 15-deoxy Delta12,14prostaglandin J2 in embryos from control and diabetic rats during early organogenesis. 2002 Reproduction pmid:12417000
Kubata BK et al. A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi. 2002 J. Exp. Med. pmid:12417633
Nencioni A et al. Cyclopentenone prostaglandins induce caspase activation and apoptosis in dendritic cells by a PPAR-gamma-independent mechanism: regulation by inflammatory and T cell-derived stimuli. 2002 Exp. Hematol. pmid:12225793
Menè P Prostaglandin D2 : a Cinderella of vascular cell biology? 2002 J. Hypertens. pmid:12131515
Hunt MJ and Tyagi SC Peroxisome proliferators compete and ameliorate Hcy-mediated endocardial endothelial cell activation. 2002 Am. J. Physiol., Cell Physiol. pmid:12225971
Negoro H et al. Endogenous prostaglandin D2 synthesis reduces an increase in plasminogen activator inhibitor-1 following interleukin stimulation in bovine endothelial cells. 2002 J. Hypertens. pmid:12131531
Stubbs VE et al. Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils. 2002 J. Biol. Chem. pmid:11980903
Suzuki-Nishimura T and Uchida MK Prostaglandin D2 generation by rat peritoneal mast cells stimulated with Datura stramonium agglutinin and its inhibition by haptenic sugar and wheat germ agglutinin. 2002 Jpn. J. Pharmacol. pmid:12396030
Kanehara H et al. Thrombomodulin expression by THP-1 but not by vascular endothelial cells is upregulated by pioglitazone. 2002 Thromb. Res. pmid:12617986
Satoh T and Watanabe Y [Cyclopentenone prostaglandin derivatives as neuroprotective compounds]. 2002 Tanpakushitsu Kakusan Koso pmid:12486935
Larsen P et al. Calcium-stimulated short-circuit currents in the canine proximal colonic epithelium: effects of DK-PGD2, a metabolite of prostaglandin D2. 2002 Can. J. Physiol. Pharmacol. pmid:12489928
Satoh T [Neurotrophin-like low molecular weight compounds]. 2002 Nippon Yakurigaku Zasshi pmid:12491808
Gueck T et al. Influence of vitamin E on mast cell mediator release. 2002 Vet. Dermatol. pmid:12464062
Sawyer N et al. Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. 2002 Br. J. Pharmacol. pmid:12466225
Yang X et al. Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells. 2002 Am. J. Respir. Cell Mol. Biol. pmid:12444028
Nikitakis NG et al. 15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells. 2002 Br. J. Cancer pmid:12454768
Fahmi H et al. 15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes. 2002 Osteoarthr. Cartil. pmid:12435328
Vitzthum H et al. Gene expression of prostanoid forming enzymes along the rat nephron. 2002 Kidney Int. pmid:12371957
Higashi N et al. A comparative study of eicosanoid concentrations in sputum and urine in patients with aspirin-intolerant asthma. 2002 Clin. Exp. Allergy pmid:12372129
Zhang J et al. 15-Deoxy-prostaglandin J(2) inhibits PDGF-A and -B chain expression in human vascular endothelial cells independent of PPAR gamma. 2002 Biochem. Biophys. Res. Commun. pmid:12379230